Ventilator output splitting interface ‘ACRA’: Description and evaluation in lung simulators and in an experimental ARDS animal model

Autores
Otero, Pablo Ezequiel; Tarragona, Lisa; Zaccagnini, Andrea Silvia; Verdier, Natali; Ceballos, Martin; Gogniat, Emiliano; Cabaleiro, Juan Martin; D'adamo, Juan Gastón Leonel; Duriez, Thomas Pierre Cornil; Garcia Eijo, Pedro Manuel; Artana, Guillermo Osvaldo
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The current COVID-19 pandemic has led the world to an unprecedented global shortage of ventilators, and its sharing has been proposed as an alternative to meet the surge. This study outlines the performance of a preformed novel interface called’ACRA’, designed to split ventilator outflow into two breathing systems. The’ACRA’ interface was built using medical use approved components. It consists of four unidirectional valves, two adjustable flow-restrictor valves placed on the inspiratory limbs of each unit, and one adjustable PEEP valve placed on the expiratory limb of the unit that would require a greater PEEP. The interface was interposed between a ventilator and two lung units (phase I), two breathing simulators (phase II) and two live pigs with heterogeneous lung conditions (phase III). The interface and ventilator adjustments tested the ability to regulate individual pressures and the resulting tidal volumes. Data were analyzed using Friedman and Wilcoxon tests test (p < 0.05). Ventilator outflow splitting, independent pressure adjustments and individual tidal volume monitoring were feasible in all phases. In all experimental measurements, dual ventilation allowed for individual and tight adjustments of the pressure, and thus volume delivered to each paired lung unit without affecting the other unit’s ventilation—all the modifications performed on the ventilator equally affected both paired lung units. Although only suggested during a dire crisis, this experiment supports dual ventilation as an alternative worth to be considered.
Fil: Otero, Pablo Ezequiel. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; Argentina
Fil: Tarragona, Lisa. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; Argentina
Fil: Zaccagnini, Andrea Silvia. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; Argentina
Fil: Verdier, Natali. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; Argentina
Fil: Ceballos, Martin. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; Argentina
Fil: Gogniat, Emiliano. Sociedad Argentina de Terapia Intensiva.; Argentina
Fil: Cabaleiro, Juan Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina
Fil: D'adamo, Juan Gastón Leonel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina
Fil: Duriez, Thomas Pierre Cornil. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina
Fil: Garcia Eijo, Pedro Manuel. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina
Fil: Artana, Guillermo Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina
Materia
COVID-19
SHARED VENTILATION
EXHALATORY DYNAMICS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/170015
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Ventilator output splitting interface ‘ACRA’: Description and evaluation in lung simulators and in an experimental ARDS animal modelOtero, Pablo EzequielTarragona, LisaZaccagnini, Andrea SilviaVerdier, NataliCeballos, MartinGogniat, EmilianoCabaleiro, Juan MartinD'adamo, Juan Gastón LeonelDuriez, Thomas Pierre CornilGarcia Eijo, Pedro ManuelArtana, Guillermo OsvaldoCOVID-19SHARED VENTILATIONEXHALATORY DYNAMICShttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4The current COVID-19 pandemic has led the world to an unprecedented global shortage of ventilators, and its sharing has been proposed as an alternative to meet the surge. This study outlines the performance of a preformed novel interface called’ACRA’, designed to split ventilator outflow into two breathing systems. The’ACRA’ interface was built using medical use approved components. It consists of four unidirectional valves, two adjustable flow-restrictor valves placed on the inspiratory limbs of each unit, and one adjustable PEEP valve placed on the expiratory limb of the unit that would require a greater PEEP. The interface was interposed between a ventilator and two lung units (phase I), two breathing simulators (phase II) and two live pigs with heterogeneous lung conditions (phase III). The interface and ventilator adjustments tested the ability to regulate individual pressures and the resulting tidal volumes. Data were analyzed using Friedman and Wilcoxon tests test (p < 0.05). Ventilator outflow splitting, independent pressure adjustments and individual tidal volume monitoring were feasible in all phases. In all experimental measurements, dual ventilation allowed for individual and tight adjustments of the pressure, and thus volume delivered to each paired lung unit without affecting the other unit’s ventilation—all the modifications performed on the ventilator equally affected both paired lung units. Although only suggested during a dire crisis, this experiment supports dual ventilation as an alternative worth to be considered.Fil: Otero, Pablo Ezequiel. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; ArgentinaFil: Tarragona, Lisa. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; ArgentinaFil: Zaccagnini, Andrea Silvia. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; ArgentinaFil: Verdier, Natali. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; ArgentinaFil: Ceballos, Martin. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; ArgentinaFil: Gogniat, Emiliano. Sociedad Argentina de Terapia Intensiva.; ArgentinaFil: Cabaleiro, Juan Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; ArgentinaFil: D'adamo, Juan Gastón Leonel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; ArgentinaFil: Duriez, Thomas Pierre Cornil. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; ArgentinaFil: Garcia Eijo, Pedro Manuel. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; ArgentinaFil: Artana, Guillermo Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; ArgentinaPublic Library of Science2021-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/170015Otero, Pablo Ezequiel; Tarragona, Lisa; Zaccagnini, Andrea Silvia; Verdier, Natali; Ceballos, Martin; et al.; Ventilator output splitting interface ‘ACRA’: Description and evaluation in lung simulators and in an experimental ARDS animal model; Public Library of Science; Plos One; 16; 8; 8-2021; 1-151932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0256469info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0256469info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:02:56Zoai:ri.conicet.gov.ar:11336/170015instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:02:57.067CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Ventilator output splitting interface ‘ACRA’: Description and evaluation in lung simulators and in an experimental ARDS animal model
title Ventilator output splitting interface ‘ACRA’: Description and evaluation in lung simulators and in an experimental ARDS animal model
spellingShingle Ventilator output splitting interface ‘ACRA’: Description and evaluation in lung simulators and in an experimental ARDS animal model
Otero, Pablo Ezequiel
COVID-19
SHARED VENTILATION
EXHALATORY DYNAMICS
title_short Ventilator output splitting interface ‘ACRA’: Description and evaluation in lung simulators and in an experimental ARDS animal model
title_full Ventilator output splitting interface ‘ACRA’: Description and evaluation in lung simulators and in an experimental ARDS animal model
title_fullStr Ventilator output splitting interface ‘ACRA’: Description and evaluation in lung simulators and in an experimental ARDS animal model
title_full_unstemmed Ventilator output splitting interface ‘ACRA’: Description and evaluation in lung simulators and in an experimental ARDS animal model
title_sort Ventilator output splitting interface ‘ACRA’: Description and evaluation in lung simulators and in an experimental ARDS animal model
dc.creator.none.fl_str_mv Otero, Pablo Ezequiel
Tarragona, Lisa
Zaccagnini, Andrea Silvia
Verdier, Natali
Ceballos, Martin
Gogniat, Emiliano
Cabaleiro, Juan Martin
D'adamo, Juan Gastón Leonel
Duriez, Thomas Pierre Cornil
Garcia Eijo, Pedro Manuel
Artana, Guillermo Osvaldo
author Otero, Pablo Ezequiel
author_facet Otero, Pablo Ezequiel
Tarragona, Lisa
Zaccagnini, Andrea Silvia
Verdier, Natali
Ceballos, Martin
Gogniat, Emiliano
Cabaleiro, Juan Martin
D'adamo, Juan Gastón Leonel
Duriez, Thomas Pierre Cornil
Garcia Eijo, Pedro Manuel
Artana, Guillermo Osvaldo
author_role author
author2 Tarragona, Lisa
Zaccagnini, Andrea Silvia
Verdier, Natali
Ceballos, Martin
Gogniat, Emiliano
Cabaleiro, Juan Martin
D'adamo, Juan Gastón Leonel
Duriez, Thomas Pierre Cornil
Garcia Eijo, Pedro Manuel
Artana, Guillermo Osvaldo
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv COVID-19
SHARED VENTILATION
EXHALATORY DYNAMICS
topic COVID-19
SHARED VENTILATION
EXHALATORY DYNAMICS
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv The current COVID-19 pandemic has led the world to an unprecedented global shortage of ventilators, and its sharing has been proposed as an alternative to meet the surge. This study outlines the performance of a preformed novel interface called’ACRA’, designed to split ventilator outflow into two breathing systems. The’ACRA’ interface was built using medical use approved components. It consists of four unidirectional valves, two adjustable flow-restrictor valves placed on the inspiratory limbs of each unit, and one adjustable PEEP valve placed on the expiratory limb of the unit that would require a greater PEEP. The interface was interposed between a ventilator and two lung units (phase I), two breathing simulators (phase II) and two live pigs with heterogeneous lung conditions (phase III). The interface and ventilator adjustments tested the ability to regulate individual pressures and the resulting tidal volumes. Data were analyzed using Friedman and Wilcoxon tests test (p < 0.05). Ventilator outflow splitting, independent pressure adjustments and individual tidal volume monitoring were feasible in all phases. In all experimental measurements, dual ventilation allowed for individual and tight adjustments of the pressure, and thus volume delivered to each paired lung unit without affecting the other unit’s ventilation—all the modifications performed on the ventilator equally affected both paired lung units. Although only suggested during a dire crisis, this experiment supports dual ventilation as an alternative worth to be considered.
Fil: Otero, Pablo Ezequiel. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; Argentina
Fil: Tarragona, Lisa. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; Argentina
Fil: Zaccagnini, Andrea Silvia. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; Argentina
Fil: Verdier, Natali. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; Argentina
Fil: Ceballos, Martin. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; Argentina
Fil: Gogniat, Emiliano. Sociedad Argentina de Terapia Intensiva.; Argentina
Fil: Cabaleiro, Juan Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina
Fil: D'adamo, Juan Gastón Leonel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina
Fil: Duriez, Thomas Pierre Cornil. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina
Fil: Garcia Eijo, Pedro Manuel. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina
Fil: Artana, Guillermo Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina
description The current COVID-19 pandemic has led the world to an unprecedented global shortage of ventilators, and its sharing has been proposed as an alternative to meet the surge. This study outlines the performance of a preformed novel interface called’ACRA’, designed to split ventilator outflow into two breathing systems. The’ACRA’ interface was built using medical use approved components. It consists of four unidirectional valves, two adjustable flow-restrictor valves placed on the inspiratory limbs of each unit, and one adjustable PEEP valve placed on the expiratory limb of the unit that would require a greater PEEP. The interface was interposed between a ventilator and two lung units (phase I), two breathing simulators (phase II) and two live pigs with heterogeneous lung conditions (phase III). The interface and ventilator adjustments tested the ability to regulate individual pressures and the resulting tidal volumes. Data were analyzed using Friedman and Wilcoxon tests test (p < 0.05). Ventilator outflow splitting, independent pressure adjustments and individual tidal volume monitoring were feasible in all phases. In all experimental measurements, dual ventilation allowed for individual and tight adjustments of the pressure, and thus volume delivered to each paired lung unit without affecting the other unit’s ventilation—all the modifications performed on the ventilator equally affected both paired lung units. Although only suggested during a dire crisis, this experiment supports dual ventilation as an alternative worth to be considered.
publishDate 2021
dc.date.none.fl_str_mv 2021-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/170015
Otero, Pablo Ezequiel; Tarragona, Lisa; Zaccagnini, Andrea Silvia; Verdier, Natali; Ceballos, Martin; et al.; Ventilator output splitting interface ‘ACRA’: Description and evaluation in lung simulators and in an experimental ARDS animal model; Public Library of Science; Plos One; 16; 8; 8-2021; 1-15
1932-6203
CONICET Digital
CONICET
url http://hdl.handle.net/11336/170015
identifier_str_mv Otero, Pablo Ezequiel; Tarragona, Lisa; Zaccagnini, Andrea Silvia; Verdier, Natali; Ceballos, Martin; et al.; Ventilator output splitting interface ‘ACRA’: Description and evaluation in lung simulators and in an experimental ARDS animal model; Public Library of Science; Plos One; 16; 8; 8-2021; 1-15
1932-6203
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0256469
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0256469
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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