Nonalcoholic fatty liver disease: Biomarkers support decisions around pharmacological intervention
- Autores
- Sookoian, Silvia Cristina; Pirola, Carlos José
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- We read with great interest the article of Ajmera et al. (1) reporting on the relationship between bio- markers and the histological disease spectrum of nonal- coholic fatty liver disease (NAFLD) in a large population of well-characterized patients from the Non- alcoholic Steatohepatitis Clinical Research Network. The researchers found a significant association between circulating levels of total plasminogen activator inhibitor 1 (tPAI1) and the presence of nonalcoholic steatohepa- titis, which was independent of clinical confounding factors. (1) The clinical value of this result should be highlighted, also having important implications for tai- loring pharmacological interventions.
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina - Materia
-
Nafld
Nash
Biomarkers
Metabolic Syndrome - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/49789
Ver los metadatos del registro completo
id |
CONICETDig_5900ac7e0ab869565ebf2c64014a8e39 |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/49789 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Nonalcoholic fatty liver disease: Biomarkers support decisions around pharmacological interventionSookoian, Silvia CristinaPirola, Carlos JoséNafldNashBiomarkersMetabolic Syndromehttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3We read with great interest the article of Ajmera et al. (1) reporting on the relationship between bio- markers and the histological disease spectrum of nonal- coholic fatty liver disease (NAFLD) in a large population of well-characterized patients from the Non- alcoholic Steatohepatitis Clinical Research Network. The researchers found a significant association between circulating levels of total plasminogen activator inhibitor 1 (tPAI1) and the presence of nonalcoholic steatohepa- titis, which was independent of clinical confounding factors. (1) The clinical value of this result should be highlighted, also having important implications for tai- loring pharmacological interventions.Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaJohn Wiley & Sons Inc2017-04-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/49789Sookoian, Silvia Cristina; Pirola, Carlos José; Nonalcoholic fatty liver disease: Biomarkers support decisions around pharmacological intervention; John Wiley & Sons Inc; Hepatology (Baltimore, Md.); 65; 4; 13-4-2017; 1417-14190270-9139CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/hep.28866info:eu-repo/semantics/altIdentifier/url/https://aasldpubs.onlinelibrary.wiley.com/doi/abs/10.1002/hep.28866info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:45:13Zoai:ri.conicet.gov.ar:11336/49789instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:45:14.065CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Nonalcoholic fatty liver disease: Biomarkers support decisions around pharmacological intervention |
title |
Nonalcoholic fatty liver disease: Biomarkers support decisions around pharmacological intervention |
spellingShingle |
Nonalcoholic fatty liver disease: Biomarkers support decisions around pharmacological intervention Sookoian, Silvia Cristina Nafld Nash Biomarkers Metabolic Syndrome |
title_short |
Nonalcoholic fatty liver disease: Biomarkers support decisions around pharmacological intervention |
title_full |
Nonalcoholic fatty liver disease: Biomarkers support decisions around pharmacological intervention |
title_fullStr |
Nonalcoholic fatty liver disease: Biomarkers support decisions around pharmacological intervention |
title_full_unstemmed |
Nonalcoholic fatty liver disease: Biomarkers support decisions around pharmacological intervention |
title_sort |
Nonalcoholic fatty liver disease: Biomarkers support decisions around pharmacological intervention |
dc.creator.none.fl_str_mv |
Sookoian, Silvia Cristina Pirola, Carlos José |
author |
Sookoian, Silvia Cristina |
author_facet |
Sookoian, Silvia Cristina Pirola, Carlos José |
author_role |
author |
author2 |
Pirola, Carlos José |
author2_role |
author |
dc.subject.none.fl_str_mv |
Nafld Nash Biomarkers Metabolic Syndrome |
topic |
Nafld Nash Biomarkers Metabolic Syndrome |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
We read with great interest the article of Ajmera et al. (1) reporting on the relationship between bio- markers and the histological disease spectrum of nonal- coholic fatty liver disease (NAFLD) in a large population of well-characterized patients from the Non- alcoholic Steatohepatitis Clinical Research Network. The researchers found a significant association between circulating levels of total plasminogen activator inhibitor 1 (tPAI1) and the presence of nonalcoholic steatohepa- titis, which was independent of clinical confounding factors. (1) The clinical value of this result should be highlighted, also having important implications for tai- loring pharmacological interventions. Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina Fil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina |
description |
We read with great interest the article of Ajmera et al. (1) reporting on the relationship between bio- markers and the histological disease spectrum of nonal- coholic fatty liver disease (NAFLD) in a large population of well-characterized patients from the Non- alcoholic Steatohepatitis Clinical Research Network. The researchers found a significant association between circulating levels of total plasminogen activator inhibitor 1 (tPAI1) and the presence of nonalcoholic steatohepa- titis, which was independent of clinical confounding factors. (1) The clinical value of this result should be highlighted, also having important implications for tai- loring pharmacological interventions. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-04-13 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/49789 Sookoian, Silvia Cristina; Pirola, Carlos José; Nonalcoholic fatty liver disease: Biomarkers support decisions around pharmacological intervention; John Wiley & Sons Inc; Hepatology (Baltimore, Md.); 65; 4; 13-4-2017; 1417-1419 0270-9139 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/49789 |
identifier_str_mv |
Sookoian, Silvia Cristina; Pirola, Carlos José; Nonalcoholic fatty liver disease: Biomarkers support decisions around pharmacological intervention; John Wiley & Sons Inc; Hepatology (Baltimore, Md.); 65; 4; 13-4-2017; 1417-1419 0270-9139 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1002/hep.28866 info:eu-repo/semantics/altIdentifier/url/https://aasldpubs.onlinelibrary.wiley.com/doi/abs/10.1002/hep.28866 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
John Wiley & Sons Inc |
publisher.none.fl_str_mv |
John Wiley & Sons Inc |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1842268715205263360 |
score |
13.13397 |