Eye Movement Alterations During Reading in Patients With Early Alzheimer Disease

Autores
Fernández, Gerardo Abel; Mandolesi, Pablo Sergio; Rotstein, Nora Patricia; Colombo, Oscar; Agamennoni, Osvaldo Enrique; Politi, Luis Enrique
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Purpose Eye movements follow a reproducible pattern during normal reading. Each eye movement ends up in a fixation point, which allows the brain to process the incoming information and to program the following saccade. Alzheimer disease (AD) produces eye movement abnormalities and disturbances in reading. In this work we investigated whether eye movement alterations during reading might be already present at very early stages of the disease. Methods Twenty female and male adult patients with the diagnosis of probable AD and 20 age-matching individuals with no evidence of cognitive decline participated in the study. Participants were seated in front of a 20-inch LCD monitor and single sentences were presented on it. Eye movements were recorded with an eyetracker, with a sampling rate of 1000 Hz and an eye position resolution of 20-s arc. Results Analysis of eye movements during reading revealed that patients with early AD decreased the amount of words with only one fixations, increased their total number of first and second pass fixations, the amount of saccade regressions and the number of words skipped, compared with healthy individuals (controls). They also reduced the size of outgoing saccades, simultaneously increasing fixation duration. Conclusions The present study shows that patients with mild AD evidenced marked alterations in eye movement behavior during reading, even at early stages of the disease. Hence, evaluation of eye movement behavior during reading might provide a useful tool for a more precise early diagnosis of AD and for dynamical monitoring of the pathology.
Fil: Fernández, Gerardo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Conicet - Bahía Blanca. Instituto de Investigación En Ingeniería Eléctrica; Argentina. Universidad Nacional del Sur; Argentina
Fil: Mandolesi, Pablo Sergio. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - Bahía Blanca. Instituto de Investigación en Ingeniería Eléctrica; Argentina
Fil: Rotstein, Nora Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET Bahía Blanca. Instituto de Investigaciones Bioquímicas Bahía Blanca (i); Argentina. Universidad Nacional del Sur; Argentina
Fil: Colombo, Oscar. Hospital Municipal de Agudos, Bahia Blanca; Argentina
Fil: Agamennoni, Osvaldo Enrique. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - Bahía Blanca. Instituto de Investigación en Ingeniería Eléctrica; Argentina
Fil: Politi, Luis Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET Bahía Blanca. Instituto de Investigaciones Bioquímicas Bahía Blanca (i); Argentina. Universidad Nacional del Sur; Argentina
Materia
Alzheimer Disease
Reading
Eye Tracking
Cognitive Impairment
Saccadic Movements
Eye Fixation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/4532
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Eye Movement Alterations During Reading in Patients With Early Alzheimer DiseaseFernández, Gerardo AbelMandolesi, Pablo SergioRotstein, Nora PatriciaColombo, OscarAgamennoni, Osvaldo EnriquePoliti, Luis EnriqueAlzheimer DiseaseReadingEye TrackingCognitive ImpairmentSaccadic MovementsEye Fixationhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Purpose Eye movements follow a reproducible pattern during normal reading. Each eye movement ends up in a fixation point, which allows the brain to process the incoming information and to program the following saccade. Alzheimer disease (AD) produces eye movement abnormalities and disturbances in reading. In this work we investigated whether eye movement alterations during reading might be already present at very early stages of the disease. Methods Twenty female and male adult patients with the diagnosis of probable AD and 20 age-matching individuals with no evidence of cognitive decline participated in the study. Participants were seated in front of a 20-inch LCD monitor and single sentences were presented on it. Eye movements were recorded with an eyetracker, with a sampling rate of 1000 Hz and an eye position resolution of 20-s arc. Results Analysis of eye movements during reading revealed that patients with early AD decreased the amount of words with only one fixations, increased their total number of first and second pass fixations, the amount of saccade regressions and the number of words skipped, compared with healthy individuals (controls). They also reduced the size of outgoing saccades, simultaneously increasing fixation duration. Conclusions The present study shows that patients with mild AD evidenced marked alterations in eye movement behavior during reading, even at early stages of the disease. Hence, evaluation of eye movement behavior during reading might provide a useful tool for a more precise early diagnosis of AD and for dynamical monitoring of the pathology.Fil: Fernández, Gerardo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Conicet - Bahía Blanca. Instituto de Investigación En Ingeniería Eléctrica; Argentina. Universidad Nacional del Sur; ArgentinaFil: Mandolesi, Pablo Sergio. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - Bahía Blanca. Instituto de Investigación en Ingeniería Eléctrica; ArgentinaFil: Rotstein, Nora Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET Bahía Blanca. Instituto de Investigaciones Bioquímicas Bahía Blanca (i); Argentina. Universidad Nacional del Sur; ArgentinaFil: Colombo, Oscar. Hospital Municipal de Agudos, Bahia Blanca; ArgentinaFil: Agamennoni, Osvaldo Enrique. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - Bahía Blanca. Instituto de Investigación en Ingeniería Eléctrica; ArgentinaFil: Politi, Luis Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET Bahía Blanca. Instituto de Investigaciones Bioquímicas Bahía Blanca (i); Argentina. Universidad Nacional del Sur; ArgentinaAssociation For Research In Vision And Ophthalmology2013-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/4532Fernández, Gerardo Abel; Mandolesi, Pablo Sergio; Rotstein, Nora Patricia; Colombo, Oscar; Agamennoni, Osvaldo Enrique; et al.; Eye Movement Alterations During Reading in Patients With Early Alzheimer Disease; Association For Research In Vision And Ophthalmology; Investigative Ophthalmology & Visual Science; 54; 13; 12-2013; 8345-83520146-0404enginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pubmed/24282223info:eu-repo/semantics/altIdentifier/ark/http://www.iovs.org/content/early/2013/11/25/iovs.13-12877.abstract?sid=5ca3fa0b-b958-4c69-a27e-a2b20c678254info:eu-repo/semantics/altIdentifier/doi/10.1167/iovs.13-12877info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T10:42:05Zoai:ri.conicet.gov.ar:11336/4532instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 10:42:05.873CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Eye Movement Alterations During Reading in Patients With Early Alzheimer Disease
title Eye Movement Alterations During Reading in Patients With Early Alzheimer Disease
spellingShingle Eye Movement Alterations During Reading in Patients With Early Alzheimer Disease
Fernández, Gerardo Abel
Alzheimer Disease
Reading
Eye Tracking
Cognitive Impairment
Saccadic Movements
Eye Fixation
title_short Eye Movement Alterations During Reading in Patients With Early Alzheimer Disease
title_full Eye Movement Alterations During Reading in Patients With Early Alzheimer Disease
title_fullStr Eye Movement Alterations During Reading in Patients With Early Alzheimer Disease
title_full_unstemmed Eye Movement Alterations During Reading in Patients With Early Alzheimer Disease
title_sort Eye Movement Alterations During Reading in Patients With Early Alzheimer Disease
dc.creator.none.fl_str_mv Fernández, Gerardo Abel
Mandolesi, Pablo Sergio
Rotstein, Nora Patricia
Colombo, Oscar
Agamennoni, Osvaldo Enrique
Politi, Luis Enrique
author Fernández, Gerardo Abel
author_facet Fernández, Gerardo Abel
Mandolesi, Pablo Sergio
Rotstein, Nora Patricia
Colombo, Oscar
Agamennoni, Osvaldo Enrique
Politi, Luis Enrique
author_role author
author2 Mandolesi, Pablo Sergio
Rotstein, Nora Patricia
Colombo, Oscar
Agamennoni, Osvaldo Enrique
Politi, Luis Enrique
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Alzheimer Disease
Reading
Eye Tracking
Cognitive Impairment
Saccadic Movements
Eye Fixation
topic Alzheimer Disease
Reading
Eye Tracking
Cognitive Impairment
Saccadic Movements
Eye Fixation
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Purpose Eye movements follow a reproducible pattern during normal reading. Each eye movement ends up in a fixation point, which allows the brain to process the incoming information and to program the following saccade. Alzheimer disease (AD) produces eye movement abnormalities and disturbances in reading. In this work we investigated whether eye movement alterations during reading might be already present at very early stages of the disease. Methods Twenty female and male adult patients with the diagnosis of probable AD and 20 age-matching individuals with no evidence of cognitive decline participated in the study. Participants were seated in front of a 20-inch LCD monitor and single sentences were presented on it. Eye movements were recorded with an eyetracker, with a sampling rate of 1000 Hz and an eye position resolution of 20-s arc. Results Analysis of eye movements during reading revealed that patients with early AD decreased the amount of words with only one fixations, increased their total number of first and second pass fixations, the amount of saccade regressions and the number of words skipped, compared with healthy individuals (controls). They also reduced the size of outgoing saccades, simultaneously increasing fixation duration. Conclusions The present study shows that patients with mild AD evidenced marked alterations in eye movement behavior during reading, even at early stages of the disease. Hence, evaluation of eye movement behavior during reading might provide a useful tool for a more precise early diagnosis of AD and for dynamical monitoring of the pathology.
Fil: Fernández, Gerardo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Conicet - Bahía Blanca. Instituto de Investigación En Ingeniería Eléctrica; Argentina. Universidad Nacional del Sur; Argentina
Fil: Mandolesi, Pablo Sergio. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - Bahía Blanca. Instituto de Investigación en Ingeniería Eléctrica; Argentina
Fil: Rotstein, Nora Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET Bahía Blanca. Instituto de Investigaciones Bioquímicas Bahía Blanca (i); Argentina. Universidad Nacional del Sur; Argentina
Fil: Colombo, Oscar. Hospital Municipal de Agudos, Bahia Blanca; Argentina
Fil: Agamennoni, Osvaldo Enrique. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - Bahía Blanca. Instituto de Investigación en Ingeniería Eléctrica; Argentina
Fil: Politi, Luis Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET Bahía Blanca. Instituto de Investigaciones Bioquímicas Bahía Blanca (i); Argentina. Universidad Nacional del Sur; Argentina
description Purpose Eye movements follow a reproducible pattern during normal reading. Each eye movement ends up in a fixation point, which allows the brain to process the incoming information and to program the following saccade. Alzheimer disease (AD) produces eye movement abnormalities and disturbances in reading. In this work we investigated whether eye movement alterations during reading might be already present at very early stages of the disease. Methods Twenty female and male adult patients with the diagnosis of probable AD and 20 age-matching individuals with no evidence of cognitive decline participated in the study. Participants were seated in front of a 20-inch LCD monitor and single sentences were presented on it. Eye movements were recorded with an eyetracker, with a sampling rate of 1000 Hz and an eye position resolution of 20-s arc. Results Analysis of eye movements during reading revealed that patients with early AD decreased the amount of words with only one fixations, increased their total number of first and second pass fixations, the amount of saccade regressions and the number of words skipped, compared with healthy individuals (controls). They also reduced the size of outgoing saccades, simultaneously increasing fixation duration. Conclusions The present study shows that patients with mild AD evidenced marked alterations in eye movement behavior during reading, even at early stages of the disease. Hence, evaluation of eye movement behavior during reading might provide a useful tool for a more precise early diagnosis of AD and for dynamical monitoring of the pathology.
publishDate 2013
dc.date.none.fl_str_mv 2013-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/4532
Fernández, Gerardo Abel; Mandolesi, Pablo Sergio; Rotstein, Nora Patricia; Colombo, Oscar; Agamennoni, Osvaldo Enrique; et al.; Eye Movement Alterations During Reading in Patients With Early Alzheimer Disease; Association For Research In Vision And Ophthalmology; Investigative Ophthalmology & Visual Science; 54; 13; 12-2013; 8345-8352
0146-0404
url http://hdl.handle.net/11336/4532
identifier_str_mv Fernández, Gerardo Abel; Mandolesi, Pablo Sergio; Rotstein, Nora Patricia; Colombo, Oscar; Agamennoni, Osvaldo Enrique; et al.; Eye Movement Alterations During Reading in Patients With Early Alzheimer Disease; Association For Research In Vision And Ophthalmology; Investigative Ophthalmology & Visual Science; 54; 13; 12-2013; 8345-8352
0146-0404
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pubmed/24282223
info:eu-repo/semantics/altIdentifier/ark/http://www.iovs.org/content/early/2013/11/25/iovs.13-12877.abstract?sid=5ca3fa0b-b958-4c69-a27e-a2b20c678254
info:eu-repo/semantics/altIdentifier/doi/10.1167/iovs.13-12877
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
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dc.publisher.none.fl_str_mv Association For Research In Vision And Ophthalmology
publisher.none.fl_str_mv Association For Research In Vision And Ophthalmology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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