Testing the combination of albendazole, ivermectin and levamisole in lambs parasitized with multiple-resistant gastrointestinal nematodes
- Autores
- Suarez, Gonzalo; Lorenzelli, Eduardo; Macchi, María Isabel; Salada, Daniel; Lanusse, Carlos Edmundo; Alvarez, Luis Ignacio
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- The goal of the current trial were: a) to characterize the efficacy of albendazole (ABZ), ivermectin (IVM) and levamisole (LEV), administered either alone or co-administered to lambs infected with multiple-resistant nematodes. One hundred and sixty eight (168) Corriedale lambs, naturally infected (epg range 200-5200) with multiple resistant gastrointestinal nematodes, were involved in the current trial. The animals were randomly allocated into eight groups (n=21 each), and orally treated either with ABZ (5 mg/kg), IVM (0.2 mg/kg), LEV (8 mg/kg) or with a combined formulation of ABZ+LEV, ABZ+IVM, LEV+IVM, ABZ+IVM+LEV, used at the same dose for each active ingredient. Fecal samples were collected a 4 (LEV), 10 (ABZ) and 14 (IVM) days post-treatment for clinical efficacy assessment by the faecal egg count reduction test (FECRT). The efficacy was 68% (IC95 34:85) for ABZ, 45% (IC95 -0.3:70) for LEV, 0% for IVM. Considering that only the incident rate for ABZ (day 10) was significantly higher than the observed for the control group, maintaining constant other variables, a positive interaction among the combined treatments was not observed (73% (IC95 49:86) for ABZ+LEV, 63% (IC95 31:81) for ABZ+IVM and 71% (IC95 33:87) for ABZ+IVM+LEV. In conclusion, with the high resistance status observed, the combined treatments did not offer a clinically relevant increase in efficacy against resistant nematodes.
Fil: Suarez, Gonzalo. Universidad de la República; Uruguay
Fil: Lorenzelli, Eduardo. Universidad de la República; Uruguay
Fil: Macchi, María Isabel. Universidad de la República; Uruguay
Fil: Salada, Daniel. Universidad de la República; Uruguay
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
XVIII Congreso Brasilero de Parasitologia Veterinaria
Gramado
Brasil
Colégio Brasileiro de Parasitologia Veterinária - Materia
-
COMBINACIONES
ANTIHELMINTICOS
ABZ - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/253112
Ver los metadatos del registro completo
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Testing the combination of albendazole, ivermectin and levamisole in lambs parasitized with multiple-resistant gastrointestinal nematodesSuarez, GonzaloLorenzelli, EduardoMacchi, María IsabelSalada, DanielLanusse, Carlos EdmundoAlvarez, Luis IgnacioCOMBINACIONESANTIHELMINTICOSABZhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4The goal of the current trial were: a) to characterize the efficacy of albendazole (ABZ), ivermectin (IVM) and levamisole (LEV), administered either alone or co-administered to lambs infected with multiple-resistant nematodes. One hundred and sixty eight (168) Corriedale lambs, naturally infected (epg range 200-5200) with multiple resistant gastrointestinal nematodes, were involved in the current trial. The animals were randomly allocated into eight groups (n=21 each), and orally treated either with ABZ (5 mg/kg), IVM (0.2 mg/kg), LEV (8 mg/kg) or with a combined formulation of ABZ+LEV, ABZ+IVM, LEV+IVM, ABZ+IVM+LEV, used at the same dose for each active ingredient. Fecal samples were collected a 4 (LEV), 10 (ABZ) and 14 (IVM) days post-treatment for clinical efficacy assessment by the faecal egg count reduction test (FECRT). The efficacy was 68% (IC95 34:85) for ABZ, 45% (IC95 -0.3:70) for LEV, 0% for IVM. Considering that only the incident rate for ABZ (day 10) was significantly higher than the observed for the control group, maintaining constant other variables, a positive interaction among the combined treatments was not observed (73% (IC95 49:86) for ABZ+LEV, 63% (IC95 31:81) for ABZ+IVM and 71% (IC95 33:87) for ABZ+IVM+LEV. In conclusion, with the high resistance status observed, the combined treatments did not offer a clinically relevant increase in efficacy against resistant nematodes.Fil: Suarez, Gonzalo. Universidad de la República; UruguayFil: Lorenzelli, Eduardo. Universidad de la República; UruguayFil: Macchi, María Isabel. Universidad de la República; UruguayFil: Salada, Daniel. Universidad de la República; UruguayFil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaXVIII Congreso Brasilero de Parasitologia VeterinariaGramadoBrasilColégio Brasileiro de Parasitologia VeterináriaColégio Brasileiro de Parasitologia Veterinária2014info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/253112Testing the combination of albendazole, ivermectin and levamisole in lambs parasitized with multiple-resistant gastrointestinal nematodes; XVIII Congreso Brasilero de Parasitologia Veterinaria; Gramado; Brasil; 2014; 1-1CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.cbpv.org.br/congressos/parasitologia_2014_anais_online/trabalhos/trabalho_1906.htmlInternacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:50:44Zoai:ri.conicet.gov.ar:11336/253112instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:50:44.846CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Testing the combination of albendazole, ivermectin and levamisole in lambs parasitized with multiple-resistant gastrointestinal nematodes |
title |
Testing the combination of albendazole, ivermectin and levamisole in lambs parasitized with multiple-resistant gastrointestinal nematodes |
spellingShingle |
Testing the combination of albendazole, ivermectin and levamisole in lambs parasitized with multiple-resistant gastrointestinal nematodes Suarez, Gonzalo COMBINACIONES ANTIHELMINTICOS ABZ |
title_short |
Testing the combination of albendazole, ivermectin and levamisole in lambs parasitized with multiple-resistant gastrointestinal nematodes |
title_full |
Testing the combination of albendazole, ivermectin and levamisole in lambs parasitized with multiple-resistant gastrointestinal nematodes |
title_fullStr |
Testing the combination of albendazole, ivermectin and levamisole in lambs parasitized with multiple-resistant gastrointestinal nematodes |
title_full_unstemmed |
Testing the combination of albendazole, ivermectin and levamisole in lambs parasitized with multiple-resistant gastrointestinal nematodes |
title_sort |
Testing the combination of albendazole, ivermectin and levamisole in lambs parasitized with multiple-resistant gastrointestinal nematodes |
dc.creator.none.fl_str_mv |
Suarez, Gonzalo Lorenzelli, Eduardo Macchi, María Isabel Salada, Daniel Lanusse, Carlos Edmundo Alvarez, Luis Ignacio |
author |
Suarez, Gonzalo |
author_facet |
Suarez, Gonzalo Lorenzelli, Eduardo Macchi, María Isabel Salada, Daniel Lanusse, Carlos Edmundo Alvarez, Luis Ignacio |
author_role |
author |
author2 |
Lorenzelli, Eduardo Macchi, María Isabel Salada, Daniel Lanusse, Carlos Edmundo Alvarez, Luis Ignacio |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
COMBINACIONES ANTIHELMINTICOS ABZ |
topic |
COMBINACIONES ANTIHELMINTICOS ABZ |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/4.3 https://purl.org/becyt/ford/4 |
dc.description.none.fl_txt_mv |
The goal of the current trial were: a) to characterize the efficacy of albendazole (ABZ), ivermectin (IVM) and levamisole (LEV), administered either alone or co-administered to lambs infected with multiple-resistant nematodes. One hundred and sixty eight (168) Corriedale lambs, naturally infected (epg range 200-5200) with multiple resistant gastrointestinal nematodes, were involved in the current trial. The animals were randomly allocated into eight groups (n=21 each), and orally treated either with ABZ (5 mg/kg), IVM (0.2 mg/kg), LEV (8 mg/kg) or with a combined formulation of ABZ+LEV, ABZ+IVM, LEV+IVM, ABZ+IVM+LEV, used at the same dose for each active ingredient. Fecal samples were collected a 4 (LEV), 10 (ABZ) and 14 (IVM) days post-treatment for clinical efficacy assessment by the faecal egg count reduction test (FECRT). The efficacy was 68% (IC95 34:85) for ABZ, 45% (IC95 -0.3:70) for LEV, 0% for IVM. Considering that only the incident rate for ABZ (day 10) was significantly higher than the observed for the control group, maintaining constant other variables, a positive interaction among the combined treatments was not observed (73% (IC95 49:86) for ABZ+LEV, 63% (IC95 31:81) for ABZ+IVM and 71% (IC95 33:87) for ABZ+IVM+LEV. In conclusion, with the high resistance status observed, the combined treatments did not offer a clinically relevant increase in efficacy against resistant nematodes. Fil: Suarez, Gonzalo. Universidad de la República; Uruguay Fil: Lorenzelli, Eduardo. Universidad de la República; Uruguay Fil: Macchi, María Isabel. Universidad de la República; Uruguay Fil: Salada, Daniel. Universidad de la República; Uruguay Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina XVIII Congreso Brasilero de Parasitologia Veterinaria Gramado Brasil Colégio Brasileiro de Parasitologia Veterinária |
description |
The goal of the current trial were: a) to characterize the efficacy of albendazole (ABZ), ivermectin (IVM) and levamisole (LEV), administered either alone or co-administered to lambs infected with multiple-resistant nematodes. One hundred and sixty eight (168) Corriedale lambs, naturally infected (epg range 200-5200) with multiple resistant gastrointestinal nematodes, were involved in the current trial. The animals were randomly allocated into eight groups (n=21 each), and orally treated either with ABZ (5 mg/kg), IVM (0.2 mg/kg), LEV (8 mg/kg) or with a combined formulation of ABZ+LEV, ABZ+IVM, LEV+IVM, ABZ+IVM+LEV, used at the same dose for each active ingredient. Fecal samples were collected a 4 (LEV), 10 (ABZ) and 14 (IVM) days post-treatment for clinical efficacy assessment by the faecal egg count reduction test (FECRT). The efficacy was 68% (IC95 34:85) for ABZ, 45% (IC95 -0.3:70) for LEV, 0% for IVM. Considering that only the incident rate for ABZ (day 10) was significantly higher than the observed for the control group, maintaining constant other variables, a positive interaction among the combined treatments was not observed (73% (IC95 49:86) for ABZ+LEV, 63% (IC95 31:81) for ABZ+IVM and 71% (IC95 33:87) for ABZ+IVM+LEV. In conclusion, with the high resistance status observed, the combined treatments did not offer a clinically relevant increase in efficacy against resistant nematodes. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/conferenceObject Congreso Book http://purl.org/coar/resource_type/c_5794 info:ar-repo/semantics/documentoDeConferencia |
status_str |
publishedVersion |
format |
conferenceObject |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/253112 Testing the combination of albendazole, ivermectin and levamisole in lambs parasitized with multiple-resistant gastrointestinal nematodes; XVIII Congreso Brasilero de Parasitologia Veterinaria; Gramado; Brasil; 2014; 1-1 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/253112 |
identifier_str_mv |
Testing the combination of albendazole, ivermectin and levamisole in lambs parasitized with multiple-resistant gastrointestinal nematodes; XVIII Congreso Brasilero de Parasitologia Veterinaria; Gramado; Brasil; 2014; 1-1 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
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eng |
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info:eu-repo/semantics/altIdentifier/url/http://www.cbpv.org.br/congressos/parasitologia_2014_anais_online/trabalhos/trabalho_1906.html |
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info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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application/pdf application/msword application/pdf |
dc.coverage.none.fl_str_mv |
Internacional |
dc.publisher.none.fl_str_mv |
Colégio Brasileiro de Parasitologia Veterinária |
publisher.none.fl_str_mv |
Colégio Brasileiro de Parasitologia Veterinária |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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