Nonneuronal cholinergic system in breast tumors and dendritic cells: does it improve or worsen the response to tumor?

Autores
Vulcano, Marisa; Sales, Maria Elena; Lombardi, Maria Gabriela
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Besides being the main neurotransmitter in the parasympathetic nervous system, acetylcholine (ACh) can act as a signaling molecule in nonneuronal tissues. For this reason, ACh and the enzymes that synthesize and degrade it (choline acetyltransferase and acetylcholinesterase) as well as muscarinic (mAChRs) and nicotinic receptors conform the non-neuronal cholinergic system (nNCS). It has been reported that nNCS regulates basal cellular functions including survival, proliferation, adhesion, and migration. Moreover, nNCS is broadly expressed in tumors and in different components of the immune system. In this review, we summarize the role of nNCS in tumors and in different immune cell types focusing on the expression and function of mAChRs in breast tumors and dendritic cells (DCs) and discussing the role of DCs in breast cancer.
Fil: Vulcano, Marisa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Sales, Maria Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Lombardi, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina
Materia
nonneuronal cholinergic system
breast tumors
dendritic cells
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/13996
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/13996
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Nonneuronal cholinergic system in breast tumors and dendritic cells: does it improve or worsen the response to tumor?Vulcano, MarisaSales, Maria ElenaLombardi, Maria Gabrielanonneuronal cholinergic systembreast tumorsdendritic cellshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Besides being the main neurotransmitter in the parasympathetic nervous system, acetylcholine (ACh) can act as a signaling molecule in nonneuronal tissues. For this reason, ACh and the enzymes that synthesize and degrade it (choline acetyltransferase and acetylcholinesterase) as well as muscarinic (mAChRs) and nicotinic receptors conform the non-neuronal cholinergic system (nNCS). It has been reported that nNCS regulates basal cellular functions including survival, proliferation, adhesion, and migration. Moreover, nNCS is broadly expressed in tumors and in different components of the immune system. In this review, we summarize the role of nNCS in tumors and in different immune cell types focusing on the expression and function of mAChRs in breast tumors and dendritic cells (DCs) and discussing the role of DCs in breast cancer.Fil: Vulcano, Marisa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Sales, Maria Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Lombardi, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; ArgentinaHindawi Publishing Corporation2013-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13996Vulcano, Marisa; Sales, Maria Elena; Lombardi, Maria Gabriela; Nonneuronal cholinergic system in breast tumors and dendritic cells: does it improve or worsen the response to tumor?; Hindawi Publishing Corporation; International Scholarly Research Notices; 2013; 486545; 10-2013; 1-122356-7872enginfo:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/isrn/2013/486545/info:eu-repo/semantics/altIdentifier/doi/10.1155/2013/486545info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:04:47Zoai:ri.conicet.gov.ar:11336/13996instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:04:47.706CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Nonneuronal cholinergic system in breast tumors and dendritic cells: does it improve or worsen the response to tumor?
title Nonneuronal cholinergic system in breast tumors and dendritic cells: does it improve or worsen the response to tumor?
spellingShingle Nonneuronal cholinergic system in breast tumors and dendritic cells: does it improve or worsen the response to tumor?
Vulcano, Marisa
nonneuronal cholinergic system
breast tumors
dendritic cells
title_short Nonneuronal cholinergic system in breast tumors and dendritic cells: does it improve or worsen the response to tumor?
title_full Nonneuronal cholinergic system in breast tumors and dendritic cells: does it improve or worsen the response to tumor?
title_fullStr Nonneuronal cholinergic system in breast tumors and dendritic cells: does it improve or worsen the response to tumor?
title_full_unstemmed Nonneuronal cholinergic system in breast tumors and dendritic cells: does it improve or worsen the response to tumor?
title_sort Nonneuronal cholinergic system in breast tumors and dendritic cells: does it improve or worsen the response to tumor?
dc.creator.none.fl_str_mv Vulcano, Marisa
Sales, Maria Elena
Lombardi, Maria Gabriela
author Vulcano, Marisa
author_facet Vulcano, Marisa
Sales, Maria Elena
Lombardi, Maria Gabriela
author_role author
author2 Sales, Maria Elena
Lombardi, Maria Gabriela
author2_role author
author
dc.subject.none.fl_str_mv nonneuronal cholinergic system
breast tumors
dendritic cells
topic nonneuronal cholinergic system
breast tumors
dendritic cells
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Besides being the main neurotransmitter in the parasympathetic nervous system, acetylcholine (ACh) can act as a signaling molecule in nonneuronal tissues. For this reason, ACh and the enzymes that synthesize and degrade it (choline acetyltransferase and acetylcholinesterase) as well as muscarinic (mAChRs) and nicotinic receptors conform the non-neuronal cholinergic system (nNCS). It has been reported that nNCS regulates basal cellular functions including survival, proliferation, adhesion, and migration. Moreover, nNCS is broadly expressed in tumors and in different components of the immune system. In this review, we summarize the role of nNCS in tumors and in different immune cell types focusing on the expression and function of mAChRs in breast tumors and dendritic cells (DCs) and discussing the role of DCs in breast cancer.
Fil: Vulcano, Marisa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Sales, Maria Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Lombardi, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina
description Besides being the main neurotransmitter in the parasympathetic nervous system, acetylcholine (ACh) can act as a signaling molecule in nonneuronal tissues. For this reason, ACh and the enzymes that synthesize and degrade it (choline acetyltransferase and acetylcholinesterase) as well as muscarinic (mAChRs) and nicotinic receptors conform the non-neuronal cholinergic system (nNCS). It has been reported that nNCS regulates basal cellular functions including survival, proliferation, adhesion, and migration. Moreover, nNCS is broadly expressed in tumors and in different components of the immune system. In this review, we summarize the role of nNCS in tumors and in different immune cell types focusing on the expression and function of mAChRs in breast tumors and dendritic cells (DCs) and discussing the role of DCs in breast cancer.
publishDate 2013
dc.date.none.fl_str_mv 2013-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/13996
Vulcano, Marisa; Sales, Maria Elena; Lombardi, Maria Gabriela; Nonneuronal cholinergic system in breast tumors and dendritic cells: does it improve or worsen the response to tumor?; Hindawi Publishing Corporation; International Scholarly Research Notices; 2013; 486545; 10-2013; 1-12
2356-7872
url http://hdl.handle.net/11336/13996
identifier_str_mv Vulcano, Marisa; Sales, Maria Elena; Lombardi, Maria Gabriela; Nonneuronal cholinergic system in breast tumors and dendritic cells: does it improve or worsen the response to tumor?; Hindawi Publishing Corporation; International Scholarly Research Notices; 2013; 486545; 10-2013; 1-12
2356-7872
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/isrn/2013/486545/
info:eu-repo/semantics/altIdentifier/doi/10.1155/2013/486545
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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