Longitudinal relationship between clinical course and neurocognitive impairments in bipolar disorder

Autores
Martino, Diego Javier; Igoa, Ana; Marengo, Eliana; Scápola, María; Strejilevich, Sergio
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background The aim of this study was to estimate the relationship between clinical course and trajectory of neurocognitive functioning during a follow-up period in a sample of euthymic bipolar patients. Methods Fifty-one patients with BD performed two-neurocognitive assessment separated by a period of at least 48 months. The clinical course during the follow-up period was documented by: three measures 1) number of affective episodes, 2) time spent ill, and 3) mood instability. Results Patients were followed-up for a mean period of 73.21 months. Neurocognitive performance tended to be stable throughout the follow-up. Performance in verbal memory and executive functions at the end of study were related with the number of hypo/manic episodes and time spent with hypo/manic symptoms during the follow-up. None of the clinical measures considered were related to changes in neurocognitive performance over the follow-up period. Limitations The relatively small sample size limits the value of subgroup analysis. The study design does not rule out some risk of selection bias. Conclusions Although there may be a positive relationship between number of episodes and neurocognitive deficits in patients with bipolar disorder, successive episodes do not seem to modify the trajectory of neurocognitive functioning over time. Theoretical implications of these findings are discussed.
Fil: Martino, Diego Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Área de Investigación y Desarrollo; Argentina
Fil: Igoa, Ana. Universidad Favaloro. Área de Investigación y Desarrollo; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Emergencias Psiquiáicas "Torcuato de Alvear"; Argentina
Fil: Marengo, Eliana. Universidad Favaloro. Área de Investigación y Desarrollo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Scápola, María. Universidad Favaloro. Área de Investigación y Desarrollo; Argentina
Fil: Strejilevich, Sergio. Universidad Favaloro. Área de Investigación y Desarrollo; Argentina
Materia
AFFECTIVE EPISODES
EXECUTIVE FUNCTIONS
NEUROPROGRESSION
RECURRENCES
SATGING
VERBAL MEMORY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/98878
Acceder
id CONICETDig_093e07c6aef7e824f8bc1f945f898605
oai_identifier_str oai:ri.conicet.gov.ar:11336/98878
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Longitudinal relationship between clinical course and neurocognitive impairments in bipolar disorderMartino, Diego JavierIgoa, AnaMarengo, ElianaScápola, MaríaStrejilevich, SergioAFFECTIVE EPISODESEXECUTIVE FUNCTIONSNEUROPROGRESSIONRECURRENCESSATGINGVERBAL MEMORYhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background The aim of this study was to estimate the relationship between clinical course and trajectory of neurocognitive functioning during a follow-up period in a sample of euthymic bipolar patients. Methods Fifty-one patients with BD performed two-neurocognitive assessment separated by a period of at least 48 months. The clinical course during the follow-up period was documented by: three measures 1) number of affective episodes, 2) time spent ill, and 3) mood instability. Results Patients were followed-up for a mean period of 73.21 months. Neurocognitive performance tended to be stable throughout the follow-up. Performance in verbal memory and executive functions at the end of study were related with the number of hypo/manic episodes and time spent with hypo/manic symptoms during the follow-up. None of the clinical measures considered were related to changes in neurocognitive performance over the follow-up period. Limitations The relatively small sample size limits the value of subgroup analysis. The study design does not rule out some risk of selection bias. Conclusions Although there may be a positive relationship between number of episodes and neurocognitive deficits in patients with bipolar disorder, successive episodes do not seem to modify the trajectory of neurocognitive functioning over time. Theoretical implications of these findings are discussed.Fil: Martino, Diego Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Área de Investigación y Desarrollo; ArgentinaFil: Igoa, Ana. Universidad Favaloro. Área de Investigación y Desarrollo; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Emergencias Psiquiáicas "Torcuato de Alvear"; ArgentinaFil: Marengo, Eliana. Universidad Favaloro. Área de Investigación y Desarrollo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Scápola, María. Universidad Favaloro. Área de Investigación y Desarrollo; ArgentinaFil: Strejilevich, Sergio. Universidad Favaloro. Área de Investigación y Desarrollo; ArgentinaElsevier Science2018-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/98878Martino, Diego Javier; Igoa, Ana; Marengo, Eliana; Scápola, María; Strejilevich, Sergio; Longitudinal relationship between clinical course and neurocognitive impairments in bipolar disorder; Elsevier Science; Journal of Affective Disorders; 225; 1-2018; 250-2550165-0327CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jad.2017.08.011info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0165032717308704info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:36:50Zoai:ri.conicet.gov.ar:11336/98878instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:36:51.251CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Longitudinal relationship between clinical course and neurocognitive impairments in bipolar disorder
title Longitudinal relationship between clinical course and neurocognitive impairments in bipolar disorder
spellingShingle Longitudinal relationship between clinical course and neurocognitive impairments in bipolar disorder
Martino, Diego Javier
AFFECTIVE EPISODES
EXECUTIVE FUNCTIONS
NEUROPROGRESSION
RECURRENCES
SATGING
VERBAL MEMORY
title_short Longitudinal relationship between clinical course and neurocognitive impairments in bipolar disorder
title_full Longitudinal relationship between clinical course and neurocognitive impairments in bipolar disorder
title_fullStr Longitudinal relationship between clinical course and neurocognitive impairments in bipolar disorder
title_full_unstemmed Longitudinal relationship between clinical course and neurocognitive impairments in bipolar disorder
title_sort Longitudinal relationship between clinical course and neurocognitive impairments in bipolar disorder
dc.creator.none.fl_str_mv Martino, Diego Javier
Igoa, Ana
Marengo, Eliana
Scápola, María
Strejilevich, Sergio
author Martino, Diego Javier
author_facet Martino, Diego Javier
Igoa, Ana
Marengo, Eliana
Scápola, María
Strejilevich, Sergio
author_role author
author2 Igoa, Ana
Marengo, Eliana
Scápola, María
Strejilevich, Sergio
author2_role author
author
author
author
dc.subject.none.fl_str_mv AFFECTIVE EPISODES
EXECUTIVE FUNCTIONS
NEUROPROGRESSION
RECURRENCES
SATGING
VERBAL MEMORY
topic AFFECTIVE EPISODES
EXECUTIVE FUNCTIONS
NEUROPROGRESSION
RECURRENCES
SATGING
VERBAL MEMORY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background The aim of this study was to estimate the relationship between clinical course and trajectory of neurocognitive functioning during a follow-up period in a sample of euthymic bipolar patients. Methods Fifty-one patients with BD performed two-neurocognitive assessment separated by a period of at least 48 months. The clinical course during the follow-up period was documented by: three measures 1) number of affective episodes, 2) time spent ill, and 3) mood instability. Results Patients were followed-up for a mean period of 73.21 months. Neurocognitive performance tended to be stable throughout the follow-up. Performance in verbal memory and executive functions at the end of study were related with the number of hypo/manic episodes and time spent with hypo/manic symptoms during the follow-up. None of the clinical measures considered were related to changes in neurocognitive performance over the follow-up period. Limitations The relatively small sample size limits the value of subgroup analysis. The study design does not rule out some risk of selection bias. Conclusions Although there may be a positive relationship between number of episodes and neurocognitive deficits in patients with bipolar disorder, successive episodes do not seem to modify the trajectory of neurocognitive functioning over time. Theoretical implications of these findings are discussed.
Fil: Martino, Diego Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Área de Investigación y Desarrollo; Argentina
Fil: Igoa, Ana. Universidad Favaloro. Área de Investigación y Desarrollo; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Emergencias Psiquiáicas "Torcuato de Alvear"; Argentina
Fil: Marengo, Eliana. Universidad Favaloro. Área de Investigación y Desarrollo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Scápola, María. Universidad Favaloro. Área de Investigación y Desarrollo; Argentina
Fil: Strejilevich, Sergio. Universidad Favaloro. Área de Investigación y Desarrollo; Argentina
description Background The aim of this study was to estimate the relationship between clinical course and trajectory of neurocognitive functioning during a follow-up period in a sample of euthymic bipolar patients. Methods Fifty-one patients with BD performed two-neurocognitive assessment separated by a period of at least 48 months. The clinical course during the follow-up period was documented by: three measures 1) number of affective episodes, 2) time spent ill, and 3) mood instability. Results Patients were followed-up for a mean period of 73.21 months. Neurocognitive performance tended to be stable throughout the follow-up. Performance in verbal memory and executive functions at the end of study were related with the number of hypo/manic episodes and time spent with hypo/manic symptoms during the follow-up. None of the clinical measures considered were related to changes in neurocognitive performance over the follow-up period. Limitations The relatively small sample size limits the value of subgroup analysis. The study design does not rule out some risk of selection bias. Conclusions Although there may be a positive relationship between number of episodes and neurocognitive deficits in patients with bipolar disorder, successive episodes do not seem to modify the trajectory of neurocognitive functioning over time. Theoretical implications of these findings are discussed.
publishDate 2018
dc.date.none.fl_str_mv 2018-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/98878
Martino, Diego Javier; Igoa, Ana; Marengo, Eliana; Scápola, María; Strejilevich, Sergio; Longitudinal relationship between clinical course and neurocognitive impairments in bipolar disorder; Elsevier Science; Journal of Affective Disorders; 225; 1-2018; 250-255
0165-0327
CONICET Digital
CONICET
url http://hdl.handle.net/11336/98878
identifier_str_mv Martino, Diego Javier; Igoa, Ana; Marengo, Eliana; Scápola, María; Strejilevich, Sergio; Longitudinal relationship between clinical course and neurocognitive impairments in bipolar disorder; Elsevier Science; Journal of Affective Disorders; 225; 1-2018; 250-255
0165-0327
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jad.2017.08.011
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0165032717308704
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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