Doramectin percutaneous absorption in dogs: in vivo and in vitro characterization

Autores
Nejamkin, Pablo; Albarellos, Gabriela Alejandra; Sallovitz, Juan Manuel; Lanusse, Carlos Edmundo
Año de publicación
2012
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Endectocides (avermectins and milbemycins) are important antiparasitic drugs owing to their wide spectrum of activity, high potency, safety margin and unique mode of action. They are mainly licensed for use in large animals and only few formulations have been approved to control endoparasites in companion animals. Due to its ease and practical administration, topical formulations have received great acceptance by pet owners. However, limited information is available on dermal absorption and disposition of endectocides, particularly doramectin (DRM), in dogs. Time saving in vitro methods that allow characterising topical drug absorption and influence of different excipients are also lacking. The objectives of the present work were to characterize doramectin percutaneous permeation both in vivo and in vitro and to correlate in vivo absorption with in vitro permeation parameters.
Fil: Nejamkin, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Albarellos, Gabriela Alejandra. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Sallovitz, Juan Manuel. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
12th International Congress of the European Association for Veterinary Pharmacology and Toxicology
Noordwijkerhout
Países Bajos
European Association for Veterinary Pharmacology and Toxicology
Materia
Doramectin
Percutaneous
Dogs
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/241032
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Doramectin percutaneous absorption in dogs: in vivo and in vitro characterizationNejamkin, PabloAlbarellos, Gabriela AlejandraSallovitz, Juan ManuelLanusse, Carlos EdmundoDoramectinPercutaneousDogshttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Endectocides (avermectins and milbemycins) are important antiparasitic drugs owing to their wide spectrum of activity, high potency, safety margin and unique mode of action. They are mainly licensed for use in large animals and only few formulations have been approved to control endoparasites in companion animals. Due to its ease and practical administration, topical formulations have received great acceptance by pet owners. However, limited information is available on dermal absorption and disposition of endectocides, particularly doramectin (DRM), in dogs. Time saving in vitro methods that allow characterising topical drug absorption and influence of different excipients are also lacking. The objectives of the present work were to characterize doramectin percutaneous permeation both in vivo and in vitro and to correlate in vivo absorption with in vitro permeation parameters.Fil: Nejamkin, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Albarellos, Gabriela Alejandra. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Sallovitz, Juan Manuel. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina12th International Congress of the European Association for Veterinary Pharmacology and ToxicologyNoordwijkerhoutPaíses BajosEuropean Association for Veterinary Pharmacology and ToxicologyWiley2012info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/241032Doramectin percutaneous absorption in dogs: in vivo and in vitro characterization; 12th International Congress of the European Association for Veterinary Pharmacology and Toxicology; Noordwijkerhout; Países Bajos; 2012; 24-240140-7783CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/url/https://doi.org/10.1111/jvp.12006Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:22:10Zoai:ri.conicet.gov.ar:11336/241032instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:22:11.251CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Doramectin percutaneous absorption in dogs: in vivo and in vitro characterization
title Doramectin percutaneous absorption in dogs: in vivo and in vitro characterization
spellingShingle Doramectin percutaneous absorption in dogs: in vivo and in vitro characterization
Nejamkin, Pablo
Doramectin
Percutaneous
Dogs
title_short Doramectin percutaneous absorption in dogs: in vivo and in vitro characterization
title_full Doramectin percutaneous absorption in dogs: in vivo and in vitro characterization
title_fullStr Doramectin percutaneous absorption in dogs: in vivo and in vitro characterization
title_full_unstemmed Doramectin percutaneous absorption in dogs: in vivo and in vitro characterization
title_sort Doramectin percutaneous absorption in dogs: in vivo and in vitro characterization
dc.creator.none.fl_str_mv Nejamkin, Pablo
Albarellos, Gabriela Alejandra
Sallovitz, Juan Manuel
Lanusse, Carlos Edmundo
author Nejamkin, Pablo
author_facet Nejamkin, Pablo
Albarellos, Gabriela Alejandra
Sallovitz, Juan Manuel
Lanusse, Carlos Edmundo
author_role author
author2 Albarellos, Gabriela Alejandra
Sallovitz, Juan Manuel
Lanusse, Carlos Edmundo
author2_role author
author
author
dc.subject.none.fl_str_mv Doramectin
Percutaneous
Dogs
topic Doramectin
Percutaneous
Dogs
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Endectocides (avermectins and milbemycins) are important antiparasitic drugs owing to their wide spectrum of activity, high potency, safety margin and unique mode of action. They are mainly licensed for use in large animals and only few formulations have been approved to control endoparasites in companion animals. Due to its ease and practical administration, topical formulations have received great acceptance by pet owners. However, limited information is available on dermal absorption and disposition of endectocides, particularly doramectin (DRM), in dogs. Time saving in vitro methods that allow characterising topical drug absorption and influence of different excipients are also lacking. The objectives of the present work were to characterize doramectin percutaneous permeation both in vivo and in vitro and to correlate in vivo absorption with in vitro permeation parameters.
Fil: Nejamkin, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Albarellos, Gabriela Alejandra. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Sallovitz, Juan Manuel. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
12th International Congress of the European Association for Veterinary Pharmacology and Toxicology
Noordwijkerhout
Países Bajos
European Association for Veterinary Pharmacology and Toxicology
description Endectocides (avermectins and milbemycins) are important antiparasitic drugs owing to their wide spectrum of activity, high potency, safety margin and unique mode of action. They are mainly licensed for use in large animals and only few formulations have been approved to control endoparasites in companion animals. Due to its ease and practical administration, topical formulations have received great acceptance by pet owners. However, limited information is available on dermal absorption and disposition of endectocides, particularly doramectin (DRM), in dogs. Time saving in vitro methods that allow characterising topical drug absorption and influence of different excipients are also lacking. The objectives of the present work were to characterize doramectin percutaneous permeation both in vivo and in vitro and to correlate in vivo absorption with in vitro permeation parameters.
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Congreso
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/241032
Doramectin percutaneous absorption in dogs: in vivo and in vitro characterization; 12th International Congress of the European Association for Veterinary Pharmacology and Toxicology; Noordwijkerhout; Países Bajos; 2012; 24-24
0140-7783
CONICET Digital
CONICET
url http://hdl.handle.net/11336/241032
identifier_str_mv Doramectin percutaneous absorption in dogs: in vivo and in vitro characterization; 12th International Congress of the European Association for Veterinary Pharmacology and Toxicology; Noordwijkerhout; Países Bajos; 2012; 24-24
0140-7783
CONICET Digital
CONICET
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language eng
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/msword
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
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