The radiobiological principles of boron neutron capture therapy: A critical review

Autores
Hopewell, J. W.; Morris, G. M.; Schwint, Amanda Elena; Coderre, J. A.
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The radiobiology of the dose components in a BNCT exposure is examined. The effect of exposure time in determining the biological effectiveness of γ-rays, due to the repair of sublethal damage, has been largely overlooked in the application of BNCT. Recoil protons from fast neutrons vary in their relative biological effectiveness (RBE) as a function of energy and tissue endpoint. Thus the energy spectrum of a beam will influence the RBE of this dose component. Protons from the neutron capture reaction in nitrogen have not been studied but in practice protons from nitrogen capture have been combined with the recoil proton contribution into a total proton dose. The relative biological effectiveness of the products of the neutron capture reaction in boron is derived from two factors, the RBE of the short range particles and the bio-distribution of boron, referred to collectively as the compound biological effectiveness factor. Caution is needed in the application of these factors for different normal tissues and tumors.
Fil: Hopewell, J. W.. University of Oxford; Reino Unido
Fil: Morris, G. M.. Brookhaven National Laboratory; Estados Unidos
Fil: Schwint, Amanda Elena. Comision Nacional de Energia Atomica. Gerencia de Area de Aplicaciones de la Tecnología Nuclear; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Coderre, J. A.. No especifíca;
Materia
BIOLOGICAL EFFECTIVENESS
BNCT
RADIOBIOLOGICAL PRINCIPLES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/188765
Acceder
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network_name_str CONICET Digital (CONICET)
spelling The radiobiological principles of boron neutron capture therapy: A critical reviewHopewell, J. W.Morris, G. M.Schwint, Amanda ElenaCoderre, J. A.BIOLOGICAL EFFECTIVENESSBNCTRADIOBIOLOGICAL PRINCIPLEShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The radiobiology of the dose components in a BNCT exposure is examined. The effect of exposure time in determining the biological effectiveness of γ-rays, due to the repair of sublethal damage, has been largely overlooked in the application of BNCT. Recoil protons from fast neutrons vary in their relative biological effectiveness (RBE) as a function of energy and tissue endpoint. Thus the energy spectrum of a beam will influence the RBE of this dose component. Protons from the neutron capture reaction in nitrogen have not been studied but in practice protons from nitrogen capture have been combined with the recoil proton contribution into a total proton dose. The relative biological effectiveness of the products of the neutron capture reaction in boron is derived from two factors, the RBE of the short range particles and the bio-distribution of boron, referred to collectively as the compound biological effectiveness factor. Caution is needed in the application of these factors for different normal tissues and tumors.Fil: Hopewell, J. W.. University of Oxford; Reino UnidoFil: Morris, G. M.. Brookhaven National Laboratory; Estados UnidosFil: Schwint, Amanda Elena. Comision Nacional de Energia Atomica. Gerencia de Area de Aplicaciones de la Tecnología Nuclear; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Coderre, J. A.. No especifíca;Pergamon-Elsevier Science Ltd2011-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/188765Hopewell, J. W.; Morris, G. M.; Schwint, Amanda Elena; Coderre, J. A.; The radiobiological principles of boron neutron capture therapy: A critical review; Pergamon-Elsevier Science Ltd; Applied Radiation and Isotopes; 69; 12; 12-2011; 1756-17590969-8043CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0969804311002533info:eu-repo/semantics/altIdentifier/doi/10.1016/j.apradiso.2011.04.019info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:10:56Zoai:ri.conicet.gov.ar:11336/188765instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:10:56.538CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The radiobiological principles of boron neutron capture therapy: A critical review
title The radiobiological principles of boron neutron capture therapy: A critical review
spellingShingle The radiobiological principles of boron neutron capture therapy: A critical review
Hopewell, J. W.
BIOLOGICAL EFFECTIVENESS
BNCT
RADIOBIOLOGICAL PRINCIPLES
title_short The radiobiological principles of boron neutron capture therapy: A critical review
title_full The radiobiological principles of boron neutron capture therapy: A critical review
title_fullStr The radiobiological principles of boron neutron capture therapy: A critical review
title_full_unstemmed The radiobiological principles of boron neutron capture therapy: A critical review
title_sort The radiobiological principles of boron neutron capture therapy: A critical review
dc.creator.none.fl_str_mv Hopewell, J. W.
Morris, G. M.
Schwint, Amanda Elena
Coderre, J. A.
author Hopewell, J. W.
author_facet Hopewell, J. W.
Morris, G. M.
Schwint, Amanda Elena
Coderre, J. A.
author_role author
author2 Morris, G. M.
Schwint, Amanda Elena
Coderre, J. A.
author2_role author
author
author
dc.subject.none.fl_str_mv BIOLOGICAL EFFECTIVENESS
BNCT
RADIOBIOLOGICAL PRINCIPLES
topic BIOLOGICAL EFFECTIVENESS
BNCT
RADIOBIOLOGICAL PRINCIPLES
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The radiobiology of the dose components in a BNCT exposure is examined. The effect of exposure time in determining the biological effectiveness of γ-rays, due to the repair of sublethal damage, has been largely overlooked in the application of BNCT. Recoil protons from fast neutrons vary in their relative biological effectiveness (RBE) as a function of energy and tissue endpoint. Thus the energy spectrum of a beam will influence the RBE of this dose component. Protons from the neutron capture reaction in nitrogen have not been studied but in practice protons from nitrogen capture have been combined with the recoil proton contribution into a total proton dose. The relative biological effectiveness of the products of the neutron capture reaction in boron is derived from two factors, the RBE of the short range particles and the bio-distribution of boron, referred to collectively as the compound biological effectiveness factor. Caution is needed in the application of these factors for different normal tissues and tumors.
Fil: Hopewell, J. W.. University of Oxford; Reino Unido
Fil: Morris, G. M.. Brookhaven National Laboratory; Estados Unidos
Fil: Schwint, Amanda Elena. Comision Nacional de Energia Atomica. Gerencia de Area de Aplicaciones de la Tecnología Nuclear; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Coderre, J. A.. No especifíca;
description The radiobiology of the dose components in a BNCT exposure is examined. The effect of exposure time in determining the biological effectiveness of γ-rays, due to the repair of sublethal damage, has been largely overlooked in the application of BNCT. Recoil protons from fast neutrons vary in their relative biological effectiveness (RBE) as a function of energy and tissue endpoint. Thus the energy spectrum of a beam will influence the RBE of this dose component. Protons from the neutron capture reaction in nitrogen have not been studied but in practice protons from nitrogen capture have been combined with the recoil proton contribution into a total proton dose. The relative biological effectiveness of the products of the neutron capture reaction in boron is derived from two factors, the RBE of the short range particles and the bio-distribution of boron, referred to collectively as the compound biological effectiveness factor. Caution is needed in the application of these factors for different normal tissues and tumors.
publishDate 2011
dc.date.none.fl_str_mv 2011-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/188765
Hopewell, J. W.; Morris, G. M.; Schwint, Amanda Elena; Coderre, J. A.; The radiobiological principles of boron neutron capture therapy: A critical review; Pergamon-Elsevier Science Ltd; Applied Radiation and Isotopes; 69; 12; 12-2011; 1756-1759
0969-8043
CONICET Digital
CONICET
url http://hdl.handle.net/11336/188765
identifier_str_mv Hopewell, J. W.; Morris, G. M.; Schwint, Amanda Elena; Coderre, J. A.; The radiobiological principles of boron neutron capture therapy: A critical review; Pergamon-Elsevier Science Ltd; Applied Radiation and Isotopes; 69; 12; 12-2011; 1756-1759
0969-8043
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0969804311002533
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.apradiso.2011.04.019
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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