Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons

Autores
Furigo, Isadora C.; Teixeira, Pryscila D. S.; de Souza, Gabriel O.; Couto, Gisele C. L.; Garcia Romero, Guadalupe; Perello, Mario; Frazão, Renata; Elias, Lucila L.; Metzger, Martin; List, Edward O.; Kopchick, John J.; Donato Jr, Jose
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Weight loss triggers important metabolic responses to conserve energy, especially via the fall in leptin levels. Consequently, weight loss becomes increasingly difficult with weight regain commonly occurring in most dieters. Here we show that central growth hormone (GH) signaling also promotes neuroendocrine adaptations during food deprivation. GH activates agouti-related protein (AgRP) neurons and GH receptor (GHR) ablation in AgRP cells mitigates highly characteristic hypothalamic and metabolic adaptations induced by weight loss. Thus, the capacity of mice carrying an AgRP-specific GHR ablation to save energy during food deprivation is impaired, leading to increased fat loss. Additionally, administration of a clinically available GHR antagonist (pegvisomant) attenuates the fall of whole-body energy expenditure of food-deprived mice, similarly as seen by leptin treatment. Our findings indicate GH as a starvation signal that alerts the brain about energy deficiency, triggering key adaptive responses to conserve limited fuel stores.
Fil: Furigo, Isadora C.. Universidade de Sao Paulo; Brasil
Fil: Teixeira, Pryscila D. S.. Universidade de Sao Paulo; Brasil
Fil: de Souza, Gabriel O.. Universidade de Sao Paulo; Brasil
Fil: Couto, Gisele C. L.. Universidade de Sao Paulo; Brasil
Fil: Garcia Romero, Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Perello, Mario. Multidisciplinary Institute Of Cell Biology; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Frazão, Renata. Universidade de Sao Paulo; Brasil
Fil: Elias, Lucila L.. Universidade de Sao Paulo; Brasil
Fil: Metzger, Martin. Universidade de Sao Paulo; Brasil
Fil: List, Edward O.. Universidade de Sao Paulo; Brasil
Fil: Kopchick, John J.. Ohio University; Estados Unidos
Fil: Donato Jr, Jose. Ohio University College Of Osteopathic Medicine; Estados Unidos. Ohio University; Estados Unidos
Materia
FASTING
GROWTH HORMONE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/129034

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network_name_str CONICET Digital (CONICET)
spelling Growth hormone regulates neuroendocrine responses to weight loss via AgRP neuronsFurigo, Isadora C.Teixeira, Pryscila D. S.de Souza, Gabriel O.Couto, Gisele C. L.Garcia Romero, GuadalupePerello, MarioFrazão, RenataElias, Lucila L.Metzger, MartinList, Edward O.Kopchick, John J.Donato Jr, JoseFASTINGGROWTH HORMONEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Weight loss triggers important metabolic responses to conserve energy, especially via the fall in leptin levels. Consequently, weight loss becomes increasingly difficult with weight regain commonly occurring in most dieters. Here we show that central growth hormone (GH) signaling also promotes neuroendocrine adaptations during food deprivation. GH activates agouti-related protein (AgRP) neurons and GH receptor (GHR) ablation in AgRP cells mitigates highly characteristic hypothalamic and metabolic adaptations induced by weight loss. Thus, the capacity of mice carrying an AgRP-specific GHR ablation to save energy during food deprivation is impaired, leading to increased fat loss. Additionally, administration of a clinically available GHR antagonist (pegvisomant) attenuates the fall of whole-body energy expenditure of food-deprived mice, similarly as seen by leptin treatment. Our findings indicate GH as a starvation signal that alerts the brain about energy deficiency, triggering key adaptive responses to conserve limited fuel stores.Fil: Furigo, Isadora C.. Universidade de Sao Paulo; BrasilFil: Teixeira, Pryscila D. S.. Universidade de Sao Paulo; BrasilFil: de Souza, Gabriel O.. Universidade de Sao Paulo; BrasilFil: Couto, Gisele C. L.. Universidade de Sao Paulo; BrasilFil: Garcia Romero, Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Perello, Mario. Multidisciplinary Institute Of Cell Biology; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Frazão, Renata. Universidade de Sao Paulo; BrasilFil: Elias, Lucila L.. Universidade de Sao Paulo; BrasilFil: Metzger, Martin. Universidade de Sao Paulo; BrasilFil: List, Edward O.. Universidade de Sao Paulo; BrasilFil: Kopchick, John J.. Ohio University; Estados UnidosFil: Donato Jr, Jose. Ohio University College Of Osteopathic Medicine; Estados Unidos. Ohio University; Estados UnidosNature Publishing Group2019-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/129034Furigo, Isadora C.; Teixeira, Pryscila D. S.; de Souza, Gabriel O.; Couto, Gisele C. L.; Garcia Romero, Guadalupe; et al.; Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons; Nature Publishing Group; Nature Communications; 10; 662; 12-2019; 1-112041-1723CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41467-019-08607-1info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41467-019-08607-1info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:03:49Zoai:ri.conicet.gov.ar:11336/129034instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:03:50.31CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons
title Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons
spellingShingle Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons
Furigo, Isadora C.
FASTING
GROWTH HORMONE
title_short Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons
title_full Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons
title_fullStr Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons
title_full_unstemmed Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons
title_sort Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons
dc.creator.none.fl_str_mv Furigo, Isadora C.
Teixeira, Pryscila D. S.
de Souza, Gabriel O.
Couto, Gisele C. L.
Garcia Romero, Guadalupe
Perello, Mario
Frazão, Renata
Elias, Lucila L.
Metzger, Martin
List, Edward O.
Kopchick, John J.
Donato Jr, Jose
author Furigo, Isadora C.
author_facet Furigo, Isadora C.
Teixeira, Pryscila D. S.
de Souza, Gabriel O.
Couto, Gisele C. L.
Garcia Romero, Guadalupe
Perello, Mario
Frazão, Renata
Elias, Lucila L.
Metzger, Martin
List, Edward O.
Kopchick, John J.
Donato Jr, Jose
author_role author
author2 Teixeira, Pryscila D. S.
de Souza, Gabriel O.
Couto, Gisele C. L.
Garcia Romero, Guadalupe
Perello, Mario
Frazão, Renata
Elias, Lucila L.
Metzger, Martin
List, Edward O.
Kopchick, John J.
Donato Jr, Jose
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv FASTING
GROWTH HORMONE
topic FASTING
GROWTH HORMONE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Weight loss triggers important metabolic responses to conserve energy, especially via the fall in leptin levels. Consequently, weight loss becomes increasingly difficult with weight regain commonly occurring in most dieters. Here we show that central growth hormone (GH) signaling also promotes neuroendocrine adaptations during food deprivation. GH activates agouti-related protein (AgRP) neurons and GH receptor (GHR) ablation in AgRP cells mitigates highly characteristic hypothalamic and metabolic adaptations induced by weight loss. Thus, the capacity of mice carrying an AgRP-specific GHR ablation to save energy during food deprivation is impaired, leading to increased fat loss. Additionally, administration of a clinically available GHR antagonist (pegvisomant) attenuates the fall of whole-body energy expenditure of food-deprived mice, similarly as seen by leptin treatment. Our findings indicate GH as a starvation signal that alerts the brain about energy deficiency, triggering key adaptive responses to conserve limited fuel stores.
Fil: Furigo, Isadora C.. Universidade de Sao Paulo; Brasil
Fil: Teixeira, Pryscila D. S.. Universidade de Sao Paulo; Brasil
Fil: de Souza, Gabriel O.. Universidade de Sao Paulo; Brasil
Fil: Couto, Gisele C. L.. Universidade de Sao Paulo; Brasil
Fil: Garcia Romero, Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Perello, Mario. Multidisciplinary Institute Of Cell Biology; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Frazão, Renata. Universidade de Sao Paulo; Brasil
Fil: Elias, Lucila L.. Universidade de Sao Paulo; Brasil
Fil: Metzger, Martin. Universidade de Sao Paulo; Brasil
Fil: List, Edward O.. Universidade de Sao Paulo; Brasil
Fil: Kopchick, John J.. Ohio University; Estados Unidos
Fil: Donato Jr, Jose. Ohio University College Of Osteopathic Medicine; Estados Unidos. Ohio University; Estados Unidos
description Weight loss triggers important metabolic responses to conserve energy, especially via the fall in leptin levels. Consequently, weight loss becomes increasingly difficult with weight regain commonly occurring in most dieters. Here we show that central growth hormone (GH) signaling also promotes neuroendocrine adaptations during food deprivation. GH activates agouti-related protein (AgRP) neurons and GH receptor (GHR) ablation in AgRP cells mitigates highly characteristic hypothalamic and metabolic adaptations induced by weight loss. Thus, the capacity of mice carrying an AgRP-specific GHR ablation to save energy during food deprivation is impaired, leading to increased fat loss. Additionally, administration of a clinically available GHR antagonist (pegvisomant) attenuates the fall of whole-body energy expenditure of food-deprived mice, similarly as seen by leptin treatment. Our findings indicate GH as a starvation signal that alerts the brain about energy deficiency, triggering key adaptive responses to conserve limited fuel stores.
publishDate 2019
dc.date.none.fl_str_mv 2019-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/129034
Furigo, Isadora C.; Teixeira, Pryscila D. S.; de Souza, Gabriel O.; Couto, Gisele C. L.; Garcia Romero, Guadalupe; et al.; Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons; Nature Publishing Group; Nature Communications; 10; 662; 12-2019; 1-11
2041-1723
CONICET Digital
CONICET
url http://hdl.handle.net/11336/129034
identifier_str_mv Furigo, Isadora C.; Teixeira, Pryscila D. S.; de Souza, Gabriel O.; Couto, Gisele C. L.; Garcia Romero, Guadalupe; et al.; Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons; Nature Publishing Group; Nature Communications; 10; 662; 12-2019; 1-11
2041-1723
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/s41467-019-08607-1
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41467-019-08607-1
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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