Testing the combination of albendazole, ivermectin and levamisole in lambs parasitized with multiple-resistant gastrointestinal nematodes

Autores
Suarez, Gonzalo; Lorenzelli, Eduardo; Macchi, María Isabel; Salada, Daniel; Lanusse, Carlos Edmundo; Alvarez, Luis Ignacio
Año de publicación
2014
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
The goal of the current trial were: a) to characterize the efficacy of albendazole (ABZ), ivermectin (IVM) and levamisole (LEV), administered either alone or co-administered to lambs infected with multiple-resistant nematodes. One hundred and sixty eight (168) Corriedale lambs, naturally infected (epg range 200-5200) with multiple resistant gastrointestinal nematodes, were involved in the current trial. The animals were randomly allocated into eight groups (n=21 each), and orally treated either with ABZ (5 mg/kg), IVM (0.2 mg/kg), LEV (8 mg/kg) or with a combined formulation of ABZ+LEV, ABZ+IVM, LEV+IVM, ABZ+IVM+LEV, used at the same dose for each active ingredient. Fecal samples were collected a 4 (LEV), 10 (ABZ) and 14 (IVM) days post-treatment for clinical efficacy assessment by the faecal egg count reduction test (FECRT). The efficacy was 68% (IC95 34:85) for ABZ, 45% (IC95 -0.3:70) for LEV, 0% for IVM. Considering that only the incident rate for ABZ (day 10) was significantly higher than the observed for the control group, maintaining constant other variables, a positive interaction among the combined treatments was not observed (73% (IC95 49:86) for ABZ+LEV, 63% (IC95 31:81) for ABZ+IVM and 71% (IC95 33:87) for ABZ+IVM+LEV. In conclusion, with the high resistance status observed, the combined treatments did not offer a clinically relevant increase in efficacy against resistant nematodes.
Fil: Suarez, Gonzalo. Universidad de la República; Uruguay
Fil: Lorenzelli, Eduardo. Universidad de la República; Uruguay
Fil: Macchi, María Isabel. Universidad de la República; Uruguay
Fil: Salada, Daniel. Universidad de la República; Uruguay
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
XVIII Congreso Brasilero de Parasitologia Veterinaria
Gramado
Brasil
Colégio Brasileiro de Parasitologia Veterinária
Materia
COMBINACIONES
ANTIHELMINTICOS
ABZ
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/253112
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/253112
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Testing the combination of albendazole, ivermectin and levamisole in lambs parasitized with multiple-resistant gastrointestinal nematodesSuarez, GonzaloLorenzelli, EduardoMacchi, María IsabelSalada, DanielLanusse, Carlos EdmundoAlvarez, Luis IgnacioCOMBINACIONESANTIHELMINTICOSABZhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4The goal of the current trial were: a) to characterize the efficacy of albendazole (ABZ), ivermectin (IVM) and levamisole (LEV), administered either alone or co-administered to lambs infected with multiple-resistant nematodes. One hundred and sixty eight (168) Corriedale lambs, naturally infected (epg range 200-5200) with multiple resistant gastrointestinal nematodes, were involved in the current trial. The animals were randomly allocated into eight groups (n=21 each), and orally treated either with ABZ (5 mg/kg), IVM (0.2 mg/kg), LEV (8 mg/kg) or with a combined formulation of ABZ+LEV, ABZ+IVM, LEV+IVM, ABZ+IVM+LEV, used at the same dose for each active ingredient. Fecal samples were collected a 4 (LEV), 10 (ABZ) and 14 (IVM) days post-treatment for clinical efficacy assessment by the faecal egg count reduction test (FECRT). The efficacy was 68% (IC95 34:85) for ABZ, 45% (IC95 -0.3:70) for LEV, 0% for IVM. Considering that only the incident rate for ABZ (day 10) was significantly higher than the observed for the control group, maintaining constant other variables, a positive interaction among the combined treatments was not observed (73% (IC95 49:86) for ABZ+LEV, 63% (IC95 31:81) for ABZ+IVM and 71% (IC95 33:87) for ABZ+IVM+LEV. In conclusion, with the high resistance status observed, the combined treatments did not offer a clinically relevant increase in efficacy against resistant nematodes.Fil: Suarez, Gonzalo. Universidad de la República; UruguayFil: Lorenzelli, Eduardo. Universidad de la República; UruguayFil: Macchi, María Isabel. Universidad de la República; UruguayFil: Salada, Daniel. Universidad de la República; UruguayFil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaXVIII Congreso Brasilero de Parasitologia VeterinariaGramadoBrasilColégio Brasileiro de Parasitologia VeterináriaColégio Brasileiro de Parasitologia Veterinária2014info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/253112Testing the combination of albendazole, ivermectin and levamisole in lambs parasitized with multiple-resistant gastrointestinal nematodes; XVIII Congreso Brasilero de Parasitologia Veterinaria; Gramado; Brasil; 2014; 1-1CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.cbpv.org.br/congressos/parasitologia_2014_anais_online/trabalhos/trabalho_1906.htmlInternacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:46:07Zoai:ri.conicet.gov.ar:11336/253112instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:46:07.352CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Testing the combination of albendazole, ivermectin and levamisole in lambs parasitized with multiple-resistant gastrointestinal nematodes
title Testing the combination of albendazole, ivermectin and levamisole in lambs parasitized with multiple-resistant gastrointestinal nematodes
spellingShingle Testing the combination of albendazole, ivermectin and levamisole in lambs parasitized with multiple-resistant gastrointestinal nematodes
Suarez, Gonzalo
COMBINACIONES
ANTIHELMINTICOS
ABZ
title_short Testing the combination of albendazole, ivermectin and levamisole in lambs parasitized with multiple-resistant gastrointestinal nematodes
title_full Testing the combination of albendazole, ivermectin and levamisole in lambs parasitized with multiple-resistant gastrointestinal nematodes
title_fullStr Testing the combination of albendazole, ivermectin and levamisole in lambs parasitized with multiple-resistant gastrointestinal nematodes
title_full_unstemmed Testing the combination of albendazole, ivermectin and levamisole in lambs parasitized with multiple-resistant gastrointestinal nematodes
title_sort Testing the combination of albendazole, ivermectin and levamisole in lambs parasitized with multiple-resistant gastrointestinal nematodes
dc.creator.none.fl_str_mv Suarez, Gonzalo
Lorenzelli, Eduardo
Macchi, María Isabel
Salada, Daniel
Lanusse, Carlos Edmundo
Alvarez, Luis Ignacio
author Suarez, Gonzalo
author_facet Suarez, Gonzalo
Lorenzelli, Eduardo
Macchi, María Isabel
Salada, Daniel
Lanusse, Carlos Edmundo
Alvarez, Luis Ignacio
author_role author
author2 Lorenzelli, Eduardo
Macchi, María Isabel
Salada, Daniel
Lanusse, Carlos Edmundo
Alvarez, Luis Ignacio
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv COMBINACIONES
ANTIHELMINTICOS
ABZ
topic COMBINACIONES
ANTIHELMINTICOS
ABZ
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv The goal of the current trial were: a) to characterize the efficacy of albendazole (ABZ), ivermectin (IVM) and levamisole (LEV), administered either alone or co-administered to lambs infected with multiple-resistant nematodes. One hundred and sixty eight (168) Corriedale lambs, naturally infected (epg range 200-5200) with multiple resistant gastrointestinal nematodes, were involved in the current trial. The animals were randomly allocated into eight groups (n=21 each), and orally treated either with ABZ (5 mg/kg), IVM (0.2 mg/kg), LEV (8 mg/kg) or with a combined formulation of ABZ+LEV, ABZ+IVM, LEV+IVM, ABZ+IVM+LEV, used at the same dose for each active ingredient. Fecal samples were collected a 4 (LEV), 10 (ABZ) and 14 (IVM) days post-treatment for clinical efficacy assessment by the faecal egg count reduction test (FECRT). The efficacy was 68% (IC95 34:85) for ABZ, 45% (IC95 -0.3:70) for LEV, 0% for IVM. Considering that only the incident rate for ABZ (day 10) was significantly higher than the observed for the control group, maintaining constant other variables, a positive interaction among the combined treatments was not observed (73% (IC95 49:86) for ABZ+LEV, 63% (IC95 31:81) for ABZ+IVM and 71% (IC95 33:87) for ABZ+IVM+LEV. In conclusion, with the high resistance status observed, the combined treatments did not offer a clinically relevant increase in efficacy against resistant nematodes.
Fil: Suarez, Gonzalo. Universidad de la República; Uruguay
Fil: Lorenzelli, Eduardo. Universidad de la República; Uruguay
Fil: Macchi, María Isabel. Universidad de la República; Uruguay
Fil: Salada, Daniel. Universidad de la República; Uruguay
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
XVIII Congreso Brasilero de Parasitologia Veterinaria
Gramado
Brasil
Colégio Brasileiro de Parasitologia Veterinária
description The goal of the current trial were: a) to characterize the efficacy of albendazole (ABZ), ivermectin (IVM) and levamisole (LEV), administered either alone or co-administered to lambs infected with multiple-resistant nematodes. One hundred and sixty eight (168) Corriedale lambs, naturally infected (epg range 200-5200) with multiple resistant gastrointestinal nematodes, were involved in the current trial. The animals were randomly allocated into eight groups (n=21 each), and orally treated either with ABZ (5 mg/kg), IVM (0.2 mg/kg), LEV (8 mg/kg) or with a combined formulation of ABZ+LEV, ABZ+IVM, LEV+IVM, ABZ+IVM+LEV, used at the same dose for each active ingredient. Fecal samples were collected a 4 (LEV), 10 (ABZ) and 14 (IVM) days post-treatment for clinical efficacy assessment by the faecal egg count reduction test (FECRT). The efficacy was 68% (IC95 34:85) for ABZ, 45% (IC95 -0.3:70) for LEV, 0% for IVM. Considering that only the incident rate for ABZ (day 10) was significantly higher than the observed for the control group, maintaining constant other variables, a positive interaction among the combined treatments was not observed (73% (IC95 49:86) for ABZ+LEV, 63% (IC95 31:81) for ABZ+IVM and 71% (IC95 33:87) for ABZ+IVM+LEV. In conclusion, with the high resistance status observed, the combined treatments did not offer a clinically relevant increase in efficacy against resistant nematodes.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Congreso
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/253112
Testing the combination of albendazole, ivermectin and levamisole in lambs parasitized with multiple-resistant gastrointestinal nematodes; XVIII Congreso Brasilero de Parasitologia Veterinaria; Gramado; Brasil; 2014; 1-1
CONICET Digital
CONICET
url http://hdl.handle.net/11336/253112
identifier_str_mv Testing the combination of albendazole, ivermectin and levamisole in lambs parasitized with multiple-resistant gastrointestinal nematodes; XVIII Congreso Brasilero de Parasitologia Veterinaria; Gramado; Brasil; 2014; 1-1
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.cbpv.org.br/congressos/parasitologia_2014_anais_online/trabalhos/trabalho_1906.html
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/msword
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Colégio Brasileiro de Parasitologia Veterinária
publisher.none.fl_str_mv Colégio Brasileiro de Parasitologia Veterinária
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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