The role of ACTH in the pathogenesis of Polycystic Ovarian Syndrome in the rat: hormonal profiles and ovarian morphology.

Autores
Baravalle, Celina; Salvetti, Natalia Raquel; Mira, G. A.; Lorente, J. A.; Ortega, Hugo Hector
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Numerous hypotheses have been proposed about the pathogenia of the polycystic ovarian syndrome (PCOS). However, hormonal control of the persistent follicle has not been established. The objective of the present study was to compare the follicular structure and hormonal profiles of rats treated with adrenocorticotrophic hormone (ACTH) with two experimental models of PCOS. ACTH-treated animals were compared with those exposed to continuous light, treated with estradiol valerate, and control (in proestrous and diestrous). Serum hormone levels, histomorphometrical changes, and immunoexpression of vimentin, cytokeratins, cadherins, and proliferating cell nuclear antigen (PCNA) were examined. Treatment with ACTH resulted in an elevation of corticosterone secretion with LH reduction but without changes in ovarian morphology. Although stress (or ACTH) stimulation may be only one pathophysiological mechanism involved in follicular cyst pathogenia in other species, we do not find important evidence to suppose that this would happen in rats.
Fil: Baravalle, Celina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas. Laboratorio de Biología Celular y Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Salvetti, Natalia Raquel. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas. Laboratorio de Biología Celular y Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mira, G. A.. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina
Fil: Lorente, J. A.. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina
Fil: Ortega, Hugo Hector. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas. Laboratorio de Biología Celular y Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
PCOD
rat
ACTH
proliferation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/114384
Acceder
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network_name_str CONICET Digital (CONICET)
spelling The role of ACTH in the pathogenesis of Polycystic Ovarian Syndrome in the rat: hormonal profiles and ovarian morphology.Baravalle, CelinaSalvetti, Natalia RaquelMira, G. A.Lorente, J. A.Ortega, Hugo HectorPCODratACTHproliferationhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Numerous hypotheses have been proposed about the pathogenia of the polycystic ovarian syndrome (PCOS). However, hormonal control of the persistent follicle has not been established. The objective of the present study was to compare the follicular structure and hormonal profiles of rats treated with adrenocorticotrophic hormone (ACTH) with two experimental models of PCOS. ACTH-treated animals were compared with those exposed to continuous light, treated with estradiol valerate, and control (in proestrous and diestrous). Serum hormone levels, histomorphometrical changes, and immunoexpression of vimentin, cytokeratins, cadherins, and proliferating cell nuclear antigen (PCNA) were examined. Treatment with ACTH resulted in an elevation of corticosterone secretion with LH reduction but without changes in ovarian morphology. Although stress (or ACTH) stimulation may be only one pathophysiological mechanism involved in follicular cyst pathogenia in other species, we do not find important evidence to suppose that this would happen in rats.Fil: Baravalle, Celina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas. Laboratorio de Biología Celular y Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Salvetti, Natalia Raquel. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas. Laboratorio de Biología Celular y Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mira, G. A.. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; ArgentinaFil: Lorente, J. A.. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; ArgentinaFil: Ortega, Hugo Hector. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas. Laboratorio de Biología Celular y Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAcad Sciences Czech Republic2007-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/114384Baravalle, Celina; Salvetti, Natalia Raquel; Mira, G. A.; Lorente, J. A.; Ortega, Hugo Hector; The role of ACTH in the pathogenesis of Polycystic Ovarian Syndrome in the rat: hormonal profiles and ovarian morphology.; Acad Sciences Czech Republic; Physiological Research; 56; 12-2007; 67-780862-8408CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.biomed.cas.cz/physiolres/pdf/56/56_67.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:11:42Zoai:ri.conicet.gov.ar:11336/114384instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:11:42.614CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The role of ACTH in the pathogenesis of Polycystic Ovarian Syndrome in the rat: hormonal profiles and ovarian morphology.
title The role of ACTH in the pathogenesis of Polycystic Ovarian Syndrome in the rat: hormonal profiles and ovarian morphology.
spellingShingle The role of ACTH in the pathogenesis of Polycystic Ovarian Syndrome in the rat: hormonal profiles and ovarian morphology.
Baravalle, Celina
PCOD
rat
ACTH
proliferation
title_short The role of ACTH in the pathogenesis of Polycystic Ovarian Syndrome in the rat: hormonal profiles and ovarian morphology.
title_full The role of ACTH in the pathogenesis of Polycystic Ovarian Syndrome in the rat: hormonal profiles and ovarian morphology.
title_fullStr The role of ACTH in the pathogenesis of Polycystic Ovarian Syndrome in the rat: hormonal profiles and ovarian morphology.
title_full_unstemmed The role of ACTH in the pathogenesis of Polycystic Ovarian Syndrome in the rat: hormonal profiles and ovarian morphology.
title_sort The role of ACTH in the pathogenesis of Polycystic Ovarian Syndrome in the rat: hormonal profiles and ovarian morphology.
dc.creator.none.fl_str_mv Baravalle, Celina
Salvetti, Natalia Raquel
Mira, G. A.
Lorente, J. A.
Ortega, Hugo Hector
author Baravalle, Celina
author_facet Baravalle, Celina
Salvetti, Natalia Raquel
Mira, G. A.
Lorente, J. A.
Ortega, Hugo Hector
author_role author
author2 Salvetti, Natalia Raquel
Mira, G. A.
Lorente, J. A.
Ortega, Hugo Hector
author2_role author
author
author
author
dc.subject.none.fl_str_mv PCOD
rat
ACTH
proliferation
topic PCOD
rat
ACTH
proliferation
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Numerous hypotheses have been proposed about the pathogenia of the polycystic ovarian syndrome (PCOS). However, hormonal control of the persistent follicle has not been established. The objective of the present study was to compare the follicular structure and hormonal profiles of rats treated with adrenocorticotrophic hormone (ACTH) with two experimental models of PCOS. ACTH-treated animals were compared with those exposed to continuous light, treated with estradiol valerate, and control (in proestrous and diestrous). Serum hormone levels, histomorphometrical changes, and immunoexpression of vimentin, cytokeratins, cadherins, and proliferating cell nuclear antigen (PCNA) were examined. Treatment with ACTH resulted in an elevation of corticosterone secretion with LH reduction but without changes in ovarian morphology. Although stress (or ACTH) stimulation may be only one pathophysiological mechanism involved in follicular cyst pathogenia in other species, we do not find important evidence to suppose that this would happen in rats.
Fil: Baravalle, Celina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas. Laboratorio de Biología Celular y Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Salvetti, Natalia Raquel. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas. Laboratorio de Biología Celular y Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mira, G. A.. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina
Fil: Lorente, J. A.. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina
Fil: Ortega, Hugo Hector. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas. Laboratorio de Biología Celular y Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Numerous hypotheses have been proposed about the pathogenia of the polycystic ovarian syndrome (PCOS). However, hormonal control of the persistent follicle has not been established. The objective of the present study was to compare the follicular structure and hormonal profiles of rats treated with adrenocorticotrophic hormone (ACTH) with two experimental models of PCOS. ACTH-treated animals were compared with those exposed to continuous light, treated with estradiol valerate, and control (in proestrous and diestrous). Serum hormone levels, histomorphometrical changes, and immunoexpression of vimentin, cytokeratins, cadherins, and proliferating cell nuclear antigen (PCNA) were examined. Treatment with ACTH resulted in an elevation of corticosterone secretion with LH reduction but without changes in ovarian morphology. Although stress (or ACTH) stimulation may be only one pathophysiological mechanism involved in follicular cyst pathogenia in other species, we do not find important evidence to suppose that this would happen in rats.
publishDate 2007
dc.date.none.fl_str_mv 2007-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/114384
Baravalle, Celina; Salvetti, Natalia Raquel; Mira, G. A.; Lorente, J. A.; Ortega, Hugo Hector; The role of ACTH in the pathogenesis of Polycystic Ovarian Syndrome in the rat: hormonal profiles and ovarian morphology.; Acad Sciences Czech Republic; Physiological Research; 56; 12-2007; 67-78
0862-8408
CONICET Digital
CONICET
url http://hdl.handle.net/11336/114384
identifier_str_mv Baravalle, Celina; Salvetti, Natalia Raquel; Mira, G. A.; Lorente, J. A.; Ortega, Hugo Hector; The role of ACTH in the pathogenesis of Polycystic Ovarian Syndrome in the rat: hormonal profiles and ovarian morphology.; Acad Sciences Czech Republic; Physiological Research; 56; 12-2007; 67-78
0862-8408
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.biomed.cas.cz/physiolres/pdf/56/56_67.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Acad Sciences Czech Republic
publisher.none.fl_str_mv Acad Sciences Czech Republic
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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