Thyroid hormones in male reproductive development: Evidence for direct crosstalk between the androgen and thyroid hormone axes

Autores
Flood, Diana E. K.; Fernandino, Juan Ignacio; Langlois, Valerie
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Thyroid hormones (THs) exert a broad range of effects on development in vertebrate species, demonstrating connections in nearly every biological endocrine system. Studies have shown that THs play a role in sexual differentiation and gonadal development in mammalian and non-mammalian species. There is considerable evidence that the effects of THs on reproductive development are mediated through the female hormonal axis; however, recent findings suggest a more direct crosstalk between THs and the androgen axis. These findings demonstrate that THs have considerable influence in the sexual ontogeny of male vertebrates, through direct interactions with select sex-determining-genes and regulation of gonadotropin production in the hypothalamus-pituitary-gonad axis. THs also regulate androgen biosynthesis and signalling through direct and indirect regulation of steroidogenic enzyme expression and activity. Novel promoter analysis presented in this work demonstrates the potential for direct and vertebrate wide crosstalk at the transcriptional level in mouse (Mus musculus), Western clawed frog (Silurana tropicalis) and medaka (Oryzias latipes). Cumulative evidence from previous studies, coupled with novel promoter analysis suggests mechanisms for a more direct crosstalk between TH and male reproductive axis across vertebrate species.
Fil: Flood, Diana E. K.. Royal Military College of Canada; Canadá. Queens University; Canadá
Fil: Fernandino, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina
Fil: Langlois, Valerie. Royal Military College of Canada; Canadá
Materia
Thyroid Hormone
Androgen
Hypothalamus-Pituitary-Thyroid/Gonadal Axis
Steroidogenesis
Promoter Analysis
Sex-Determining-Genes
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/24236
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Thyroid hormones in male reproductive development: Evidence for direct crosstalk between the androgen and thyroid hormone axesFlood, Diana E. K.Fernandino, Juan IgnacioLanglois, ValerieThyroid HormoneAndrogenHypothalamus-Pituitary-Thyroid/Gonadal AxisSteroidogenesisPromoter AnalysisSex-Determining-Geneshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Thyroid hormones (THs) exert a broad range of effects on development in vertebrate species, demonstrating connections in nearly every biological endocrine system. Studies have shown that THs play a role in sexual differentiation and gonadal development in mammalian and non-mammalian species. There is considerable evidence that the effects of THs on reproductive development are mediated through the female hormonal axis; however, recent findings suggest a more direct crosstalk between THs and the androgen axis. These findings demonstrate that THs have considerable influence in the sexual ontogeny of male vertebrates, through direct interactions with select sex-determining-genes and regulation of gonadotropin production in the hypothalamus-pituitary-gonad axis. THs also regulate androgen biosynthesis and signalling through direct and indirect regulation of steroidogenic enzyme expression and activity. Novel promoter analysis presented in this work demonstrates the potential for direct and vertebrate wide crosstalk at the transcriptional level in mouse (Mus musculus), Western clawed frog (Silurana tropicalis) and medaka (Oryzias latipes). Cumulative evidence from previous studies, coupled with novel promoter analysis suggests mechanisms for a more direct crosstalk between TH and male reproductive axis across vertebrate species.Fil: Flood, Diana E. K.. Royal Military College of Canada; Canadá. Queens University; CanadáFil: Fernandino, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); ArgentinaFil: Langlois, Valerie. Royal Military College of Canada; CanadáAcademic Press Inc Elsevier Science2013-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/24236Flood, Diana E. K.; Fernandino, Juan Ignacio; Langlois, Valerie; Thyroid hormones in male reproductive development: Evidence for direct crosstalk between the androgen and thyroid hormone axes; Academic Press Inc Elsevier Science; General and Comparative Endocrinology; 192; 1-10-2013; 2-140016-6480CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ygcen.2013.02.038info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0016648013001159info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:42:07Zoai:ri.conicet.gov.ar:11336/24236instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:42:07.389CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Thyroid hormones in male reproductive development: Evidence for direct crosstalk between the androgen and thyroid hormone axes
title Thyroid hormones in male reproductive development: Evidence for direct crosstalk between the androgen and thyroid hormone axes
spellingShingle Thyroid hormones in male reproductive development: Evidence for direct crosstalk between the androgen and thyroid hormone axes
Flood, Diana E. K.
Thyroid Hormone
Androgen
Hypothalamus-Pituitary-Thyroid/Gonadal Axis
Steroidogenesis
Promoter Analysis
Sex-Determining-Genes
title_short Thyroid hormones in male reproductive development: Evidence for direct crosstalk between the androgen and thyroid hormone axes
title_full Thyroid hormones in male reproductive development: Evidence for direct crosstalk between the androgen and thyroid hormone axes
title_fullStr Thyroid hormones in male reproductive development: Evidence for direct crosstalk between the androgen and thyroid hormone axes
title_full_unstemmed Thyroid hormones in male reproductive development: Evidence for direct crosstalk between the androgen and thyroid hormone axes
title_sort Thyroid hormones in male reproductive development: Evidence for direct crosstalk between the androgen and thyroid hormone axes
dc.creator.none.fl_str_mv Flood, Diana E. K.
Fernandino, Juan Ignacio
Langlois, Valerie
author Flood, Diana E. K.
author_facet Flood, Diana E. K.
Fernandino, Juan Ignacio
Langlois, Valerie
author_role author
author2 Fernandino, Juan Ignacio
Langlois, Valerie
author2_role author
author
dc.subject.none.fl_str_mv Thyroid Hormone
Androgen
Hypothalamus-Pituitary-Thyroid/Gonadal Axis
Steroidogenesis
Promoter Analysis
Sex-Determining-Genes
topic Thyroid Hormone
Androgen
Hypothalamus-Pituitary-Thyroid/Gonadal Axis
Steroidogenesis
Promoter Analysis
Sex-Determining-Genes
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Thyroid hormones (THs) exert a broad range of effects on development in vertebrate species, demonstrating connections in nearly every biological endocrine system. Studies have shown that THs play a role in sexual differentiation and gonadal development in mammalian and non-mammalian species. There is considerable evidence that the effects of THs on reproductive development are mediated through the female hormonal axis; however, recent findings suggest a more direct crosstalk between THs and the androgen axis. These findings demonstrate that THs have considerable influence in the sexual ontogeny of male vertebrates, through direct interactions with select sex-determining-genes and regulation of gonadotropin production in the hypothalamus-pituitary-gonad axis. THs also regulate androgen biosynthesis and signalling through direct and indirect regulation of steroidogenic enzyme expression and activity. Novel promoter analysis presented in this work demonstrates the potential for direct and vertebrate wide crosstalk at the transcriptional level in mouse (Mus musculus), Western clawed frog (Silurana tropicalis) and medaka (Oryzias latipes). Cumulative evidence from previous studies, coupled with novel promoter analysis suggests mechanisms for a more direct crosstalk between TH and male reproductive axis across vertebrate species.
Fil: Flood, Diana E. K.. Royal Military College of Canada; Canadá. Queens University; Canadá
Fil: Fernandino, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina
Fil: Langlois, Valerie. Royal Military College of Canada; Canadá
description Thyroid hormones (THs) exert a broad range of effects on development in vertebrate species, demonstrating connections in nearly every biological endocrine system. Studies have shown that THs play a role in sexual differentiation and gonadal development in mammalian and non-mammalian species. There is considerable evidence that the effects of THs on reproductive development are mediated through the female hormonal axis; however, recent findings suggest a more direct crosstalk between THs and the androgen axis. These findings demonstrate that THs have considerable influence in the sexual ontogeny of male vertebrates, through direct interactions with select sex-determining-genes and regulation of gonadotropin production in the hypothalamus-pituitary-gonad axis. THs also regulate androgen biosynthesis and signalling through direct and indirect regulation of steroidogenic enzyme expression and activity. Novel promoter analysis presented in this work demonstrates the potential for direct and vertebrate wide crosstalk at the transcriptional level in mouse (Mus musculus), Western clawed frog (Silurana tropicalis) and medaka (Oryzias latipes). Cumulative evidence from previous studies, coupled with novel promoter analysis suggests mechanisms for a more direct crosstalk between TH and male reproductive axis across vertebrate species.
publishDate 2013
dc.date.none.fl_str_mv 2013-10-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/24236
Flood, Diana E. K.; Fernandino, Juan Ignacio; Langlois, Valerie; Thyroid hormones in male reproductive development: Evidence for direct crosstalk between the androgen and thyroid hormone axes; Academic Press Inc Elsevier Science; General and Comparative Endocrinology; 192; 1-10-2013; 2-14
0016-6480
CONICET Digital
CONICET
url http://hdl.handle.net/11336/24236
identifier_str_mv Flood, Diana E. K.; Fernandino, Juan Ignacio; Langlois, Valerie; Thyroid hormones in male reproductive development: Evidence for direct crosstalk between the androgen and thyroid hormone axes; Academic Press Inc Elsevier Science; General and Comparative Endocrinology; 192; 1-10-2013; 2-14
0016-6480
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ygcen.2013.02.038
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0016648013001159
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Inc Elsevier Science
publisher.none.fl_str_mv Academic Press Inc Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082921619783680
score 13.22299

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