The Emergence of the Spatial Structure of Tectal Spontaneous Activity Is Independent of Visual Inputs

Autores
Pietri, Thomas; Romano, Sebastián A.; Pérez Schuster, Verónica; Boulanger Weill, Jonathan; Candat, Virginie; Sumbre, Germán
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The brain is spontaneously active, even in the absence of sensory stimulation. The functionally mature zebrafish optic tectum shows spontaneous activity patterns reflecting a functional connectivity adapted for the circuit's functional role and predictive of behavior. However, neither the emergence of these patterns during development nor the role of retinal inputs in their maturation has been characterized. Using two-photon calcium imaging, we analyzed spontaneous activity in intact and enucleated zebrafish larvae throughout tectum development. At the onset of retinotectal connections, intact larvae showed major changes in the spatiotemporal structure of spontaneous activity. Although the absence of retinal inputs had a significant impact on the development of the temporal structure, the tectum was still capable of developing a spatial structure associated with the circuit's functional roles and predictive of behavior. We conclude that neither visual experience nor intrinsic retinal activity is essential for the emergence of a spatially structured functional circuit.
Fil: Pietri, Thomas. Centre National de la Recherche Scientifique. Ecole Normale Supérieure; Francia. New Jersey Institute of Technology; Estados Unidos
Fil: Romano, Sebastián A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina. Centre National de la Recherche Scientifique. Ecole Normale Supérieure; Francia
Fil: Pérez Schuster, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Centre National de la Recherche Scientifique. Ecole Normale Supérieure; Francia
Fil: Boulanger Weill, Jonathan. Centre National de la Recherche Scientifique. Ecole Normale Supérieure; Francia
Fil: Candat, Virginie. Centre National de la Recherche Scientifique. Ecole Normale Supérieure; Francia
Fil: Sumbre, Germán. Centre National de la Recherche Scientifique. Ecole Normale Supérieure; Francia
Materia
BEHAVIOR
DEVELOPMENT OF SPONTANEOUS ACTIVITY
NEURONAL CIRCUIT DYNAMICS
OPTIC TECTUM
RETINAL INPUT
VISUAL SYSTEM
ZEBRAFISH
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/64413
Acceder
id CONICETDig_af69e406a7886a4fdc26870f60559dc6
oai_identifier_str oai:ri.conicet.gov.ar:11336/64413
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The Emergence of the Spatial Structure of Tectal Spontaneous Activity Is Independent of Visual InputsPietri, ThomasRomano, Sebastián A.Pérez Schuster, VerónicaBoulanger Weill, JonathanCandat, VirginieSumbre, GermánBEHAVIORDEVELOPMENT OF SPONTANEOUS ACTIVITYNEURONAL CIRCUIT DYNAMICSOPTIC TECTUMRETINAL INPUTVISUAL SYSTEMZEBRAFISHhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The brain is spontaneously active, even in the absence of sensory stimulation. The functionally mature zebrafish optic tectum shows spontaneous activity patterns reflecting a functional connectivity adapted for the circuit's functional role and predictive of behavior. However, neither the emergence of these patterns during development nor the role of retinal inputs in their maturation has been characterized. Using two-photon calcium imaging, we analyzed spontaneous activity in intact and enucleated zebrafish larvae throughout tectum development. At the onset of retinotectal connections, intact larvae showed major changes in the spatiotemporal structure of spontaneous activity. Although the absence of retinal inputs had a significant impact on the development of the temporal structure, the tectum was still capable of developing a spatial structure associated with the circuit's functional roles and predictive of behavior. We conclude that neither visual experience nor intrinsic retinal activity is essential for the emergence of a spatially structured functional circuit.Fil: Pietri, Thomas. Centre National de la Recherche Scientifique. Ecole Normale Supérieure; Francia. New Jersey Institute of Technology; Estados UnidosFil: Romano, Sebastián A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina. Centre National de la Recherche Scientifique. Ecole Normale Supérieure; FranciaFil: Pérez Schuster, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Centre National de la Recherche Scientifique. Ecole Normale Supérieure; FranciaFil: Boulanger Weill, Jonathan. Centre National de la Recherche Scientifique. Ecole Normale Supérieure; FranciaFil: Candat, Virginie. Centre National de la Recherche Scientifique. Ecole Normale Supérieure; FranciaFil: Sumbre, Germán. Centre National de la Recherche Scientifique. Ecole Normale Supérieure; FranciaElsevier2017-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/zipapplication/pdfhttp://hdl.handle.net/11336/64413Pietri, Thomas; Romano, Sebastián A.; Pérez Schuster, Verónica; Boulanger Weill, Jonathan; Candat, Virginie; et al.; The Emergence of the Spatial Structure of Tectal Spontaneous Activity Is Independent of Visual Inputs; Elsevier; Cell Reports; 19; 5; 5-2017; 939-9482211-1247CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.celrep.2017.04.015info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2211124717304904info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-05T09:36:22Zoai:ri.conicet.gov.ar:11336/64413instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-05 09:36:22.531CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The Emergence of the Spatial Structure of Tectal Spontaneous Activity Is Independent of Visual Inputs
title The Emergence of the Spatial Structure of Tectal Spontaneous Activity Is Independent of Visual Inputs
spellingShingle The Emergence of the Spatial Structure of Tectal Spontaneous Activity Is Independent of Visual Inputs
Pietri, Thomas
BEHAVIOR
DEVELOPMENT OF SPONTANEOUS ACTIVITY
NEURONAL CIRCUIT DYNAMICS
OPTIC TECTUM
RETINAL INPUT
VISUAL SYSTEM
ZEBRAFISH
title_short The Emergence of the Spatial Structure of Tectal Spontaneous Activity Is Independent of Visual Inputs
title_full The Emergence of the Spatial Structure of Tectal Spontaneous Activity Is Independent of Visual Inputs
title_fullStr The Emergence of the Spatial Structure of Tectal Spontaneous Activity Is Independent of Visual Inputs
title_full_unstemmed The Emergence of the Spatial Structure of Tectal Spontaneous Activity Is Independent of Visual Inputs
title_sort The Emergence of the Spatial Structure of Tectal Spontaneous Activity Is Independent of Visual Inputs
dc.creator.none.fl_str_mv Pietri, Thomas
Romano, Sebastián A.
Pérez Schuster, Verónica
Boulanger Weill, Jonathan
Candat, Virginie
Sumbre, Germán
author Pietri, Thomas
author_facet Pietri, Thomas
Romano, Sebastián A.
Pérez Schuster, Verónica
Boulanger Weill, Jonathan
Candat, Virginie
Sumbre, Germán
author_role author
author2 Romano, Sebastián A.
Pérez Schuster, Verónica
Boulanger Weill, Jonathan
Candat, Virginie
Sumbre, Germán
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv BEHAVIOR
DEVELOPMENT OF SPONTANEOUS ACTIVITY
NEURONAL CIRCUIT DYNAMICS
OPTIC TECTUM
RETINAL INPUT
VISUAL SYSTEM
ZEBRAFISH
topic BEHAVIOR
DEVELOPMENT OF SPONTANEOUS ACTIVITY
NEURONAL CIRCUIT DYNAMICS
OPTIC TECTUM
RETINAL INPUT
VISUAL SYSTEM
ZEBRAFISH
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The brain is spontaneously active, even in the absence of sensory stimulation. The functionally mature zebrafish optic tectum shows spontaneous activity patterns reflecting a functional connectivity adapted for the circuit's functional role and predictive of behavior. However, neither the emergence of these patterns during development nor the role of retinal inputs in their maturation has been characterized. Using two-photon calcium imaging, we analyzed spontaneous activity in intact and enucleated zebrafish larvae throughout tectum development. At the onset of retinotectal connections, intact larvae showed major changes in the spatiotemporal structure of spontaneous activity. Although the absence of retinal inputs had a significant impact on the development of the temporal structure, the tectum was still capable of developing a spatial structure associated with the circuit's functional roles and predictive of behavior. We conclude that neither visual experience nor intrinsic retinal activity is essential for the emergence of a spatially structured functional circuit.
Fil: Pietri, Thomas. Centre National de la Recherche Scientifique. Ecole Normale Supérieure; Francia. New Jersey Institute of Technology; Estados Unidos
Fil: Romano, Sebastián A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina. Centre National de la Recherche Scientifique. Ecole Normale Supérieure; Francia
Fil: Pérez Schuster, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Centre National de la Recherche Scientifique. Ecole Normale Supérieure; Francia
Fil: Boulanger Weill, Jonathan. Centre National de la Recherche Scientifique. Ecole Normale Supérieure; Francia
Fil: Candat, Virginie. Centre National de la Recherche Scientifique. Ecole Normale Supérieure; Francia
Fil: Sumbre, Germán. Centre National de la Recherche Scientifique. Ecole Normale Supérieure; Francia
description The brain is spontaneously active, even in the absence of sensory stimulation. The functionally mature zebrafish optic tectum shows spontaneous activity patterns reflecting a functional connectivity adapted for the circuit's functional role and predictive of behavior. However, neither the emergence of these patterns during development nor the role of retinal inputs in their maturation has been characterized. Using two-photon calcium imaging, we analyzed spontaneous activity in intact and enucleated zebrafish larvae throughout tectum development. At the onset of retinotectal connections, intact larvae showed major changes in the spatiotemporal structure of spontaneous activity. Although the absence of retinal inputs had a significant impact on the development of the temporal structure, the tectum was still capable of developing a spatial structure associated with the circuit's functional roles and predictive of behavior. We conclude that neither visual experience nor intrinsic retinal activity is essential for the emergence of a spatially structured functional circuit.
publishDate 2017
dc.date.none.fl_str_mv 2017-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/64413
Pietri, Thomas; Romano, Sebastián A.; Pérez Schuster, Verónica; Boulanger Weill, Jonathan; Candat, Virginie; et al.; The Emergence of the Spatial Structure of Tectal Spontaneous Activity Is Independent of Visual Inputs; Elsevier; Cell Reports; 19; 5; 5-2017; 939-948
2211-1247
CONICET Digital
CONICET
url http://hdl.handle.net/11336/64413
identifier_str_mv Pietri, Thomas; Romano, Sebastián A.; Pérez Schuster, Verónica; Boulanger Weill, Jonathan; Candat, Virginie; et al.; The Emergence of the Spatial Structure of Tectal Spontaneous Activity Is Independent of Visual Inputs; Elsevier; Cell Reports; 19; 5; 5-2017; 939-948
2211-1247
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.celrep.2017.04.015
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2211124717304904
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/zip
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1847976812369412096
score 13.087074

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