A Novel Approach to Design and Evaluate BNCT Neutron Beams Combining Physical, Radiobiological, and Dosimetric Figures of Merit

Autores
Postuma, Ian; González, Sara Josefina; Herrera, Maria Silvia; Provenzano, Lucas; Ferrarini, Michele; Magni, Chiara; Protti, Nicoletta; Fatemi, Setareh; Vercesi, Valerio; Giuseppe Battistoni; Tamburini, Umberto Anselmi; Liu, Yuan Hao; Kankaanranta, Leena; Koivunoro, Hanna; Altieri, Saverio; Bortolussi, Silva
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
(1) Background:The quality of neutron beams for Boron Neutron Capture Therapy (BNCT) is currently defined by its physical characteristics in air. Recommendations exist to define whether a designed beam is useful for clinical treatment. This work presents a new way to evaluate neutron beams based on their clinical performance and on their safety, employing radiobiological quantities. (2) Methods: The case study is a neutron beam for deep-seated tumors from a 5 MeV proton beam coupled to a beryllium target. Physical Figures of Merit were used to design five beams; however, they did not allow a clear ranking of their quality in terms of therapeutic potential. The latter was then evaluated based on in-phantom dose distributions and on the calculation of the Uncomplicated Tumor Control Probability (UTCP). The safety of the beams was also evaluated calculating the in-patient out-of-beam dosimetry. (3) Results: All the beams ensured a UTCP comparable to the one of a clinical beam in phantom; the safety criterion allowed to choose the best candidate. When this was tested in the treatment planning of a real patient treated in Finland, the UTCP was still comparable to the one of the clinical beam. (4) Conclusions: Even when standard physical recommendations are not met, radiobiological and dosimetric criteria demonstrate to be a valid tool to select an effective and safe beam for patient treatment.
Fil: Postuma, Ian. Istituto Nazionale di Fisica Nucleare; Italia
Fil: González, Sara Josefina. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Herrera, Maria Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Provenzano, Lucas. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ferrarini, Michele. Centro Nazionale Di Adroterapia Oncologica; Italia
Fil: Magni, Chiara. Istituto Nazionale di Fisica Nucleare; Italia. Universita degli Studi di Pavia; Italia
Fil: Protti, Nicoletta. Istituto Nazionale di Fisica Nucleare; Italia. Universita degli Studi di Pavia; Italia
Fil: Fatemi, Setareh. Istituto Nazionale di Fisica Nucleare; Italia
Fil: Vercesi, Valerio. Istituto Nazionale di Fisica Nucleare; Italia
Fil: Giuseppe Battistoni. Istituto Nazionale di Fisica Nucleare; Italia
Fil: Tamburini, Umberto Anselmi. Istituto Nazionale di Fisica Nucleare; Italia. Universita degli Studi di Pavia; Italia
Fil: Liu, Yuan Hao. Neuboron Medtech; China. Nanjing University of Aeronautics and Astronautics; China
Fil: Kankaanranta, Leena. University of Helsinki; Finlandia
Fil: Koivunoro, Hanna. Neutron Therapeutics; Estados Unidos
Fil: Altieri, Saverio. Istituto Nazionale di Fisica Nucleare; Italia. Universita degli Studi di Pavia; Italia
Fil: Bortolussi, Silva. Istituto Nazionale di Fisica Nucleare; Italia. Universita degli Studi di Pavia; Italia
Materia
BNCT
BSA
UTCP
EPITHERMAL NEUTRON BEAM
RADIOBIOLOGICAL FIGURES OF MERIT
OUT-OF-BEAM DOSIMETRY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/155264
Acceder
id CONICETDig_30974b593bf92dd03da51a73fa132564
oai_identifier_str oai:ri.conicet.gov.ar:11336/155264
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A Novel Approach to Design and Evaluate BNCT Neutron Beams Combining Physical, Radiobiological, and Dosimetric Figures of MeritPostuma, IanGonzález, Sara JosefinaHerrera, Maria SilviaProvenzano, LucasFerrarini, MicheleMagni, ChiaraProtti, NicolettaFatemi, SetarehVercesi, ValerioGiuseppe BattistoniTamburini, Umberto AnselmiLiu, Yuan HaoKankaanranta, LeenaKoivunoro, HannaAltieri, SaverioBortolussi, SilvaBNCTBSAUTCPEPITHERMAL NEUTRON BEAMRADIOBIOLOGICAL FIGURES OF MERITOUT-OF-BEAM DOSIMETRYhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1(1) Background:The quality of neutron beams for Boron Neutron Capture Therapy (BNCT) is currently defined by its physical characteristics in air. Recommendations exist to define whether a designed beam is useful for clinical treatment. This work presents a new way to evaluate neutron beams based on their clinical performance and on their safety, employing radiobiological quantities. (2) Methods: The case study is a neutron beam for deep-seated tumors from a 5 MeV proton beam coupled to a beryllium target. Physical Figures of Merit were used to design five beams; however, they did not allow a clear ranking of their quality in terms of therapeutic potential. The latter was then evaluated based on in-phantom dose distributions and on the calculation of the Uncomplicated Tumor Control Probability (UTCP). The safety of the beams was also evaluated calculating the in-patient out-of-beam dosimetry. (3) Results: All the beams ensured a UTCP comparable to the one of a clinical beam in phantom; the safety criterion allowed to choose the best candidate. When this was tested in the treatment planning of a real patient treated in Finland, the UTCP was still comparable to the one of the clinical beam. (4) Conclusions: Even when standard physical recommendations are not met, radiobiological and dosimetric criteria demonstrate to be a valid tool to select an effective and safe beam for patient treatment.Fil: Postuma, Ian. Istituto Nazionale di Fisica Nucleare; ItaliaFil: González, Sara Josefina. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Herrera, Maria Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Provenzano, Lucas. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ferrarini, Michele. Centro Nazionale Di Adroterapia Oncologica; ItaliaFil: Magni, Chiara. Istituto Nazionale di Fisica Nucleare; Italia. Universita degli Studi di Pavia; ItaliaFil: Protti, Nicoletta. Istituto Nazionale di Fisica Nucleare; Italia. Universita degli Studi di Pavia; ItaliaFil: Fatemi, Setareh. Istituto Nazionale di Fisica Nucleare; ItaliaFil: Vercesi, Valerio. Istituto Nazionale di Fisica Nucleare; ItaliaFil: Giuseppe Battistoni. Istituto Nazionale di Fisica Nucleare; ItaliaFil: Tamburini, Umberto Anselmi. Istituto Nazionale di Fisica Nucleare; Italia. Universita degli Studi di Pavia; ItaliaFil: Liu, Yuan Hao. Neuboron Medtech; China. Nanjing University of Aeronautics and Astronautics; ChinaFil: Kankaanranta, Leena. University of Helsinki; FinlandiaFil: Koivunoro, Hanna. Neutron Therapeutics; Estados UnidosFil: Altieri, Saverio. Istituto Nazionale di Fisica Nucleare; Italia. Universita degli Studi di Pavia; ItaliaFil: Bortolussi, Silva. Istituto Nazionale di Fisica Nucleare; Italia. Universita degli Studi di Pavia; ItaliaMDPI2021-02-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/155264Postuma, Ian; González, Sara Josefina; Herrera, Maria Silvia; Provenzano, Lucas; Ferrarini, Michele; et al.; A Novel Approach to Design and Evaluate BNCT Neutron Beams Combining Physical, Radiobiological, and Dosimetric Figures of Merit; MDPI; Biology; 10; 3; 26-2-2021; 174-1912079-77372079-7737CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2079-7737/10/3/174info:eu-repo/semantics/altIdentifier/doi/10.3390/biology10030174info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:21:55Zoai:ri.conicet.gov.ar:11336/155264instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:21:56.246CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A Novel Approach to Design and Evaluate BNCT Neutron Beams Combining Physical, Radiobiological, and Dosimetric Figures of Merit
title A Novel Approach to Design and Evaluate BNCT Neutron Beams Combining Physical, Radiobiological, and Dosimetric Figures of Merit
spellingShingle A Novel Approach to Design and Evaluate BNCT Neutron Beams Combining Physical, Radiobiological, and Dosimetric Figures of Merit
Postuma, Ian
BNCT
BSA
UTCP
EPITHERMAL NEUTRON BEAM
RADIOBIOLOGICAL FIGURES OF MERIT
OUT-OF-BEAM DOSIMETRY
title_short A Novel Approach to Design and Evaluate BNCT Neutron Beams Combining Physical, Radiobiological, and Dosimetric Figures of Merit
title_full A Novel Approach to Design and Evaluate BNCT Neutron Beams Combining Physical, Radiobiological, and Dosimetric Figures of Merit
title_fullStr A Novel Approach to Design and Evaluate BNCT Neutron Beams Combining Physical, Radiobiological, and Dosimetric Figures of Merit
title_full_unstemmed A Novel Approach to Design and Evaluate BNCT Neutron Beams Combining Physical, Radiobiological, and Dosimetric Figures of Merit
title_sort A Novel Approach to Design and Evaluate BNCT Neutron Beams Combining Physical, Radiobiological, and Dosimetric Figures of Merit
dc.creator.none.fl_str_mv Postuma, Ian
González, Sara Josefina
Herrera, Maria Silvia
Provenzano, Lucas
Ferrarini, Michele
Magni, Chiara
Protti, Nicoletta
Fatemi, Setareh
Vercesi, Valerio
Giuseppe Battistoni
Tamburini, Umberto Anselmi
Liu, Yuan Hao
Kankaanranta, Leena
Koivunoro, Hanna
Altieri, Saverio
Bortolussi, Silva
author Postuma, Ian
author_facet Postuma, Ian
González, Sara Josefina
Herrera, Maria Silvia
Provenzano, Lucas
Ferrarini, Michele
Magni, Chiara
Protti, Nicoletta
Fatemi, Setareh
Vercesi, Valerio
Giuseppe Battistoni
Tamburini, Umberto Anselmi
Liu, Yuan Hao
Kankaanranta, Leena
Koivunoro, Hanna
Altieri, Saverio
Bortolussi, Silva
author_role author
author2 González, Sara Josefina
Herrera, Maria Silvia
Provenzano, Lucas
Ferrarini, Michele
Magni, Chiara
Protti, Nicoletta
Fatemi, Setareh
Vercesi, Valerio
Giuseppe Battistoni
Tamburini, Umberto Anselmi
Liu, Yuan Hao
Kankaanranta, Leena
Koivunoro, Hanna
Altieri, Saverio
Bortolussi, Silva
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BNCT
BSA
UTCP
EPITHERMAL NEUTRON BEAM
RADIOBIOLOGICAL FIGURES OF MERIT
OUT-OF-BEAM DOSIMETRY
topic BNCT
BSA
UTCP
EPITHERMAL NEUTRON BEAM
RADIOBIOLOGICAL FIGURES OF MERIT
OUT-OF-BEAM DOSIMETRY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv (1) Background:The quality of neutron beams for Boron Neutron Capture Therapy (BNCT) is currently defined by its physical characteristics in air. Recommendations exist to define whether a designed beam is useful for clinical treatment. This work presents a new way to evaluate neutron beams based on their clinical performance and on their safety, employing radiobiological quantities. (2) Methods: The case study is a neutron beam for deep-seated tumors from a 5 MeV proton beam coupled to a beryllium target. Physical Figures of Merit were used to design five beams; however, they did not allow a clear ranking of their quality in terms of therapeutic potential. The latter was then evaluated based on in-phantom dose distributions and on the calculation of the Uncomplicated Tumor Control Probability (UTCP). The safety of the beams was also evaluated calculating the in-patient out-of-beam dosimetry. (3) Results: All the beams ensured a UTCP comparable to the one of a clinical beam in phantom; the safety criterion allowed to choose the best candidate. When this was tested in the treatment planning of a real patient treated in Finland, the UTCP was still comparable to the one of the clinical beam. (4) Conclusions: Even when standard physical recommendations are not met, radiobiological and dosimetric criteria demonstrate to be a valid tool to select an effective and safe beam for patient treatment.
Fil: Postuma, Ian. Istituto Nazionale di Fisica Nucleare; Italia
Fil: González, Sara Josefina. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Herrera, Maria Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Provenzano, Lucas. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ferrarini, Michele. Centro Nazionale Di Adroterapia Oncologica; Italia
Fil: Magni, Chiara. Istituto Nazionale di Fisica Nucleare; Italia. Universita degli Studi di Pavia; Italia
Fil: Protti, Nicoletta. Istituto Nazionale di Fisica Nucleare; Italia. Universita degli Studi di Pavia; Italia
Fil: Fatemi, Setareh. Istituto Nazionale di Fisica Nucleare; Italia
Fil: Vercesi, Valerio. Istituto Nazionale di Fisica Nucleare; Italia
Fil: Giuseppe Battistoni. Istituto Nazionale di Fisica Nucleare; Italia
Fil: Tamburini, Umberto Anselmi. Istituto Nazionale di Fisica Nucleare; Italia. Universita degli Studi di Pavia; Italia
Fil: Liu, Yuan Hao. Neuboron Medtech; China. Nanjing University of Aeronautics and Astronautics; China
Fil: Kankaanranta, Leena. University of Helsinki; Finlandia
Fil: Koivunoro, Hanna. Neutron Therapeutics; Estados Unidos
Fil: Altieri, Saverio. Istituto Nazionale di Fisica Nucleare; Italia. Universita degli Studi di Pavia; Italia
Fil: Bortolussi, Silva. Istituto Nazionale di Fisica Nucleare; Italia. Universita degli Studi di Pavia; Italia
description (1) Background:The quality of neutron beams for Boron Neutron Capture Therapy (BNCT) is currently defined by its physical characteristics in air. Recommendations exist to define whether a designed beam is useful for clinical treatment. This work presents a new way to evaluate neutron beams based on their clinical performance and on their safety, employing radiobiological quantities. (2) Methods: The case study is a neutron beam for deep-seated tumors from a 5 MeV proton beam coupled to a beryllium target. Physical Figures of Merit were used to design five beams; however, they did not allow a clear ranking of their quality in terms of therapeutic potential. The latter was then evaluated based on in-phantom dose distributions and on the calculation of the Uncomplicated Tumor Control Probability (UTCP). The safety of the beams was also evaluated calculating the in-patient out-of-beam dosimetry. (3) Results: All the beams ensured a UTCP comparable to the one of a clinical beam in phantom; the safety criterion allowed to choose the best candidate. When this was tested in the treatment planning of a real patient treated in Finland, the UTCP was still comparable to the one of the clinical beam. (4) Conclusions: Even when standard physical recommendations are not met, radiobiological and dosimetric criteria demonstrate to be a valid tool to select an effective and safe beam for patient treatment.
publishDate 2021
dc.date.none.fl_str_mv 2021-02-26
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/155264
Postuma, Ian; González, Sara Josefina; Herrera, Maria Silvia; Provenzano, Lucas; Ferrarini, Michele; et al.; A Novel Approach to Design and Evaluate BNCT Neutron Beams Combining Physical, Radiobiological, and Dosimetric Figures of Merit; MDPI; Biology; 10; 3; 26-2-2021; 174-191
2079-7737
2079-7737
CONICET Digital
CONICET
url http://hdl.handle.net/11336/155264
identifier_str_mv Postuma, Ian; González, Sara Josefina; Herrera, Maria Silvia; Provenzano, Lucas; Ferrarini, Michele; et al.; A Novel Approach to Design and Evaluate BNCT Neutron Beams Combining Physical, Radiobiological, and Dosimetric Figures of Merit; MDPI; Biology; 10; 3; 26-2-2021; 174-191
2079-7737
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2079-7737/10/3/174
info:eu-repo/semantics/altIdentifier/doi/10.3390/biology10030174
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842981206591799296
score 12.48226

Publicaciones similares