Thyroid hormones in male reproductive development: Evidence for direct crosstalk between the androgen and thyroid hormone axes
- Autores
- Flood, Diana E. K.; Fernandino, Juan Ignacio; Langlois, Valerie
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Thyroid hormones (THs) exert a broad range of effects on development in vertebrate species, demonstrating connections in nearly every biological endocrine system. Studies have shown that THs play a role in sexual differentiation and gonadal development in mammalian and non-mammalian species. There is considerable evidence that the effects of THs on reproductive development are mediated through the female hormonal axis; however, recent findings suggest a more direct crosstalk between THs and the androgen axis. These findings demonstrate that THs have considerable influence in the sexual ontogeny of male vertebrates, through direct interactions with select sex-determining-genes and regulation of gonadotropin production in the hypothalamus-pituitary-gonad axis. THs also regulate androgen biosynthesis and signalling through direct and indirect regulation of steroidogenic enzyme expression and activity. Novel promoter analysis presented in this work demonstrates the potential for direct and vertebrate wide crosstalk at the transcriptional level in mouse (Mus musculus), Western clawed frog (Silurana tropicalis) and medaka (Oryzias latipes). Cumulative evidence from previous studies, coupled with novel promoter analysis suggests mechanisms for a more direct crosstalk between TH and male reproductive axis across vertebrate species.
Fil: Flood, Diana E. K.. Royal Military College of Canada; Canadá. Queens University; Canadá
Fil: Fernandino, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina
Fil: Langlois, Valerie. Royal Military College of Canada; Canadá - Materia
-
Thyroid Hormone
Androgen
Hypothalamus-Pituitary-Thyroid/Gonadal Axis
Steroidogenesis
Promoter Analysis
Sex-Determining-Genes - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/24236
Ver los metadatos del registro completo
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Thyroid hormones in male reproductive development: Evidence for direct crosstalk between the androgen and thyroid hormone axesFlood, Diana E. K.Fernandino, Juan IgnacioLanglois, ValerieThyroid HormoneAndrogenHypothalamus-Pituitary-Thyroid/Gonadal AxisSteroidogenesisPromoter AnalysisSex-Determining-Geneshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Thyroid hormones (THs) exert a broad range of effects on development in vertebrate species, demonstrating connections in nearly every biological endocrine system. Studies have shown that THs play a role in sexual differentiation and gonadal development in mammalian and non-mammalian species. There is considerable evidence that the effects of THs on reproductive development are mediated through the female hormonal axis; however, recent findings suggest a more direct crosstalk between THs and the androgen axis. These findings demonstrate that THs have considerable influence in the sexual ontogeny of male vertebrates, through direct interactions with select sex-determining-genes and regulation of gonadotropin production in the hypothalamus-pituitary-gonad axis. THs also regulate androgen biosynthesis and signalling through direct and indirect regulation of steroidogenic enzyme expression and activity. Novel promoter analysis presented in this work demonstrates the potential for direct and vertebrate wide crosstalk at the transcriptional level in mouse (Mus musculus), Western clawed frog (Silurana tropicalis) and medaka (Oryzias latipes). Cumulative evidence from previous studies, coupled with novel promoter analysis suggests mechanisms for a more direct crosstalk between TH and male reproductive axis across vertebrate species.Fil: Flood, Diana E. K.. Royal Military College of Canada; Canadá. Queens University; CanadáFil: Fernandino, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); ArgentinaFil: Langlois, Valerie. Royal Military College of Canada; CanadáAcademic Press Inc Elsevier Science2013-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/24236Flood, Diana E. K.; Fernandino, Juan Ignacio; Langlois, Valerie; Thyroid hormones in male reproductive development: Evidence for direct crosstalk between the androgen and thyroid hormone axes; Academic Press Inc Elsevier Science; General and Comparative Endocrinology; 192; 1-10-2013; 2-140016-6480CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ygcen.2013.02.038info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0016648013001159info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:42:07Zoai:ri.conicet.gov.ar:11336/24236instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:42:07.389CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Thyroid hormones in male reproductive development: Evidence for direct crosstalk between the androgen and thyroid hormone axes |
title |
Thyroid hormones in male reproductive development: Evidence for direct crosstalk between the androgen and thyroid hormone axes |
spellingShingle |
Thyroid hormones in male reproductive development: Evidence for direct crosstalk between the androgen and thyroid hormone axes Flood, Diana E. K. Thyroid Hormone Androgen Hypothalamus-Pituitary-Thyroid/Gonadal Axis Steroidogenesis Promoter Analysis Sex-Determining-Genes |
title_short |
Thyroid hormones in male reproductive development: Evidence for direct crosstalk between the androgen and thyroid hormone axes |
title_full |
Thyroid hormones in male reproductive development: Evidence for direct crosstalk between the androgen and thyroid hormone axes |
title_fullStr |
Thyroid hormones in male reproductive development: Evidence for direct crosstalk between the androgen and thyroid hormone axes |
title_full_unstemmed |
Thyroid hormones in male reproductive development: Evidence for direct crosstalk between the androgen and thyroid hormone axes |
title_sort |
Thyroid hormones in male reproductive development: Evidence for direct crosstalk between the androgen and thyroid hormone axes |
dc.creator.none.fl_str_mv |
Flood, Diana E. K. Fernandino, Juan Ignacio Langlois, Valerie |
author |
Flood, Diana E. K. |
author_facet |
Flood, Diana E. K. Fernandino, Juan Ignacio Langlois, Valerie |
author_role |
author |
author2 |
Fernandino, Juan Ignacio Langlois, Valerie |
author2_role |
author author |
dc.subject.none.fl_str_mv |
Thyroid Hormone Androgen Hypothalamus-Pituitary-Thyroid/Gonadal Axis Steroidogenesis Promoter Analysis Sex-Determining-Genes |
topic |
Thyroid Hormone Androgen Hypothalamus-Pituitary-Thyroid/Gonadal Axis Steroidogenesis Promoter Analysis Sex-Determining-Genes |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Thyroid hormones (THs) exert a broad range of effects on development in vertebrate species, demonstrating connections in nearly every biological endocrine system. Studies have shown that THs play a role in sexual differentiation and gonadal development in mammalian and non-mammalian species. There is considerable evidence that the effects of THs on reproductive development are mediated through the female hormonal axis; however, recent findings suggest a more direct crosstalk between THs and the androgen axis. These findings demonstrate that THs have considerable influence in the sexual ontogeny of male vertebrates, through direct interactions with select sex-determining-genes and regulation of gonadotropin production in the hypothalamus-pituitary-gonad axis. THs also regulate androgen biosynthesis and signalling through direct and indirect regulation of steroidogenic enzyme expression and activity. Novel promoter analysis presented in this work demonstrates the potential for direct and vertebrate wide crosstalk at the transcriptional level in mouse (Mus musculus), Western clawed frog (Silurana tropicalis) and medaka (Oryzias latipes). Cumulative evidence from previous studies, coupled with novel promoter analysis suggests mechanisms for a more direct crosstalk between TH and male reproductive axis across vertebrate species. Fil: Flood, Diana E. K.. Royal Military College of Canada; Canadá. Queens University; Canadá Fil: Fernandino, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina Fil: Langlois, Valerie. Royal Military College of Canada; Canadá |
description |
Thyroid hormones (THs) exert a broad range of effects on development in vertebrate species, demonstrating connections in nearly every biological endocrine system. Studies have shown that THs play a role in sexual differentiation and gonadal development in mammalian and non-mammalian species. There is considerable evidence that the effects of THs on reproductive development are mediated through the female hormonal axis; however, recent findings suggest a more direct crosstalk between THs and the androgen axis. These findings demonstrate that THs have considerable influence in the sexual ontogeny of male vertebrates, through direct interactions with select sex-determining-genes and regulation of gonadotropin production in the hypothalamus-pituitary-gonad axis. THs also regulate androgen biosynthesis and signalling through direct and indirect regulation of steroidogenic enzyme expression and activity. Novel promoter analysis presented in this work demonstrates the potential for direct and vertebrate wide crosstalk at the transcriptional level in mouse (Mus musculus), Western clawed frog (Silurana tropicalis) and medaka (Oryzias latipes). Cumulative evidence from previous studies, coupled with novel promoter analysis suggests mechanisms for a more direct crosstalk between TH and male reproductive axis across vertebrate species. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-10-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/24236 Flood, Diana E. K.; Fernandino, Juan Ignacio; Langlois, Valerie; Thyroid hormones in male reproductive development: Evidence for direct crosstalk between the androgen and thyroid hormone axes; Academic Press Inc Elsevier Science; General and Comparative Endocrinology; 192; 1-10-2013; 2-14 0016-6480 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/24236 |
identifier_str_mv |
Flood, Diana E. K.; Fernandino, Juan Ignacio; Langlois, Valerie; Thyroid hormones in male reproductive development: Evidence for direct crosstalk between the androgen and thyroid hormone axes; Academic Press Inc Elsevier Science; General and Comparative Endocrinology; 192; 1-10-2013; 2-14 0016-6480 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ygcen.2013.02.038 info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0016648013001159 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Academic Press Inc Elsevier Science |
publisher.none.fl_str_mv |
Academic Press Inc Elsevier Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1846082921619783680 |
score |
13.22299 |