A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymerase
- Autores
- Garro, Hugo Alejandro; García, Celina E.; Martín, Víctor S.; Tonn, Carlos Eugenio; Pungitore, Carlos Rodolfo
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- DNA polymerases are enzymes that play a crucial role in DNA metabolism such as replication, repair, transcription, recombination, and chromosome segregation during mitosis. Herein we report the isolation of a new iridoid (6-epi-catalpol, 2) and per-O-acetyl-verbascoside (11) from aerial part of Buddleja cordobensis Grisebach (Buddlejaceae). From compound 2, we have obtained eight compounds by chemical transformation. This group of compounds at a concentration of 500 μM was assayed against Taq DNA polymerase. Compound 11 (per-O-acetyl-verbascoside) was the most active with an IC50 of 1.21 + 0.18 μM; compounds 9, 2 and 8 were strong inhibitors with IC50 values of 5.57 + 0.70, 21.62 + 0.22 and 78.13 + 0.93 μM, respectively. Compounds 11 and 9 could be a leader structures to development new anticancer chemotherapy medicines and a useful tool to investigate DNA polymerase activity.
Fil: Garro, Hugo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; Argentina
Fil: García, Celina E.. Universidad de la Laguna; España
Fil: Martín, Víctor S.. Universidad de la Laguna; España
Fil: Tonn, Carlos Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; Argentina
Fil: Pungitore, Carlos Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; Argentina - Materia
-
Natural Products
Taq Dna Polymerase Inhibitors
6-Epi-Catalpol
Sylil Derivatives
Verbascoside - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/5821
Ver los metadatos del registro completo
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A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymeraseGarro, Hugo AlejandroGarcía, Celina E.Martín, Víctor S.Tonn, Carlos EugenioPungitore, Carlos RodolfoNatural ProductsTaq Dna Polymerase Inhibitors6-Epi-CatalpolSylil DerivativesVerbascosidehttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1DNA polymerases are enzymes that play a crucial role in DNA metabolism such as replication, repair, transcription, recombination, and chromosome segregation during mitosis. Herein we report the isolation of a new iridoid (6-epi-catalpol, 2) and per-O-acetyl-verbascoside (11) from aerial part of Buddleja cordobensis Grisebach (Buddlejaceae). From compound 2, we have obtained eight compounds by chemical transformation. This group of compounds at a concentration of 500 μM was assayed against Taq DNA polymerase. Compound 11 (per-O-acetyl-verbascoside) was the most active with an IC50 of 1.21 + 0.18 μM; compounds 9, 2 and 8 were strong inhibitors with IC50 values of 5.57 + 0.70, 21.62 + 0.22 and 78.13 + 0.93 μM, respectively. Compounds 11 and 9 could be a leader structures to development new anticancer chemotherapy medicines and a useful tool to investigate DNA polymerase activity.Fil: Garro, Hugo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; ArgentinaFil: García, Celina E.. Universidad de la Laguna; EspañaFil: Martín, Víctor S.. Universidad de la Laguna; EspañaFil: Tonn, Carlos Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; ArgentinaFil: Pungitore, Carlos Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; ArgentinaElsevier2015-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/5821Garro, Hugo Alejandro; García, Celina E.; Martín, Víctor S.; Tonn, Carlos Eugenio; Pungitore, Carlos Rodolfo; A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymerase; Elsevier; Bioorganic & Medicinal Chemistry Letters; 25; 4; 1-2015; 914-9180960-894Xenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0960894X14013602info:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bmcl.2014.12.052info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:16:37Zoai:ri.conicet.gov.ar:11336/5821instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:16:38.154CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymerase |
title |
A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymerase |
spellingShingle |
A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymerase Garro, Hugo Alejandro Natural Products Taq Dna Polymerase Inhibitors 6-Epi-Catalpol Sylil Derivatives Verbascoside |
title_short |
A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymerase |
title_full |
A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymerase |
title_fullStr |
A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymerase |
title_full_unstemmed |
A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymerase |
title_sort |
A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymerase |
dc.creator.none.fl_str_mv |
Garro, Hugo Alejandro García, Celina E. Martín, Víctor S. Tonn, Carlos Eugenio Pungitore, Carlos Rodolfo |
author |
Garro, Hugo Alejandro |
author_facet |
Garro, Hugo Alejandro García, Celina E. Martín, Víctor S. Tonn, Carlos Eugenio Pungitore, Carlos Rodolfo |
author_role |
author |
author2 |
García, Celina E. Martín, Víctor S. Tonn, Carlos Eugenio Pungitore, Carlos Rodolfo |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Natural Products Taq Dna Polymerase Inhibitors 6-Epi-Catalpol Sylil Derivatives Verbascoside |
topic |
Natural Products Taq Dna Polymerase Inhibitors 6-Epi-Catalpol Sylil Derivatives Verbascoside |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
DNA polymerases are enzymes that play a crucial role in DNA metabolism such as replication, repair, transcription, recombination, and chromosome segregation during mitosis. Herein we report the isolation of a new iridoid (6-epi-catalpol, 2) and per-O-acetyl-verbascoside (11) from aerial part of Buddleja cordobensis Grisebach (Buddlejaceae). From compound 2, we have obtained eight compounds by chemical transformation. This group of compounds at a concentration of 500 μM was assayed against Taq DNA polymerase. Compound 11 (per-O-acetyl-verbascoside) was the most active with an IC50 of 1.21 + 0.18 μM; compounds 9, 2 and 8 were strong inhibitors with IC50 values of 5.57 + 0.70, 21.62 + 0.22 and 78.13 + 0.93 μM, respectively. Compounds 11 and 9 could be a leader structures to development new anticancer chemotherapy medicines and a useful tool to investigate DNA polymerase activity. Fil: Garro, Hugo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; Argentina Fil: García, Celina E.. Universidad de la Laguna; España Fil: Martín, Víctor S.. Universidad de la Laguna; España Fil: Tonn, Carlos Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; Argentina Fil: Pungitore, Carlos Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; Argentina |
description |
DNA polymerases are enzymes that play a crucial role in DNA metabolism such as replication, repair, transcription, recombination, and chromosome segregation during mitosis. Herein we report the isolation of a new iridoid (6-epi-catalpol, 2) and per-O-acetyl-verbascoside (11) from aerial part of Buddleja cordobensis Grisebach (Buddlejaceae). From compound 2, we have obtained eight compounds by chemical transformation. This group of compounds at a concentration of 500 μM was assayed against Taq DNA polymerase. Compound 11 (per-O-acetyl-verbascoside) was the most active with an IC50 of 1.21 + 0.18 μM; compounds 9, 2 and 8 were strong inhibitors with IC50 values of 5.57 + 0.70, 21.62 + 0.22 and 78.13 + 0.93 μM, respectively. Compounds 11 and 9 could be a leader structures to development new anticancer chemotherapy medicines and a useful tool to investigate DNA polymerase activity. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/5821 Garro, Hugo Alejandro; García, Celina E.; Martín, Víctor S.; Tonn, Carlos Eugenio; Pungitore, Carlos Rodolfo; A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymerase; Elsevier; Bioorganic & Medicinal Chemistry Letters; 25; 4; 1-2015; 914-918 0960-894X |
url |
http://hdl.handle.net/11336/5821 |
identifier_str_mv |
Garro, Hugo Alejandro; García, Celina E.; Martín, Víctor S.; Tonn, Carlos Eugenio; Pungitore, Carlos Rodolfo; A new iridoid, verbascoside and derivatives with inhibitory activity against Taq DNA polymerase; Elsevier; Bioorganic & Medicinal Chemistry Letters; 25; 4; 1-2015; 914-918 0960-894X |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0960894X14013602 info:eu-repo/semantics/altIdentifier/doi/ info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bmcl.2014.12.052 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1846083315052838912 |
score |
13.22299 |