Crossover of the hypothalamic pituitary–adrenal/interrenal, –thyroid, and –gonadal axes in testicular development

Autores
Castañeda Cortes, Diana Carolina; Langlois, Valerie; Fernandino, Juan Ignacio
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Besides the well-known function of thyroid hormones (THs) for regulating metabolism, ithas recently been discovered that THs are also involved in testicular development in mam-malian and non-mammalian species. THs, in combination with follicle stimulating hormone,lead to androgen synthesis inDanio rerio, which results in the onset of spermatogen-esis in the testis, potentially relating the hypothalamic–pituitary–thyroid (HPT) gland tothe hypothalamic–pituitary–gonadal (HPG) axes. Furthermore, studies in non-mammalianspecies have suggested that by stimulating the thyroid-stimulating hormone (TSH), THscan be induced by corticotropin-releasing hormone. This suggests that the hypothalamic–pituitary–adrenal/interrenal gland (HPA) axis might influence the HPT axis. Additionally, itwas shown that hormones pertaining to both HPT and HPA could also influence the HPGendocrine axis. For example, high levels of androgens were observed in the testis inOdon-thestes bonariensisduring a period of stress-induced sex-determination, which suggeststhat stress hormones influence the gonadal fate toward masculinization. Thus, this reviewhighlights the hormonal interactions observed between the HPT, HPA, and HPG axes usinga comparative approach in order to better understand how these endocrine systems couldinteract with each other to influence the development of testes.
Fil: Castañeda Cortes, Diana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina
Fil: Langlois, Valerie. Royal Military College of Canada; Canadá
Fil: Fernandino, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina
Materia
thyroid hormone
corticotropin-releasing hormone
gonadotropins
androgen
testis
fish
amphibians
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/32706
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/32706
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Crossover of the hypothalamic pituitary–adrenal/interrenal, –thyroid, and –gonadal axes in testicular developmentCastañeda Cortes, Diana CarolinaLanglois, ValerieFernandino, Juan Ignaciothyroid hormonecorticotropin-releasing hormonegonadotropinsandrogentestisfishamphibianshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Besides the well-known function of thyroid hormones (THs) for regulating metabolism, ithas recently been discovered that THs are also involved in testicular development in mam-malian and non-mammalian species. THs, in combination with follicle stimulating hormone,lead to androgen synthesis inDanio rerio, which results in the onset of spermatogen-esis in the testis, potentially relating the hypothalamic–pituitary–thyroid (HPT) gland tothe hypothalamic–pituitary–gonadal (HPG) axes. Furthermore, studies in non-mammalianspecies have suggested that by stimulating the thyroid-stimulating hormone (TSH), THscan be induced by corticotropin-releasing hormone. This suggests that the hypothalamic–pituitary–adrenal/interrenal gland (HPA) axis might influence the HPT axis. Additionally, itwas shown that hormones pertaining to both HPT and HPA could also influence the HPGendocrine axis. For example, high levels of androgens were observed in the testis inOdon-thestes bonariensisduring a period of stress-induced sex-determination, which suggeststhat stress hormones influence the gonadal fate toward masculinization. Thus, this reviewhighlights the hormonal interactions observed between the HPT, HPA, and HPG axes usinga comparative approach in order to better understand how these endocrine systems couldinteract with each other to influence the development of testes.Fil: Castañeda Cortes, Diana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); ArgentinaFil: Langlois, Valerie. Royal Military College of Canada; CanadáFil: Fernandino, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); ArgentinaFrontiers2014-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/32706Fernandino, Juan Ignacio; Castañeda Cortes, Diana Carolina; Langlois, Valerie; Crossover of the hypothalamic pituitary–adrenal/interrenal, –thyroid, and –gonadal axes in testicular development; Frontiers; Frontiers in Endocrinology; 5; 139; 8-2014; 1-111664-2392CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fendo.2014.00139info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fendo.2014.00139/fullinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:04:22Zoai:ri.conicet.gov.ar:11336/32706instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:04:23.365CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Crossover of the hypothalamic pituitary–adrenal/interrenal, –thyroid, and –gonadal axes in testicular development
title Crossover of the hypothalamic pituitary–adrenal/interrenal, –thyroid, and –gonadal axes in testicular development
spellingShingle Crossover of the hypothalamic pituitary–adrenal/interrenal, –thyroid, and –gonadal axes in testicular development
Castañeda Cortes, Diana Carolina
thyroid hormone
corticotropin-releasing hormone
gonadotropins
androgen
testis
fish
amphibians
title_short Crossover of the hypothalamic pituitary–adrenal/interrenal, –thyroid, and –gonadal axes in testicular development
title_full Crossover of the hypothalamic pituitary–adrenal/interrenal, –thyroid, and –gonadal axes in testicular development
title_fullStr Crossover of the hypothalamic pituitary–adrenal/interrenal, –thyroid, and –gonadal axes in testicular development
title_full_unstemmed Crossover of the hypothalamic pituitary–adrenal/interrenal, –thyroid, and –gonadal axes in testicular development
title_sort Crossover of the hypothalamic pituitary–adrenal/interrenal, –thyroid, and –gonadal axes in testicular development
dc.creator.none.fl_str_mv Castañeda Cortes, Diana Carolina
Langlois, Valerie
Fernandino, Juan Ignacio
author Castañeda Cortes, Diana Carolina
author_facet Castañeda Cortes, Diana Carolina
Langlois, Valerie
Fernandino, Juan Ignacio
author_role author
author2 Langlois, Valerie
Fernandino, Juan Ignacio
author2_role author
author
dc.subject.none.fl_str_mv thyroid hormone
corticotropin-releasing hormone
gonadotropins
androgen
testis
fish
amphibians
topic thyroid hormone
corticotropin-releasing hormone
gonadotropins
androgen
testis
fish
amphibians
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Besides the well-known function of thyroid hormones (THs) for regulating metabolism, ithas recently been discovered that THs are also involved in testicular development in mam-malian and non-mammalian species. THs, in combination with follicle stimulating hormone,lead to androgen synthesis inDanio rerio, which results in the onset of spermatogen-esis in the testis, potentially relating the hypothalamic–pituitary–thyroid (HPT) gland tothe hypothalamic–pituitary–gonadal (HPG) axes. Furthermore, studies in non-mammalianspecies have suggested that by stimulating the thyroid-stimulating hormone (TSH), THscan be induced by corticotropin-releasing hormone. This suggests that the hypothalamic–pituitary–adrenal/interrenal gland (HPA) axis might influence the HPT axis. Additionally, itwas shown that hormones pertaining to both HPT and HPA could also influence the HPGendocrine axis. For example, high levels of androgens were observed in the testis inOdon-thestes bonariensisduring a period of stress-induced sex-determination, which suggeststhat stress hormones influence the gonadal fate toward masculinization. Thus, this reviewhighlights the hormonal interactions observed between the HPT, HPA, and HPG axes usinga comparative approach in order to better understand how these endocrine systems couldinteract with each other to influence the development of testes.
Fil: Castañeda Cortes, Diana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina
Fil: Langlois, Valerie. Royal Military College of Canada; Canadá
Fil: Fernandino, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina
description Besides the well-known function of thyroid hormones (THs) for regulating metabolism, ithas recently been discovered that THs are also involved in testicular development in mam-malian and non-mammalian species. THs, in combination with follicle stimulating hormone,lead to androgen synthesis inDanio rerio, which results in the onset of spermatogen-esis in the testis, potentially relating the hypothalamic–pituitary–thyroid (HPT) gland tothe hypothalamic–pituitary–gonadal (HPG) axes. Furthermore, studies in non-mammalianspecies have suggested that by stimulating the thyroid-stimulating hormone (TSH), THscan be induced by corticotropin-releasing hormone. This suggests that the hypothalamic–pituitary–adrenal/interrenal gland (HPA) axis might influence the HPT axis. Additionally, itwas shown that hormones pertaining to both HPT and HPA could also influence the HPGendocrine axis. For example, high levels of androgens were observed in the testis inOdon-thestes bonariensisduring a period of stress-induced sex-determination, which suggeststhat stress hormones influence the gonadal fate toward masculinization. Thus, this reviewhighlights the hormonal interactions observed between the HPT, HPA, and HPG axes usinga comparative approach in order to better understand how these endocrine systems couldinteract with each other to influence the development of testes.
publishDate 2014
dc.date.none.fl_str_mv 2014-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/32706
Fernandino, Juan Ignacio; Castañeda Cortes, Diana Carolina; Langlois, Valerie; Crossover of the hypothalamic pituitary–adrenal/interrenal, –thyroid, and –gonadal axes in testicular development; Frontiers; Frontiers in Endocrinology; 5; 139; 8-2014; 1-11
1664-2392
CONICET Digital
CONICET
url http://hdl.handle.net/11336/32706
identifier_str_mv Fernandino, Juan Ignacio; Castañeda Cortes, Diana Carolina; Langlois, Valerie; Crossover of the hypothalamic pituitary–adrenal/interrenal, –thyroid, and –gonadal axes in testicular development; Frontiers; Frontiers in Endocrinology; 5; 139; 8-2014; 1-11
1664-2392
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fendo.2014.00139
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fendo.2014.00139/full
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269854311120896
score 13.13397

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