Ectopic ACTH syndrome in a dog with a mesenteric neuroendocrine tumour: a case report

Autores
Castillo, V. A.; Pessina, P. P.; García, J. D.; Hall, P.; Galleli, M. F.; Miceli, Diego Daniel; Cabrera Blatter, M. F.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Ectopic ACTH secretion is provoked by extra-pituitary tumours that secrete ACTH, constituting an infrequent type of Cushing Syndrome in the dog. Neuroendocrine tumours (NET) are characterised by the synthesis of peptides with hormone activity. A dog with clinical diagnosis of Cushing?s syndrome and presenting an abdominal tumour located in the area of the left adrenal gland was sent to the hospital. Cortisol was not inhibited at four and eight hours after the application of low-dose dexamethasone and the cortisol/creatinine ratio was elevated (93 × 10-6, reference values < 10 × 10?6). Plasma ACTH measurements were high (28.6 pmol/l, reference values 5.5?14.3 pmol/l). On computed tomography, the tumour was found in the meso-epigastrium, with both adrenal glands hyperplasic and no alteration of the pituitary image. The tumour was located between the two layers of the meso-colon and was removed using laparoscopy. After surgery, ACTH concentrations became normal and clinical signs remitted. The histopathological diagnosis was NET, with positive ACTH immunostaining.
Fil: Castillo, V. A.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Pessina, P. P.. Universidad de la Republica; Uruguay
Fil: García, J. D.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Hall, P.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Galleli, M. F.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Miceli, Diego Daniel. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Peque?os; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Cabrera Blatter, M. F.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Materia
SINDROME DE CUSHING
ACTH ECTÒPICA
TUMOR NEUROENDÒCRINO
ACTH
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/9057
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Ectopic ACTH syndrome in a dog with a mesenteric neuroendocrine tumour: a case reportCastillo, V. A.Pessina, P. P.García, J. D.Hall, P.Galleli, M. F.Miceli, Diego DanielCabrera Blatter, M. F.SINDROME DE CUSHINGACTH ECTÒPICATUMOR NEUROENDÒCRINOACTHhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Ectopic ACTH secretion is provoked by extra-pituitary tumours that secrete ACTH, constituting an infrequent type of Cushing Syndrome in the dog. Neuroendocrine tumours (NET) are characterised by the synthesis of peptides with hormone activity. A dog with clinical diagnosis of Cushing?s syndrome and presenting an abdominal tumour located in the area of the left adrenal gland was sent to the hospital. Cortisol was not inhibited at four and eight hours after the application of low-dose dexamethasone and the cortisol/creatinine ratio was elevated (93 × 10-6, reference values < 10 × 10?6). Plasma ACTH measurements were high (28.6 pmol/l, reference values 5.5?14.3 pmol/l). On computed tomography, the tumour was found in the meso-epigastrium, with both adrenal glands hyperplasic and no alteration of the pituitary image. The tumour was located between the two layers of the meso-colon and was removed using laparoscopy. After surgery, ACTH concentrations became normal and clinical signs remitted. The histopathological diagnosis was NET, with positive ACTH immunostaining.Fil: Castillo, V. A.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Pessina, P. P.. Universidad de la Republica; UruguayFil: García, J. D.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Hall, P.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Galleli, M. F.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Miceli, Diego Daniel. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Peque?os; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Cabrera Blatter, M. F.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaVeterinary Research Inst2014-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/9057Castillo, V. A.; Pessina, P. P.; García, J. D.; Hall, P.; Galleli, M. F.; et al.; Ectopic ACTH syndrome in a dog with a mesenteric neuroendocrine tumour: a case report; Veterinary Research Inst; Veterinární Medicína; 59; 7; 7-2014; 352-3580375-84271805-9392enginfo:eu-repo/semantics/altIdentifier/url/http://vri.cz/docs/vetmed/59-7-352.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:22Zoai:ri.conicet.gov.ar:11336/9057instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:22.683CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Ectopic ACTH syndrome in a dog with a mesenteric neuroendocrine tumour: a case report
title Ectopic ACTH syndrome in a dog with a mesenteric neuroendocrine tumour: a case report
spellingShingle Ectopic ACTH syndrome in a dog with a mesenteric neuroendocrine tumour: a case report
Castillo, V. A.
SINDROME DE CUSHING
ACTH ECTÒPICA
TUMOR NEUROENDÒCRINO
ACTH
title_short Ectopic ACTH syndrome in a dog with a mesenteric neuroendocrine tumour: a case report
title_full Ectopic ACTH syndrome in a dog with a mesenteric neuroendocrine tumour: a case report
title_fullStr Ectopic ACTH syndrome in a dog with a mesenteric neuroendocrine tumour: a case report
title_full_unstemmed Ectopic ACTH syndrome in a dog with a mesenteric neuroendocrine tumour: a case report
title_sort Ectopic ACTH syndrome in a dog with a mesenteric neuroendocrine tumour: a case report
dc.creator.none.fl_str_mv Castillo, V. A.
Pessina, P. P.
García, J. D.
Hall, P.
Galleli, M. F.
Miceli, Diego Daniel
Cabrera Blatter, M. F.
author Castillo, V. A.
author_facet Castillo, V. A.
Pessina, P. P.
García, J. D.
Hall, P.
Galleli, M. F.
Miceli, Diego Daniel
Cabrera Blatter, M. F.
author_role author
author2 Pessina, P. P.
García, J. D.
Hall, P.
Galleli, M. F.
Miceli, Diego Daniel
Cabrera Blatter, M. F.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv SINDROME DE CUSHING
ACTH ECTÒPICA
TUMOR NEUROENDÒCRINO
ACTH
topic SINDROME DE CUSHING
ACTH ECTÒPICA
TUMOR NEUROENDÒCRINO
ACTH
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Ectopic ACTH secretion is provoked by extra-pituitary tumours that secrete ACTH, constituting an infrequent type of Cushing Syndrome in the dog. Neuroendocrine tumours (NET) are characterised by the synthesis of peptides with hormone activity. A dog with clinical diagnosis of Cushing?s syndrome and presenting an abdominal tumour located in the area of the left adrenal gland was sent to the hospital. Cortisol was not inhibited at four and eight hours after the application of low-dose dexamethasone and the cortisol/creatinine ratio was elevated (93 × 10-6, reference values < 10 × 10?6). Plasma ACTH measurements were high (28.6 pmol/l, reference values 5.5?14.3 pmol/l). On computed tomography, the tumour was found in the meso-epigastrium, with both adrenal glands hyperplasic and no alteration of the pituitary image. The tumour was located between the two layers of the meso-colon and was removed using laparoscopy. After surgery, ACTH concentrations became normal and clinical signs remitted. The histopathological diagnosis was NET, with positive ACTH immunostaining.
Fil: Castillo, V. A.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Pessina, P. P.. Universidad de la Republica; Uruguay
Fil: García, J. D.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Hall, P.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Galleli, M. F.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Miceli, Diego Daniel. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Peque?os; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Cabrera Blatter, M. F.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
description Ectopic ACTH secretion is provoked by extra-pituitary tumours that secrete ACTH, constituting an infrequent type of Cushing Syndrome in the dog. Neuroendocrine tumours (NET) are characterised by the synthesis of peptides with hormone activity. A dog with clinical diagnosis of Cushing?s syndrome and presenting an abdominal tumour located in the area of the left adrenal gland was sent to the hospital. Cortisol was not inhibited at four and eight hours after the application of low-dose dexamethasone and the cortisol/creatinine ratio was elevated (93 × 10-6, reference values < 10 × 10?6). Plasma ACTH measurements were high (28.6 pmol/l, reference values 5.5?14.3 pmol/l). On computed tomography, the tumour was found in the meso-epigastrium, with both adrenal glands hyperplasic and no alteration of the pituitary image. The tumour was located between the two layers of the meso-colon and was removed using laparoscopy. After surgery, ACTH concentrations became normal and clinical signs remitted. The histopathological diagnosis was NET, with positive ACTH immunostaining.
publishDate 2014
dc.date.none.fl_str_mv 2014-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/9057
Castillo, V. A.; Pessina, P. P.; García, J. D.; Hall, P.; Galleli, M. F.; et al.; Ectopic ACTH syndrome in a dog with a mesenteric neuroendocrine tumour: a case report; Veterinary Research Inst; Veterinární Medicína; 59; 7; 7-2014; 352-358
0375-8427
1805-9392
url http://hdl.handle.net/11336/9057
identifier_str_mv Castillo, V. A.; Pessina, P. P.; García, J. D.; Hall, P.; Galleli, M. F.; et al.; Ectopic ACTH syndrome in a dog with a mesenteric neuroendocrine tumour: a case report; Veterinary Research Inst; Veterinární Medicína; 59; 7; 7-2014; 352-358
0375-8427
1805-9392
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://vri.cz/docs/vetmed/59-7-352.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Veterinary Research Inst
publisher.none.fl_str_mv Veterinary Research Inst
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268970950852608
score 13.13397

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