Signaling pathways of nucleic acids for bone healing: A review

Autores
Camal Ruggieri, Iván Nadir; Feldman, Sara
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Different kinds of nucleic acid (NA) molecules are promising therapeutic tools in a variety of tissues and their pathogenesis, and bone pathologies are not the exception. NAs interact in cytosol or nucleus to generate a specific response. Some of these NAs can be used to generate a positive response in relation to bone formation and differentiation in osteoblast and osteocyte. This work aims to briefly and clearly show main signaling pathways in osteoblasts and osteocytes, and to state the mechanism of how miRNA agonists (miRNA) and miRNA antagonists (antagomir) affect them. Thus, this summarizes the mechanism of promising therapeutic strategies for bone repair. NAs are fragile and can be degraded quickly outside the cells. These problems are more and more frequently resolved by nanotechnology and tissue engineering approaches. Further research in this field wills probably generate safe and therapeutic effective therapy in relation to bone healing.
Fil: Camal Ruggieri, Iván Nadir. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
Fil: Feldman, Sara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina. Universidad Nacional de Rosario. Consejo de Investigaciones de la Universidad de Rosario; Argentina
Materia
BONE
REPAIR
MIRNA
PATHWAY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/174489
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Signaling pathways of nucleic acids for bone healing: A reviewCamal Ruggieri, Iván NadirFeldman, SaraBONEREPAIRMIRNAPATHWAYhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Different kinds of nucleic acid (NA) molecules are promising therapeutic tools in a variety of tissues and their pathogenesis, and bone pathologies are not the exception. NAs interact in cytosol or nucleus to generate a specific response. Some of these NAs can be used to generate a positive response in relation to bone formation and differentiation in osteoblast and osteocyte. This work aims to briefly and clearly show main signaling pathways in osteoblasts and osteocytes, and to state the mechanism of how miRNA agonists (miRNA) and miRNA antagonists (antagomir) affect them. Thus, this summarizes the mechanism of promising therapeutic strategies for bone repair. NAs are fragile and can be degraded quickly outside the cells. These problems are more and more frequently resolved by nanotechnology and tissue engineering approaches. Further research in this field wills probably generate safe and therapeutic effective therapy in relation to bone healing.Fil: Camal Ruggieri, Iván Nadir. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; ArgentinaFil: Feldman, Sara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina. Universidad Nacional de Rosario. Consejo de Investigaciones de la Universidad de Rosario; ArgentinaMedCrave Group2020-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/174489Camal Ruggieri, Iván Nadir; Feldman, Sara; Signaling pathways of nucleic acids for bone healing: A review; MedCrave Group; Pharmacy & Pharmacology International Journal; 8; 5; 10-2020; 291-2952379-6367CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.15406/ppij.2020.08.00308info:eu-repo/semantics/altIdentifier/url/https://medcraveonline.com/PPIJ/signaling-pathways-of-nucleic-acids-for-bone-healing-a-review.htmlinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:13:20Zoai:ri.conicet.gov.ar:11336/174489instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:13:20.858CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Signaling pathways of nucleic acids for bone healing: A review
title Signaling pathways of nucleic acids for bone healing: A review
spellingShingle Signaling pathways of nucleic acids for bone healing: A review
Camal Ruggieri, Iván Nadir
BONE
REPAIR
MIRNA
PATHWAY
title_short Signaling pathways of nucleic acids for bone healing: A review
title_full Signaling pathways of nucleic acids for bone healing: A review
title_fullStr Signaling pathways of nucleic acids for bone healing: A review
title_full_unstemmed Signaling pathways of nucleic acids for bone healing: A review
title_sort Signaling pathways of nucleic acids for bone healing: A review
dc.creator.none.fl_str_mv Camal Ruggieri, Iván Nadir
Feldman, Sara
author Camal Ruggieri, Iván Nadir
author_facet Camal Ruggieri, Iván Nadir
Feldman, Sara
author_role author
author2 Feldman, Sara
author2_role author
dc.subject.none.fl_str_mv BONE
REPAIR
MIRNA
PATHWAY
topic BONE
REPAIR
MIRNA
PATHWAY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Different kinds of nucleic acid (NA) molecules are promising therapeutic tools in a variety of tissues and their pathogenesis, and bone pathologies are not the exception. NAs interact in cytosol or nucleus to generate a specific response. Some of these NAs can be used to generate a positive response in relation to bone formation and differentiation in osteoblast and osteocyte. This work aims to briefly and clearly show main signaling pathways in osteoblasts and osteocytes, and to state the mechanism of how miRNA agonists (miRNA) and miRNA antagonists (antagomir) affect them. Thus, this summarizes the mechanism of promising therapeutic strategies for bone repair. NAs are fragile and can be degraded quickly outside the cells. These problems are more and more frequently resolved by nanotechnology and tissue engineering approaches. Further research in this field wills probably generate safe and therapeutic effective therapy in relation to bone healing.
Fil: Camal Ruggieri, Iván Nadir. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
Fil: Feldman, Sara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina. Universidad Nacional de Rosario. Consejo de Investigaciones de la Universidad de Rosario; Argentina
description Different kinds of nucleic acid (NA) molecules are promising therapeutic tools in a variety of tissues and their pathogenesis, and bone pathologies are not the exception. NAs interact in cytosol or nucleus to generate a specific response. Some of these NAs can be used to generate a positive response in relation to bone formation and differentiation in osteoblast and osteocyte. This work aims to briefly and clearly show main signaling pathways in osteoblasts and osteocytes, and to state the mechanism of how miRNA agonists (miRNA) and miRNA antagonists (antagomir) affect them. Thus, this summarizes the mechanism of promising therapeutic strategies for bone repair. NAs are fragile and can be degraded quickly outside the cells. These problems are more and more frequently resolved by nanotechnology and tissue engineering approaches. Further research in this field wills probably generate safe and therapeutic effective therapy in relation to bone healing.
publishDate 2020
dc.date.none.fl_str_mv 2020-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/174489
Camal Ruggieri, Iván Nadir; Feldman, Sara; Signaling pathways of nucleic acids for bone healing: A review; MedCrave Group; Pharmacy & Pharmacology International Journal; 8; 5; 10-2020; 291-295
2379-6367
CONICET Digital
CONICET
url http://hdl.handle.net/11336/174489
identifier_str_mv Camal Ruggieri, Iván Nadir; Feldman, Sara; Signaling pathways of nucleic acids for bone healing: A review; MedCrave Group; Pharmacy & Pharmacology International Journal; 8; 5; 10-2020; 291-295
2379-6367
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.15406/ppij.2020.08.00308
info:eu-repo/semantics/altIdentifier/url/https://medcraveonline.com/PPIJ/signaling-pathways-of-nucleic-acids-for-bone-healing-a-review.html
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MedCrave Group
publisher.none.fl_str_mv MedCrave Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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