Post-surgical treatment of thyroid carcinoma in dogs with retinoic acid 9 cis improves patient outcome

Autores
Castillo, Victor Alejandro; Pessina, P.; Blatter, M. F.; Miceli, Diego Daniel; Soler Arias, E.; Vidal, P.
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The objective of the present study was to compare the effects of isotretinoin 9-cis (RA9-cis) as a post-surgery treatmentof thyroid carcinoma to a traditional treatment (doxorubicin) and no treatment. Owners who did not want their dogsto receive treatment were placed into the control group A (GA; n=10). The remaining dogs were randomly placed intoeither group B (GB; n=12) and received doxorubicin at a dose of 30 mg/m2 every three weeks, for six complete cyclesor group C (GC; n=15) and treated with RA9-cis at a dose of 2 mg/kg/day for 6 months. The time of the recurrencewas significantly shorter in the GA and GB compared to GC (P=0.0007; P=0.0015 respectively), while we did notdetect differences between GA and GB. The hazard ratio of recurrence between GA and GB compared to GC were7.25 and 5.60 times shorter, respectively. We did not detect any differences between the other groups. The risk ratioof recurrence was 2.0 times higher in GA compared to GC and 2.1 times higher in GB compared to GC. The typeof carcinoma had an effect on time of survival with follicular carcinomas having an increased mean survival timethan follicular-compact carcinomas (P<0.0001) and follicular-compact carcinomas had a longer mean survival timethan compact carcinomas. The interaction among treatment and type was significant, but survival time in follicularcarcinomas did not differ between treatments. In follicular-compact carcinomas the survival time of GC was greaterthan GB (P<0.05), but we did not detect a difference between GA and GB. In conclusion, this study shows that theuse of surgery in combination with RA9-cis treatment significantly increases survival rate and decreases the timeto tumor recurrence when compared to doxorubicin treated or untreated dogs. The histological type of carcinomainteracted with treatment for time to recurrence and survival time, with more undifferentiated carcinomas having aworse prognosis than differentiated carcinomas.
Fil: Castillo, Victor Alejandro. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Pessina, P.. Universidad de la República; Uruguay
Fil: Blatter, M. F.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Miceli, Diego Daniel. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Soler Arias, E.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Vidal, P.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Materia
THYROID CARCINOMA
RETINOIC ACID
DOGS
POST-SURGICAL TREATMENT
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/23041
Acceder
id CONICETDig_657d13c9fe79ecd13160f638274ba748
oai_identifier_str oai:ri.conicet.gov.ar:11336/23041
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Post-surgical treatment of thyroid carcinoma in dogs with retinoic acid 9 cis improves patient outcomeCastillo, Victor AlejandroPessina, P.Blatter, M. F.Miceli, Diego DanielSoler Arias, E.Vidal, P.THYROID CARCINOMARETINOIC ACIDDOGSPOST-SURGICAL TREATMENThttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The objective of the present study was to compare the effects of isotretinoin 9-cis (RA9-cis) as a post-surgery treatmentof thyroid carcinoma to a traditional treatment (doxorubicin) and no treatment. Owners who did not want their dogsto receive treatment were placed into the control group A (GA; n=10). The remaining dogs were randomly placed intoeither group B (GB; n=12) and received doxorubicin at a dose of 30 mg/m2 every three weeks, for six complete cyclesor group C (GC; n=15) and treated with RA9-cis at a dose of 2 mg/kg/day for 6 months. The time of the recurrencewas significantly shorter in the GA and GB compared to GC (P=0.0007; P=0.0015 respectively), while we did notdetect differences between GA and GB. The hazard ratio of recurrence between GA and GB compared to GC were7.25 and 5.60 times shorter, respectively. We did not detect any differences between the other groups. The risk ratioof recurrence was 2.0 times higher in GA compared to GC and 2.1 times higher in GB compared to GC. The typeof carcinoma had an effect on time of survival with follicular carcinomas having an increased mean survival timethan follicular-compact carcinomas (P<0.0001) and follicular-compact carcinomas had a longer mean survival timethan compact carcinomas. The interaction among treatment and type was significant, but survival time in follicularcarcinomas did not differ between treatments. In follicular-compact carcinomas the survival time of GC was greaterthan GB (P<0.05), but we did not detect a difference between GA and GB. In conclusion, this study shows that theuse of surgery in combination with RA9-cis treatment significantly increases survival rate and decreases the timeto tumor recurrence when compared to doxorubicin treated or untreated dogs. The histological type of carcinomainteracted with treatment for time to recurrence and survival time, with more undifferentiated carcinomas having aworse prognosis than differentiated carcinomas.Fil: Castillo, Victor Alejandro. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Pessina, P.. Universidad de la República; UruguayFil: Blatter, M. F.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Miceli, Diego Daniel. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Soler Arias, E.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Vidal, P.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaUniversity of Tripoli2016-01-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/23041Castillo, Victor Alejandro; Pessina, P.; Blatter, M. F.; Miceli, Diego Daniel; Soler Arias, E.; et al.; Post-surgical treatment of thyroid carcinoma in dogs with retinoic acid 9 cis improves patient outcome; University of Tripoli; Open Veterinary Journal; 6; 1; 20-1-2016; 6-142226-44852218-6050CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.openveterinaryjournal.com/volume6no12016.htminfo:eu-repo/semantics/altIdentifier/doi/ 10.4314/ovj.v6i1.2info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744371/info:eu-repo/semantics/altIdentifier/url/26862515info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:04:00Zoai:ri.conicet.gov.ar:11336/23041instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:04:01.147CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Post-surgical treatment of thyroid carcinoma in dogs with retinoic acid 9 cis improves patient outcome
title Post-surgical treatment of thyroid carcinoma in dogs with retinoic acid 9 cis improves patient outcome
spellingShingle Post-surgical treatment of thyroid carcinoma in dogs with retinoic acid 9 cis improves patient outcome
Castillo, Victor Alejandro
THYROID CARCINOMA
RETINOIC ACID
DOGS
POST-SURGICAL TREATMENT
title_short Post-surgical treatment of thyroid carcinoma in dogs with retinoic acid 9 cis improves patient outcome
title_full Post-surgical treatment of thyroid carcinoma in dogs with retinoic acid 9 cis improves patient outcome
title_fullStr Post-surgical treatment of thyroid carcinoma in dogs with retinoic acid 9 cis improves patient outcome
title_full_unstemmed Post-surgical treatment of thyroid carcinoma in dogs with retinoic acid 9 cis improves patient outcome
title_sort Post-surgical treatment of thyroid carcinoma in dogs with retinoic acid 9 cis improves patient outcome
dc.creator.none.fl_str_mv Castillo, Victor Alejandro
Pessina, P.
Blatter, M. F.
Miceli, Diego Daniel
Soler Arias, E.
Vidal, P.
author Castillo, Victor Alejandro
author_facet Castillo, Victor Alejandro
Pessina, P.
Blatter, M. F.
Miceli, Diego Daniel
Soler Arias, E.
Vidal, P.
author_role author
author2 Pessina, P.
Blatter, M. F.
Miceli, Diego Daniel
Soler Arias, E.
Vidal, P.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv THYROID CARCINOMA
RETINOIC ACID
DOGS
POST-SURGICAL TREATMENT
topic THYROID CARCINOMA
RETINOIC ACID
DOGS
POST-SURGICAL TREATMENT
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The objective of the present study was to compare the effects of isotretinoin 9-cis (RA9-cis) as a post-surgery treatmentof thyroid carcinoma to a traditional treatment (doxorubicin) and no treatment. Owners who did not want their dogsto receive treatment were placed into the control group A (GA; n=10). The remaining dogs were randomly placed intoeither group B (GB; n=12) and received doxorubicin at a dose of 30 mg/m2 every three weeks, for six complete cyclesor group C (GC; n=15) and treated with RA9-cis at a dose of 2 mg/kg/day for 6 months. The time of the recurrencewas significantly shorter in the GA and GB compared to GC (P=0.0007; P=0.0015 respectively), while we did notdetect differences between GA and GB. The hazard ratio of recurrence between GA and GB compared to GC were7.25 and 5.60 times shorter, respectively. We did not detect any differences between the other groups. The risk ratioof recurrence was 2.0 times higher in GA compared to GC and 2.1 times higher in GB compared to GC. The typeof carcinoma had an effect on time of survival with follicular carcinomas having an increased mean survival timethan follicular-compact carcinomas (P<0.0001) and follicular-compact carcinomas had a longer mean survival timethan compact carcinomas. The interaction among treatment and type was significant, but survival time in follicularcarcinomas did not differ between treatments. In follicular-compact carcinomas the survival time of GC was greaterthan GB (P<0.05), but we did not detect a difference between GA and GB. In conclusion, this study shows that theuse of surgery in combination with RA9-cis treatment significantly increases survival rate and decreases the timeto tumor recurrence when compared to doxorubicin treated or untreated dogs. The histological type of carcinomainteracted with treatment for time to recurrence and survival time, with more undifferentiated carcinomas having aworse prognosis than differentiated carcinomas.
Fil: Castillo, Victor Alejandro. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Pessina, P.. Universidad de la República; Uruguay
Fil: Blatter, M. F.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Miceli, Diego Daniel. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Soler Arias, E.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Vidal, P.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
description The objective of the present study was to compare the effects of isotretinoin 9-cis (RA9-cis) as a post-surgery treatmentof thyroid carcinoma to a traditional treatment (doxorubicin) and no treatment. Owners who did not want their dogsto receive treatment were placed into the control group A (GA; n=10). The remaining dogs were randomly placed intoeither group B (GB; n=12) and received doxorubicin at a dose of 30 mg/m2 every three weeks, for six complete cyclesor group C (GC; n=15) and treated with RA9-cis at a dose of 2 mg/kg/day for 6 months. The time of the recurrencewas significantly shorter in the GA and GB compared to GC (P=0.0007; P=0.0015 respectively), while we did notdetect differences between GA and GB. The hazard ratio of recurrence between GA and GB compared to GC were7.25 and 5.60 times shorter, respectively. We did not detect any differences between the other groups. The risk ratioof recurrence was 2.0 times higher in GA compared to GC and 2.1 times higher in GB compared to GC. The typeof carcinoma had an effect on time of survival with follicular carcinomas having an increased mean survival timethan follicular-compact carcinomas (P<0.0001) and follicular-compact carcinomas had a longer mean survival timethan compact carcinomas. The interaction among treatment and type was significant, but survival time in follicularcarcinomas did not differ between treatments. In follicular-compact carcinomas the survival time of GC was greaterthan GB (P<0.05), but we did not detect a difference between GA and GB. In conclusion, this study shows that theuse of surgery in combination with RA9-cis treatment significantly increases survival rate and decreases the timeto tumor recurrence when compared to doxorubicin treated or untreated dogs. The histological type of carcinomainteracted with treatment for time to recurrence and survival time, with more undifferentiated carcinomas having aworse prognosis than differentiated carcinomas.
publishDate 2016
dc.date.none.fl_str_mv 2016-01-20
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/23041
Castillo, Victor Alejandro; Pessina, P.; Blatter, M. F.; Miceli, Diego Daniel; Soler Arias, E.; et al.; Post-surgical treatment of thyroid carcinoma in dogs with retinoic acid 9 cis improves patient outcome; University of Tripoli; Open Veterinary Journal; 6; 1; 20-1-2016; 6-14
2226-4485
2218-6050
CONICET Digital
CONICET
url http://hdl.handle.net/11336/23041
identifier_str_mv Castillo, Victor Alejandro; Pessina, P.; Blatter, M. F.; Miceli, Diego Daniel; Soler Arias, E.; et al.; Post-surgical treatment of thyroid carcinoma in dogs with retinoic acid 9 cis improves patient outcome; University of Tripoli; Open Veterinary Journal; 6; 1; 20-1-2016; 6-14
2226-4485
2218-6050
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.openveterinaryjournal.com/volume6no12016.htm
info:eu-repo/semantics/altIdentifier/doi/ 10.4314/ovj.v6i1.2
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744371/
info:eu-repo/semantics/altIdentifier/url/26862515
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv University of Tripoli
publisher.none.fl_str_mv University of Tripoli
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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