Clinical efficacy assessment of the albendazole-ivermectin combination in lambs parasitized with resistant nematodes

Autores
Entrocasso, Carlos; Alvarez, Luis Ignacio; Manazza, Jorge Alberto; Lifschitz, Adrian Luis; Borda, Bernardino; Virkel, Guillermo Leon; Mottier, Maria de Lourdes; Lanusse, Carlos Edmundo
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Combination of anthelmintic drugs from different chemical groups has been proposed as alternative parasite control strategies where failure of individual drugs is documented. The main goal of the current trial was to compare the clinical anthelmintic efficacy of albendazole (ABZ) and ivermectin (IVM) given either separately or co-administered to lambs naturally infected with gastrointestinal nematodes resistant to both molecules. Seventy (70) Corriedale lambs naturally infected with multiple resistant gastrointestinal nematodes were involved in the efficacy trial: the animals were allocated into 7 experimental groups (n = 10) and treated with either ABZ intravenously (iv) (ABZIV), IVMIV, ABZIV + IVMIV, ABZ intraruminally (ir) (ABZIR), IVM subcutaneously (sc) (IVMSC) and ABZIR + IVMSC or kept as untreated controls. The indirect estimation of the efficacy of the different treatments was performed by the faecal egg count reduction test (FECRT). Additionally, four animals randomly chosen from the untreated control and ABZIV, IVMIV and ABZIV + IVMIV experimental groups were sacrificed 15 days post-treatment to evaluate the efficacy against different adult resistant nematode parasites. The results were statistically compared by a non-parametric ANOVA (Kruskal-Wallis test). The following egg output reduction values were obtained: 73.4% (ABZIV), 79.0% (IVMIV), 91.9% (ABZIV + IVMIV), 43.5% (ABZIR), 79.8% (IVMSC) and 70.8% (ABZIR + IVMSC). The efficacy against Haemonchus spp. was 95.1 (ABZIV), 99.3 (IVMIV) and 99.9% (ABZIV + IVMIV), while the efficacy against Trichostrongylus colubriformis for the same treatment groups was 79.6, 100 and 99.9%. The data obtained on the assessment of the ABZ-IVM combination indicates that no potentiation synergism is observed. This work is complementary to a parallel study that demonstrated the lack of negative pharmacokinetic interactions between the two anthelmintics acting by different mode of action. Thus, an additive effect may be achieved against nematodes resistant to both compounds. Further work is required to understand the implications of potential pharmacokinetic/pharmacodynamic interactions between anthelmintics before drug combined formulations are developed to be introduced into the pharmaceutical market.
Fil: Entrocasso, Carlos. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce. Área de Investigación en Producción y Sanidad Animal; Argentina
Fil: Alvarez, Luis Ignacio. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Manazza, Jorge Alberto. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce. Área de Investigación en Producción y Sanidad Animal; Argentina
Fil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Borda, Bernardino. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce. Área de Investigación en Producción y Sanidad Animal; Argentina
Fil: Virkel, Guillermo Leon. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Mottier, Maria de Lourdes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Materia
ALBENDAZOLE
DRUG COMBINATION
EFFICACY
IVERMECTIN
RESISTANCE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/94855
Acceder
id CONICETDig_9be03178a626ddfdac47dd5d52f4ccaf
oai_identifier_str oai:ri.conicet.gov.ar:11336/94855
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Clinical efficacy assessment of the albendazole-ivermectin combination in lambs parasitized with resistant nematodesEntrocasso, CarlosAlvarez, Luis IgnacioManazza, Jorge AlbertoLifschitz, Adrian LuisBorda, BernardinoVirkel, Guillermo LeonMottier, Maria de LourdesLanusse, Carlos EdmundoALBENDAZOLEDRUG COMBINATIONEFFICACYIVERMECTINRESISTANCEhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Combination of anthelmintic drugs from different chemical groups has been proposed as alternative parasite control strategies where failure of individual drugs is documented. The main goal of the current trial was to compare the clinical anthelmintic efficacy of albendazole (ABZ) and ivermectin (IVM) given either separately or co-administered to lambs naturally infected with gastrointestinal nematodes resistant to both molecules. Seventy (70) Corriedale lambs naturally infected with multiple resistant gastrointestinal nematodes were involved in the efficacy trial: the animals were allocated into 7 experimental groups (n = 10) and treated with either ABZ intravenously (iv) (ABZIV), IVMIV, ABZIV + IVMIV, ABZ intraruminally (ir) (ABZIR), IVM subcutaneously (sc) (IVMSC) and ABZIR + IVMSC or kept as untreated controls. The indirect estimation of the efficacy of the different treatments was performed by the faecal egg count reduction test (FECRT). Additionally, four animals randomly chosen from the untreated control and ABZIV, IVMIV and ABZIV + IVMIV experimental groups were sacrificed 15 days post-treatment to evaluate the efficacy against different adult resistant nematode parasites. The results were statistically compared by a non-parametric ANOVA (Kruskal-Wallis test). The following egg output reduction values were obtained: 73.4% (ABZIV), 79.0% (IVMIV), 91.9% (ABZIV + IVMIV), 43.5% (ABZIR), 79.8% (IVMSC) and 70.8% (ABZIR + IVMSC). The efficacy against Haemonchus spp. was 95.1 (ABZIV), 99.3 (IVMIV) and 99.9% (ABZIV + IVMIV), while the efficacy against Trichostrongylus colubriformis for the same treatment groups was 79.6, 100 and 99.9%. The data obtained on the assessment of the ABZ-IVM combination indicates that no potentiation synergism is observed. This work is complementary to a parallel study that demonstrated the lack of negative pharmacokinetic interactions between the two anthelmintics acting by different mode of action. Thus, an additive effect may be achieved against nematodes resistant to both compounds. Further work is required to understand the implications of potential pharmacokinetic/pharmacodynamic interactions between anthelmintics before drug combined formulations are developed to be introduced into the pharmaceutical market.Fil: Entrocasso, Carlos. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce. Área de Investigación en Producción y Sanidad Animal; ArgentinaFil: Alvarez, Luis Ignacio. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Manazza, Jorge Alberto. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce. Área de Investigación en Producción y Sanidad Animal; ArgentinaFil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Borda, Bernardino. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce. Área de Investigación en Producción y Sanidad Animal; ArgentinaFil: Virkel, Guillermo Leon. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Mottier, Maria de Lourdes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaElsevier Science2008-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/94855Entrocasso, Carlos; Alvarez, Luis Ignacio; Manazza, Jorge Alberto; Lifschitz, Adrian Luis; Borda, Bernardino; et al.; Clinical efficacy assessment of the albendazole-ivermectin combination in lambs parasitized with resistant nematodes; Elsevier Science; Veterinary Parasitology; 155; 3-4; 8-2008; 249-2560304-4017CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0304401708002380info:eu-repo/semantics/altIdentifier/doi/10.1016/j.vetpar.2008.04.015info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:19Zoai:ri.conicet.gov.ar:11336/94855instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:19.999CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Clinical efficacy assessment of the albendazole-ivermectin combination in lambs parasitized with resistant nematodes
title Clinical efficacy assessment of the albendazole-ivermectin combination in lambs parasitized with resistant nematodes
spellingShingle Clinical efficacy assessment of the albendazole-ivermectin combination in lambs parasitized with resistant nematodes
Entrocasso, Carlos
ALBENDAZOLE
DRUG COMBINATION
EFFICACY
IVERMECTIN
RESISTANCE
title_short Clinical efficacy assessment of the albendazole-ivermectin combination in lambs parasitized with resistant nematodes
title_full Clinical efficacy assessment of the albendazole-ivermectin combination in lambs parasitized with resistant nematodes
title_fullStr Clinical efficacy assessment of the albendazole-ivermectin combination in lambs parasitized with resistant nematodes
title_full_unstemmed Clinical efficacy assessment of the albendazole-ivermectin combination in lambs parasitized with resistant nematodes
title_sort Clinical efficacy assessment of the albendazole-ivermectin combination in lambs parasitized with resistant nematodes
dc.creator.none.fl_str_mv Entrocasso, Carlos
Alvarez, Luis Ignacio
Manazza, Jorge Alberto
Lifschitz, Adrian Luis
Borda, Bernardino
Virkel, Guillermo Leon
Mottier, Maria de Lourdes
Lanusse, Carlos Edmundo
author Entrocasso, Carlos
author_facet Entrocasso, Carlos
Alvarez, Luis Ignacio
Manazza, Jorge Alberto
Lifschitz, Adrian Luis
Borda, Bernardino
Virkel, Guillermo Leon
Mottier, Maria de Lourdes
Lanusse, Carlos Edmundo
author_role author
author2 Alvarez, Luis Ignacio
Manazza, Jorge Alberto
Lifschitz, Adrian Luis
Borda, Bernardino
Virkel, Guillermo Leon
Mottier, Maria de Lourdes
Lanusse, Carlos Edmundo
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ALBENDAZOLE
DRUG COMBINATION
EFFICACY
IVERMECTIN
RESISTANCE
topic ALBENDAZOLE
DRUG COMBINATION
EFFICACY
IVERMECTIN
RESISTANCE
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Combination of anthelmintic drugs from different chemical groups has been proposed as alternative parasite control strategies where failure of individual drugs is documented. The main goal of the current trial was to compare the clinical anthelmintic efficacy of albendazole (ABZ) and ivermectin (IVM) given either separately or co-administered to lambs naturally infected with gastrointestinal nematodes resistant to both molecules. Seventy (70) Corriedale lambs naturally infected with multiple resistant gastrointestinal nematodes were involved in the efficacy trial: the animals were allocated into 7 experimental groups (n = 10) and treated with either ABZ intravenously (iv) (ABZIV), IVMIV, ABZIV + IVMIV, ABZ intraruminally (ir) (ABZIR), IVM subcutaneously (sc) (IVMSC) and ABZIR + IVMSC or kept as untreated controls. The indirect estimation of the efficacy of the different treatments was performed by the faecal egg count reduction test (FECRT). Additionally, four animals randomly chosen from the untreated control and ABZIV, IVMIV and ABZIV + IVMIV experimental groups were sacrificed 15 days post-treatment to evaluate the efficacy against different adult resistant nematode parasites. The results were statistically compared by a non-parametric ANOVA (Kruskal-Wallis test). The following egg output reduction values were obtained: 73.4% (ABZIV), 79.0% (IVMIV), 91.9% (ABZIV + IVMIV), 43.5% (ABZIR), 79.8% (IVMSC) and 70.8% (ABZIR + IVMSC). The efficacy against Haemonchus spp. was 95.1 (ABZIV), 99.3 (IVMIV) and 99.9% (ABZIV + IVMIV), while the efficacy against Trichostrongylus colubriformis for the same treatment groups was 79.6, 100 and 99.9%. The data obtained on the assessment of the ABZ-IVM combination indicates that no potentiation synergism is observed. This work is complementary to a parallel study that demonstrated the lack of negative pharmacokinetic interactions between the two anthelmintics acting by different mode of action. Thus, an additive effect may be achieved against nematodes resistant to both compounds. Further work is required to understand the implications of potential pharmacokinetic/pharmacodynamic interactions between anthelmintics before drug combined formulations are developed to be introduced into the pharmaceutical market.
Fil: Entrocasso, Carlos. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce. Área de Investigación en Producción y Sanidad Animal; Argentina
Fil: Alvarez, Luis Ignacio. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Manazza, Jorge Alberto. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce. Área de Investigación en Producción y Sanidad Animal; Argentina
Fil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Borda, Bernardino. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce. Área de Investigación en Producción y Sanidad Animal; Argentina
Fil: Virkel, Guillermo Leon. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Mottier, Maria de Lourdes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
description Combination of anthelmintic drugs from different chemical groups has been proposed as alternative parasite control strategies where failure of individual drugs is documented. The main goal of the current trial was to compare the clinical anthelmintic efficacy of albendazole (ABZ) and ivermectin (IVM) given either separately or co-administered to lambs naturally infected with gastrointestinal nematodes resistant to both molecules. Seventy (70) Corriedale lambs naturally infected with multiple resistant gastrointestinal nematodes were involved in the efficacy trial: the animals were allocated into 7 experimental groups (n = 10) and treated with either ABZ intravenously (iv) (ABZIV), IVMIV, ABZIV + IVMIV, ABZ intraruminally (ir) (ABZIR), IVM subcutaneously (sc) (IVMSC) and ABZIR + IVMSC or kept as untreated controls. The indirect estimation of the efficacy of the different treatments was performed by the faecal egg count reduction test (FECRT). Additionally, four animals randomly chosen from the untreated control and ABZIV, IVMIV and ABZIV + IVMIV experimental groups were sacrificed 15 days post-treatment to evaluate the efficacy against different adult resistant nematode parasites. The results were statistically compared by a non-parametric ANOVA (Kruskal-Wallis test). The following egg output reduction values were obtained: 73.4% (ABZIV), 79.0% (IVMIV), 91.9% (ABZIV + IVMIV), 43.5% (ABZIR), 79.8% (IVMSC) and 70.8% (ABZIR + IVMSC). The efficacy against Haemonchus spp. was 95.1 (ABZIV), 99.3 (IVMIV) and 99.9% (ABZIV + IVMIV), while the efficacy against Trichostrongylus colubriformis for the same treatment groups was 79.6, 100 and 99.9%. The data obtained on the assessment of the ABZ-IVM combination indicates that no potentiation synergism is observed. This work is complementary to a parallel study that demonstrated the lack of negative pharmacokinetic interactions between the two anthelmintics acting by different mode of action. Thus, an additive effect may be achieved against nematodes resistant to both compounds. Further work is required to understand the implications of potential pharmacokinetic/pharmacodynamic interactions between anthelmintics before drug combined formulations are developed to be introduced into the pharmaceutical market.
publishDate 2008
dc.date.none.fl_str_mv 2008-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/94855
Entrocasso, Carlos; Alvarez, Luis Ignacio; Manazza, Jorge Alberto; Lifschitz, Adrian Luis; Borda, Bernardino; et al.; Clinical efficacy assessment of the albendazole-ivermectin combination in lambs parasitized with resistant nematodes; Elsevier Science; Veterinary Parasitology; 155; 3-4; 8-2008; 249-256
0304-4017
CONICET Digital
CONICET
url http://hdl.handle.net/11336/94855
identifier_str_mv Entrocasso, Carlos; Alvarez, Luis Ignacio; Manazza, Jorge Alberto; Lifschitz, Adrian Luis; Borda, Bernardino; et al.; Clinical efficacy assessment of the albendazole-ivermectin combination in lambs parasitized with resistant nematodes; Elsevier Science; Veterinary Parasitology; 155; 3-4; 8-2008; 249-256
0304-4017
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0304401708002380
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.vetpar.2008.04.015
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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