Ventilator output splitting interface ‘ACRA’: Description and evaluation in lung simulators and in an experimental ARDS animal model
- Autores
- Otero, Pablo Ezequiel; Tarragona, Lisa; Zaccagnini, Andrea Silvia; Verdier, Natali; Ceballos, Martin; Gogniat, Emiliano; Cabaleiro, Juan Martin; D'adamo, Juan Gastón Leonel; Duriez, Thomas Pierre Cornil; Garcia Eijo, Pedro Manuel; Artana, Guillermo Osvaldo
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The current COVID-19 pandemic has led the world to an unprecedented global shortage of ventilators, and its sharing has been proposed as an alternative to meet the surge. This study outlines the performance of a preformed novel interface called’ACRA’, designed to split ventilator outflow into two breathing systems. The’ACRA’ interface was built using medical use approved components. It consists of four unidirectional valves, two adjustable flow-restrictor valves placed on the inspiratory limbs of each unit, and one adjustable PEEP valve placed on the expiratory limb of the unit that would require a greater PEEP. The interface was interposed between a ventilator and two lung units (phase I), two breathing simulators (phase II) and two live pigs with heterogeneous lung conditions (phase III). The interface and ventilator adjustments tested the ability to regulate individual pressures and the resulting tidal volumes. Data were analyzed using Friedman and Wilcoxon tests test (p < 0.05). Ventilator outflow splitting, independent pressure adjustments and individual tidal volume monitoring were feasible in all phases. In all experimental measurements, dual ventilation allowed for individual and tight adjustments of the pressure, and thus volume delivered to each paired lung unit without affecting the other unit’s ventilation—all the modifications performed on the ventilator equally affected both paired lung units. Although only suggested during a dire crisis, this experiment supports dual ventilation as an alternative worth to be considered.
Fil: Otero, Pablo Ezequiel. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; Argentina
Fil: Tarragona, Lisa. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; Argentina
Fil: Zaccagnini, Andrea Silvia. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; Argentina
Fil: Verdier, Natali. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; Argentina
Fil: Ceballos, Martin. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; Argentina
Fil: Gogniat, Emiliano. Sociedad Argentina de Terapia Intensiva.; Argentina
Fil: Cabaleiro, Juan Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina
Fil: D'adamo, Juan Gastón Leonel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina
Fil: Duriez, Thomas Pierre Cornil. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina
Fil: Garcia Eijo, Pedro Manuel. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina
Fil: Artana, Guillermo Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina - Materia
-
COVID-19
SHARED VENTILATION
EXHALATORY DYNAMICS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/170015
Ver los metadatos del registro completo
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Ventilator output splitting interface ‘ACRA’: Description and evaluation in lung simulators and in an experimental ARDS animal modelOtero, Pablo EzequielTarragona, LisaZaccagnini, Andrea SilviaVerdier, NataliCeballos, MartinGogniat, EmilianoCabaleiro, Juan MartinD'adamo, Juan Gastón LeonelDuriez, Thomas Pierre CornilGarcia Eijo, Pedro ManuelArtana, Guillermo OsvaldoCOVID-19SHARED VENTILATIONEXHALATORY DYNAMICShttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4The current COVID-19 pandemic has led the world to an unprecedented global shortage of ventilators, and its sharing has been proposed as an alternative to meet the surge. This study outlines the performance of a preformed novel interface called’ACRA’, designed to split ventilator outflow into two breathing systems. The’ACRA’ interface was built using medical use approved components. It consists of four unidirectional valves, two adjustable flow-restrictor valves placed on the inspiratory limbs of each unit, and one adjustable PEEP valve placed on the expiratory limb of the unit that would require a greater PEEP. The interface was interposed between a ventilator and two lung units (phase I), two breathing simulators (phase II) and two live pigs with heterogeneous lung conditions (phase III). The interface and ventilator adjustments tested the ability to regulate individual pressures and the resulting tidal volumes. Data were analyzed using Friedman and Wilcoxon tests test (p < 0.05). Ventilator outflow splitting, independent pressure adjustments and individual tidal volume monitoring were feasible in all phases. In all experimental measurements, dual ventilation allowed for individual and tight adjustments of the pressure, and thus volume delivered to each paired lung unit without affecting the other unit’s ventilation—all the modifications performed on the ventilator equally affected both paired lung units. Although only suggested during a dire crisis, this experiment supports dual ventilation as an alternative worth to be considered.Fil: Otero, Pablo Ezequiel. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; ArgentinaFil: Tarragona, Lisa. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; ArgentinaFil: Zaccagnini, Andrea Silvia. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; ArgentinaFil: Verdier, Natali. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; ArgentinaFil: Ceballos, Martin. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; ArgentinaFil: Gogniat, Emiliano. Sociedad Argentina de Terapia Intensiva.; ArgentinaFil: Cabaleiro, Juan Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; ArgentinaFil: D'adamo, Juan Gastón Leonel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; ArgentinaFil: Duriez, Thomas Pierre Cornil. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; ArgentinaFil: Garcia Eijo, Pedro Manuel. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; ArgentinaFil: Artana, Guillermo Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; ArgentinaPublic Library of Science2021-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/170015Otero, Pablo Ezequiel; Tarragona, Lisa; Zaccagnini, Andrea Silvia; Verdier, Natali; Ceballos, Martin; et al.; Ventilator output splitting interface ‘ACRA’: Description and evaluation in lung simulators and in an experimental ARDS animal model; Public Library of Science; Plos One; 16; 8; 8-2021; 1-151932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0256469info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0256469info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:30:27Zoai:ri.conicet.gov.ar:11336/170015instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:30:28.144CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Ventilator output splitting interface ‘ACRA’: Description and evaluation in lung simulators and in an experimental ARDS animal model |
title |
Ventilator output splitting interface ‘ACRA’: Description and evaluation in lung simulators and in an experimental ARDS animal model |
spellingShingle |
Ventilator output splitting interface ‘ACRA’: Description and evaluation in lung simulators and in an experimental ARDS animal model Otero, Pablo Ezequiel COVID-19 SHARED VENTILATION EXHALATORY DYNAMICS |
title_short |
Ventilator output splitting interface ‘ACRA’: Description and evaluation in lung simulators and in an experimental ARDS animal model |
title_full |
Ventilator output splitting interface ‘ACRA’: Description and evaluation in lung simulators and in an experimental ARDS animal model |
title_fullStr |
Ventilator output splitting interface ‘ACRA’: Description and evaluation in lung simulators and in an experimental ARDS animal model |
title_full_unstemmed |
Ventilator output splitting interface ‘ACRA’: Description and evaluation in lung simulators and in an experimental ARDS animal model |
title_sort |
Ventilator output splitting interface ‘ACRA’: Description and evaluation in lung simulators and in an experimental ARDS animal model |
dc.creator.none.fl_str_mv |
Otero, Pablo Ezequiel Tarragona, Lisa Zaccagnini, Andrea Silvia Verdier, Natali Ceballos, Martin Gogniat, Emiliano Cabaleiro, Juan Martin D'adamo, Juan Gastón Leonel Duriez, Thomas Pierre Cornil Garcia Eijo, Pedro Manuel Artana, Guillermo Osvaldo |
author |
Otero, Pablo Ezequiel |
author_facet |
Otero, Pablo Ezequiel Tarragona, Lisa Zaccagnini, Andrea Silvia Verdier, Natali Ceballos, Martin Gogniat, Emiliano Cabaleiro, Juan Martin D'adamo, Juan Gastón Leonel Duriez, Thomas Pierre Cornil Garcia Eijo, Pedro Manuel Artana, Guillermo Osvaldo |
author_role |
author |
author2 |
Tarragona, Lisa Zaccagnini, Andrea Silvia Verdier, Natali Ceballos, Martin Gogniat, Emiliano Cabaleiro, Juan Martin D'adamo, Juan Gastón Leonel Duriez, Thomas Pierre Cornil Garcia Eijo, Pedro Manuel Artana, Guillermo Osvaldo |
author2_role |
author author author author author author author author author author |
dc.subject.none.fl_str_mv |
COVID-19 SHARED VENTILATION EXHALATORY DYNAMICS |
topic |
COVID-19 SHARED VENTILATION EXHALATORY DYNAMICS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/4.3 https://purl.org/becyt/ford/4 |
dc.description.none.fl_txt_mv |
The current COVID-19 pandemic has led the world to an unprecedented global shortage of ventilators, and its sharing has been proposed as an alternative to meet the surge. This study outlines the performance of a preformed novel interface called’ACRA’, designed to split ventilator outflow into two breathing systems. The’ACRA’ interface was built using medical use approved components. It consists of four unidirectional valves, two adjustable flow-restrictor valves placed on the inspiratory limbs of each unit, and one adjustable PEEP valve placed on the expiratory limb of the unit that would require a greater PEEP. The interface was interposed between a ventilator and two lung units (phase I), two breathing simulators (phase II) and two live pigs with heterogeneous lung conditions (phase III). The interface and ventilator adjustments tested the ability to regulate individual pressures and the resulting tidal volumes. Data were analyzed using Friedman and Wilcoxon tests test (p < 0.05). Ventilator outflow splitting, independent pressure adjustments and individual tidal volume monitoring were feasible in all phases. In all experimental measurements, dual ventilation allowed for individual and tight adjustments of the pressure, and thus volume delivered to each paired lung unit without affecting the other unit’s ventilation—all the modifications performed on the ventilator equally affected both paired lung units. Although only suggested during a dire crisis, this experiment supports dual ventilation as an alternative worth to be considered. Fil: Otero, Pablo Ezequiel. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; Argentina Fil: Tarragona, Lisa. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; Argentina Fil: Zaccagnini, Andrea Silvia. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; Argentina Fil: Verdier, Natali. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; Argentina Fil: Ceballos, Martin. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; Argentina Fil: Gogniat, Emiliano. Sociedad Argentina de Terapia Intensiva.; Argentina Fil: Cabaleiro, Juan Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina Fil: D'adamo, Juan Gastón Leonel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina Fil: Duriez, Thomas Pierre Cornil. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina Fil: Garcia Eijo, Pedro Manuel. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina Fil: Artana, Guillermo Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina |
description |
The current COVID-19 pandemic has led the world to an unprecedented global shortage of ventilators, and its sharing has been proposed as an alternative to meet the surge. This study outlines the performance of a preformed novel interface called’ACRA’, designed to split ventilator outflow into two breathing systems. The’ACRA’ interface was built using medical use approved components. It consists of four unidirectional valves, two adjustable flow-restrictor valves placed on the inspiratory limbs of each unit, and one adjustable PEEP valve placed on the expiratory limb of the unit that would require a greater PEEP. The interface was interposed between a ventilator and two lung units (phase I), two breathing simulators (phase II) and two live pigs with heterogeneous lung conditions (phase III). The interface and ventilator adjustments tested the ability to regulate individual pressures and the resulting tidal volumes. Data were analyzed using Friedman and Wilcoxon tests test (p < 0.05). Ventilator outflow splitting, independent pressure adjustments and individual tidal volume monitoring were feasible in all phases. In all experimental measurements, dual ventilation allowed for individual and tight adjustments of the pressure, and thus volume delivered to each paired lung unit without affecting the other unit’s ventilation—all the modifications performed on the ventilator equally affected both paired lung units. Although only suggested during a dire crisis, this experiment supports dual ventilation as an alternative worth to be considered. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/170015 Otero, Pablo Ezequiel; Tarragona, Lisa; Zaccagnini, Andrea Silvia; Verdier, Natali; Ceballos, Martin; et al.; Ventilator output splitting interface ‘ACRA’: Description and evaluation in lung simulators and in an experimental ARDS animal model; Public Library of Science; Plos One; 16; 8; 8-2021; 1-15 1932-6203 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/170015 |
identifier_str_mv |
Otero, Pablo Ezequiel; Tarragona, Lisa; Zaccagnini, Andrea Silvia; Verdier, Natali; Ceballos, Martin; et al.; Ventilator output splitting interface ‘ACRA’: Description and evaluation in lung simulators and in an experimental ARDS animal model; Public Library of Science; Plos One; 16; 8; 8-2021; 1-15 1932-6203 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0256469 info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0256469 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Public Library of Science |
publisher.none.fl_str_mv |
Public Library of Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614312874737664 |
score |
13.070432 |