Effects of Cecropia pachystachya and Larrea divaricata aqueous extracts in mice

Autores
Bigliani, María Celeste; Grondona, Ezequiel; Zunino, María Paula; Ponce, A. A.
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Our studies were performed to investigate the effects of the aqueous extracts of Cecropia pachystachya and Larrea divaricata. These plants are used in folkloric medicine in infusion and were administered orally (0.76 g/kg) to male Albino Swiss mice for 16 days, on drink intake, organ weight/body weight (OW/BW × 100) ratio, histology, broqueoalveolar fluid (BALF) and elevated plus-maze (EPM). Feeding as well as body weight were unaffected by the consumption of these extracts. There were no signs of toxicity in BALF, morbidity or mortality during the study. C. pachystachya caused an increase in relative kidney OW/BW (p ≤.05 vs control). The macroscopic and microscopic morphologic analyses of the organs were not altered by administration of these plants. A non-anxiolytic-like activity of an aqueous extract prepared from the leaves of C. pachystachya and L. divaricata in EPM was observed. We conclude that the crude aqueous extracts of leaves tested on mice orally did not produce signs of toxicity or behavioral changes in routine histological and clinical evaluation. However, knowledge of the biological activity of many herbal medicine used in Latin American is still deficient and more studies will be needed to elucidate the possible toxic effects.
Fil: Bigliani, María Celeste. Universidad Nacional de la Rioja. Departamento de Cs.de la Salud y Educacion; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Grondona, Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Zunino, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Ponce, A. A.. Universidad Nacional de la Rioja. Departamento de Cs.de la Salud y Educacion; Argentina
Materia
CECROPIA PACHYSTACHYA
LARREA DIVARICATA
MICE
PLANTS
PLUS-MAZE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/85708
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/85708
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network_name_str CONICET Digital (CONICET)
spelling Effects of Cecropia pachystachya and Larrea divaricata aqueous extracts in miceBigliani, María CelesteGrondona, EzequielZunino, María PaulaPonce, A. A.CECROPIA PACHYSTACHYALARREA DIVARICATAMICEPLANTSPLUS-MAZEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Our studies were performed to investigate the effects of the aqueous extracts of Cecropia pachystachya and Larrea divaricata. These plants are used in folkloric medicine in infusion and were administered orally (0.76 g/kg) to male Albino Swiss mice for 16 days, on drink intake, organ weight/body weight (OW/BW × 100) ratio, histology, broqueoalveolar fluid (BALF) and elevated plus-maze (EPM). Feeding as well as body weight were unaffected by the consumption of these extracts. There were no signs of toxicity in BALF, morbidity or mortality during the study. C. pachystachya caused an increase in relative kidney OW/BW (p ≤.05 vs control). The macroscopic and microscopic morphologic analyses of the organs were not altered by administration of these plants. A non-anxiolytic-like activity of an aqueous extract prepared from the leaves of C. pachystachya and L. divaricata in EPM was observed. We conclude that the crude aqueous extracts of leaves tested on mice orally did not produce signs of toxicity or behavioral changes in routine histological and clinical evaluation. However, knowledge of the biological activity of many herbal medicine used in Latin American is still deficient and more studies will be needed to elucidate the possible toxic effects.Fil: Bigliani, María Celeste. Universidad Nacional de la Rioja. Departamento de Cs.de la Salud y Educacion; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Grondona, Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Zunino, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Ponce, A. A.. Universidad Nacional de la Rioja. Departamento de Cs.de la Salud y Educacion; ArgentinaSage Publications Ltd2010-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/85708Bigliani, María Celeste; Grondona, Ezequiel; Zunino, María Paula; Ponce, A. A.; Effects of Cecropia pachystachya and Larrea divaricata aqueous extracts in mice; Sage Publications Ltd; Human and Experimental Toxicoloxy; 29; 7; 7-2010; 601-6060960-32711477-0903CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/20051458info:eu-repo/semantics/altIdentifier/doi/10.1177/0960327109358613info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:59:08Zoai:ri.conicet.gov.ar:11336/85708instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:59:08.825CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effects of Cecropia pachystachya and Larrea divaricata aqueous extracts in mice
title Effects of Cecropia pachystachya and Larrea divaricata aqueous extracts in mice
spellingShingle Effects of Cecropia pachystachya and Larrea divaricata aqueous extracts in mice
Bigliani, María Celeste
CECROPIA PACHYSTACHYA
LARREA DIVARICATA
MICE
PLANTS
PLUS-MAZE
title_short Effects of Cecropia pachystachya and Larrea divaricata aqueous extracts in mice
title_full Effects of Cecropia pachystachya and Larrea divaricata aqueous extracts in mice
title_fullStr Effects of Cecropia pachystachya and Larrea divaricata aqueous extracts in mice
title_full_unstemmed Effects of Cecropia pachystachya and Larrea divaricata aqueous extracts in mice
title_sort Effects of Cecropia pachystachya and Larrea divaricata aqueous extracts in mice
dc.creator.none.fl_str_mv Bigliani, María Celeste
Grondona, Ezequiel
Zunino, María Paula
Ponce, A. A.
author Bigliani, María Celeste
author_facet Bigliani, María Celeste
Grondona, Ezequiel
Zunino, María Paula
Ponce, A. A.
author_role author
author2 Grondona, Ezequiel
Zunino, María Paula
Ponce, A. A.
author2_role author
author
author
dc.subject.none.fl_str_mv CECROPIA PACHYSTACHYA
LARREA DIVARICATA
MICE
PLANTS
PLUS-MAZE
topic CECROPIA PACHYSTACHYA
LARREA DIVARICATA
MICE
PLANTS
PLUS-MAZE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Our studies were performed to investigate the effects of the aqueous extracts of Cecropia pachystachya and Larrea divaricata. These plants are used in folkloric medicine in infusion and were administered orally (0.76 g/kg) to male Albino Swiss mice for 16 days, on drink intake, organ weight/body weight (OW/BW × 100) ratio, histology, broqueoalveolar fluid (BALF) and elevated plus-maze (EPM). Feeding as well as body weight were unaffected by the consumption of these extracts. There were no signs of toxicity in BALF, morbidity or mortality during the study. C. pachystachya caused an increase in relative kidney OW/BW (p ≤.05 vs control). The macroscopic and microscopic morphologic analyses of the organs were not altered by administration of these plants. A non-anxiolytic-like activity of an aqueous extract prepared from the leaves of C. pachystachya and L. divaricata in EPM was observed. We conclude that the crude aqueous extracts of leaves tested on mice orally did not produce signs of toxicity or behavioral changes in routine histological and clinical evaluation. However, knowledge of the biological activity of many herbal medicine used in Latin American is still deficient and more studies will be needed to elucidate the possible toxic effects.
Fil: Bigliani, María Celeste. Universidad Nacional de la Rioja. Departamento de Cs.de la Salud y Educacion; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Grondona, Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Zunino, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Ponce, A. A.. Universidad Nacional de la Rioja. Departamento de Cs.de la Salud y Educacion; Argentina
description Our studies were performed to investigate the effects of the aqueous extracts of Cecropia pachystachya and Larrea divaricata. These plants are used in folkloric medicine in infusion and were administered orally (0.76 g/kg) to male Albino Swiss mice for 16 days, on drink intake, organ weight/body weight (OW/BW × 100) ratio, histology, broqueoalveolar fluid (BALF) and elevated plus-maze (EPM). Feeding as well as body weight were unaffected by the consumption of these extracts. There were no signs of toxicity in BALF, morbidity or mortality during the study. C. pachystachya caused an increase in relative kidney OW/BW (p ≤.05 vs control). The macroscopic and microscopic morphologic analyses of the organs were not altered by administration of these plants. A non-anxiolytic-like activity of an aqueous extract prepared from the leaves of C. pachystachya and L. divaricata in EPM was observed. We conclude that the crude aqueous extracts of leaves tested on mice orally did not produce signs of toxicity or behavioral changes in routine histological and clinical evaluation. However, knowledge of the biological activity of many herbal medicine used in Latin American is still deficient and more studies will be needed to elucidate the possible toxic effects.
publishDate 2010
dc.date.none.fl_str_mv 2010-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/85708
Bigliani, María Celeste; Grondona, Ezequiel; Zunino, María Paula; Ponce, A. A.; Effects of Cecropia pachystachya and Larrea divaricata aqueous extracts in mice; Sage Publications Ltd; Human and Experimental Toxicoloxy; 29; 7; 7-2010; 601-606
0960-3271
1477-0903
CONICET Digital
CONICET
url http://hdl.handle.net/11336/85708
identifier_str_mv Bigliani, María Celeste; Grondona, Ezequiel; Zunino, María Paula; Ponce, A. A.; Effects of Cecropia pachystachya and Larrea divaricata aqueous extracts in mice; Sage Publications Ltd; Human and Experimental Toxicoloxy; 29; 7; 7-2010; 601-606
0960-3271
1477-0903
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/20051458
info:eu-repo/semantics/altIdentifier/doi/10.1177/0960327109358613
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Sage Publications Ltd
publisher.none.fl_str_mv Sage Publications Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.069144

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