Differentiated thyroid carcinoma: presentation and follow-up in children and adolescents

Autores
Papendieck, Patricia; Gruñeiro Papendieck, Laura; Venara, Marcela Cristina; Achad, Mario Oscar; Maglio, Silvana; Bergadá, Ignacio; Chiesa, Ana Elena
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
To review our Pediatric Endocrinology Division ’ s experience with differentiated thyroid carcinoma (DTC) we analyzed retrospectively the records of patients with DTC that had been seen between June 1988 and June 2008. Results: Forty-fi ve patients (median age 13.7 years, 36 female) were diagnosed (papillary: 40, follicular: 5) with DTC presenting as a solitary nodule (n: 25), thyroid nodule with cervical adenopathy (n: 9) and multinodular goiter (n: 11). All underwent total thyroidectomy with resection of suspicious cervical lymph nodes (CLN). DTC was multicentric in 59 % and revealed extrathyroidal extension in 44 % . Initially, 44 % had CLN metastases and 24 % distant metastases. All patients underwent thyroid remnant ablation with 131 I and suppressive treatment. Median follow-up was 5.1 years with a diseasefree survival rate at 5 years of follow-up of 75 % . Eleven percent presented recurrences. Conclusion: Pediatric DTC has an aggressive behavior at presentation. Higher preoperative TSH levels were signifi - cantly associated with a more advanced disease at diagnosis. CLT was present concomitantly in a quarter of the patients and further studies are needed to establish differences in these patients ’ outcome. Diagnostic approach, total thyroidectomy, 131 I treatment and thyrotropin suppression allowed a good progression-free survival rate.
Fil: Papendieck, Patricia. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina
Fil: Gruñeiro Papendieck, Laura. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina
Fil: Venara, Marcela Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina
Fil: Achad, Mario Oscar. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina
Fil: Maglio, Silvana. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina
Fil: Bergadá, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina
Fil: Chiesa, Ana Elena. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
ADOLESCENCE
CHILDHOOD
DIFFERENTIATED THYROID CARCINOMA
FOLLICULAR CARCINOMA
FOLLOW-UP PAPILLARY CARCINOMA
RADIOACTIVE IODINE THYROIDECTOMY
THYROTROPIN STIMULATING HORMONE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/103121
Acceder
id CONICETDig_a3c39617e5c7ac5c5fd03950703bc9fb
oai_identifier_str oai:ri.conicet.gov.ar:11336/103121
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Differentiated thyroid carcinoma: presentation and follow-up in children and adolescentsPapendieck, PatriciaGruñeiro Papendieck, LauraVenara, Marcela CristinaAchad, Mario OscarMaglio, SilvanaBergadá, IgnacioChiesa, Ana ElenaADOLESCENCECHILDHOODDIFFERENTIATED THYROID CARCINOMAFOLLICULAR CARCINOMAFOLLOW-UP PAPILLARY CARCINOMARADIOACTIVE IODINE THYROIDECTOMYTHYROTROPIN STIMULATING HORMONEhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3To review our Pediatric Endocrinology Division ’ s experience with differentiated thyroid carcinoma (DTC) we analyzed retrospectively the records of patients with DTC that had been seen between June 1988 and June 2008. Results: Forty-fi ve patients (median age 13.7 years, 36 female) were diagnosed (papillary: 40, follicular: 5) with DTC presenting as a solitary nodule (n: 25), thyroid nodule with cervical adenopathy (n: 9) and multinodular goiter (n: 11). All underwent total thyroidectomy with resection of suspicious cervical lymph nodes (CLN). DTC was multicentric in 59 % and revealed extrathyroidal extension in 44 % . Initially, 44 % had CLN metastases and 24 % distant metastases. All patients underwent thyroid remnant ablation with 131 I and suppressive treatment. Median follow-up was 5.1 years with a diseasefree survival rate at 5 years of follow-up of 75 % . Eleven percent presented recurrences. Conclusion: Pediatric DTC has an aggressive behavior at presentation. Higher preoperative TSH levels were signifi - cantly associated with a more advanced disease at diagnosis. CLT was present concomitantly in a quarter of the patients and further studies are needed to establish differences in these patients ’ outcome. Diagnostic approach, total thyroidectomy, 131 I treatment and thyrotropin suppression allowed a good progression-free survival rate.Fil: Papendieck, Patricia. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; ArgentinaFil: Gruñeiro Papendieck, Laura. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; ArgentinaFil: Venara, Marcela Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; ArgentinaFil: Achad, Mario Oscar. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; ArgentinaFil: Maglio, Silvana. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; ArgentinaFil: Bergadá, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; ArgentinaFil: Chiesa, Ana Elena. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFreund Publishing House Ltd2011-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/103121Papendieck, Patricia; Gruñeiro Papendieck, Laura; Venara, Marcela Cristina; Achad, Mario Oscar; Maglio, Silvana; et al.; Differentiated thyroid carcinoma: presentation and follow-up in children and adolescents; Freund Publishing House Ltd; Journal Of Pediatric Endocrinology; 24; 9-10; 1-2011; 743-7480334-018X2191-0251CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1515/jpem.2011.241info:eu-repo/semantics/altIdentifier/url/https://www.degruyter.com/view/journals/jpem/24/9-10/article-p743.xmlinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:45:46Zoai:ri.conicet.gov.ar:11336/103121instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:45:46.799CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Differentiated thyroid carcinoma: presentation and follow-up in children and adolescents
title Differentiated thyroid carcinoma: presentation and follow-up in children and adolescents
spellingShingle Differentiated thyroid carcinoma: presentation and follow-up in children and adolescents
Papendieck, Patricia
ADOLESCENCE
CHILDHOOD
DIFFERENTIATED THYROID CARCINOMA
FOLLICULAR CARCINOMA
FOLLOW-UP PAPILLARY CARCINOMA
RADIOACTIVE IODINE THYROIDECTOMY
THYROTROPIN STIMULATING HORMONE
title_short Differentiated thyroid carcinoma: presentation and follow-up in children and adolescents
title_full Differentiated thyroid carcinoma: presentation and follow-up in children and adolescents
title_fullStr Differentiated thyroid carcinoma: presentation and follow-up in children and adolescents
title_full_unstemmed Differentiated thyroid carcinoma: presentation and follow-up in children and adolescents
title_sort Differentiated thyroid carcinoma: presentation and follow-up in children and adolescents
dc.creator.none.fl_str_mv Papendieck, Patricia
Gruñeiro Papendieck, Laura
Venara, Marcela Cristina
Achad, Mario Oscar
Maglio, Silvana
Bergadá, Ignacio
Chiesa, Ana Elena
author Papendieck, Patricia
author_facet Papendieck, Patricia
Gruñeiro Papendieck, Laura
Venara, Marcela Cristina
Achad, Mario Oscar
Maglio, Silvana
Bergadá, Ignacio
Chiesa, Ana Elena
author_role author
author2 Gruñeiro Papendieck, Laura
Venara, Marcela Cristina
Achad, Mario Oscar
Maglio, Silvana
Bergadá, Ignacio
Chiesa, Ana Elena
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ADOLESCENCE
CHILDHOOD
DIFFERENTIATED THYROID CARCINOMA
FOLLICULAR CARCINOMA
FOLLOW-UP PAPILLARY CARCINOMA
RADIOACTIVE IODINE THYROIDECTOMY
THYROTROPIN STIMULATING HORMONE
topic ADOLESCENCE
CHILDHOOD
DIFFERENTIATED THYROID CARCINOMA
FOLLICULAR CARCINOMA
FOLLOW-UP PAPILLARY CARCINOMA
RADIOACTIVE IODINE THYROIDECTOMY
THYROTROPIN STIMULATING HORMONE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv To review our Pediatric Endocrinology Division ’ s experience with differentiated thyroid carcinoma (DTC) we analyzed retrospectively the records of patients with DTC that had been seen between June 1988 and June 2008. Results: Forty-fi ve patients (median age 13.7 years, 36 female) were diagnosed (papillary: 40, follicular: 5) with DTC presenting as a solitary nodule (n: 25), thyroid nodule with cervical adenopathy (n: 9) and multinodular goiter (n: 11). All underwent total thyroidectomy with resection of suspicious cervical lymph nodes (CLN). DTC was multicentric in 59 % and revealed extrathyroidal extension in 44 % . Initially, 44 % had CLN metastases and 24 % distant metastases. All patients underwent thyroid remnant ablation with 131 I and suppressive treatment. Median follow-up was 5.1 years with a diseasefree survival rate at 5 years of follow-up of 75 % . Eleven percent presented recurrences. Conclusion: Pediatric DTC has an aggressive behavior at presentation. Higher preoperative TSH levels were signifi - cantly associated with a more advanced disease at diagnosis. CLT was present concomitantly in a quarter of the patients and further studies are needed to establish differences in these patients ’ outcome. Diagnostic approach, total thyroidectomy, 131 I treatment and thyrotropin suppression allowed a good progression-free survival rate.
Fil: Papendieck, Patricia. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina
Fil: Gruñeiro Papendieck, Laura. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina
Fil: Venara, Marcela Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina
Fil: Achad, Mario Oscar. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina
Fil: Maglio, Silvana. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina
Fil: Bergadá, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina
Fil: Chiesa, Ana Elena. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description To review our Pediatric Endocrinology Division ’ s experience with differentiated thyroid carcinoma (DTC) we analyzed retrospectively the records of patients with DTC that had been seen between June 1988 and June 2008. Results: Forty-fi ve patients (median age 13.7 years, 36 female) were diagnosed (papillary: 40, follicular: 5) with DTC presenting as a solitary nodule (n: 25), thyroid nodule with cervical adenopathy (n: 9) and multinodular goiter (n: 11). All underwent total thyroidectomy with resection of suspicious cervical lymph nodes (CLN). DTC was multicentric in 59 % and revealed extrathyroidal extension in 44 % . Initially, 44 % had CLN metastases and 24 % distant metastases. All patients underwent thyroid remnant ablation with 131 I and suppressive treatment. Median follow-up was 5.1 years with a diseasefree survival rate at 5 years of follow-up of 75 % . Eleven percent presented recurrences. Conclusion: Pediatric DTC has an aggressive behavior at presentation. Higher preoperative TSH levels were signifi - cantly associated with a more advanced disease at diagnosis. CLT was present concomitantly in a quarter of the patients and further studies are needed to establish differences in these patients ’ outcome. Diagnostic approach, total thyroidectomy, 131 I treatment and thyrotropin suppression allowed a good progression-free survival rate.
publishDate 2011
dc.date.none.fl_str_mv 2011-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/103121
Papendieck, Patricia; Gruñeiro Papendieck, Laura; Venara, Marcela Cristina; Achad, Mario Oscar; Maglio, Silvana; et al.; Differentiated thyroid carcinoma: presentation and follow-up in children and adolescents; Freund Publishing House Ltd; Journal Of Pediatric Endocrinology; 24; 9-10; 1-2011; 743-748
0334-018X
2191-0251
CONICET Digital
CONICET
url http://hdl.handle.net/11336/103121
identifier_str_mv Papendieck, Patricia; Gruñeiro Papendieck, Laura; Venara, Marcela Cristina; Achad, Mario Oscar; Maglio, Silvana; et al.; Differentiated thyroid carcinoma: presentation and follow-up in children and adolescents; Freund Publishing House Ltd; Journal Of Pediatric Endocrinology; 24; 9-10; 1-2011; 743-748
0334-018X
2191-0251
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1515/jpem.2011.241
info:eu-repo/semantics/altIdentifier/url/https://www.degruyter.com/view/journals/jpem/24/9-10/article-p743.xml
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Freund Publishing House Ltd
publisher.none.fl_str_mv Freund Publishing House Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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