Inhibition of Taq DNA polymerase by iridoid aglycone derivates

Autores
Pungitore, Carlos Rodolfo; García, Celina E.; Martín García, Victor Sotero; Tonn, Carlos Eugenio
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Faithful replication of DNA molecules by DNA polymerases is essential for genome integrity and correct transmission of genetic information in all living organisms. DNA polymerases have recently emerged as important cellular targets for chemical intervention in the development of anti-cancer agents. Herein we report additional synthesis of simplified bicyclic aglycones of iridoids and their biological activity against Taq DNA polymerase with the object to find out some of the likely molecular targets implicated in the biological activity showed for this kind of compounds. The compounds 14, 33 and 34 showed inhibitory activity against Taq DNA polymerase with IC50 values of 13.47, 17.65 and 18.31 microMolar, respectively. These results would allow proposing to DNA polymerases as the molecular targets implicated in this bioactivity and enhance the iridoid aglycones as leader molecule to develop new drugs for cancer therapy.
Fil: Pungitore, Carlos Rodolfo. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina
Fil: García, Celina E.. Universidad de La Laguna; España
Fil: Martín García, Victor Sotero. Universidad de La Laguna; España
Fil: Tonn, Carlos Eugenio. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; Argentina
Materia
Iridoid aglycones
DNA polymerases
Natural products
Biological activity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/174075
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Inhibition of Taq DNA polymerase by iridoid aglycone derivatesPungitore, Carlos RodolfoGarcía, Celina E.Martín García, Victor SoteroTonn, Carlos EugenioIridoid aglyconesDNA polymerasesNatural productsBiological activityhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Faithful replication of DNA molecules by DNA polymerases is essential for genome integrity and correct transmission of genetic information in all living organisms. DNA polymerases have recently emerged as important cellular targets for chemical intervention in the development of anti-cancer agents. Herein we report additional synthesis of simplified bicyclic aglycones of iridoids and their biological activity against Taq DNA polymerase with the object to find out some of the likely molecular targets implicated in the biological activity showed for this kind of compounds. The compounds 14, 33 and 34 showed inhibitory activity against Taq DNA polymerase with IC50 values of 13.47, 17.65 and 18.31 microMolar, respectively. These results would allow proposing to DNA polymerases as the molecular targets implicated in this bioactivity and enhance the iridoid aglycones as leader molecule to develop new drugs for cancer therapy.Fil: Pungitore, Carlos Rodolfo. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; ArgentinaFil: García, Celina E.. Universidad de La Laguna; EspañaFil: Martín García, Victor Sotero. Universidad de La Laguna; EspañaFil: Tonn, Carlos Eugenio. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; ArgentinaC M B Association2012-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/174075Pungitore, Carlos Rodolfo; García, Celina E.; Martín García, Victor Sotero; Tonn, Carlos Eugenio; Inhibition of Taq DNA polymerase by iridoid aglycone derivates; C M B Association; Cellular and Molecular Biology; 58; supp; 11-2012; 1786-17900145-5680CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1170/210info:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/23137851/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:48:02Zoai:ri.conicet.gov.ar:11336/174075instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:48:02.856CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Inhibition of Taq DNA polymerase by iridoid aglycone derivates
title Inhibition of Taq DNA polymerase by iridoid aglycone derivates
spellingShingle Inhibition of Taq DNA polymerase by iridoid aglycone derivates
Pungitore, Carlos Rodolfo
Iridoid aglycones
DNA polymerases
Natural products
Biological activity
title_short Inhibition of Taq DNA polymerase by iridoid aglycone derivates
title_full Inhibition of Taq DNA polymerase by iridoid aglycone derivates
title_fullStr Inhibition of Taq DNA polymerase by iridoid aglycone derivates
title_full_unstemmed Inhibition of Taq DNA polymerase by iridoid aglycone derivates
title_sort Inhibition of Taq DNA polymerase by iridoid aglycone derivates
dc.creator.none.fl_str_mv Pungitore, Carlos Rodolfo
García, Celina E.
Martín García, Victor Sotero
Tonn, Carlos Eugenio
author Pungitore, Carlos Rodolfo
author_facet Pungitore, Carlos Rodolfo
García, Celina E.
Martín García, Victor Sotero
Tonn, Carlos Eugenio
author_role author
author2 García, Celina E.
Martín García, Victor Sotero
Tonn, Carlos Eugenio
author2_role author
author
author
dc.subject.none.fl_str_mv Iridoid aglycones
DNA polymerases
Natural products
Biological activity
topic Iridoid aglycones
DNA polymerases
Natural products
Biological activity
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Faithful replication of DNA molecules by DNA polymerases is essential for genome integrity and correct transmission of genetic information in all living organisms. DNA polymerases have recently emerged as important cellular targets for chemical intervention in the development of anti-cancer agents. Herein we report additional synthesis of simplified bicyclic aglycones of iridoids and their biological activity against Taq DNA polymerase with the object to find out some of the likely molecular targets implicated in the biological activity showed for this kind of compounds. The compounds 14, 33 and 34 showed inhibitory activity against Taq DNA polymerase with IC50 values of 13.47, 17.65 and 18.31 microMolar, respectively. These results would allow proposing to DNA polymerases as the molecular targets implicated in this bioactivity and enhance the iridoid aglycones as leader molecule to develop new drugs for cancer therapy.
Fil: Pungitore, Carlos Rodolfo. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina
Fil: García, Celina E.. Universidad de La Laguna; España
Fil: Martín García, Victor Sotero. Universidad de La Laguna; España
Fil: Tonn, Carlos Eugenio. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; Argentina
description Faithful replication of DNA molecules by DNA polymerases is essential for genome integrity and correct transmission of genetic information in all living organisms. DNA polymerases have recently emerged as important cellular targets for chemical intervention in the development of anti-cancer agents. Herein we report additional synthesis of simplified bicyclic aglycones of iridoids and their biological activity against Taq DNA polymerase with the object to find out some of the likely molecular targets implicated in the biological activity showed for this kind of compounds. The compounds 14, 33 and 34 showed inhibitory activity against Taq DNA polymerase with IC50 values of 13.47, 17.65 and 18.31 microMolar, respectively. These results would allow proposing to DNA polymerases as the molecular targets implicated in this bioactivity and enhance the iridoid aglycones as leader molecule to develop new drugs for cancer therapy.
publishDate 2012
dc.date.none.fl_str_mv 2012-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/174075
Pungitore, Carlos Rodolfo; García, Celina E.; Martín García, Victor Sotero; Tonn, Carlos Eugenio; Inhibition of Taq DNA polymerase by iridoid aglycone derivates; C M B Association; Cellular and Molecular Biology; 58; supp; 11-2012; 1786-1790
0145-5680
CONICET Digital
CONICET
url http://hdl.handle.net/11336/174075
identifier_str_mv Pungitore, Carlos Rodolfo; García, Celina E.; Martín García, Victor Sotero; Tonn, Carlos Eugenio; Inhibition of Taq DNA polymerase by iridoid aglycone derivates; C M B Association; Cellular and Molecular Biology; 58; supp; 11-2012; 1786-1790
0145-5680
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1170/210
info:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/23137851/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv C M B Association
publisher.none.fl_str_mv C M B Association
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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