Impact of lipid sources on quality traits of medical cannabis-based oil preparations

Autores
Ramella, Alberto; Roda, Gabriella; Pavlovic, Radmila; Cas, Michele Dei; Casagni, Eleonora; Mosconi, Giacomo; Cecati, Francisco Miguel; Minghetti, Paola; Grizzetti, Carlo
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The feasibility of the use of two lipid sources and their impact on the cannabinoid profile, terpene fingerprint, and degradation products in medical cannabis oil preparations during 3 months of refrigerated storage time were investigated. LCHRMS-Orbitrap® and HS-SPME coupled to GC-MS for the investigation of targeted and untargeted cannabinoids, terpenes, and lipid degradation products in Bedrocan® and Bediol® macerated oils were used as analytical approaches. As regards the cannabinoid trend during 90 days of storage, there were no differences between PhEur-grade olive oil (OOPH) and medium-chain triglycerides oil (MCT oil) coupled to a good stability of preparations for the first 60 days both in Bedrocan® and Bediol® oils. MCT lipid source extracted a significant concentration of terpenes compared to olive oil. Terpenes showed a different scenario since MCT oil displayed the strongest extraction capacity and conservation trend of all compounds during the shelf life. Terpenes remained stable throughout the entire storage period in MCT formulations while a significant decrease after 15 and 30 days in Bediol® and Bedrocan® was observed in olive oil. Therefore, MCT oil could be considered a more suitable lipid source compared to olive oil involved in the extraction of medical cannabis for magistral preparations.
Fil: Ramella, Alberto. Farmacia Dott.ri Giuliana E Alberto Ramellasas; Italia
Fil: Roda, Gabriella. Università degli Studi di Milano; Italia
Fil: Pavlovic, Radmila. Universita Degli Studi Di Milano. Medicina Veterinaria. Dipartimento Di Scienze Veterinarie Per la Salute.; Italia
Fil: Cas, Michele Dei. Università degli Studi di Milano; Italia
Fil: Casagni, Eleonora. Università degli Studi di Milano; Italia
Fil: Mosconi, Giacomo. Universita Degli Studi Di Milano. Medicina Veterinaria. Dipartimento Di Scienze Veterinarie Per la Salute.; Italia
Fil: Cecati, Francisco Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; Argentina
Fil: Minghetti, Paola. Università degli Studi di Milano; Italia
Fil: Grizzetti, Carlo. Ospedale Di Circolofondazione Macchi, Asst Sette Laghi; Italia
Materia
CANNABINOIDS
CANNABIS OILS
HS-SPME-GC/MS
LCHRMS-ORBITRAP
MCT OIL
OLIVE OIL
TERPENES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/143868
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/143868
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Impact of lipid sources on quality traits of medical cannabis-based oil preparationsRamella, AlbertoRoda, GabriellaPavlovic, RadmilaCas, Michele DeiCasagni, EleonoraMosconi, GiacomoCecati, Francisco MiguelMinghetti, PaolaGrizzetti, CarloCANNABINOIDSCANNABIS OILSHS-SPME-GC/MSLCHRMS-ORBITRAPMCT OILOLIVE OILTERPENEShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The feasibility of the use of two lipid sources and their impact on the cannabinoid profile, terpene fingerprint, and degradation products in medical cannabis oil preparations during 3 months of refrigerated storage time were investigated. LCHRMS-Orbitrap® and HS-SPME coupled to GC-MS for the investigation of targeted and untargeted cannabinoids, terpenes, and lipid degradation products in Bedrocan® and Bediol® macerated oils were used as analytical approaches. As regards the cannabinoid trend during 90 days of storage, there were no differences between PhEur-grade olive oil (OOPH) and medium-chain triglycerides oil (MCT oil) coupled to a good stability of preparations for the first 60 days both in Bedrocan® and Bediol® oils. MCT lipid source extracted a significant concentration of terpenes compared to olive oil. Terpenes showed a different scenario since MCT oil displayed the strongest extraction capacity and conservation trend of all compounds during the shelf life. Terpenes remained stable throughout the entire storage period in MCT formulations while a significant decrease after 15 and 30 days in Bediol® and Bedrocan® was observed in olive oil. Therefore, MCT oil could be considered a more suitable lipid source compared to olive oil involved in the extraction of medical cannabis for magistral preparations.Fil: Ramella, Alberto. Farmacia Dott.ri Giuliana E Alberto Ramellasas; ItaliaFil: Roda, Gabriella. Università degli Studi di Milano; ItaliaFil: Pavlovic, Radmila. Universita Degli Studi Di Milano. Medicina Veterinaria. Dipartimento Di Scienze Veterinarie Per la Salute.; ItaliaFil: Cas, Michele Dei. Università degli Studi di Milano; ItaliaFil: Casagni, Eleonora. Università degli Studi di Milano; ItaliaFil: Mosconi, Giacomo. Universita Degli Studi Di Milano. Medicina Veterinaria. Dipartimento Di Scienze Veterinarie Per la Salute.; ItaliaFil: Cecati, Francisco Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; ArgentinaFil: Minghetti, Paola. Università degli Studi di Milano; ItaliaFil: Grizzetti, Carlo. Ospedale Di Circolofondazione Macchi, Asst Sette Laghi; ItaliaMolecular Diversity Preservation International2020-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/143868Ramella, Alberto; Roda, Gabriella; Pavlovic, Radmila; Cas, Michele Dei; Casagni, Eleonora; et al.; Impact of lipid sources on quality traits of medical cannabis-based oil preparations; Molecular Diversity Preservation International; Molecules; 25; 13; 7-2020; 1-181420-3049CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/25/13/2986info:eu-repo/semantics/altIdentifier/doi/10.3390/molecules25132986info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:41Zoai:ri.conicet.gov.ar:11336/143868instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:41.994CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Impact of lipid sources on quality traits of medical cannabis-based oil preparations
title Impact of lipid sources on quality traits of medical cannabis-based oil preparations
spellingShingle Impact of lipid sources on quality traits of medical cannabis-based oil preparations
Ramella, Alberto
CANNABINOIDS
CANNABIS OILS
HS-SPME-GC/MS
LCHRMS-ORBITRAP
MCT OIL
OLIVE OIL
TERPENES
title_short Impact of lipid sources on quality traits of medical cannabis-based oil preparations
title_full Impact of lipid sources on quality traits of medical cannabis-based oil preparations
title_fullStr Impact of lipid sources on quality traits of medical cannabis-based oil preparations
title_full_unstemmed Impact of lipid sources on quality traits of medical cannabis-based oil preparations
title_sort Impact of lipid sources on quality traits of medical cannabis-based oil preparations
dc.creator.none.fl_str_mv Ramella, Alberto
Roda, Gabriella
Pavlovic, Radmila
Cas, Michele Dei
Casagni, Eleonora
Mosconi, Giacomo
Cecati, Francisco Miguel
Minghetti, Paola
Grizzetti, Carlo
author Ramella, Alberto
author_facet Ramella, Alberto
Roda, Gabriella
Pavlovic, Radmila
Cas, Michele Dei
Casagni, Eleonora
Mosconi, Giacomo
Cecati, Francisco Miguel
Minghetti, Paola
Grizzetti, Carlo
author_role author
author2 Roda, Gabriella
Pavlovic, Radmila
Cas, Michele Dei
Casagni, Eleonora
Mosconi, Giacomo
Cecati, Francisco Miguel
Minghetti, Paola
Grizzetti, Carlo
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CANNABINOIDS
CANNABIS OILS
HS-SPME-GC/MS
LCHRMS-ORBITRAP
MCT OIL
OLIVE OIL
TERPENES
topic CANNABINOIDS
CANNABIS OILS
HS-SPME-GC/MS
LCHRMS-ORBITRAP
MCT OIL
OLIVE OIL
TERPENES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The feasibility of the use of two lipid sources and their impact on the cannabinoid profile, terpene fingerprint, and degradation products in medical cannabis oil preparations during 3 months of refrigerated storage time were investigated. LCHRMS-Orbitrap® and HS-SPME coupled to GC-MS for the investigation of targeted and untargeted cannabinoids, terpenes, and lipid degradation products in Bedrocan® and Bediol® macerated oils were used as analytical approaches. As regards the cannabinoid trend during 90 days of storage, there were no differences between PhEur-grade olive oil (OOPH) and medium-chain triglycerides oil (MCT oil) coupled to a good stability of preparations for the first 60 days both in Bedrocan® and Bediol® oils. MCT lipid source extracted a significant concentration of terpenes compared to olive oil. Terpenes showed a different scenario since MCT oil displayed the strongest extraction capacity and conservation trend of all compounds during the shelf life. Terpenes remained stable throughout the entire storage period in MCT formulations while a significant decrease after 15 and 30 days in Bediol® and Bedrocan® was observed in olive oil. Therefore, MCT oil could be considered a more suitable lipid source compared to olive oil involved in the extraction of medical cannabis for magistral preparations.
Fil: Ramella, Alberto. Farmacia Dott.ri Giuliana E Alberto Ramellasas; Italia
Fil: Roda, Gabriella. Università degli Studi di Milano; Italia
Fil: Pavlovic, Radmila. Universita Degli Studi Di Milano. Medicina Veterinaria. Dipartimento Di Scienze Veterinarie Per la Salute.; Italia
Fil: Cas, Michele Dei. Università degli Studi di Milano; Italia
Fil: Casagni, Eleonora. Università degli Studi di Milano; Italia
Fil: Mosconi, Giacomo. Universita Degli Studi Di Milano. Medicina Veterinaria. Dipartimento Di Scienze Veterinarie Per la Salute.; Italia
Fil: Cecati, Francisco Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; Argentina
Fil: Minghetti, Paola. Università degli Studi di Milano; Italia
Fil: Grizzetti, Carlo. Ospedale Di Circolofondazione Macchi, Asst Sette Laghi; Italia
description The feasibility of the use of two lipid sources and their impact on the cannabinoid profile, terpene fingerprint, and degradation products in medical cannabis oil preparations during 3 months of refrigerated storage time were investigated. LCHRMS-Orbitrap® and HS-SPME coupled to GC-MS for the investigation of targeted and untargeted cannabinoids, terpenes, and lipid degradation products in Bedrocan® and Bediol® macerated oils were used as analytical approaches. As regards the cannabinoid trend during 90 days of storage, there were no differences between PhEur-grade olive oil (OOPH) and medium-chain triglycerides oil (MCT oil) coupled to a good stability of preparations for the first 60 days both in Bedrocan® and Bediol® oils. MCT lipid source extracted a significant concentration of terpenes compared to olive oil. Terpenes showed a different scenario since MCT oil displayed the strongest extraction capacity and conservation trend of all compounds during the shelf life. Terpenes remained stable throughout the entire storage period in MCT formulations while a significant decrease after 15 and 30 days in Bediol® and Bedrocan® was observed in olive oil. Therefore, MCT oil could be considered a more suitable lipid source compared to olive oil involved in the extraction of medical cannabis for magistral preparations.
publishDate 2020
dc.date.none.fl_str_mv 2020-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/143868
Ramella, Alberto; Roda, Gabriella; Pavlovic, Radmila; Cas, Michele Dei; Casagni, Eleonora; et al.; Impact of lipid sources on quality traits of medical cannabis-based oil preparations; Molecular Diversity Preservation International; Molecules; 25; 13; 7-2020; 1-18
1420-3049
CONICET Digital
CONICET
url http://hdl.handle.net/11336/143868
identifier_str_mv Ramella, Alberto; Roda, Gabriella; Pavlovic, Radmila; Cas, Michele Dei; Casagni, Eleonora; et al.; Impact of lipid sources on quality traits of medical cannabis-based oil preparations; Molecular Diversity Preservation International; Molecules; 25; 13; 7-2020; 1-18
1420-3049
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/25/13/2986
info:eu-repo/semantics/altIdentifier/doi/10.3390/molecules25132986
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268682890248192
score 13.13397

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