Signaling pathways of nucleic acids for bone healing: A review
- Autores
- Camal Ruggieri, Iván Nadir; Feldman, Sara
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Different kinds of nucleic acid (NA) molecules are promising therapeutic tools in a variety of tissues and their pathogenesis, and bone pathologies are not the exception. NAs interact in cytosol or nucleus to generate a specific response. Some of these NAs can be used to generate a positive response in relation to bone formation and differentiation in osteoblast and osteocyte. This work aims to briefly and clearly show main signaling pathways in osteoblasts and osteocytes, and to state the mechanism of how miRNA agonists (miRNA) and miRNA antagonists (antagomir) affect them. Thus, this summarizes the mechanism of promising therapeutic strategies for bone repair. NAs are fragile and can be degraded quickly outside the cells. These problems are more and more frequently resolved by nanotechnology and tissue engineering approaches. Further research in this field wills probably generate safe and therapeutic effective therapy in relation to bone healing.
Fil: Camal Ruggieri, Iván Nadir. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
Fil: Feldman, Sara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina. Universidad Nacional de Rosario. Consejo de Investigaciones de la Universidad de Rosario; Argentina - Materia
-
BONE
REPAIR
MIRNA
PATHWAY - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/174489
Ver los metadatos del registro completo
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Signaling pathways of nucleic acids for bone healing: A reviewCamal Ruggieri, Iván NadirFeldman, SaraBONEREPAIRMIRNAPATHWAYhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Different kinds of nucleic acid (NA) molecules are promising therapeutic tools in a variety of tissues and their pathogenesis, and bone pathologies are not the exception. NAs interact in cytosol or nucleus to generate a specific response. Some of these NAs can be used to generate a positive response in relation to bone formation and differentiation in osteoblast and osteocyte. This work aims to briefly and clearly show main signaling pathways in osteoblasts and osteocytes, and to state the mechanism of how miRNA agonists (miRNA) and miRNA antagonists (antagomir) affect them. Thus, this summarizes the mechanism of promising therapeutic strategies for bone repair. NAs are fragile and can be degraded quickly outside the cells. These problems are more and more frequently resolved by nanotechnology and tissue engineering approaches. Further research in this field wills probably generate safe and therapeutic effective therapy in relation to bone healing.Fil: Camal Ruggieri, Iván Nadir. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; ArgentinaFil: Feldman, Sara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina. Universidad Nacional de Rosario. Consejo de Investigaciones de la Universidad de Rosario; ArgentinaMedCrave Group2020-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/174489Camal Ruggieri, Iván Nadir; Feldman, Sara; Signaling pathways of nucleic acids for bone healing: A review; MedCrave Group; Pharmacy & Pharmacology International Journal; 8; 5; 10-2020; 291-2952379-6367CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.15406/ppij.2020.08.00308info:eu-repo/semantics/altIdentifier/url/https://medcraveonline.com/PPIJ/signaling-pathways-of-nucleic-acids-for-bone-healing-a-review.htmlinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:44:31Zoai:ri.conicet.gov.ar:11336/174489instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:44:31.864CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Signaling pathways of nucleic acids for bone healing: A review |
title |
Signaling pathways of nucleic acids for bone healing: A review |
spellingShingle |
Signaling pathways of nucleic acids for bone healing: A review Camal Ruggieri, Iván Nadir BONE REPAIR MIRNA PATHWAY |
title_short |
Signaling pathways of nucleic acids for bone healing: A review |
title_full |
Signaling pathways of nucleic acids for bone healing: A review |
title_fullStr |
Signaling pathways of nucleic acids for bone healing: A review |
title_full_unstemmed |
Signaling pathways of nucleic acids for bone healing: A review |
title_sort |
Signaling pathways of nucleic acids for bone healing: A review |
dc.creator.none.fl_str_mv |
Camal Ruggieri, Iván Nadir Feldman, Sara |
author |
Camal Ruggieri, Iván Nadir |
author_facet |
Camal Ruggieri, Iván Nadir Feldman, Sara |
author_role |
author |
author2 |
Feldman, Sara |
author2_role |
author |
dc.subject.none.fl_str_mv |
BONE REPAIR MIRNA PATHWAY |
topic |
BONE REPAIR MIRNA PATHWAY |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Different kinds of nucleic acid (NA) molecules are promising therapeutic tools in a variety of tissues and their pathogenesis, and bone pathologies are not the exception. NAs interact in cytosol or nucleus to generate a specific response. Some of these NAs can be used to generate a positive response in relation to bone formation and differentiation in osteoblast and osteocyte. This work aims to briefly and clearly show main signaling pathways in osteoblasts and osteocytes, and to state the mechanism of how miRNA agonists (miRNA) and miRNA antagonists (antagomir) affect them. Thus, this summarizes the mechanism of promising therapeutic strategies for bone repair. NAs are fragile and can be degraded quickly outside the cells. These problems are more and more frequently resolved by nanotechnology and tissue engineering approaches. Further research in this field wills probably generate safe and therapeutic effective therapy in relation to bone healing. Fil: Camal Ruggieri, Iván Nadir. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina Fil: Feldman, Sara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina. Universidad Nacional de Rosario. Consejo de Investigaciones de la Universidad de Rosario; Argentina |
description |
Different kinds of nucleic acid (NA) molecules are promising therapeutic tools in a variety of tissues and their pathogenesis, and bone pathologies are not the exception. NAs interact in cytosol or nucleus to generate a specific response. Some of these NAs can be used to generate a positive response in relation to bone formation and differentiation in osteoblast and osteocyte. This work aims to briefly and clearly show main signaling pathways in osteoblasts and osteocytes, and to state the mechanism of how miRNA agonists (miRNA) and miRNA antagonists (antagomir) affect them. Thus, this summarizes the mechanism of promising therapeutic strategies for bone repair. NAs are fragile and can be degraded quickly outside the cells. These problems are more and more frequently resolved by nanotechnology and tissue engineering approaches. Further research in this field wills probably generate safe and therapeutic effective therapy in relation to bone healing. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-10 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/174489 Camal Ruggieri, Iván Nadir; Feldman, Sara; Signaling pathways of nucleic acids for bone healing: A review; MedCrave Group; Pharmacy & Pharmacology International Journal; 8; 5; 10-2020; 291-295 2379-6367 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/174489 |
identifier_str_mv |
Camal Ruggieri, Iván Nadir; Feldman, Sara; Signaling pathways of nucleic acids for bone healing: A review; MedCrave Group; Pharmacy & Pharmacology International Journal; 8; 5; 10-2020; 291-295 2379-6367 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.15406/ppij.2020.08.00308 info:eu-repo/semantics/altIdentifier/url/https://medcraveonline.com/PPIJ/signaling-pathways-of-nucleic-acids-for-bone-healing-a-review.html |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
MedCrave Group |
publisher.none.fl_str_mv |
MedCrave Group |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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