Host-parasite interaction: Changes in human placental gene expression induced by Trypanosoma cruzi

Autores
Castillo, Christian; Carrillo, Ileana; Libisch, Gabriela; Juiz, Natalia Anahí; Schijman, Alejandro Gabriel; Robello, Carlos; Kemmerling, Ulrike
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Chagas disease is caused by Trypanosoma cruzi, a parasite endemic to Latin America. Most infections occur in children by vector or congenital transmission. Trypanosoma cruzi establishes a complexity of specific molecular parasite-host cell interactions to invade the host. However, most studies have been mainly focused on the interaction between the parasite and different cell types, but not on the infection and invasion on a tissue level. During congenital transmission, T. cruzi must cross the placental barrier, composed of epithelial and connective tissues, in order to infect the developing fetus. Here we aimed to study the global changes of transcriptome in the placental tissue after a T. cruzi challenge. Results: Strong changes in gene expression profiling were found in the different experimental conditions, involving the reprogramming of gene expression in genes involved in the innate immune response. Conclusions: Trypanosoma cruzi induces strong changes in genes involved in a wide range of pathways, especially those involved in immune response against infections.
Fil: Castillo, Christian. Universidad de Chile; Chile
Fil: Carrillo, Ileana. Universidad de Chile; Chile
Fil: Libisch, Gabriela. Universidad de la República; Uruguay
Fil: Juiz, Natalia Anahí. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Schijman, Alejandro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Robello, Carlos. Universidad de la República; Uruguay
Fil: Kemmerling, Ulrike. Universidad de Chile; Chile
Materia
GLOBAL GENE EXPRESSION
MICROARRAY
PLACENTA
TRYPANOSOMA CRUZI
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/79818
Acceder
id CONICETDig_aae57c6dd77a77b120de8fb57bd7578c
oai_identifier_str oai:ri.conicet.gov.ar:11336/79818
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Host-parasite interaction: Changes in human placental gene expression induced by Trypanosoma cruziCastillo, ChristianCarrillo, IleanaLibisch, GabrielaJuiz, Natalia AnahíSchijman, Alejandro GabrielRobello, CarlosKemmerling, UlrikeGLOBAL GENE EXPRESSIONMICROARRAYPLACENTATRYPANOSOMA CRUZIhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Background: Chagas disease is caused by Trypanosoma cruzi, a parasite endemic to Latin America. Most infections occur in children by vector or congenital transmission. Trypanosoma cruzi establishes a complexity of specific molecular parasite-host cell interactions to invade the host. However, most studies have been mainly focused on the interaction between the parasite and different cell types, but not on the infection and invasion on a tissue level. During congenital transmission, T. cruzi must cross the placental barrier, composed of epithelial and connective tissues, in order to infect the developing fetus. Here we aimed to study the global changes of transcriptome in the placental tissue after a T. cruzi challenge. Results: Strong changes in gene expression profiling were found in the different experimental conditions, involving the reprogramming of gene expression in genes involved in the innate immune response. Conclusions: Trypanosoma cruzi induces strong changes in genes involved in a wide range of pathways, especially those involved in immune response against infections.Fil: Castillo, Christian. Universidad de Chile; ChileFil: Carrillo, Ileana. Universidad de Chile; ChileFil: Libisch, Gabriela. Universidad de la República; UruguayFil: Juiz, Natalia Anahí. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Schijman, Alejandro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Robello, Carlos. Universidad de la República; UruguayFil: Kemmerling, Ulrike. Universidad de Chile; ChileBioMed Central2018-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/79818Castillo, Christian; Carrillo, Ileana; Libisch, Gabriela; Juiz, Natalia Anahí; Schijman, Alejandro Gabriel; et al.; Host-parasite interaction: Changes in human placental gene expression induced by Trypanosoma cruzi; BioMed Central; Parasites and Vectors; 11; 1; 8-2018; 1-131756-3305CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1186/s13071-018-2988-0info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/30143027/info:eu-repo/semantics/altIdentifier/url/https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-018-2988-0info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:22:26Zoai:ri.conicet.gov.ar:11336/79818instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:22:26.452CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Host-parasite interaction: Changes in human placental gene expression induced by Trypanosoma cruzi
title Host-parasite interaction: Changes in human placental gene expression induced by Trypanosoma cruzi
spellingShingle Host-parasite interaction: Changes in human placental gene expression induced by Trypanosoma cruzi
Castillo, Christian
GLOBAL GENE EXPRESSION
MICROARRAY
PLACENTA
TRYPANOSOMA CRUZI
title_short Host-parasite interaction: Changes in human placental gene expression induced by Trypanosoma cruzi
title_full Host-parasite interaction: Changes in human placental gene expression induced by Trypanosoma cruzi
title_fullStr Host-parasite interaction: Changes in human placental gene expression induced by Trypanosoma cruzi
title_full_unstemmed Host-parasite interaction: Changes in human placental gene expression induced by Trypanosoma cruzi
title_sort Host-parasite interaction: Changes in human placental gene expression induced by Trypanosoma cruzi
dc.creator.none.fl_str_mv Castillo, Christian
Carrillo, Ileana
Libisch, Gabriela
Juiz, Natalia Anahí
Schijman, Alejandro Gabriel
Robello, Carlos
Kemmerling, Ulrike
author Castillo, Christian
author_facet Castillo, Christian
Carrillo, Ileana
Libisch, Gabriela
Juiz, Natalia Anahí
Schijman, Alejandro Gabriel
Robello, Carlos
Kemmerling, Ulrike
author_role author
author2 Carrillo, Ileana
Libisch, Gabriela
Juiz, Natalia Anahí
Schijman, Alejandro Gabriel
Robello, Carlos
Kemmerling, Ulrike
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv GLOBAL GENE EXPRESSION
MICROARRAY
PLACENTA
TRYPANOSOMA CRUZI
topic GLOBAL GENE EXPRESSION
MICROARRAY
PLACENTA
TRYPANOSOMA CRUZI
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Background: Chagas disease is caused by Trypanosoma cruzi, a parasite endemic to Latin America. Most infections occur in children by vector or congenital transmission. Trypanosoma cruzi establishes a complexity of specific molecular parasite-host cell interactions to invade the host. However, most studies have been mainly focused on the interaction between the parasite and different cell types, but not on the infection and invasion on a tissue level. During congenital transmission, T. cruzi must cross the placental barrier, composed of epithelial and connective tissues, in order to infect the developing fetus. Here we aimed to study the global changes of transcriptome in the placental tissue after a T. cruzi challenge. Results: Strong changes in gene expression profiling were found in the different experimental conditions, involving the reprogramming of gene expression in genes involved in the innate immune response. Conclusions: Trypanosoma cruzi induces strong changes in genes involved in a wide range of pathways, especially those involved in immune response against infections.
Fil: Castillo, Christian. Universidad de Chile; Chile
Fil: Carrillo, Ileana. Universidad de Chile; Chile
Fil: Libisch, Gabriela. Universidad de la República; Uruguay
Fil: Juiz, Natalia Anahí. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Schijman, Alejandro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Robello, Carlos. Universidad de la República; Uruguay
Fil: Kemmerling, Ulrike. Universidad de Chile; Chile
description Background: Chagas disease is caused by Trypanosoma cruzi, a parasite endemic to Latin America. Most infections occur in children by vector or congenital transmission. Trypanosoma cruzi establishes a complexity of specific molecular parasite-host cell interactions to invade the host. However, most studies have been mainly focused on the interaction between the parasite and different cell types, but not on the infection and invasion on a tissue level. During congenital transmission, T. cruzi must cross the placental barrier, composed of epithelial and connective tissues, in order to infect the developing fetus. Here we aimed to study the global changes of transcriptome in the placental tissue after a T. cruzi challenge. Results: Strong changes in gene expression profiling were found in the different experimental conditions, involving the reprogramming of gene expression in genes involved in the innate immune response. Conclusions: Trypanosoma cruzi induces strong changes in genes involved in a wide range of pathways, especially those involved in immune response against infections.
publishDate 2018
dc.date.none.fl_str_mv 2018-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/79818
Castillo, Christian; Carrillo, Ileana; Libisch, Gabriela; Juiz, Natalia Anahí; Schijman, Alejandro Gabriel; et al.; Host-parasite interaction: Changes in human placental gene expression induced by Trypanosoma cruzi; BioMed Central; Parasites and Vectors; 11; 1; 8-2018; 1-13
1756-3305
CONICET Digital
CONICET
url http://hdl.handle.net/11336/79818
identifier_str_mv Castillo, Christian; Carrillo, Ileana; Libisch, Gabriela; Juiz, Natalia Anahí; Schijman, Alejandro Gabriel; et al.; Host-parasite interaction: Changes in human placental gene expression induced by Trypanosoma cruzi; BioMed Central; Parasites and Vectors; 11; 1; 8-2018; 1-13
1756-3305
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1186/s13071-018-2988-0
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/30143027/
info:eu-repo/semantics/altIdentifier/url/https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-018-2988-0
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842981235663568896
score 12.48226

Publicaciones similares