Inhibition of reverse transcriptase and Taq DNA polymerase by compounds possessing the coumarin framework

Autores
Garro, Hugo Alejandro; Manzur, Maria Jimena; Ciuffo, Gladys Maria; Tonn, Carlos Eugenio; Pungitore, Carlos Rodolfo
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Coumarin derivatives were prepared using natural products isolated from plants belonging in the Pterocaulon genus (Asteraceae) and commercial drugs. Some molecules have displayed interesting activity against myeloid murine leukemia virus-reverse transcriptase (MMLV-RT) (compounds 20 and 28 produced inhibition with IC50 values of 38.62 and 50.98 lM, respectively) and Taq DNA polymerase (analogues 13 and 14 produced inhibition with IC50 values of 48.08 and 57.88 lM, respectively). Such inhibitors may have importance as antiretroviral chemotherapeutic agents and also in the development of anticancer drugs.
Fil: Garro, Hugo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; Argentina
Fil: Manzur, Maria Jimena. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Ciuffo, Gladys Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Tonn, Carlos Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; Argentina
Fil: Pungitore, Carlos Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; Argentina
Materia
Coumarins
Reverse Transcriptase
Polymerase
Molecular Target
Inhibition
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/7494
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/7494
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Inhibition of reverse transcriptase and Taq DNA polymerase by compounds possessing the coumarin frameworkGarro, Hugo AlejandroManzur, Maria JimenaCiuffo, Gladys MariaTonn, Carlos EugenioPungitore, Carlos RodolfoCoumarinsReverse TranscriptasePolymeraseMolecular TargetInhibitionhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Coumarin derivatives were prepared using natural products isolated from plants belonging in the Pterocaulon genus (Asteraceae) and commercial drugs. Some molecules have displayed interesting activity against myeloid murine leukemia virus-reverse transcriptase (MMLV-RT) (compounds 20 and 28 produced inhibition with IC50 values of 38.62 and 50.98 lM, respectively) and Taq DNA polymerase (analogues 13 and 14 produced inhibition with IC50 values of 48.08 and 57.88 lM, respectively). Such inhibitors may have importance as antiretroviral chemotherapeutic agents and also in the development of anticancer drugs.Fil: Garro, Hugo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; ArgentinaFil: Manzur, Maria Jimena. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Ciuffo, Gladys Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Tonn, Carlos Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; ArgentinaFil: Pungitore, Carlos Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; ArgentinaElsevier2014-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/7494Garro, Hugo Alejandro; Manzur, Maria Jimena; Ciuffo, Gladys Maria; Tonn, Carlos Eugenio; Pungitore, Carlos Rodolfo; Inhibition of reverse transcriptase and Taq DNA polymerase by compounds possessing the coumarin framework; Elsevier; Bioorganic & Medicinal Chemistry Letters; 24; 3; 1-2014; 760-7640960-894Xenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0960894X13014881info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bmcl.2013.12.104info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:54:58Zoai:ri.conicet.gov.ar:11336/7494instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:54:58.256CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Inhibition of reverse transcriptase and Taq DNA polymerase by compounds possessing the coumarin framework
title Inhibition of reverse transcriptase and Taq DNA polymerase by compounds possessing the coumarin framework
spellingShingle Inhibition of reverse transcriptase and Taq DNA polymerase by compounds possessing the coumarin framework
Garro, Hugo Alejandro
Coumarins
Reverse Transcriptase
Polymerase
Molecular Target
Inhibition
title_short Inhibition of reverse transcriptase and Taq DNA polymerase by compounds possessing the coumarin framework
title_full Inhibition of reverse transcriptase and Taq DNA polymerase by compounds possessing the coumarin framework
title_fullStr Inhibition of reverse transcriptase and Taq DNA polymerase by compounds possessing the coumarin framework
title_full_unstemmed Inhibition of reverse transcriptase and Taq DNA polymerase by compounds possessing the coumarin framework
title_sort Inhibition of reverse transcriptase and Taq DNA polymerase by compounds possessing the coumarin framework
dc.creator.none.fl_str_mv Garro, Hugo Alejandro
Manzur, Maria Jimena
Ciuffo, Gladys Maria
Tonn, Carlos Eugenio
Pungitore, Carlos Rodolfo
author Garro, Hugo Alejandro
author_facet Garro, Hugo Alejandro
Manzur, Maria Jimena
Ciuffo, Gladys Maria
Tonn, Carlos Eugenio
Pungitore, Carlos Rodolfo
author_role author
author2 Manzur, Maria Jimena
Ciuffo, Gladys Maria
Tonn, Carlos Eugenio
Pungitore, Carlos Rodolfo
author2_role author
author
author
author
dc.subject.none.fl_str_mv Coumarins
Reverse Transcriptase
Polymerase
Molecular Target
Inhibition
topic Coumarins
Reverse Transcriptase
Polymerase
Molecular Target
Inhibition
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Coumarin derivatives were prepared using natural products isolated from plants belonging in the Pterocaulon genus (Asteraceae) and commercial drugs. Some molecules have displayed interesting activity against myeloid murine leukemia virus-reverse transcriptase (MMLV-RT) (compounds 20 and 28 produced inhibition with IC50 values of 38.62 and 50.98 lM, respectively) and Taq DNA polymerase (analogues 13 and 14 produced inhibition with IC50 values of 48.08 and 57.88 lM, respectively). Such inhibitors may have importance as antiretroviral chemotherapeutic agents and also in the development of anticancer drugs.
Fil: Garro, Hugo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; Argentina
Fil: Manzur, Maria Jimena. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Ciuffo, Gladys Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Tonn, Carlos Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; Argentina
Fil: Pungitore, Carlos Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Investigaciones En Tecnología Química; Argentina
description Coumarin derivatives were prepared using natural products isolated from plants belonging in the Pterocaulon genus (Asteraceae) and commercial drugs. Some molecules have displayed interesting activity against myeloid murine leukemia virus-reverse transcriptase (MMLV-RT) (compounds 20 and 28 produced inhibition with IC50 values of 38.62 and 50.98 lM, respectively) and Taq DNA polymerase (analogues 13 and 14 produced inhibition with IC50 values of 48.08 and 57.88 lM, respectively). Such inhibitors may have importance as antiretroviral chemotherapeutic agents and also in the development of anticancer drugs.
publishDate 2014
dc.date.none.fl_str_mv 2014-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/7494
Garro, Hugo Alejandro; Manzur, Maria Jimena; Ciuffo, Gladys Maria; Tonn, Carlos Eugenio; Pungitore, Carlos Rodolfo; Inhibition of reverse transcriptase and Taq DNA polymerase by compounds possessing the coumarin framework; Elsevier; Bioorganic & Medicinal Chemistry Letters; 24; 3; 1-2014; 760-764
0960-894X
url http://hdl.handle.net/11336/7494
identifier_str_mv Garro, Hugo Alejandro; Manzur, Maria Jimena; Ciuffo, Gladys Maria; Tonn, Carlos Eugenio; Pungitore, Carlos Rodolfo; Inhibition of reverse transcriptase and Taq DNA polymerase by compounds possessing the coumarin framework; Elsevier; Bioorganic & Medicinal Chemistry Letters; 24; 3; 1-2014; 760-764
0960-894X
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0960894X13014881
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bmcl.2013.12.104
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269314467495936
score 13.13397

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