Proteins and carbohydrates from red seaweeds: Evidence for beneficial effects on gut function and microbiota

• Autores: Cian, Raúl Esteban; Drago, Silvina Rosa; Sánchez de Medina, Fermin; Martínez Augustin, Olga
• Año de publicación: 2015
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: BIOACTIVE PEPTIDES; CELL DIFFERENTIATION; CELL PROLIFERATION; IMMUNOMODULATION; MAPK; MUCOSAL BARRIER FUNCTION; NF-ΚB; RED SEAWEEDS; RHODOPHYTA; SULFATED GALACTANS
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

Based on their composition, marine algae, and namely red seaweeds, are good potential functional foods. Intestinal mucosal barrier function refers to the capacity of the intestine to provide adequate containment of luminal microorganisms and molecules. Here, we will first outline the component of seaweeds and will summarize the effects of these on the regulation of mucosal barrier function. Special attention will be paid to unique components of red seaweeds: proteins and derived peptides (e.g., phycobiliproteins, glycoproteins that contain "cellulose binding domains", phycolectins and the related mycosporine-like amino acids) together with polysaccharides (e.g., floridean starch and sulfated galactans, such as carrageenans, agarans and "DL-hybrid") and minerals. These compounds have been shown to exert prebiotic effects, to regulate intestinal epithelial cell, macrophage and lymphocyte proliferation and differentiation and to modulate the immune response. Molecular mechanisms of action of peptides and polysaccharides are starting to be elucidated, and evidence indicating the involvement of epidermal growth factor receptor (EGFR), insulin-like growth factor receptor (IGFR), Toll-like receptors (TLR) and signal transduction pathways mediated by protein kinase B (PKB or AKT), nuclear factor-κB (NF-κB) and mitogen activated protein kinases (MAPK) will also be summarized. The need for further research is clear, but in vivo experiments point to an overall antiinflammatory effect of these algae, indicating that they can reinforce membrane barrier function.
Fil: Cian, Raúl Esteban. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Tecnología de los Alimentos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Drago, Silvina Rosa. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Tecnología de los Alimentos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sánchez de Medina, Fermin. Universidad de Granada; España
Fil: Martínez Augustin, Olga. Universidad de Granada; España