Doramectin percutaneous absorption in dogs: in vivo and in vitro characterization
- Autores
- Nejamkin, Pablo; Albarellos, Gabriela Alejandra; Sallovitz, Juan Manuel; Lanusse, Carlos Edmundo
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- Endectocides (avermectins and milbemycins) are important antiparasitic drugs owing to their wide spectrum of activity, high potency, safety margin and unique mode of action. They are mainly licensed for use in large animals and only few formulations have been approved to control endoparasites in companion animals. Due to its ease and practical administration, topical formulations have received great acceptance by pet owners. However, limited information is available on dermal absorption and disposition of endectocides, particularly doramectin (DRM), in dogs. Time saving in vitro methods that allow characterising topical drug absorption and influence of different excipients are also lacking. The objectives of the present work were to characterize doramectin percutaneous permeation both in vivo and in vitro and to correlate in vivo absorption with in vitro permeation parameters.
Fil: Nejamkin, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Albarellos, Gabriela Alejandra. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Sallovitz, Juan Manuel. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
12th International Congress of the European Association for Veterinary Pharmacology and Toxicology
Noordwijkerhout
Países Bajos
European Association for Veterinary Pharmacology and Toxicology - Materia
-
Doramectin
Percutaneous
Dogs - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/241032
Ver los metadatos del registro completo
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Doramectin percutaneous absorption in dogs: in vivo and in vitro characterizationNejamkin, PabloAlbarellos, Gabriela AlejandraSallovitz, Juan ManuelLanusse, Carlos EdmundoDoramectinPercutaneousDogshttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Endectocides (avermectins and milbemycins) are important antiparasitic drugs owing to their wide spectrum of activity, high potency, safety margin and unique mode of action. They are mainly licensed for use in large animals and only few formulations have been approved to control endoparasites in companion animals. Due to its ease and practical administration, topical formulations have received great acceptance by pet owners. However, limited information is available on dermal absorption and disposition of endectocides, particularly doramectin (DRM), in dogs. Time saving in vitro methods that allow characterising topical drug absorption and influence of different excipients are also lacking. The objectives of the present work were to characterize doramectin percutaneous permeation both in vivo and in vitro and to correlate in vivo absorption with in vitro permeation parameters.Fil: Nejamkin, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Albarellos, Gabriela Alejandra. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Sallovitz, Juan Manuel. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina12th International Congress of the European Association for Veterinary Pharmacology and ToxicologyNoordwijkerhoutPaíses BajosEuropean Association for Veterinary Pharmacology and ToxicologyWiley2012info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/241032Doramectin percutaneous absorption in dogs: in vivo and in vitro characterization; 12th International Congress of the European Association for Veterinary Pharmacology and Toxicology; Noordwijkerhout; Países Bajos; 2012; 24-240140-7783CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/url/https://doi.org/10.1111/jvp.12006Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:52:46Zoai:ri.conicet.gov.ar:11336/241032instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:52:46.715CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Doramectin percutaneous absorption in dogs: in vivo and in vitro characterization |
title |
Doramectin percutaneous absorption in dogs: in vivo and in vitro characterization |
spellingShingle |
Doramectin percutaneous absorption in dogs: in vivo and in vitro characterization Nejamkin, Pablo Doramectin Percutaneous Dogs |
title_short |
Doramectin percutaneous absorption in dogs: in vivo and in vitro characterization |
title_full |
Doramectin percutaneous absorption in dogs: in vivo and in vitro characterization |
title_fullStr |
Doramectin percutaneous absorption in dogs: in vivo and in vitro characterization |
title_full_unstemmed |
Doramectin percutaneous absorption in dogs: in vivo and in vitro characterization |
title_sort |
Doramectin percutaneous absorption in dogs: in vivo and in vitro characterization |
dc.creator.none.fl_str_mv |
Nejamkin, Pablo Albarellos, Gabriela Alejandra Sallovitz, Juan Manuel Lanusse, Carlos Edmundo |
author |
Nejamkin, Pablo |
author_facet |
Nejamkin, Pablo Albarellos, Gabriela Alejandra Sallovitz, Juan Manuel Lanusse, Carlos Edmundo |
author_role |
author |
author2 |
Albarellos, Gabriela Alejandra Sallovitz, Juan Manuel Lanusse, Carlos Edmundo |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
Doramectin Percutaneous Dogs |
topic |
Doramectin Percutaneous Dogs |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/4.3 https://purl.org/becyt/ford/4 |
dc.description.none.fl_txt_mv |
Endectocides (avermectins and milbemycins) are important antiparasitic drugs owing to their wide spectrum of activity, high potency, safety margin and unique mode of action. They are mainly licensed for use in large animals and only few formulations have been approved to control endoparasites in companion animals. Due to its ease and practical administration, topical formulations have received great acceptance by pet owners. However, limited information is available on dermal absorption and disposition of endectocides, particularly doramectin (DRM), in dogs. Time saving in vitro methods that allow characterising topical drug absorption and influence of different excipients are also lacking. The objectives of the present work were to characterize doramectin percutaneous permeation both in vivo and in vitro and to correlate in vivo absorption with in vitro permeation parameters. Fil: Nejamkin, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina Fil: Albarellos, Gabriela Alejandra. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina Fil: Sallovitz, Juan Manuel. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina 12th International Congress of the European Association for Veterinary Pharmacology and Toxicology Noordwijkerhout Países Bajos European Association for Veterinary Pharmacology and Toxicology |
description |
Endectocides (avermectins and milbemycins) are important antiparasitic drugs owing to their wide spectrum of activity, high potency, safety margin and unique mode of action. They are mainly licensed for use in large animals and only few formulations have been approved to control endoparasites in companion animals. Due to its ease and practical administration, topical formulations have received great acceptance by pet owners. However, limited information is available on dermal absorption and disposition of endectocides, particularly doramectin (DRM), in dogs. Time saving in vitro methods that allow characterising topical drug absorption and influence of different excipients are also lacking. The objectives of the present work were to characterize doramectin percutaneous permeation both in vivo and in vitro and to correlate in vivo absorption with in vitro permeation parameters. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/conferenceObject Congreso Journal http://purl.org/coar/resource_type/c_5794 info:ar-repo/semantics/documentoDeConferencia |
status_str |
publishedVersion |
format |
conferenceObject |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/241032 Doramectin percutaneous absorption in dogs: in vivo and in vitro characterization; 12th International Congress of the European Association for Veterinary Pharmacology and Toxicology; Noordwijkerhout; Países Bajos; 2012; 24-24 0140-7783 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/241032 |
identifier_str_mv |
Doramectin percutaneous absorption in dogs: in vivo and in vitro characterization; 12th International Congress of the European Association for Veterinary Pharmacology and Toxicology; Noordwijkerhout; Países Bajos; 2012; 24-24 0140-7783 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
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application/pdf application/msword application/pdf |
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Internacional |
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Wiley |
publisher.none.fl_str_mv |
Wiley |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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