Biodistribution of GB-10 (Na2 10B10H10) compound for boron neutron capture therapy (BNCT) in an experimental model of oral cancer in the hamster cheek pouch

Autores
Heber, Elisa Mercedes; Trivillin, Verónica Andrea; Nigg, David; Kreimann, Erica Lorena; Itoiz, María Elina; Jiménez Rebagliati, Raúl Alberto Jorge; Batistoni, Daniel Alberto; Schwint, Amanda Elena
Año de publicación
2004
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective: We previously proposed the hamster cheek pouch model of oral cancer for BNCT studies. We herein present the biodistribution of a non-toxic boron compound, GB-10 (Na210B10H10), in this model to assess its potential for BNCT or BNCT enhanced Fast Neutron Therapy. Materials and methods: We evaluated the uptake and retention of GB-10 in tumour and precancerous tissue and in potentially dose-limiting, clinically relevant normal tissues. Results: Mean tumour boron concentration delivered by GB-10 (50mgB/kg) peaked to 77.7±28.0ppm at 20min post-administration and remained at therapeutically useful values of 31.9±21.4ppm at 3h. The clearance rate for normal tissues was faster than for tumour tissue. The consistently low brain and spinal cord values would preclude normal tissue toxicity. The uptake of GB-10 by precancerous tissue may be of potential use in the treatment of field cancerized areas. GB-10 was deposited homogeneously in different tumour areas, an asset when treating heterogenous tumours. The data suggests that the joint administration of BPA and GB-10 may improve the therapeutic efficacy of BNCT. Conclusions: GB-10 is a potential boron carrier for BNCT of head and neck tumours and for BNCT-FNT.
Fil: Heber, Elisa Mercedes. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; Argentina
Fil: Trivillin, Verónica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; Argentina
Fil: Nigg, David. Idaho National Engineering and Environmental Laboratory; Estados Unidos
Fil: Kreimann, Erica Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; Argentina
Fil: Itoiz, María Elina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; Argentina. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Jiménez Rebagliati, Raúl Alberto Jorge. Comisión Nacional de Energía Atómica; Argentina
Fil: Batistoni, Daniel Alberto. Comisión Nacional de Energía Atómica; Argentina
Fil: Schwint, Amanda Elena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; Argentina
Materia
BNCT
GB-10
HAMSTER CHEEK POUCH
ORAL CANCER
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/162651
Acceder
id CONICETDig_8738bd63c737767f4c6bad8557e537cb
oai_identifier_str oai:ri.conicet.gov.ar:11336/162651
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Biodistribution of GB-10 (Na2 10B10H10) compound for boron neutron capture therapy (BNCT) in an experimental model of oral cancer in the hamster cheek pouchHeber, Elisa MercedesTrivillin, Verónica AndreaNigg, DavidKreimann, Erica LorenaItoiz, María ElinaJiménez Rebagliati, Raúl Alberto JorgeBatistoni, Daniel AlbertoSchwint, Amanda ElenaBNCTGB-10HAMSTER CHEEK POUCHORAL CANCERhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Objective: We previously proposed the hamster cheek pouch model of oral cancer for BNCT studies. We herein present the biodistribution of a non-toxic boron compound, GB-10 (Na210B10H10), in this model to assess its potential for BNCT or BNCT enhanced Fast Neutron Therapy. Materials and methods: We evaluated the uptake and retention of GB-10 in tumour and precancerous tissue and in potentially dose-limiting, clinically relevant normal tissues. Results: Mean tumour boron concentration delivered by GB-10 (50mgB/kg) peaked to 77.7±28.0ppm at 20min post-administration and remained at therapeutically useful values of 31.9±21.4ppm at 3h. The clearance rate for normal tissues was faster than for tumour tissue. The consistently low brain and spinal cord values would preclude normal tissue toxicity. The uptake of GB-10 by precancerous tissue may be of potential use in the treatment of field cancerized areas. GB-10 was deposited homogeneously in different tumour areas, an asset when treating heterogenous tumours. The data suggests that the joint administration of BPA and GB-10 may improve the therapeutic efficacy of BNCT. Conclusions: GB-10 is a potential boron carrier for BNCT of head and neck tumours and for BNCT-FNT.Fil: Heber, Elisa Mercedes. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; ArgentinaFil: Trivillin, Verónica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; ArgentinaFil: Nigg, David. Idaho National Engineering and Environmental Laboratory; Estados UnidosFil: Kreimann, Erica Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; ArgentinaFil: Itoiz, María Elina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; Argentina. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaFil: Jiménez Rebagliati, Raúl Alberto Jorge. Comisión Nacional de Energía Atómica; ArgentinaFil: Batistoni, Daniel Alberto. Comisión Nacional de Energía Atómica; ArgentinaFil: Schwint, Amanda Elena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; ArgentinaElsevier2004-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/162651Heber, Elisa Mercedes; Trivillin, Verónica Andrea; Nigg, David; Kreimann, Erica Lorena; Itoiz, María Elina; et al.; Biodistribution of GB-10 (Na2 10B10H10) compound for boron neutron capture therapy (BNCT) in an experimental model of oral cancer in the hamster cheek pouch; Elsevier; Archives of Oral Biology; 49; 4; 12-2004; 313-3240003-9969CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0003996903002632info:eu-repo/semantics/altIdentifier/doi/10.1016/j.archoralbio.2003.10.003info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:55:42Zoai:ri.conicet.gov.ar:11336/162651instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:55:43.074CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Biodistribution of GB-10 (Na2 10B10H10) compound for boron neutron capture therapy (BNCT) in an experimental model of oral cancer in the hamster cheek pouch
title Biodistribution of GB-10 (Na2 10B10H10) compound for boron neutron capture therapy (BNCT) in an experimental model of oral cancer in the hamster cheek pouch
spellingShingle Biodistribution of GB-10 (Na2 10B10H10) compound for boron neutron capture therapy (BNCT) in an experimental model of oral cancer in the hamster cheek pouch
Heber, Elisa Mercedes
BNCT
GB-10
HAMSTER CHEEK POUCH
ORAL CANCER
title_short Biodistribution of GB-10 (Na2 10B10H10) compound for boron neutron capture therapy (BNCT) in an experimental model of oral cancer in the hamster cheek pouch
title_full Biodistribution of GB-10 (Na2 10B10H10) compound for boron neutron capture therapy (BNCT) in an experimental model of oral cancer in the hamster cheek pouch
title_fullStr Biodistribution of GB-10 (Na2 10B10H10) compound for boron neutron capture therapy (BNCT) in an experimental model of oral cancer in the hamster cheek pouch
title_full_unstemmed Biodistribution of GB-10 (Na2 10B10H10) compound for boron neutron capture therapy (BNCT) in an experimental model of oral cancer in the hamster cheek pouch
title_sort Biodistribution of GB-10 (Na2 10B10H10) compound for boron neutron capture therapy (BNCT) in an experimental model of oral cancer in the hamster cheek pouch
dc.creator.none.fl_str_mv Heber, Elisa Mercedes
Trivillin, Verónica Andrea
Nigg, David
Kreimann, Erica Lorena
Itoiz, María Elina
Jiménez Rebagliati, Raúl Alberto Jorge
Batistoni, Daniel Alberto
Schwint, Amanda Elena
author Heber, Elisa Mercedes
author_facet Heber, Elisa Mercedes
Trivillin, Verónica Andrea
Nigg, David
Kreimann, Erica Lorena
Itoiz, María Elina
Jiménez Rebagliati, Raúl Alberto Jorge
Batistoni, Daniel Alberto
Schwint, Amanda Elena
author_role author
author2 Trivillin, Verónica Andrea
Nigg, David
Kreimann, Erica Lorena
Itoiz, María Elina
Jiménez Rebagliati, Raúl Alberto Jorge
Batistoni, Daniel Alberto
Schwint, Amanda Elena
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BNCT
GB-10
HAMSTER CHEEK POUCH
ORAL CANCER
topic BNCT
GB-10
HAMSTER CHEEK POUCH
ORAL CANCER
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Objective: We previously proposed the hamster cheek pouch model of oral cancer for BNCT studies. We herein present the biodistribution of a non-toxic boron compound, GB-10 (Na210B10H10), in this model to assess its potential for BNCT or BNCT enhanced Fast Neutron Therapy. Materials and methods: We evaluated the uptake and retention of GB-10 in tumour and precancerous tissue and in potentially dose-limiting, clinically relevant normal tissues. Results: Mean tumour boron concentration delivered by GB-10 (50mgB/kg) peaked to 77.7±28.0ppm at 20min post-administration and remained at therapeutically useful values of 31.9±21.4ppm at 3h. The clearance rate for normal tissues was faster than for tumour tissue. The consistently low brain and spinal cord values would preclude normal tissue toxicity. The uptake of GB-10 by precancerous tissue may be of potential use in the treatment of field cancerized areas. GB-10 was deposited homogeneously in different tumour areas, an asset when treating heterogenous tumours. The data suggests that the joint administration of BPA and GB-10 may improve the therapeutic efficacy of BNCT. Conclusions: GB-10 is a potential boron carrier for BNCT of head and neck tumours and for BNCT-FNT.
Fil: Heber, Elisa Mercedes. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; Argentina
Fil: Trivillin, Verónica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; Argentina
Fil: Nigg, David. Idaho National Engineering and Environmental Laboratory; Estados Unidos
Fil: Kreimann, Erica Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; Argentina
Fil: Itoiz, María Elina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; Argentina. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Jiménez Rebagliati, Raúl Alberto Jorge. Comisión Nacional de Energía Atómica; Argentina
Fil: Batistoni, Daniel Alberto. Comisión Nacional de Energía Atómica; Argentina
Fil: Schwint, Amanda Elena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; Argentina
description Objective: We previously proposed the hamster cheek pouch model of oral cancer for BNCT studies. We herein present the biodistribution of a non-toxic boron compound, GB-10 (Na210B10H10), in this model to assess its potential for BNCT or BNCT enhanced Fast Neutron Therapy. Materials and methods: We evaluated the uptake and retention of GB-10 in tumour and precancerous tissue and in potentially dose-limiting, clinically relevant normal tissues. Results: Mean tumour boron concentration delivered by GB-10 (50mgB/kg) peaked to 77.7±28.0ppm at 20min post-administration and remained at therapeutically useful values of 31.9±21.4ppm at 3h. The clearance rate for normal tissues was faster than for tumour tissue. The consistently low brain and spinal cord values would preclude normal tissue toxicity. The uptake of GB-10 by precancerous tissue may be of potential use in the treatment of field cancerized areas. GB-10 was deposited homogeneously in different tumour areas, an asset when treating heterogenous tumours. The data suggests that the joint administration of BPA and GB-10 may improve the therapeutic efficacy of BNCT. Conclusions: GB-10 is a potential boron carrier for BNCT of head and neck tumours and for BNCT-FNT.
publishDate 2004
dc.date.none.fl_str_mv 2004-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/162651
Heber, Elisa Mercedes; Trivillin, Verónica Andrea; Nigg, David; Kreimann, Erica Lorena; Itoiz, María Elina; et al.; Biodistribution of GB-10 (Na2 10B10H10) compound for boron neutron capture therapy (BNCT) in an experimental model of oral cancer in the hamster cheek pouch; Elsevier; Archives of Oral Biology; 49; 4; 12-2004; 313-324
0003-9969
CONICET Digital
CONICET
url http://hdl.handle.net/11336/162651
identifier_str_mv Heber, Elisa Mercedes; Trivillin, Verónica Andrea; Nigg, David; Kreimann, Erica Lorena; Itoiz, María Elina; et al.; Biodistribution of GB-10 (Na2 10B10H10) compound for boron neutron capture therapy (BNCT) in an experimental model of oral cancer in the hamster cheek pouch; Elsevier; Archives of Oral Biology; 49; 4; 12-2004; 313-324
0003-9969
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0003996903002632
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.archoralbio.2003.10.003
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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