Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives

Autores
Kouznetsov, Vladímir V.; Zacchino, Susana Alicia Stella; Sortino, Maximiliano Andrés; Vargas, Leonor Y.; Gupta, Mahabir P.
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Diverse α-naphthylamine derivatives were easily prepared from corresponding aldimines derived from commercially available a-naphthaldehyde and anilines or isomeric pyridinecarboxyaldehydes and á-naphthylamine. The secondary amines obtained were tested as possible antifungal and cytotoxic agents. The diverse N-aryl-N-[1-(1-naphthyl)but-3-enyl]amines obtained were active (IC50 < 10 µg/mL) against breast (MCF-7), non-small cell lung (H-460), and central nervous system (SF-268) human cancer cell lines, while N-(pyridinylmethyl)-naphthalen-1-amines resulted in activity against (MIC 25-32 µg/mL) some human opportunistic pathogenic fungi including yeasts, hialohyphomycetes, and dermatophytes.
Fil: Kouznetsov, Vladímir V.. Universidad Industrial Santander; Colombia
Fil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina
Fil: Sortino, Maximiliano Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina
Fil: Vargas, Leonor Y.. Universidad Santo Tomás;
Fil: Gupta, Mahabir P.. Universidad de Panamá; Panamá
Materia
A-Naphtylamines
Antifungal properties
Cytotoxic agents
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/274312
Acceder
id CONICETDig_a6c593335b9666e7a4fd963eaea065c1
oai_identifier_str oai:ri.conicet.gov.ar:11336/274312
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine DerivativesKouznetsov, Vladímir V.Zacchino, Susana Alicia StellaSortino, Maximiliano AndrésVargas, Leonor Y.Gupta, Mahabir P.A-NaphtylaminesAntifungal propertiesCytotoxic agentshttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Diverse α-naphthylamine derivatives were easily prepared from corresponding aldimines derived from commercially available a-naphthaldehyde and anilines or isomeric pyridinecarboxyaldehydes and á-naphthylamine. The secondary amines obtained were tested as possible antifungal and cytotoxic agents. The diverse N-aryl-N-[1-(1-naphthyl)but-3-enyl]amines obtained were active (IC50 < 10 µg/mL) against breast (MCF-7), non-small cell lung (H-460), and central nervous system (SF-268) human cancer cell lines, while N-(pyridinylmethyl)-naphthalen-1-amines resulted in activity against (MIC 25-32 µg/mL) some human opportunistic pathogenic fungi including yeasts, hialohyphomycetes, and dermatophytes.Fil: Kouznetsov, Vladímir V.. Universidad Industrial Santander; ColombiaFil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; ArgentinaFil: Sortino, Maximiliano Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; ArgentinaFil: Vargas, Leonor Y.. Universidad Santo Tomás;Fil: Gupta, Mahabir P.. Universidad de Panamá; PanamáÖsterreichische Apotheker‑Verlagsgesellschaft2012-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/274312Kouznetsov, Vladímir V.; Zacchino, Susana Alicia Stella; Sortino, Maximiliano Andrés; Vargas, Leonor Y.; Gupta, Mahabir P.; Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives; Österreichische Apotheker‑Verlagsgesellschaft; Scientia Pharmaceutica; 80; 4; 10-2012; 867-8770036-87092218-0532CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2218-0532/80/4/867info:eu-repo/semantics/altIdentifier/doi/10.3797/scipharm.1209-03info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-05T09:42:48Zoai:ri.conicet.gov.ar:11336/274312instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-05 09:42:48.457CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives
title Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives
spellingShingle Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives
Kouznetsov, Vladímir V.
A-Naphtylamines
Antifungal properties
Cytotoxic agents
title_short Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives
title_full Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives
title_fullStr Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives
title_full_unstemmed Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives
title_sort Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives
dc.creator.none.fl_str_mv Kouznetsov, Vladímir V.
Zacchino, Susana Alicia Stella
Sortino, Maximiliano Andrés
Vargas, Leonor Y.
Gupta, Mahabir P.
author Kouznetsov, Vladímir V.
author_facet Kouznetsov, Vladímir V.
Zacchino, Susana Alicia Stella
Sortino, Maximiliano Andrés
Vargas, Leonor Y.
Gupta, Mahabir P.
author_role author
author2 Zacchino, Susana Alicia Stella
Sortino, Maximiliano Andrés
Vargas, Leonor Y.
Gupta, Mahabir P.
author2_role author
author
author
author
dc.subject.none.fl_str_mv A-Naphtylamines
Antifungal properties
Cytotoxic agents
topic A-Naphtylamines
Antifungal properties
Cytotoxic agents
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Diverse α-naphthylamine derivatives were easily prepared from corresponding aldimines derived from commercially available a-naphthaldehyde and anilines or isomeric pyridinecarboxyaldehydes and á-naphthylamine. The secondary amines obtained were tested as possible antifungal and cytotoxic agents. The diverse N-aryl-N-[1-(1-naphthyl)but-3-enyl]amines obtained were active (IC50 < 10 µg/mL) against breast (MCF-7), non-small cell lung (H-460), and central nervous system (SF-268) human cancer cell lines, while N-(pyridinylmethyl)-naphthalen-1-amines resulted in activity against (MIC 25-32 µg/mL) some human opportunistic pathogenic fungi including yeasts, hialohyphomycetes, and dermatophytes.
Fil: Kouznetsov, Vladímir V.. Universidad Industrial Santander; Colombia
Fil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina
Fil: Sortino, Maximiliano Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina
Fil: Vargas, Leonor Y.. Universidad Santo Tomás;
Fil: Gupta, Mahabir P.. Universidad de Panamá; Panamá
description Diverse α-naphthylamine derivatives were easily prepared from corresponding aldimines derived from commercially available a-naphthaldehyde and anilines or isomeric pyridinecarboxyaldehydes and á-naphthylamine. The secondary amines obtained were tested as possible antifungal and cytotoxic agents. The diverse N-aryl-N-[1-(1-naphthyl)but-3-enyl]amines obtained were active (IC50 < 10 µg/mL) against breast (MCF-7), non-small cell lung (H-460), and central nervous system (SF-268) human cancer cell lines, while N-(pyridinylmethyl)-naphthalen-1-amines resulted in activity against (MIC 25-32 µg/mL) some human opportunistic pathogenic fungi including yeasts, hialohyphomycetes, and dermatophytes.
publishDate 2012
dc.date.none.fl_str_mv 2012-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/274312
Kouznetsov, Vladímir V.; Zacchino, Susana Alicia Stella; Sortino, Maximiliano Andrés; Vargas, Leonor Y.; Gupta, Mahabir P.; Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives; Österreichische Apotheker‑Verlagsgesellschaft; Scientia Pharmaceutica; 80; 4; 10-2012; 867-877
0036-8709
2218-0532
CONICET Digital
CONICET
url http://hdl.handle.net/11336/274312
identifier_str_mv Kouznetsov, Vladímir V.; Zacchino, Susana Alicia Stella; Sortino, Maximiliano Andrés; Vargas, Leonor Y.; Gupta, Mahabir P.; Cytotoxic and Antifungal Activities of Diverse α-Naphthylamine Derivatives; Österreichische Apotheker‑Verlagsgesellschaft; Scientia Pharmaceutica; 80; 4; 10-2012; 867-877
0036-8709
2218-0532
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2218-0532/80/4/867
info:eu-repo/semantics/altIdentifier/doi/10.3797/scipharm.1209-03
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Österreichische Apotheker‑Verlagsgesellschaft
publisher.none.fl_str_mv Österreichische Apotheker‑Verlagsgesellschaft
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1847977007077392384
score 13.084122

Publicaciones similares