Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons
- Autores
- Furigo, Isadora C.; Teixeira, Pryscila D. S.; de Souza, Gabriel O.; Couto, Gisele C. L.; Garcia Romero, Guadalupe; Perello, Mario; Frazão, Renata; Elias, Lucila L.; Metzger, Martin; List, Edward O.; Kopchick, John J.; Donato Jr, Jose
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Weight loss triggers important metabolic responses to conserve energy, especially via the fall in leptin levels. Consequently, weight loss becomes increasingly difficult with weight regain commonly occurring in most dieters. Here we show that central growth hormone (GH) signaling also promotes neuroendocrine adaptations during food deprivation. GH activates agouti-related protein (AgRP) neurons and GH receptor (GHR) ablation in AgRP cells mitigates highly characteristic hypothalamic and metabolic adaptations induced by weight loss. Thus, the capacity of mice carrying an AgRP-specific GHR ablation to save energy during food deprivation is impaired, leading to increased fat loss. Additionally, administration of a clinically available GHR antagonist (pegvisomant) attenuates the fall of whole-body energy expenditure of food-deprived mice, similarly as seen by leptin treatment. Our findings indicate GH as a starvation signal that alerts the brain about energy deficiency, triggering key adaptive responses to conserve limited fuel stores.
Fil: Furigo, Isadora C.. Universidade de Sao Paulo; Brasil
Fil: Teixeira, Pryscila D. S.. Universidade de Sao Paulo; Brasil
Fil: de Souza, Gabriel O.. Universidade de Sao Paulo; Brasil
Fil: Couto, Gisele C. L.. Universidade de Sao Paulo; Brasil
Fil: Garcia Romero, Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Perello, Mario. Multidisciplinary Institute Of Cell Biology; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Frazão, Renata. Universidade de Sao Paulo; Brasil
Fil: Elias, Lucila L.. Universidade de Sao Paulo; Brasil
Fil: Metzger, Martin. Universidade de Sao Paulo; Brasil
Fil: List, Edward O.. Universidade de Sao Paulo; Brasil
Fil: Kopchick, John J.. Ohio University; Estados Unidos
Fil: Donato Jr, Jose. Ohio University College Of Osteopathic Medicine; Estados Unidos. Ohio University; Estados Unidos - Materia
-
FASTING
GROWTH HORMONE - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/129034
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Growth hormone regulates neuroendocrine responses to weight loss via AgRP neuronsFurigo, Isadora C.Teixeira, Pryscila D. S.de Souza, Gabriel O.Couto, Gisele C. L.Garcia Romero, GuadalupePerello, MarioFrazão, RenataElias, Lucila L.Metzger, MartinList, Edward O.Kopchick, John J.Donato Jr, JoseFASTINGGROWTH HORMONEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Weight loss triggers important metabolic responses to conserve energy, especially via the fall in leptin levels. Consequently, weight loss becomes increasingly difficult with weight regain commonly occurring in most dieters. Here we show that central growth hormone (GH) signaling also promotes neuroendocrine adaptations during food deprivation. GH activates agouti-related protein (AgRP) neurons and GH receptor (GHR) ablation in AgRP cells mitigates highly characteristic hypothalamic and metabolic adaptations induced by weight loss. Thus, the capacity of mice carrying an AgRP-specific GHR ablation to save energy during food deprivation is impaired, leading to increased fat loss. Additionally, administration of a clinically available GHR antagonist (pegvisomant) attenuates the fall of whole-body energy expenditure of food-deprived mice, similarly as seen by leptin treatment. Our findings indicate GH as a starvation signal that alerts the brain about energy deficiency, triggering key adaptive responses to conserve limited fuel stores.Fil: Furigo, Isadora C.. Universidade de Sao Paulo; BrasilFil: Teixeira, Pryscila D. S.. Universidade de Sao Paulo; BrasilFil: de Souza, Gabriel O.. Universidade de Sao Paulo; BrasilFil: Couto, Gisele C. L.. Universidade de Sao Paulo; BrasilFil: Garcia Romero, Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Perello, Mario. Multidisciplinary Institute Of Cell Biology; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Frazão, Renata. Universidade de Sao Paulo; BrasilFil: Elias, Lucila L.. Universidade de Sao Paulo; BrasilFil: Metzger, Martin. Universidade de Sao Paulo; BrasilFil: List, Edward O.. Universidade de Sao Paulo; BrasilFil: Kopchick, John J.. Ohio University; Estados UnidosFil: Donato Jr, Jose. Ohio University College Of Osteopathic Medicine; Estados Unidos. Ohio University; Estados UnidosNature Publishing Group2019-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/129034Furigo, Isadora C.; Teixeira, Pryscila D. S.; de Souza, Gabriel O.; Couto, Gisele C. L.; Garcia Romero, Guadalupe; et al.; Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons; Nature Publishing Group; Nature Communications; 10; 662; 12-2019; 1-112041-1723CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41467-019-08607-1info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41467-019-08607-1info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:03:49Zoai:ri.conicet.gov.ar:11336/129034instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:03:50.31CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons |
title |
Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons |
spellingShingle |
Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons Furigo, Isadora C. FASTING GROWTH HORMONE |
title_short |
Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons |
title_full |
Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons |
title_fullStr |
Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons |
title_full_unstemmed |
Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons |
title_sort |
Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons |
dc.creator.none.fl_str_mv |
Furigo, Isadora C. Teixeira, Pryscila D. S. de Souza, Gabriel O. Couto, Gisele C. L. Garcia Romero, Guadalupe Perello, Mario Frazão, Renata Elias, Lucila L. Metzger, Martin List, Edward O. Kopchick, John J. Donato Jr, Jose |
author |
Furigo, Isadora C. |
author_facet |
Furigo, Isadora C. Teixeira, Pryscila D. S. de Souza, Gabriel O. Couto, Gisele C. L. Garcia Romero, Guadalupe Perello, Mario Frazão, Renata Elias, Lucila L. Metzger, Martin List, Edward O. Kopchick, John J. Donato Jr, Jose |
author_role |
author |
author2 |
Teixeira, Pryscila D. S. de Souza, Gabriel O. Couto, Gisele C. L. Garcia Romero, Guadalupe Perello, Mario Frazão, Renata Elias, Lucila L. Metzger, Martin List, Edward O. Kopchick, John J. Donato Jr, Jose |
author2_role |
author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
FASTING GROWTH HORMONE |
topic |
FASTING GROWTH HORMONE |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Weight loss triggers important metabolic responses to conserve energy, especially via the fall in leptin levels. Consequently, weight loss becomes increasingly difficult with weight regain commonly occurring in most dieters. Here we show that central growth hormone (GH) signaling also promotes neuroendocrine adaptations during food deprivation. GH activates agouti-related protein (AgRP) neurons and GH receptor (GHR) ablation in AgRP cells mitigates highly characteristic hypothalamic and metabolic adaptations induced by weight loss. Thus, the capacity of mice carrying an AgRP-specific GHR ablation to save energy during food deprivation is impaired, leading to increased fat loss. Additionally, administration of a clinically available GHR antagonist (pegvisomant) attenuates the fall of whole-body energy expenditure of food-deprived mice, similarly as seen by leptin treatment. Our findings indicate GH as a starvation signal that alerts the brain about energy deficiency, triggering key adaptive responses to conserve limited fuel stores. Fil: Furigo, Isadora C.. Universidade de Sao Paulo; Brasil Fil: Teixeira, Pryscila D. S.. Universidade de Sao Paulo; Brasil Fil: de Souza, Gabriel O.. Universidade de Sao Paulo; Brasil Fil: Couto, Gisele C. L.. Universidade de Sao Paulo; Brasil Fil: Garcia Romero, Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina Fil: Perello, Mario. Multidisciplinary Institute Of Cell Biology; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina Fil: Frazão, Renata. Universidade de Sao Paulo; Brasil Fil: Elias, Lucila L.. Universidade de Sao Paulo; Brasil Fil: Metzger, Martin. Universidade de Sao Paulo; Brasil Fil: List, Edward O.. Universidade de Sao Paulo; Brasil Fil: Kopchick, John J.. Ohio University; Estados Unidos Fil: Donato Jr, Jose. Ohio University College Of Osteopathic Medicine; Estados Unidos. Ohio University; Estados Unidos |
description |
Weight loss triggers important metabolic responses to conserve energy, especially via the fall in leptin levels. Consequently, weight loss becomes increasingly difficult with weight regain commonly occurring in most dieters. Here we show that central growth hormone (GH) signaling also promotes neuroendocrine adaptations during food deprivation. GH activates agouti-related protein (AgRP) neurons and GH receptor (GHR) ablation in AgRP cells mitigates highly characteristic hypothalamic and metabolic adaptations induced by weight loss. Thus, the capacity of mice carrying an AgRP-specific GHR ablation to save energy during food deprivation is impaired, leading to increased fat loss. Additionally, administration of a clinically available GHR antagonist (pegvisomant) attenuates the fall of whole-body energy expenditure of food-deprived mice, similarly as seen by leptin treatment. Our findings indicate GH as a starvation signal that alerts the brain about energy deficiency, triggering key adaptive responses to conserve limited fuel stores. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/129034 Furigo, Isadora C.; Teixeira, Pryscila D. S.; de Souza, Gabriel O.; Couto, Gisele C. L.; Garcia Romero, Guadalupe; et al.; Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons; Nature Publishing Group; Nature Communications; 10; 662; 12-2019; 1-11 2041-1723 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/129034 |
identifier_str_mv |
Furigo, Isadora C.; Teixeira, Pryscila D. S.; de Souza, Gabriel O.; Couto, Gisele C. L.; Garcia Romero, Guadalupe; et al.; Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons; Nature Publishing Group; Nature Communications; 10; 662; 12-2019; 1-11 2041-1723 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41467-019-08607-1 info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41467-019-08607-1 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842269822297047040 |
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13.13397 |