Registering eye movements during reading in Alzheimer disease: difficulties in predicting upcoming words

Autores
Fernández, Gerardo Abel; Laubrock, Jochen; Mandolesi, Pablo Sergio; Colombo, Oscar; Agamennoni, Osvaldo Enrique
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Reading requires the fine integration of attention, ocular movements, word identification, and language comprehension, among other cognitive parameters. Several of the associated cognitive processes such as working memory and semantic memory are known to be impaired by Alzheimer’s disease (AD). This study analyzes eye movement behavior of 18 patients with probable AD and 40 age-matched controls during Spanish sentence reading. Controls focused mainly on word properties and considered syntactic and semantic structures. At the same time, controls’ knowledge and prediction about sentence meaning and grammatical structure are quite evident when we consider some aspects of visual exploration, such as word skipping, and forward saccades. By contrast, in the AD group, the predictability effect of the upcoming word was absent, visual exploration was less focused, fixations were much longer, and outgoing saccade amplitudes were smaller than those in controls. The altered visual exploration and the absence of a contextual predictability effect might be related to impairments in working memory and long-term memory retrieval functions. These eye movement measures demonstrate considerable sensitivity with respect to evaluating cognitive processes in Alzheimer’s disease. They could provide a user-friendly marker of early disease symptoms and of its posterior progression.
Fil: Fernández, Gerardo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Investigación En Ingeniería Eléctrica; Argentina. Universidad Nacional del Sur; Argentina
Fil: Laubrock, Jochen . University of Potsdam. Department of Psychology; Alemania
Fil: Mandolesi, Pablo Sergio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Investigación en Ingeniería Eléctrica; Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Electrica y de Computadoras; Argentina
Fil: Colombo, Oscar. Hospital Municipal de Agudos de Bahía Blanca. Departamento de Neurología; Argentina
Fil: Agamennoni, Osvaldo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Investigación en Ingeniería Eléctrica; Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Electrica y de Computadoras; Argentina
Materia
Reading
Eye Movements
Word Predictability
Alzheimer Disease
Fixation Duration
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/11752
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Registering eye movements during reading in Alzheimer disease: difficulties in predicting upcoming wordsFernández, Gerardo AbelLaubrock, Jochen Mandolesi, Pablo SergioColombo, OscarAgamennoni, Osvaldo EnriqueReadingEye MovementsWord PredictabilityAlzheimer DiseaseFixation Durationhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Reading requires the fine integration of attention, ocular movements, word identification, and language comprehension, among other cognitive parameters. Several of the associated cognitive processes such as working memory and semantic memory are known to be impaired by Alzheimer’s disease (AD). This study analyzes eye movement behavior of 18 patients with probable AD and 40 age-matched controls during Spanish sentence reading. Controls focused mainly on word properties and considered syntactic and semantic structures. At the same time, controls’ knowledge and prediction about sentence meaning and grammatical structure are quite evident when we consider some aspects of visual exploration, such as word skipping, and forward saccades. By contrast, in the AD group, the predictability effect of the upcoming word was absent, visual exploration was less focused, fixations were much longer, and outgoing saccade amplitudes were smaller than those in controls. The altered visual exploration and the absence of a contextual predictability effect might be related to impairments in working memory and long-term memory retrieval functions. These eye movement measures demonstrate considerable sensitivity with respect to evaluating cognitive processes in Alzheimer’s disease. They could provide a user-friendly marker of early disease symptoms and of its posterior progression.Fil: Fernández, Gerardo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Investigación En Ingeniería Eléctrica; Argentina. Universidad Nacional del Sur; ArgentinaFil: Laubrock, Jochen . University of Potsdam. Department of Psychology; AlemaniaFil: Mandolesi, Pablo Sergio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Investigación en Ingeniería Eléctrica; Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Electrica y de Computadoras; ArgentinaFil: Colombo, Oscar. Hospital Municipal de Agudos de Bahía Blanca. Departamento de Neurología; ArgentinaFil: Agamennoni, Osvaldo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Investigación en Ingeniería Eléctrica; Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Electrica y de Computadoras; ArgentinaTaylor & Francis2014-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/11752Fernández, Gerardo Abel; Laubrock, Jochen ; Mandolesi, Pablo Sergio; Colombo, Oscar; Agamennoni, Osvaldo Enrique; Registering eye movements during reading in Alzheimer disease: difficulties in predicting upcoming words; Taylor & Francis; Journal Of Clinical And Experimental Neuropsychology; 36; 3; 3-2014; 302-3161380-3395enginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1080/13803395.2014.892060info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-12-17T15:13:43Zoai:ri.conicet.gov.ar:11336/11752instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-12-17 15:13:43.678CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Registering eye movements during reading in Alzheimer disease: difficulties in predicting upcoming words
title Registering eye movements during reading in Alzheimer disease: difficulties in predicting upcoming words
spellingShingle Registering eye movements during reading in Alzheimer disease: difficulties in predicting upcoming words
Fernández, Gerardo Abel
Reading
Eye Movements
Word Predictability
Alzheimer Disease
Fixation Duration
title_short Registering eye movements during reading in Alzheimer disease: difficulties in predicting upcoming words
title_full Registering eye movements during reading in Alzheimer disease: difficulties in predicting upcoming words
title_fullStr Registering eye movements during reading in Alzheimer disease: difficulties in predicting upcoming words
title_full_unstemmed Registering eye movements during reading in Alzheimer disease: difficulties in predicting upcoming words
title_sort Registering eye movements during reading in Alzheimer disease: difficulties in predicting upcoming words
dc.creator.none.fl_str_mv Fernández, Gerardo Abel
Laubrock, Jochen
Mandolesi, Pablo Sergio
Colombo, Oscar
Agamennoni, Osvaldo Enrique
author Fernández, Gerardo Abel
author_facet Fernández, Gerardo Abel
Laubrock, Jochen
Mandolesi, Pablo Sergio
Colombo, Oscar
Agamennoni, Osvaldo Enrique
author_role author
author2 Laubrock, Jochen
Mandolesi, Pablo Sergio
Colombo, Oscar
Agamennoni, Osvaldo Enrique
author2_role author
author
author
author
dc.subject.none.fl_str_mv Reading
Eye Movements
Word Predictability
Alzheimer Disease
Fixation Duration
topic Reading
Eye Movements
Word Predictability
Alzheimer Disease
Fixation Duration
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Reading requires the fine integration of attention, ocular movements, word identification, and language comprehension, among other cognitive parameters. Several of the associated cognitive processes such as working memory and semantic memory are known to be impaired by Alzheimer’s disease (AD). This study analyzes eye movement behavior of 18 patients with probable AD and 40 age-matched controls during Spanish sentence reading. Controls focused mainly on word properties and considered syntactic and semantic structures. At the same time, controls’ knowledge and prediction about sentence meaning and grammatical structure are quite evident when we consider some aspects of visual exploration, such as word skipping, and forward saccades. By contrast, in the AD group, the predictability effect of the upcoming word was absent, visual exploration was less focused, fixations were much longer, and outgoing saccade amplitudes were smaller than those in controls. The altered visual exploration and the absence of a contextual predictability effect might be related to impairments in working memory and long-term memory retrieval functions. These eye movement measures demonstrate considerable sensitivity with respect to evaluating cognitive processes in Alzheimer’s disease. They could provide a user-friendly marker of early disease symptoms and of its posterior progression.
Fil: Fernández, Gerardo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Investigación En Ingeniería Eléctrica; Argentina. Universidad Nacional del Sur; Argentina
Fil: Laubrock, Jochen . University of Potsdam. Department of Psychology; Alemania
Fil: Mandolesi, Pablo Sergio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Investigación en Ingeniería Eléctrica; Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Electrica y de Computadoras; Argentina
Fil: Colombo, Oscar. Hospital Municipal de Agudos de Bahía Blanca. Departamento de Neurología; Argentina
Fil: Agamennoni, Osvaldo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Investigación en Ingeniería Eléctrica; Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Electrica y de Computadoras; Argentina
description Reading requires the fine integration of attention, ocular movements, word identification, and language comprehension, among other cognitive parameters. Several of the associated cognitive processes such as working memory and semantic memory are known to be impaired by Alzheimer’s disease (AD). This study analyzes eye movement behavior of 18 patients with probable AD and 40 age-matched controls during Spanish sentence reading. Controls focused mainly on word properties and considered syntactic and semantic structures. At the same time, controls’ knowledge and prediction about sentence meaning and grammatical structure are quite evident when we consider some aspects of visual exploration, such as word skipping, and forward saccades. By contrast, in the AD group, the predictability effect of the upcoming word was absent, visual exploration was less focused, fixations were much longer, and outgoing saccade amplitudes were smaller than those in controls. The altered visual exploration and the absence of a contextual predictability effect might be related to impairments in working memory and long-term memory retrieval functions. These eye movement measures demonstrate considerable sensitivity with respect to evaluating cognitive processes in Alzheimer’s disease. They could provide a user-friendly marker of early disease symptoms and of its posterior progression.
publishDate 2014
dc.date.none.fl_str_mv 2014-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/11752
Fernández, Gerardo Abel; Laubrock, Jochen ; Mandolesi, Pablo Sergio; Colombo, Oscar; Agamennoni, Osvaldo Enrique; Registering eye movements during reading in Alzheimer disease: difficulties in predicting upcoming words; Taylor & Francis; Journal Of Clinical And Experimental Neuropsychology; 36; 3; 3-2014; 302-316
1380-3395
url http://hdl.handle.net/11336/11752
identifier_str_mv Fernández, Gerardo Abel; Laubrock, Jochen ; Mandolesi, Pablo Sergio; Colombo, Oscar; Agamennoni, Osvaldo Enrique; Registering eye movements during reading in Alzheimer disease: difficulties in predicting upcoming words; Taylor & Francis; Journal Of Clinical And Experimental Neuropsychology; 36; 3; 3-2014; 302-316
1380-3395
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1080/13803395.2014.892060
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.176297

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