A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymerase

Autores
Garro, Hugo Alejandro; García, Celina E.; Martín, Víctor S.; Tonn, Carlos Eugenio; Pungitore, Carlos Rodolfo
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
DNA polymerases are enzymes that play a crucial role in DNA metabolism such as replication, repair, transcription, recombination, and chromosome segregation during mitosis. Herein we report the isolation of a new iridoid (6-epi-catalpol, 2) and per-O-acetyl-verbascoside (11) from aerial part of Buddleja cordobensis Grisebach (Buddlejaceae). From compound 2, we have obtained eight compounds by chemical transformation. This group of compounds at a concentration of 500 μM was assayed against Taq DNA polymerase. Compound 11 (per-O-acetyl-verbascoside) was the most active with an IC50 of 1.21 + 0.18 μM; compounds 9, 2 and 8 were strong inhibitors with IC50 values of 5.57 + 0.70, 21.62 + 0.22 and 78.13 + 0.93 μM, respectively. Compounds 11 and 9 could be a leader structures to development new anticancer chemotherapy medicines and a useful tool to investigate DNA polymerase activity.
Fil: Garro, Hugo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; Argentina
Fil: García, Celina E.. Universidad de la Laguna; España
Fil: Martín, Víctor S.. Universidad de la Laguna; España
Fil: Tonn, Carlos Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; Argentina
Fil: Pungitore, Carlos Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; Argentina
Materia
Natural Products
Taq Dna Polymerase Inhibitors
6-Epi-Catalpol
Sylil Derivatives
Verbascoside
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/5821
Acceder
id CONICETDig_ab8c86631445444aa2130169b2153dc2
oai_identifier_str oai:ri.conicet.gov.ar:11336/5821
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymeraseGarro, Hugo AlejandroGarcía, Celina E.Martín, Víctor S.Tonn, Carlos EugenioPungitore, Carlos RodolfoNatural ProductsTaq Dna Polymerase Inhibitors6-Epi-CatalpolSylil DerivativesVerbascosidehttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1DNA polymerases are enzymes that play a crucial role in DNA metabolism such as replication, repair, transcription, recombination, and chromosome segregation during mitosis. Herein we report the isolation of a new iridoid (6-epi-catalpol, 2) and per-O-acetyl-verbascoside (11) from aerial part of Buddleja cordobensis Grisebach (Buddlejaceae). From compound 2, we have obtained eight compounds by chemical transformation. This group of compounds at a concentration of 500 μM was assayed against Taq DNA polymerase. Compound 11 (per-O-acetyl-verbascoside) was the most active with an IC50 of 1.21 + 0.18 μM; compounds 9, 2 and 8 were strong inhibitors with IC50 values of 5.57 + 0.70, 21.62 + 0.22 and 78.13 + 0.93 μM, respectively. Compounds 11 and 9 could be a leader structures to development new anticancer chemotherapy medicines and a useful tool to investigate DNA polymerase activity.Fil: Garro, Hugo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; ArgentinaFil: García, Celina E.. Universidad de la Laguna; EspañaFil: Martín, Víctor S.. Universidad de la Laguna; EspañaFil: Tonn, Carlos Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; ArgentinaFil: Pungitore, Carlos Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; ArgentinaElsevier2015-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/5821Garro, Hugo Alejandro; García, Celina E.; Martín, Víctor S.; Tonn, Carlos Eugenio; Pungitore, Carlos Rodolfo; A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymerase; Elsevier; Bioorganic & Medicinal Chemistry Letters; 25; 4; 1-2015; 914-9180960-894Xenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0960894X14013602info:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bmcl.2014.12.052info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:16:37Zoai:ri.conicet.gov.ar:11336/5821instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:16:38.154CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymerase
title A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymerase
spellingShingle A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymerase
Garro, Hugo Alejandro
Natural Products
Taq Dna Polymerase Inhibitors
6-Epi-Catalpol
Sylil Derivatives
Verbascoside
title_short A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymerase
title_full A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymerase
title_fullStr A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymerase
title_full_unstemmed A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymerase
title_sort A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymerase
dc.creator.none.fl_str_mv Garro, Hugo Alejandro
García, Celina E.
Martín, Víctor S.
Tonn, Carlos Eugenio
Pungitore, Carlos Rodolfo
author Garro, Hugo Alejandro
author_facet Garro, Hugo Alejandro
García, Celina E.
Martín, Víctor S.
Tonn, Carlos Eugenio
Pungitore, Carlos Rodolfo
author_role author
author2 García, Celina E.
Martín, Víctor S.
Tonn, Carlos Eugenio
Pungitore, Carlos Rodolfo
author2_role author
author
author
author
dc.subject.none.fl_str_mv Natural Products
Taq Dna Polymerase Inhibitors
6-Epi-Catalpol
Sylil Derivatives
Verbascoside
topic Natural Products
Taq Dna Polymerase Inhibitors
6-Epi-Catalpol
Sylil Derivatives
Verbascoside
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv DNA polymerases are enzymes that play a crucial role in DNA metabolism such as replication, repair, transcription, recombination, and chromosome segregation during mitosis. Herein we report the isolation of a new iridoid (6-epi-catalpol, 2) and per-O-acetyl-verbascoside (11) from aerial part of Buddleja cordobensis Grisebach (Buddlejaceae). From compound 2, we have obtained eight compounds by chemical transformation. This group of compounds at a concentration of 500 μM was assayed against Taq DNA polymerase. Compound 11 (per-O-acetyl-verbascoside) was the most active with an IC50 of 1.21 + 0.18 μM; compounds 9, 2 and 8 were strong inhibitors with IC50 values of 5.57 + 0.70, 21.62 + 0.22 and 78.13 + 0.93 μM, respectively. Compounds 11 and 9 could be a leader structures to development new anticancer chemotherapy medicines and a useful tool to investigate DNA polymerase activity.
Fil: Garro, Hugo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; Argentina
Fil: García, Celina E.. Universidad de la Laguna; España
Fil: Martín, Víctor S.. Universidad de la Laguna; España
Fil: Tonn, Carlos Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; Argentina
Fil: Pungitore, Carlos Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; Argentina
description DNA polymerases are enzymes that play a crucial role in DNA metabolism such as replication, repair, transcription, recombination, and chromosome segregation during mitosis. Herein we report the isolation of a new iridoid (6-epi-catalpol, 2) and per-O-acetyl-verbascoside (11) from aerial part of Buddleja cordobensis Grisebach (Buddlejaceae). From compound 2, we have obtained eight compounds by chemical transformation. This group of compounds at a concentration of 500 μM was assayed against Taq DNA polymerase. Compound 11 (per-O-acetyl-verbascoside) was the most active with an IC50 of 1.21 + 0.18 μM; compounds 9, 2 and 8 were strong inhibitors with IC50 values of 5.57 + 0.70, 21.62 + 0.22 and 78.13 + 0.93 μM, respectively. Compounds 11 and 9 could be a leader structures to development new anticancer chemotherapy medicines and a useful tool to investigate DNA polymerase activity.
publishDate 2015
dc.date.none.fl_str_mv 2015-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/5821
Garro, Hugo Alejandro; García, Celina E.; Martín, Víctor S.; Tonn, Carlos Eugenio; Pungitore, Carlos Rodolfo; A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymerase; Elsevier; Bioorganic & Medicinal Chemistry Letters; 25; 4; 1-2015; 914-918
0960-894X
url http://hdl.handle.net/11336/5821
identifier_str_mv Garro, Hugo Alejandro; García, Celina E.; Martín, Víctor S.; Tonn, Carlos Eugenio; Pungitore, Carlos Rodolfo; A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymerase; Elsevier; Bioorganic & Medicinal Chemistry Letters; 25; 4; 1-2015; 914-918
0960-894X
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0960894X14013602
info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bmcl.2014.12.052
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083315052838912
score 13.22299

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