Evaluation of carbon nanotubes as chiral selectors for continuous-flow enantiomeric separation of carvedilol with fluorescent detection

Autores
Silva, Raúl Alejandro; Talio, María Carolina; Luconi, Marta Olga; Fernandez, Liliana Patricia
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Single-walled carbon nanotubes (SWNT) are proposed as chiral selectors for separation of carvedilol stereoisomers beginning since its racemic mixture. The novel developed FIA-methodology employs a microcolumn (mC) packed with a few milligrams of SWNT which showed to be effective in S(-) and R(+) carvedilol separation. Attending to spectral properties of analytes, molecular fluorescence was employed in the detection step. Separation of carvedilol enantiomers was achieved in less than 70. s with an acceptable resolution factor of 3.16. Variables that influence the chiral separation such as pH and composition of eluent solution, sample injection volume and flow rate, activation mode of NTs and mass of the same in column have been examined in detail. At optimal operational conditions, well repeatability was achieved using the same column for more than 100 injections, putting in evidence the stability of nanomaterial and the efficacy and versatility of the proposed FIA-configuration. The new methodology was successfully applied to S(-) and R(+) carvedilol quantification in pharmaceutical preparations, resulting an attractive alternative to traditional separative methods being fast, simple, using low cost instrumentation and producing scarce waste.far
Fil: Silva, Raúl Alejandro. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química. Área de Química Analítica; Argentina
Fil: Talio, María Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Luconi, Marta Olga. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química. Área de Química Analítica; Argentina
Fil: Fernandez, Liliana Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Materia
CARBON NANOTUBES
CARVEDILOL STEREOISOMERS
CHIRAL SEPARATION
FIA-MOLECULAR FLUORESCENCE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/92842

id CONICETDig_b21f4f4950c557bea69babedfc9b7946
oai_identifier_str oai:ri.conicet.gov.ar:11336/92842
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Evaluation of carbon nanotubes as chiral selectors for continuous-flow enantiomeric separation of carvedilol with fluorescent detectionSilva, Raúl AlejandroTalio, María CarolinaLuconi, Marta OlgaFernandez, Liliana PatriciaCARBON NANOTUBESCARVEDILOL STEREOISOMERSCHIRAL SEPARATIONFIA-MOLECULAR FLUORESCENCEhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Single-walled carbon nanotubes (SWNT) are proposed as chiral selectors for separation of carvedilol stereoisomers beginning since its racemic mixture. The novel developed FIA-methodology employs a microcolumn (mC) packed with a few milligrams of SWNT which showed to be effective in S(-) and R(+) carvedilol separation. Attending to spectral properties of analytes, molecular fluorescence was employed in the detection step. Separation of carvedilol enantiomers was achieved in less than 70. s with an acceptable resolution factor of 3.16. Variables that influence the chiral separation such as pH and composition of eluent solution, sample injection volume and flow rate, activation mode of NTs and mass of the same in column have been examined in detail. At optimal operational conditions, well repeatability was achieved using the same column for more than 100 injections, putting in evidence the stability of nanomaterial and the efficacy and versatility of the proposed FIA-configuration. The new methodology was successfully applied to S(-) and R(+) carvedilol quantification in pharmaceutical preparations, resulting an attractive alternative to traditional separative methods being fast, simple, using low cost instrumentation and producing scarce waste.farFil: Silva, Raúl Alejandro. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química. Área de Química Analítica; ArgentinaFil: Talio, María Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Luconi, Marta Olga. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química. Área de Química Analítica; ArgentinaFil: Fernandez, Liliana Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaElsevier Science2012-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/92842Silva, Raúl Alejandro; Talio, María Carolina; Luconi, Marta Olga; Fernandez, Liliana Patricia; Evaluation of carbon nanotubes as chiral selectors for continuous-flow enantiomeric separation of carvedilol with fluorescent detection; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 70; 11-2012; 631-6350731-7085CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpba.2012.06.031info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0731708512003639info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:45:44Zoai:ri.conicet.gov.ar:11336/92842instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:45:44.366CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Evaluation of carbon nanotubes as chiral selectors for continuous-flow enantiomeric separation of carvedilol with fluorescent detection
title Evaluation of carbon nanotubes as chiral selectors for continuous-flow enantiomeric separation of carvedilol with fluorescent detection
spellingShingle Evaluation of carbon nanotubes as chiral selectors for continuous-flow enantiomeric separation of carvedilol with fluorescent detection
Silva, Raúl Alejandro
CARBON NANOTUBES
CARVEDILOL STEREOISOMERS
CHIRAL SEPARATION
FIA-MOLECULAR FLUORESCENCE
title_short Evaluation of carbon nanotubes as chiral selectors for continuous-flow enantiomeric separation of carvedilol with fluorescent detection
title_full Evaluation of carbon nanotubes as chiral selectors for continuous-flow enantiomeric separation of carvedilol with fluorescent detection
title_fullStr Evaluation of carbon nanotubes as chiral selectors for continuous-flow enantiomeric separation of carvedilol with fluorescent detection
title_full_unstemmed Evaluation of carbon nanotubes as chiral selectors for continuous-flow enantiomeric separation of carvedilol with fluorescent detection
title_sort Evaluation of carbon nanotubes as chiral selectors for continuous-flow enantiomeric separation of carvedilol with fluorescent detection
dc.creator.none.fl_str_mv Silva, Raúl Alejandro
Talio, María Carolina
Luconi, Marta Olga
Fernandez, Liliana Patricia
author Silva, Raúl Alejandro
author_facet Silva, Raúl Alejandro
Talio, María Carolina
Luconi, Marta Olga
Fernandez, Liliana Patricia
author_role author
author2 Talio, María Carolina
Luconi, Marta Olga
Fernandez, Liliana Patricia
author2_role author
author
author
dc.subject.none.fl_str_mv CARBON NANOTUBES
CARVEDILOL STEREOISOMERS
CHIRAL SEPARATION
FIA-MOLECULAR FLUORESCENCE
topic CARBON NANOTUBES
CARVEDILOL STEREOISOMERS
CHIRAL SEPARATION
FIA-MOLECULAR FLUORESCENCE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Single-walled carbon nanotubes (SWNT) are proposed as chiral selectors for separation of carvedilol stereoisomers beginning since its racemic mixture. The novel developed FIA-methodology employs a microcolumn (mC) packed with a few milligrams of SWNT which showed to be effective in S(-) and R(+) carvedilol separation. Attending to spectral properties of analytes, molecular fluorescence was employed in the detection step. Separation of carvedilol enantiomers was achieved in less than 70. s with an acceptable resolution factor of 3.16. Variables that influence the chiral separation such as pH and composition of eluent solution, sample injection volume and flow rate, activation mode of NTs and mass of the same in column have been examined in detail. At optimal operational conditions, well repeatability was achieved using the same column for more than 100 injections, putting in evidence the stability of nanomaterial and the efficacy and versatility of the proposed FIA-configuration. The new methodology was successfully applied to S(-) and R(+) carvedilol quantification in pharmaceutical preparations, resulting an attractive alternative to traditional separative methods being fast, simple, using low cost instrumentation and producing scarce waste.far
Fil: Silva, Raúl Alejandro. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química. Área de Química Analítica; Argentina
Fil: Talio, María Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Luconi, Marta Olga. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química. Área de Química Analítica; Argentina
Fil: Fernandez, Liliana Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
description Single-walled carbon nanotubes (SWNT) are proposed as chiral selectors for separation of carvedilol stereoisomers beginning since its racemic mixture. The novel developed FIA-methodology employs a microcolumn (mC) packed with a few milligrams of SWNT which showed to be effective in S(-) and R(+) carvedilol separation. Attending to spectral properties of analytes, molecular fluorescence was employed in the detection step. Separation of carvedilol enantiomers was achieved in less than 70. s with an acceptable resolution factor of 3.16. Variables that influence the chiral separation such as pH and composition of eluent solution, sample injection volume and flow rate, activation mode of NTs and mass of the same in column have been examined in detail. At optimal operational conditions, well repeatability was achieved using the same column for more than 100 injections, putting in evidence the stability of nanomaterial and the efficacy and versatility of the proposed FIA-configuration. The new methodology was successfully applied to S(-) and R(+) carvedilol quantification in pharmaceutical preparations, resulting an attractive alternative to traditional separative methods being fast, simple, using low cost instrumentation and producing scarce waste.far
publishDate 2012
dc.date.none.fl_str_mv 2012-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/92842
Silva, Raúl Alejandro; Talio, María Carolina; Luconi, Marta Olga; Fernandez, Liliana Patricia; Evaluation of carbon nanotubes as chiral selectors for continuous-flow enantiomeric separation of carvedilol with fluorescent detection; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 70; 11-2012; 631-635
0731-7085
CONICET Digital
CONICET
url http://hdl.handle.net/11336/92842
identifier_str_mv Silva, Raúl Alejandro; Talio, María Carolina; Luconi, Marta Olga; Fernandez, Liliana Patricia; Evaluation of carbon nanotubes as chiral selectors for continuous-flow enantiomeric separation of carvedilol with fluorescent detection; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 70; 11-2012; 631-635
0731-7085
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpba.2012.06.031
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0731708512003639
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614497548894208
score 13.070432