Early increases in superantigen-specific Foxp3+ regulatory T cells during mouse mammary tumor virus infection

Autores
Cabrera, Gabriel Gustavo; Burzyn, Dalia; Mundiñano, Juliana; Courreges, Cecilia; Camicia, Gabriela Lorena; Lorenzo, Daniela Mariana; Costa, Hector Luis; Ross, Susan R.; Nepomnaschy, Irene; Piazzon, Margarita Isabel
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Mouse mammary tumor virus (MMTV) is a milk-borne betaretrovirus that has developed strategies to exploit and subvert the host immune system. Here, we show in a natural model of MMTV infection that the virus causes early and progressive increases in superantigen-specific Foxp3+ regulatory T cells (Treg) in Peyer´s patches (PP). These increases were shown to be dependent on the presence of dendritic cells (DCs). CD4+CD25+ T cells from the PP of infected mice preferentially suppress the proliferative response of T cells to Sag-expressing APCs ex vivo. We investigated the influence of the depletion of CD25+ cells at different stages of the infection. When CD25+ cells were depleted before MMTV infection, an increase in the number of PP Sag-cognate Foxp3- T cells was found at day six of infection. Since the Sag response is associated with viral amplification, the possibility exists that Treg cells attenuate the increase in viral load at the beginning of the infection. In contrast, depletion of CD25+ cells once the initial Sag response has developed caused lower viral load, suggesting that at later stages Treg cells may favor viral persistence. Thus, our results indicated that Treg cells play an important and complex role during MMTV infection
Fil: Cabrera, Gabriel Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Burzyn, Dalia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mundiñano, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Courreges, Cecilia. State University of Pennsylvania; Estados Unidos
Fil: Camicia, Gabriela Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lorenzo, Daniela Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Costa, Hector Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ross, Susan R.. State University of Pennsylvania; Estados Unidos
Fil: Nepomnaschy, Irene. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Piazzon, Margarita Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
MAMMARY TUMOR VIRUS
FOXP3+ REGULATORY T CELLS
PEYER´S PATCHES
MOUSE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/27496
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/27496
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Early increases in superantigen-specific Foxp3+ regulatory T cells during mouse mammary tumor virus infectionCabrera, Gabriel GustavoBurzyn, DaliaMundiñano, JulianaCourreges, CeciliaCamicia, Gabriela LorenaLorenzo, Daniela MarianaCosta, Hector LuisRoss, Susan R.Nepomnaschy, IrenePiazzon, Margarita IsabelMAMMARY TUMOR VIRUSFOXP3+ REGULATORY T CELLSPEYER´S PATCHESMOUSEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Mouse mammary tumor virus (MMTV) is a milk-borne betaretrovirus that has developed strategies to exploit and subvert the host immune system. Here, we show in a natural model of MMTV infection that the virus causes early and progressive increases in superantigen-specific Foxp3+ regulatory T cells (Treg) in Peyer´s patches (PP). These increases were shown to be dependent on the presence of dendritic cells (DCs). CD4+CD25+ T cells from the PP of infected mice preferentially suppress the proliferative response of T cells to Sag-expressing APCs ex vivo. We investigated the influence of the depletion of CD25+ cells at different stages of the infection. When CD25+ cells were depleted before MMTV infection, an increase in the number of PP Sag-cognate Foxp3- T cells was found at day six of infection. Since the Sag response is associated with viral amplification, the possibility exists that Treg cells attenuate the increase in viral load at the beginning of the infection. In contrast, depletion of CD25+ cells once the initial Sag response has developed caused lower viral load, suggesting that at later stages Treg cells may favor viral persistence. Thus, our results indicated that Treg cells play an important and complex role during MMTV infectionFil: Cabrera, Gabriel Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Burzyn, Dalia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mundiñano, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Courreges, Cecilia. State University of Pennsylvania; Estados UnidosFil: Camicia, Gabriela Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Lorenzo, Daniela Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Costa, Hector Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ross, Susan R.. State University of Pennsylvania; Estados UnidosFil: Nepomnaschy, Irene. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Piazzon, Margarita Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAmerican Society for Microbiology2008info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/27496Cabrera, Gabriel Gustavo; Burzyn, Dalia; Mundiñano, Juliana; Courreges, Cecilia; Camicia, Gabriela Lorena; et al.; Early increases in superantigen-specific Foxp3+ regulatory T cells during mouse mammary tumor virus infection; American Society for Microbiology; Journal of Virology; 82; 15; -1-2008; 7422-74310022-538X1098-5514CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://jvi.asm.org/content/82/15/7422.longinfo:eu-repo/semantics/altIdentifier/doi/10.1128/JVI.00102-08info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493342/info:eu-repo/semantics/altIdentifier/pmid/18495774info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:07:00Zoai:ri.conicet.gov.ar:11336/27496instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:07:01.169CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Early increases in superantigen-specific Foxp3+ regulatory T cells during mouse mammary tumor virus infection
title Early increases in superantigen-specific Foxp3+ regulatory T cells during mouse mammary tumor virus infection
spellingShingle Early increases in superantigen-specific Foxp3+ regulatory T cells during mouse mammary tumor virus infection
Cabrera, Gabriel Gustavo
MAMMARY TUMOR VIRUS
FOXP3+ REGULATORY T CELLS
PEYER´S PATCHES
MOUSE
title_short Early increases in superantigen-specific Foxp3+ regulatory T cells during mouse mammary tumor virus infection
title_full Early increases in superantigen-specific Foxp3+ regulatory T cells during mouse mammary tumor virus infection
title_fullStr Early increases in superantigen-specific Foxp3+ regulatory T cells during mouse mammary tumor virus infection
title_full_unstemmed Early increases in superantigen-specific Foxp3+ regulatory T cells during mouse mammary tumor virus infection
title_sort Early increases in superantigen-specific Foxp3+ regulatory T cells during mouse mammary tumor virus infection
dc.creator.none.fl_str_mv Cabrera, Gabriel Gustavo
Burzyn, Dalia
Mundiñano, Juliana
Courreges, Cecilia
Camicia, Gabriela Lorena
Lorenzo, Daniela Mariana
Costa, Hector Luis
Ross, Susan R.
Nepomnaschy, Irene
Piazzon, Margarita Isabel
author Cabrera, Gabriel Gustavo
author_facet Cabrera, Gabriel Gustavo
Burzyn, Dalia
Mundiñano, Juliana
Courreges, Cecilia
Camicia, Gabriela Lorena
Lorenzo, Daniela Mariana
Costa, Hector Luis
Ross, Susan R.
Nepomnaschy, Irene
Piazzon, Margarita Isabel
author_role author
author2 Burzyn, Dalia
Mundiñano, Juliana
Courreges, Cecilia
Camicia, Gabriela Lorena
Lorenzo, Daniela Mariana
Costa, Hector Luis
Ross, Susan R.
Nepomnaschy, Irene
Piazzon, Margarita Isabel
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv MAMMARY TUMOR VIRUS
FOXP3+ REGULATORY T CELLS
PEYER´S PATCHES
MOUSE
topic MAMMARY TUMOR VIRUS
FOXP3+ REGULATORY T CELLS
PEYER´S PATCHES
MOUSE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Mouse mammary tumor virus (MMTV) is a milk-borne betaretrovirus that has developed strategies to exploit and subvert the host immune system. Here, we show in a natural model of MMTV infection that the virus causes early and progressive increases in superantigen-specific Foxp3+ regulatory T cells (Treg) in Peyer´s patches (PP). These increases were shown to be dependent on the presence of dendritic cells (DCs). CD4+CD25+ T cells from the PP of infected mice preferentially suppress the proliferative response of T cells to Sag-expressing APCs ex vivo. We investigated the influence of the depletion of CD25+ cells at different stages of the infection. When CD25+ cells were depleted before MMTV infection, an increase in the number of PP Sag-cognate Foxp3- T cells was found at day six of infection. Since the Sag response is associated with viral amplification, the possibility exists that Treg cells attenuate the increase in viral load at the beginning of the infection. In contrast, depletion of CD25+ cells once the initial Sag response has developed caused lower viral load, suggesting that at later stages Treg cells may favor viral persistence. Thus, our results indicated that Treg cells play an important and complex role during MMTV infection
Fil: Cabrera, Gabriel Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Burzyn, Dalia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mundiñano, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Courreges, Cecilia. State University of Pennsylvania; Estados Unidos
Fil: Camicia, Gabriela Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lorenzo, Daniela Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Costa, Hector Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ross, Susan R.. State University of Pennsylvania; Estados Unidos
Fil: Nepomnaschy, Irene. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Piazzon, Margarita Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Mouse mammary tumor virus (MMTV) is a milk-borne betaretrovirus that has developed strategies to exploit and subvert the host immune system. Here, we show in a natural model of MMTV infection that the virus causes early and progressive increases in superantigen-specific Foxp3+ regulatory T cells (Treg) in Peyer´s patches (PP). These increases were shown to be dependent on the presence of dendritic cells (DCs). CD4+CD25+ T cells from the PP of infected mice preferentially suppress the proliferative response of T cells to Sag-expressing APCs ex vivo. We investigated the influence of the depletion of CD25+ cells at different stages of the infection. When CD25+ cells were depleted before MMTV infection, an increase in the number of PP Sag-cognate Foxp3- T cells was found at day six of infection. Since the Sag response is associated with viral amplification, the possibility exists that Treg cells attenuate the increase in viral load at the beginning of the infection. In contrast, depletion of CD25+ cells once the initial Sag response has developed caused lower viral load, suggesting that at later stages Treg cells may favor viral persistence. Thus, our results indicated that Treg cells play an important and complex role during MMTV infection
publishDate 2008
dc.date.none.fl_str_mv 2008
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/27496
Cabrera, Gabriel Gustavo; Burzyn, Dalia; Mundiñano, Juliana; Courreges, Cecilia; Camicia, Gabriela Lorena; et al.; Early increases in superantigen-specific Foxp3+ regulatory T cells during mouse mammary tumor virus infection; American Society for Microbiology; Journal of Virology; 82; 15; -1-2008; 7422-7431
0022-538X
1098-5514
CONICET Digital
CONICET
url http://hdl.handle.net/11336/27496
identifier_str_mv Cabrera, Gabriel Gustavo; Burzyn, Dalia; Mundiñano, Juliana; Courreges, Cecilia; Camicia, Gabriela Lorena; et al.; Early increases in superantigen-specific Foxp3+ regulatory T cells during mouse mammary tumor virus infection; American Society for Microbiology; Journal of Virology; 82; 15; -1-2008; 7422-7431
0022-538X
1098-5514
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://jvi.asm.org/content/82/15/7422.long
info:eu-repo/semantics/altIdentifier/doi/10.1128/JVI.00102-08
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493342/
info:eu-repo/semantics/altIdentifier/pmid/18495774
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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