Immunomodulation of Lactobacillus reuteri CRL1324 on group b streptococcus vaginal colonization in a murine experimental model

Autores
de Gregorio, Priscilla Romina; Juárez Tomás, María Silvina; Nader, Maria Elena Fatima
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Problem Maternal Group B Streptococcus (GBS) colonization is a risk factor for infectious disease in newborns. One promising strategy is the modulation of vaginal defense to increase the hosts ability to combat infection. Methods of studyThe effect of intravaginal (i.va.) Lactobacillus reuteri CRL1324 inoculation on different immune cell populations, cytokines and immunoglobulin isotypes in a murine model of GBS vaginal colonization was evaluated ResultsSeven i.va. inoculations of L. reuteri CRL1324 previous to GBS challenge showed an immunomodulatory effect on the cells and mediators of innate immunity, decreasing the number of neutrophils induced by the pathogen and increasing the activated macrophage population. Moreover, increases of B-lymphocytes and IgA and IgG subclasses were observed in mice inoculated with L. reuteri CRL1324 and then challenged with GBS. ConclusionL. reuteri CRL1324 shows a protective effect against GBS colonization that could be mediated by the modulation of the immune response.
Fil: de Gregorio, Priscilla Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
Fil: Juárez Tomás, María Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
Fil: Nader, Maria Elena Fatima. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
Materia
Group B Streptococci
Immune Cells
Lactobacillus
Mice
Preventive Effect
Vaginal Tract
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/28640
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/28640
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Immunomodulation of Lactobacillus reuteri CRL1324 on group b streptococcus vaginal colonization in a murine experimental modelde Gregorio, Priscilla RominaJuárez Tomás, María SilvinaNader, Maria Elena FatimaGroup B StreptococciImmune CellsLactobacillusMicePreventive EffectVaginal Tracthttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Problem Maternal Group B Streptococcus (GBS) colonization is a risk factor for infectious disease in newborns. One promising strategy is the modulation of vaginal defense to increase the hosts ability to combat infection. Methods of studyThe effect of intravaginal (i.va.) Lactobacillus reuteri CRL1324 inoculation on different immune cell populations, cytokines and immunoglobulin isotypes in a murine model of GBS vaginal colonization was evaluated ResultsSeven i.va. inoculations of L. reuteri CRL1324 previous to GBS challenge showed an immunomodulatory effect on the cells and mediators of innate immunity, decreasing the number of neutrophils induced by the pathogen and increasing the activated macrophage population. Moreover, increases of B-lymphocytes and IgA and IgG subclasses were observed in mice inoculated with L. reuteri CRL1324 and then challenged with GBS. ConclusionL. reuteri CRL1324 shows a protective effect against GBS colonization that could be mediated by the modulation of the immune response.Fil: de Gregorio, Priscilla Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; ArgentinaFil: Juárez Tomás, María Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; ArgentinaFil: Nader, Maria Elena Fatima. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; ArgentinaWiley2016-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/28640de Gregorio, Priscilla Romina; Juárez Tomás, María Silvina; Nader, Maria Elena Fatima; Immunomodulation of Lactobacillus reuteri CRL1324 on group b streptococcus vaginal colonization in a murine experimental model; Wiley; American Journal of Reproductive Immunology; 75; 1; 1-2016; 23-351046-74081600-0897CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/aji.12445/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1111/aji.12445info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:08:45Zoai:ri.conicet.gov.ar:11336/28640instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:08:46.089CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Immunomodulation of Lactobacillus reuteri CRL1324 on group b streptococcus vaginal colonization in a murine experimental model
title Immunomodulation of Lactobacillus reuteri CRL1324 on group b streptococcus vaginal colonization in a murine experimental model
spellingShingle Immunomodulation of Lactobacillus reuteri CRL1324 on group b streptococcus vaginal colonization in a murine experimental model
de Gregorio, Priscilla Romina
Group B Streptococci
Immune Cells
Lactobacillus
Mice
Preventive Effect
Vaginal Tract
title_short Immunomodulation of Lactobacillus reuteri CRL1324 on group b streptococcus vaginal colonization in a murine experimental model
title_full Immunomodulation of Lactobacillus reuteri CRL1324 on group b streptococcus vaginal colonization in a murine experimental model
title_fullStr Immunomodulation of Lactobacillus reuteri CRL1324 on group b streptococcus vaginal colonization in a murine experimental model
title_full_unstemmed Immunomodulation of Lactobacillus reuteri CRL1324 on group b streptococcus vaginal colonization in a murine experimental model
title_sort Immunomodulation of Lactobacillus reuteri CRL1324 on group b streptococcus vaginal colonization in a murine experimental model
dc.creator.none.fl_str_mv de Gregorio, Priscilla Romina
Juárez Tomás, María Silvina
Nader, Maria Elena Fatima
author de Gregorio, Priscilla Romina
author_facet de Gregorio, Priscilla Romina
Juárez Tomás, María Silvina
Nader, Maria Elena Fatima
author_role author
author2 Juárez Tomás, María Silvina
Nader, Maria Elena Fatima
author2_role author
author
dc.subject.none.fl_str_mv Group B Streptococci
Immune Cells
Lactobacillus
Mice
Preventive Effect
Vaginal Tract
topic Group B Streptococci
Immune Cells
Lactobacillus
Mice
Preventive Effect
Vaginal Tract
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Problem Maternal Group B Streptococcus (GBS) colonization is a risk factor for infectious disease in newborns. One promising strategy is the modulation of vaginal defense to increase the hosts ability to combat infection. Methods of studyThe effect of intravaginal (i.va.) Lactobacillus reuteri CRL1324 inoculation on different immune cell populations, cytokines and immunoglobulin isotypes in a murine model of GBS vaginal colonization was evaluated ResultsSeven i.va. inoculations of L. reuteri CRL1324 previous to GBS challenge showed an immunomodulatory effect on the cells and mediators of innate immunity, decreasing the number of neutrophils induced by the pathogen and increasing the activated macrophage population. Moreover, increases of B-lymphocytes and IgA and IgG subclasses were observed in mice inoculated with L. reuteri CRL1324 and then challenged with GBS. ConclusionL. reuteri CRL1324 shows a protective effect against GBS colonization that could be mediated by the modulation of the immune response.
Fil: de Gregorio, Priscilla Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
Fil: Juárez Tomás, María Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
Fil: Nader, Maria Elena Fatima. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
description Problem Maternal Group B Streptococcus (GBS) colonization is a risk factor for infectious disease in newborns. One promising strategy is the modulation of vaginal defense to increase the hosts ability to combat infection. Methods of studyThe effect of intravaginal (i.va.) Lactobacillus reuteri CRL1324 inoculation on different immune cell populations, cytokines and immunoglobulin isotypes in a murine model of GBS vaginal colonization was evaluated ResultsSeven i.va. inoculations of L. reuteri CRL1324 previous to GBS challenge showed an immunomodulatory effect on the cells and mediators of innate immunity, decreasing the number of neutrophils induced by the pathogen and increasing the activated macrophage population. Moreover, increases of B-lymphocytes and IgA and IgG subclasses were observed in mice inoculated with L. reuteri CRL1324 and then challenged with GBS. ConclusionL. reuteri CRL1324 shows a protective effect against GBS colonization that could be mediated by the modulation of the immune response.
publishDate 2016
dc.date.none.fl_str_mv 2016-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/28640
de Gregorio, Priscilla Romina; Juárez Tomás, María Silvina; Nader, Maria Elena Fatima; Immunomodulation of Lactobacillus reuteri CRL1324 on group b streptococcus vaginal colonization in a murine experimental model; Wiley; American Journal of Reproductive Immunology; 75; 1; 1-2016; 23-35
1046-7408
1600-0897
CONICET Digital
CONICET
url http://hdl.handle.net/11336/28640
identifier_str_mv de Gregorio, Priscilla Romina; Juárez Tomás, María Silvina; Nader, Maria Elena Fatima; Immunomodulation of Lactobacillus reuteri CRL1324 on group b streptococcus vaginal colonization in a murine experimental model; Wiley; American Journal of Reproductive Immunology; 75; 1; 1-2016; 23-35
1046-7408
1600-0897
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/aji.12445/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1111/aji.12445
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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