Chronic Inflammation in Non-Healing Skin Wounds and Promising Natural Bioactive Compounds Treatment

Autores
Schilrreff, Priscila; Alexiev, Ulrike
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Chronic inflammation is one of the hallmarks of chronic wounds and is tightly coupled to immune regulation. The dysregulation of the immune system leads to continuing inflammation and impaired wound healing and, subsequently, to chronic skin wounds. In this review, we discuss the role of the immune system, the involvement of inflammatory mediators and reactive oxygen species, the complication of bacterial infections in chronic wound healing, and the still-underexplored potential of natural bioactive compounds in wound treatment. We focus on natural compounds with antioxidant, anti-inflammatory, and antibacterial activities and their mechanisms of action, as well as on recent wound treatments and therapeutic advancements capitalizing on nanotechnology or new biomaterial platforms.
Fil: Schilrreff, Priscila. Freie Universität Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Alexiev, Ulrike. Freie Universität Berlin; Alemania
Materia
CHRONIC WOUNDS
IMMUNITY
INFLAMMATION
NATURAL BIOACTIVE COMPOUNDS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/200335
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Chronic Inflammation in Non-Healing Skin Wounds and Promising Natural Bioactive Compounds TreatmentSchilrreff, PriscilaAlexiev, UlrikeCHRONIC WOUNDSIMMUNITYINFLAMMATIONNATURAL BIOACTIVE COMPOUNDShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Chronic inflammation is one of the hallmarks of chronic wounds and is tightly coupled to immune regulation. The dysregulation of the immune system leads to continuing inflammation and impaired wound healing and, subsequently, to chronic skin wounds. In this review, we discuss the role of the immune system, the involvement of inflammatory mediators and reactive oxygen species, the complication of bacterial infections in chronic wound healing, and the still-underexplored potential of natural bioactive compounds in wound treatment. We focus on natural compounds with antioxidant, anti-inflammatory, and antibacterial activities and their mechanisms of action, as well as on recent wound treatments and therapeutic advancements capitalizing on nanotechnology or new biomaterial platforms.Fil: Schilrreff, Priscila. Freie Universität Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Alexiev, Ulrike. Freie Universität Berlin; AlemaniaMDPI2022-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/200335Schilrreff, Priscila; Alexiev, Ulrike; Chronic Inflammation in Non-Healing Skin Wounds and Promising Natural Bioactive Compounds Treatment; MDPI; International Journal of Molecular Sciences; 23; 9; 5-2022; 1-311422-0067CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/ijms23094928info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:41:04Zoai:ri.conicet.gov.ar:11336/200335instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:41:04.458CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Chronic Inflammation in Non-Healing Skin Wounds and Promising Natural Bioactive Compounds Treatment
title Chronic Inflammation in Non-Healing Skin Wounds and Promising Natural Bioactive Compounds Treatment
spellingShingle Chronic Inflammation in Non-Healing Skin Wounds and Promising Natural Bioactive Compounds Treatment
Schilrreff, Priscila
CHRONIC WOUNDS
IMMUNITY
INFLAMMATION
NATURAL BIOACTIVE COMPOUNDS
title_short Chronic Inflammation in Non-Healing Skin Wounds and Promising Natural Bioactive Compounds Treatment
title_full Chronic Inflammation in Non-Healing Skin Wounds and Promising Natural Bioactive Compounds Treatment
title_fullStr Chronic Inflammation in Non-Healing Skin Wounds and Promising Natural Bioactive Compounds Treatment
title_full_unstemmed Chronic Inflammation in Non-Healing Skin Wounds and Promising Natural Bioactive Compounds Treatment
title_sort Chronic Inflammation in Non-Healing Skin Wounds and Promising Natural Bioactive Compounds Treatment
dc.creator.none.fl_str_mv Schilrreff, Priscila
Alexiev, Ulrike
author Schilrreff, Priscila
author_facet Schilrreff, Priscila
Alexiev, Ulrike
author_role author
author2 Alexiev, Ulrike
author2_role author
dc.subject.none.fl_str_mv CHRONIC WOUNDS
IMMUNITY
INFLAMMATION
NATURAL BIOACTIVE COMPOUNDS
topic CHRONIC WOUNDS
IMMUNITY
INFLAMMATION
NATURAL BIOACTIVE COMPOUNDS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Chronic inflammation is one of the hallmarks of chronic wounds and is tightly coupled to immune regulation. The dysregulation of the immune system leads to continuing inflammation and impaired wound healing and, subsequently, to chronic skin wounds. In this review, we discuss the role of the immune system, the involvement of inflammatory mediators and reactive oxygen species, the complication of bacterial infections in chronic wound healing, and the still-underexplored potential of natural bioactive compounds in wound treatment. We focus on natural compounds with antioxidant, anti-inflammatory, and antibacterial activities and their mechanisms of action, as well as on recent wound treatments and therapeutic advancements capitalizing on nanotechnology or new biomaterial platforms.
Fil: Schilrreff, Priscila. Freie Universität Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Alexiev, Ulrike. Freie Universität Berlin; Alemania
description Chronic inflammation is one of the hallmarks of chronic wounds and is tightly coupled to immune regulation. The dysregulation of the immune system leads to continuing inflammation and impaired wound healing and, subsequently, to chronic skin wounds. In this review, we discuss the role of the immune system, the involvement of inflammatory mediators and reactive oxygen species, the complication of bacterial infections in chronic wound healing, and the still-underexplored potential of natural bioactive compounds in wound treatment. We focus on natural compounds with antioxidant, anti-inflammatory, and antibacterial activities and their mechanisms of action, as well as on recent wound treatments and therapeutic advancements capitalizing on nanotechnology or new biomaterial platforms.
publishDate 2022
dc.date.none.fl_str_mv 2022-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/200335
Schilrreff, Priscila; Alexiev, Ulrike; Chronic Inflammation in Non-Healing Skin Wounds and Promising Natural Bioactive Compounds Treatment; MDPI; International Journal of Molecular Sciences; 23; 9; 5-2022; 1-31
1422-0067
CONICET Digital
CONICET
url http://hdl.handle.net/11336/200335
identifier_str_mv Schilrreff, Priscila; Alexiev, Ulrike; Chronic Inflammation in Non-Healing Skin Wounds and Promising Natural Bioactive Compounds Treatment; MDPI; International Journal of Molecular Sciences; 23; 9; 5-2022; 1-31
1422-0067
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/ijms23094928
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613298573541376
score 13.070432

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