Exhalatory dynamic interactions between patients connected to a shared ventilation device

Autores
Garcia Eijo, Pedro Manuel; D'adamo, Juan Gastón Leonel; Bianchetti, Arturo Abel; Duriez, Thomas Pierre Cornil; Cabaleiro, Juan Martin; Irrazabal, Célica; Otero, Pablo; Artana, Guillermo Osvaldo
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this work a shared pressure-controlled ventilation device for two patients is considered. By the use of different valves incorporated to the circuit, the device enables the restriction of possible cross contamination and the individualization of tidal volumes, driving pressures, and positive end expiratory pressure PEEP. Possible interactions in the expiratory dynamics of different pairs of patients are evaluated in terms of the characteristic exhalatory times. These characteristic times can not be easily established using simple linear lumped element models. For this purpose, a 1D model using the Hydraulic and Mechanical libraries in Matlab Simulink was developed. In this sense, experiments accompany this study to validate the model and characterize the different valves of the circuit. Our results show that connecting two patients in parallel to a ventilator always resulted in delays of time during the exhalation. The size of this effect depends on different parameters associated with the patients, the circuit and the ventilator. The dynamics of the exhalation of both patients is determined by the ratios between patients exhalatory resistances, compliances, driving pressures and PEEPs. Adverse effects on exhalations became less noticeable when respiratory parameters of both patients were similar, flow resistances of valves added to the circuit were negligible, and when the ventilator exhalatory valve resistance was also negligible. The asymmetries of driving pressures, compliances or resistances exacerbated the possibility of auto-PEEP and the increase in relaxation times became greater in one patient than in the other. In contrast, exhalatory dynamics were less sensitive to the ratio of PEEP imposed to the patients.
Fil: Garcia Eijo, Pedro Manuel. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina
Fil: D'adamo, Juan Gastón Leonel. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina
Fil: Bianchetti, Arturo Abel. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina
Fil: Duriez, Thomas Pierre Cornil. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina
Fil: Cabaleiro, Juan Martin. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina
Fil: Irrazabal, Célica. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Otero, Pablo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; Argentina
Fil: Artana, Guillermo Osvaldo. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina
Materia
COVID-19
shared ventilation
exhalatory dynamics
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/165440
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/165440
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Exhalatory dynamic interactions between patients connected to a shared ventilation deviceGarcia Eijo, Pedro ManuelD'adamo, Juan Gastón LeonelBianchetti, Arturo AbelDuriez, Thomas Pierre CornilCabaleiro, Juan MartinIrrazabal, CélicaOtero, PabloArtana, Guillermo OsvaldoCOVID-19shared ventilationexhalatory dynamicshttps://purl.org/becyt/ford/2.3https://purl.org/becyt/ford/2In this work a shared pressure-controlled ventilation device for two patients is considered. By the use of different valves incorporated to the circuit, the device enables the restriction of possible cross contamination and the individualization of tidal volumes, driving pressures, and positive end expiratory pressure PEEP. Possible interactions in the expiratory dynamics of different pairs of patients are evaluated in terms of the characteristic exhalatory times. These characteristic times can not be easily established using simple linear lumped element models. For this purpose, a 1D model using the Hydraulic and Mechanical libraries in Matlab Simulink was developed. In this sense, experiments accompany this study to validate the model and characterize the different valves of the circuit. Our results show that connecting two patients in parallel to a ventilator always resulted in delays of time during the exhalation. The size of this effect depends on different parameters associated with the patients, the circuit and the ventilator. The dynamics of the exhalation of both patients is determined by the ratios between patients exhalatory resistances, compliances, driving pressures and PEEPs. Adverse effects on exhalations became less noticeable when respiratory parameters of both patients were similar, flow resistances of valves added to the circuit were negligible, and when the ventilator exhalatory valve resistance was also negligible. The asymmetries of driving pressures, compliances or resistances exacerbated the possibility of auto-PEEP and the increase in relaxation times became greater in one patient than in the other. In contrast, exhalatory dynamics were less sensitive to the ratio of PEEP imposed to the patients.Fil: Garcia Eijo, Pedro Manuel. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; ArgentinaFil: D'adamo, Juan Gastón Leonel. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; ArgentinaFil: Bianchetti, Arturo Abel. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; ArgentinaFil: Duriez, Thomas Pierre Cornil. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; ArgentinaFil: Cabaleiro, Juan Martin. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; ArgentinaFil: Irrazabal, Célica. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Otero, Pablo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; ArgentinaFil: Artana, Guillermo Osvaldo. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; ArgentinaPublic Library of Science2021-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/165440Garcia Eijo, Pedro Manuel; D'adamo, Juan Gastón Leonel; Bianchetti, Arturo Abel; Duriez, Thomas Pierre Cornil; Cabaleiro, Juan Martin; et al.; Exhalatory dynamic interactions between patients connected to a shared ventilation device; Public Library of Science; Plos One; 16; 5; 5-2021; 1-25; e02506721932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0250672info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0250672info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:31:45Zoai:ri.conicet.gov.ar:11336/165440instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:31:45.833CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Exhalatory dynamic interactions between patients connected to a shared ventilation device
title Exhalatory dynamic interactions between patients connected to a shared ventilation device
spellingShingle Exhalatory dynamic interactions between patients connected to a shared ventilation device
Garcia Eijo, Pedro Manuel
COVID-19
shared ventilation
exhalatory dynamics
title_short Exhalatory dynamic interactions between patients connected to a shared ventilation device
title_full Exhalatory dynamic interactions between patients connected to a shared ventilation device
title_fullStr Exhalatory dynamic interactions between patients connected to a shared ventilation device
title_full_unstemmed Exhalatory dynamic interactions between patients connected to a shared ventilation device
title_sort Exhalatory dynamic interactions between patients connected to a shared ventilation device
dc.creator.none.fl_str_mv Garcia Eijo, Pedro Manuel
D'adamo, Juan Gastón Leonel
Bianchetti, Arturo Abel
Duriez, Thomas Pierre Cornil
Cabaleiro, Juan Martin
Irrazabal, Célica
Otero, Pablo
Artana, Guillermo Osvaldo
author Garcia Eijo, Pedro Manuel
author_facet Garcia Eijo, Pedro Manuel
D'adamo, Juan Gastón Leonel
Bianchetti, Arturo Abel
Duriez, Thomas Pierre Cornil
Cabaleiro, Juan Martin
Irrazabal, Célica
Otero, Pablo
Artana, Guillermo Osvaldo
author_role author
author2 D'adamo, Juan Gastón Leonel
Bianchetti, Arturo Abel
Duriez, Thomas Pierre Cornil
Cabaleiro, Juan Martin
Irrazabal, Célica
Otero, Pablo
Artana, Guillermo Osvaldo
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv COVID-19
shared ventilation
exhalatory dynamics
topic COVID-19
shared ventilation
exhalatory dynamics
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.3
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv In this work a shared pressure-controlled ventilation device for two patients is considered. By the use of different valves incorporated to the circuit, the device enables the restriction of possible cross contamination and the individualization of tidal volumes, driving pressures, and positive end expiratory pressure PEEP. Possible interactions in the expiratory dynamics of different pairs of patients are evaluated in terms of the characteristic exhalatory times. These characteristic times can not be easily established using simple linear lumped element models. For this purpose, a 1D model using the Hydraulic and Mechanical libraries in Matlab Simulink was developed. In this sense, experiments accompany this study to validate the model and characterize the different valves of the circuit. Our results show that connecting two patients in parallel to a ventilator always resulted in delays of time during the exhalation. The size of this effect depends on different parameters associated with the patients, the circuit and the ventilator. The dynamics of the exhalation of both patients is determined by the ratios between patients exhalatory resistances, compliances, driving pressures and PEEPs. Adverse effects on exhalations became less noticeable when respiratory parameters of both patients were similar, flow resistances of valves added to the circuit were negligible, and when the ventilator exhalatory valve resistance was also negligible. The asymmetries of driving pressures, compliances or resistances exacerbated the possibility of auto-PEEP and the increase in relaxation times became greater in one patient than in the other. In contrast, exhalatory dynamics were less sensitive to the ratio of PEEP imposed to the patients.
Fil: Garcia Eijo, Pedro Manuel. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina
Fil: D'adamo, Juan Gastón Leonel. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina
Fil: Bianchetti, Arturo Abel. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina
Fil: Duriez, Thomas Pierre Cornil. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina
Fil: Cabaleiro, Juan Martin. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina
Fil: Irrazabal, Célica. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Otero, Pablo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; Argentina
Fil: Artana, Guillermo Osvaldo. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Ingeniería Mecánica. Laboratorio de Fluidodinámica; Argentina
description In this work a shared pressure-controlled ventilation device for two patients is considered. By the use of different valves incorporated to the circuit, the device enables the restriction of possible cross contamination and the individualization of tidal volumes, driving pressures, and positive end expiratory pressure PEEP. Possible interactions in the expiratory dynamics of different pairs of patients are evaluated in terms of the characteristic exhalatory times. These characteristic times can not be easily established using simple linear lumped element models. For this purpose, a 1D model using the Hydraulic and Mechanical libraries in Matlab Simulink was developed. In this sense, experiments accompany this study to validate the model and characterize the different valves of the circuit. Our results show that connecting two patients in parallel to a ventilator always resulted in delays of time during the exhalation. The size of this effect depends on different parameters associated with the patients, the circuit and the ventilator. The dynamics of the exhalation of both patients is determined by the ratios between patients exhalatory resistances, compliances, driving pressures and PEEPs. Adverse effects on exhalations became less noticeable when respiratory parameters of both patients were similar, flow resistances of valves added to the circuit were negligible, and when the ventilator exhalatory valve resistance was also negligible. The asymmetries of driving pressures, compliances or resistances exacerbated the possibility of auto-PEEP and the increase in relaxation times became greater in one patient than in the other. In contrast, exhalatory dynamics were less sensitive to the ratio of PEEP imposed to the patients.
publishDate 2021
dc.date.none.fl_str_mv 2021-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/165440
Garcia Eijo, Pedro Manuel; D'adamo, Juan Gastón Leonel; Bianchetti, Arturo Abel; Duriez, Thomas Pierre Cornil; Cabaleiro, Juan Martin; et al.; Exhalatory dynamic interactions between patients connected to a shared ventilation device; Public Library of Science; Plos One; 16; 5; 5-2021; 1-25; e0250672
1932-6203
CONICET Digital
CONICET
url http://hdl.handle.net/11336/165440
identifier_str_mv Garcia Eijo, Pedro Manuel; D'adamo, Juan Gastón Leonel; Bianchetti, Arturo Abel; Duriez, Thomas Pierre Cornil; Cabaleiro, Juan Martin; et al.; Exhalatory dynamic interactions between patients connected to a shared ventilation device; Public Library of Science; Plos One; 16; 5; 5-2021; 1-25; e0250672
1932-6203
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0250672
info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0250672
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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