Pattern of ivermectin (sheep) and doramectin (cattle) residues in muscular tissue from various anatomical locations

Autores
Moreno Torrejon, Laura; Alvarez, Luis Ignacio; Ceballos, Laura; Sanchez Bruni, Sergio Fabian; Lanusse, Carlos Edmundo
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This trial reports comparative drug residual concentrations in muscular tissue obtained from various anatomical locations after subcutaneous administration of ivermectin (IVM) to sheep and topical treatment with doramectin (DRM) to calves at recommended therapeutic dose rates. Seven muscle samples from different anatomical locations (rhomboideus, supraspinatus, semitendinosus, gluteus medius, longissimus dorsi thoracis, intercostales and diaphragma) were collected at several post-treatment sampling times. Samples were frozen at-20 degrees C until analyzed by HPLC. The highest IVM residual concentrations in muscular tissue from the different locations were found at 15 days post-treatment in sheep. Although the highest IVM mean concentrations were measured at 15 (16.8 +/- 5.17 ng g(-1)) and 20 (10.5 +/- 4.06 ng g(-1)) days post-administration in the intercostales muscles, at 30 days post-administration, the IVM concentration in this location was similar to that measured in the rhomboideus and diaphragma muscles. DRM residual concentrations were quantified in muscular tissue from all anatomical locations after topical administration to calves. Maximum residue level was observed at 10 days post-treatment in all anatomical sites. The diaphragma muscle showed the highest DRM residue levels at 2 (22.0 +/- 4.35 ng g(-1)), 5 (45.2 +/- 3.78 ng g(-1)) and 10 (57.9 +/- 9.57 ng g(-1)) days post-treatment in calves. These results demonstrated that the pattern of residue depletion from muscular tissue may differ according to its anatomical locations and/or physiological role. This should be considered in implementing residue control strategies in meat safety assurance for human consumption.
Fil: Moreno Torrejon, Laura. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Ceballos, Laura. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sanchez Bruni, Sergio Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Lanusse, Carlos Edmundo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
DRUGS RESIDUES
IVERMECTINS
SHEEP
MUSCLE
DORAMECTIN
CATTLE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/104024
Acceder
id CONICETDig_98bde658fbed2f23c5096fe0e94c1d9d
oai_identifier_str oai:ri.conicet.gov.ar:11336/104024
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Pattern of ivermectin (sheep) and doramectin (cattle) residues in muscular tissue from various anatomical locationsMoreno Torrejon, LauraAlvarez, Luis IgnacioCeballos, LauraSanchez Bruni, Sergio FabianLanusse, Carlos EdmundoDRUGS RESIDUESIVERMECTINSSHEEPMUSCLEDORAMECTINCATTLEhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4This trial reports comparative drug residual concentrations in muscular tissue obtained from various anatomical locations after subcutaneous administration of ivermectin (IVM) to sheep and topical treatment with doramectin (DRM) to calves at recommended therapeutic dose rates. Seven muscle samples from different anatomical locations (rhomboideus, supraspinatus, semitendinosus, gluteus medius, longissimus dorsi thoracis, intercostales and diaphragma) were collected at several post-treatment sampling times. Samples were frozen at-20 degrees C until analyzed by HPLC. The highest IVM residual concentrations in muscular tissue from the different locations were found at 15 days post-treatment in sheep. Although the highest IVM mean concentrations were measured at 15 (16.8 +/- 5.17 ng g(-1)) and 20 (10.5 +/- 4.06 ng g(-1)) days post-administration in the intercostales muscles, at 30 days post-administration, the IVM concentration in this location was similar to that measured in the rhomboideus and diaphragma muscles. DRM residual concentrations were quantified in muscular tissue from all anatomical locations after topical administration to calves. Maximum residue level was observed at 10 days post-treatment in all anatomical sites. The diaphragma muscle showed the highest DRM residue levels at 2 (22.0 +/- 4.35 ng g(-1)), 5 (45.2 +/- 3.78 ng g(-1)) and 10 (57.9 +/- 9.57 ng g(-1)) days post-treatment in calves. These results demonstrated that the pattern of residue depletion from muscular tissue may differ according to its anatomical locations and/or physiological role. This should be considered in implementing residue control strategies in meat safety assurance for human consumption.Fil: Moreno Torrejon, Laura. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Ceballos, Laura. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sanchez Bruni, Sergio Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Lanusse, Carlos Edmundo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaTaylor & Francis Ltd2008-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/104024Moreno Torrejon, Laura; Alvarez, Luis Ignacio; Ceballos, Laura; Sanchez Bruni, Sergio Fabian; Lanusse, Carlos Edmundo; Pattern of ivermectin (sheep) and doramectin (cattle) residues in muscular tissue from various anatomical locations; Taylor & Francis Ltd; Food Additives and Contaminants; 25; 4; 4-2008; 406-4120265-203X1464-5122CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1080/02652030701552972info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1080/02652030701552972info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:52:52Zoai:ri.conicet.gov.ar:11336/104024instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:52:53.284CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pattern of ivermectin (sheep) and doramectin (cattle) residues in muscular tissue from various anatomical locations
title Pattern of ivermectin (sheep) and doramectin (cattle) residues in muscular tissue from various anatomical locations
spellingShingle Pattern of ivermectin (sheep) and doramectin (cattle) residues in muscular tissue from various anatomical locations
Moreno Torrejon, Laura
DRUGS RESIDUES
IVERMECTINS
SHEEP
MUSCLE
DORAMECTIN
CATTLE
title_short Pattern of ivermectin (sheep) and doramectin (cattle) residues in muscular tissue from various anatomical locations
title_full Pattern of ivermectin (sheep) and doramectin (cattle) residues in muscular tissue from various anatomical locations
title_fullStr Pattern of ivermectin (sheep) and doramectin (cattle) residues in muscular tissue from various anatomical locations
title_full_unstemmed Pattern of ivermectin (sheep) and doramectin (cattle) residues in muscular tissue from various anatomical locations
title_sort Pattern of ivermectin (sheep) and doramectin (cattle) residues in muscular tissue from various anatomical locations
dc.creator.none.fl_str_mv Moreno Torrejon, Laura
Alvarez, Luis Ignacio
Ceballos, Laura
Sanchez Bruni, Sergio Fabian
Lanusse, Carlos Edmundo
author Moreno Torrejon, Laura
author_facet Moreno Torrejon, Laura
Alvarez, Luis Ignacio
Ceballos, Laura
Sanchez Bruni, Sergio Fabian
Lanusse, Carlos Edmundo
author_role author
author2 Alvarez, Luis Ignacio
Ceballos, Laura
Sanchez Bruni, Sergio Fabian
Lanusse, Carlos Edmundo
author2_role author
author
author
author
dc.subject.none.fl_str_mv DRUGS RESIDUES
IVERMECTINS
SHEEP
MUSCLE
DORAMECTIN
CATTLE
topic DRUGS RESIDUES
IVERMECTINS
SHEEP
MUSCLE
DORAMECTIN
CATTLE
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv This trial reports comparative drug residual concentrations in muscular tissue obtained from various anatomical locations after subcutaneous administration of ivermectin (IVM) to sheep and topical treatment with doramectin (DRM) to calves at recommended therapeutic dose rates. Seven muscle samples from different anatomical locations (rhomboideus, supraspinatus, semitendinosus, gluteus medius, longissimus dorsi thoracis, intercostales and diaphragma) were collected at several post-treatment sampling times. Samples were frozen at-20 degrees C until analyzed by HPLC. The highest IVM residual concentrations in muscular tissue from the different locations were found at 15 days post-treatment in sheep. Although the highest IVM mean concentrations were measured at 15 (16.8 +/- 5.17 ng g(-1)) and 20 (10.5 +/- 4.06 ng g(-1)) days post-administration in the intercostales muscles, at 30 days post-administration, the IVM concentration in this location was similar to that measured in the rhomboideus and diaphragma muscles. DRM residual concentrations were quantified in muscular tissue from all anatomical locations after topical administration to calves. Maximum residue level was observed at 10 days post-treatment in all anatomical sites. The diaphragma muscle showed the highest DRM residue levels at 2 (22.0 +/- 4.35 ng g(-1)), 5 (45.2 +/- 3.78 ng g(-1)) and 10 (57.9 +/- 9.57 ng g(-1)) days post-treatment in calves. These results demonstrated that the pattern of residue depletion from muscular tissue may differ according to its anatomical locations and/or physiological role. This should be considered in implementing residue control strategies in meat safety assurance for human consumption.
Fil: Moreno Torrejon, Laura. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Ceballos, Laura. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sanchez Bruni, Sergio Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Lanusse, Carlos Edmundo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description This trial reports comparative drug residual concentrations in muscular tissue obtained from various anatomical locations after subcutaneous administration of ivermectin (IVM) to sheep and topical treatment with doramectin (DRM) to calves at recommended therapeutic dose rates. Seven muscle samples from different anatomical locations (rhomboideus, supraspinatus, semitendinosus, gluteus medius, longissimus dorsi thoracis, intercostales and diaphragma) were collected at several post-treatment sampling times. Samples were frozen at-20 degrees C until analyzed by HPLC. The highest IVM residual concentrations in muscular tissue from the different locations were found at 15 days post-treatment in sheep. Although the highest IVM mean concentrations were measured at 15 (16.8 +/- 5.17 ng g(-1)) and 20 (10.5 +/- 4.06 ng g(-1)) days post-administration in the intercostales muscles, at 30 days post-administration, the IVM concentration in this location was similar to that measured in the rhomboideus and diaphragma muscles. DRM residual concentrations were quantified in muscular tissue from all anatomical locations after topical administration to calves. Maximum residue level was observed at 10 days post-treatment in all anatomical sites. The diaphragma muscle showed the highest DRM residue levels at 2 (22.0 +/- 4.35 ng g(-1)), 5 (45.2 +/- 3.78 ng g(-1)) and 10 (57.9 +/- 9.57 ng g(-1)) days post-treatment in calves. These results demonstrated that the pattern of residue depletion from muscular tissue may differ according to its anatomical locations and/or physiological role. This should be considered in implementing residue control strategies in meat safety assurance for human consumption.
publishDate 2008
dc.date.none.fl_str_mv 2008-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/104024
Moreno Torrejon, Laura; Alvarez, Luis Ignacio; Ceballos, Laura; Sanchez Bruni, Sergio Fabian; Lanusse, Carlos Edmundo; Pattern of ivermectin (sheep) and doramectin (cattle) residues in muscular tissue from various anatomical locations; Taylor & Francis Ltd; Food Additives and Contaminants; 25; 4; 4-2008; 406-412
0265-203X
1464-5122
CONICET Digital
CONICET
url http://hdl.handle.net/11336/104024
identifier_str_mv Moreno Torrejon, Laura; Alvarez, Luis Ignacio; Ceballos, Laura; Sanchez Bruni, Sergio Fabian; Lanusse, Carlos Edmundo; Pattern of ivermectin (sheep) and doramectin (cattle) residues in muscular tissue from various anatomical locations; Taylor & Francis Ltd; Food Additives and Contaminants; 25; 4; 4-2008; 406-412
0265-203X
1464-5122
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1080/02652030701552972
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1080/02652030701552972
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis Ltd
publisher.none.fl_str_mv Taylor & Francis Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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