Effects of Cecropia pachystachya and Larrea divaricata aqueous extracts in mice
- Autores
- Bigliani, María Celeste; Grondona, Ezequiel; Zunino, María Paula; Ponce, A. A.
- Año de publicación
- 2010
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Our studies were performed to investigate the effects of the aqueous extracts of Cecropia pachystachya and Larrea divaricata. These plants are used in folkloric medicine in infusion and were administered orally (0.76 g/kg) to male Albino Swiss mice for 16 days, on drink intake, organ weight/body weight (OW/BW × 100) ratio, histology, broqueoalveolar fluid (BALF) and elevated plus-maze (EPM). Feeding as well as body weight were unaffected by the consumption of these extracts. There were no signs of toxicity in BALF, morbidity or mortality during the study. C. pachystachya caused an increase in relative kidney OW/BW (p ≤.05 vs control). The macroscopic and microscopic morphologic analyses of the organs were not altered by administration of these plants. A non-anxiolytic-like activity of an aqueous extract prepared from the leaves of C. pachystachya and L. divaricata in EPM was observed. We conclude that the crude aqueous extracts of leaves tested on mice orally did not produce signs of toxicity or behavioral changes in routine histological and clinical evaluation. However, knowledge of the biological activity of many herbal medicine used in Latin American is still deficient and more studies will be needed to elucidate the possible toxic effects.
Fil: Bigliani, María Celeste. Universidad Nacional de la Rioja. Departamento de Cs.de la Salud y Educacion; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Grondona, Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Zunino, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Ponce, A. A.. Universidad Nacional de la Rioja. Departamento de Cs.de la Salud y Educacion; Argentina - Materia
-
CECROPIA PACHYSTACHYA
LARREA DIVARICATA
MICE
PLANTS
PLUS-MAZE - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/85708
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Effects of Cecropia pachystachya and Larrea divaricata aqueous extracts in miceBigliani, María CelesteGrondona, EzequielZunino, María PaulaPonce, A. A.CECROPIA PACHYSTACHYALARREA DIVARICATAMICEPLANTSPLUS-MAZEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Our studies were performed to investigate the effects of the aqueous extracts of Cecropia pachystachya and Larrea divaricata. These plants are used in folkloric medicine in infusion and were administered orally (0.76 g/kg) to male Albino Swiss mice for 16 days, on drink intake, organ weight/body weight (OW/BW × 100) ratio, histology, broqueoalveolar fluid (BALF) and elevated plus-maze (EPM). Feeding as well as body weight were unaffected by the consumption of these extracts. There were no signs of toxicity in BALF, morbidity or mortality during the study. C. pachystachya caused an increase in relative kidney OW/BW (p ≤.05 vs control). The macroscopic and microscopic morphologic analyses of the organs were not altered by administration of these plants. A non-anxiolytic-like activity of an aqueous extract prepared from the leaves of C. pachystachya and L. divaricata in EPM was observed. We conclude that the crude aqueous extracts of leaves tested on mice orally did not produce signs of toxicity or behavioral changes in routine histological and clinical evaluation. However, knowledge of the biological activity of many herbal medicine used in Latin American is still deficient and more studies will be needed to elucidate the possible toxic effects.Fil: Bigliani, María Celeste. Universidad Nacional de la Rioja. Departamento de Cs.de la Salud y Educacion; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Grondona, Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Zunino, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Ponce, A. A.. Universidad Nacional de la Rioja. Departamento de Cs.de la Salud y Educacion; ArgentinaSage Publications Ltd2010-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/85708Bigliani, María Celeste; Grondona, Ezequiel; Zunino, María Paula; Ponce, A. A.; Effects of Cecropia pachystachya and Larrea divaricata aqueous extracts in mice; Sage Publications Ltd; Human and Experimental Toxicoloxy; 29; 7; 7-2010; 601-6060960-32711477-0903CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/20051458info:eu-repo/semantics/altIdentifier/doi/10.1177/0960327109358613info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:55:49Zoai:ri.conicet.gov.ar:11336/85708instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:55:50.024CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Effects of Cecropia pachystachya and Larrea divaricata aqueous extracts in mice |
title |
Effects of Cecropia pachystachya and Larrea divaricata aqueous extracts in mice |
spellingShingle |
Effects of Cecropia pachystachya and Larrea divaricata aqueous extracts in mice Bigliani, María Celeste CECROPIA PACHYSTACHYA LARREA DIVARICATA MICE PLANTS PLUS-MAZE |
title_short |
Effects of Cecropia pachystachya and Larrea divaricata aqueous extracts in mice |
title_full |
Effects of Cecropia pachystachya and Larrea divaricata aqueous extracts in mice |
title_fullStr |
Effects of Cecropia pachystachya and Larrea divaricata aqueous extracts in mice |
title_full_unstemmed |
Effects of Cecropia pachystachya and Larrea divaricata aqueous extracts in mice |
title_sort |
Effects of Cecropia pachystachya and Larrea divaricata aqueous extracts in mice |
dc.creator.none.fl_str_mv |
Bigliani, María Celeste Grondona, Ezequiel Zunino, María Paula Ponce, A. A. |
author |
Bigliani, María Celeste |
author_facet |
Bigliani, María Celeste Grondona, Ezequiel Zunino, María Paula Ponce, A. A. |
author_role |
author |
author2 |
Grondona, Ezequiel Zunino, María Paula Ponce, A. A. |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
CECROPIA PACHYSTACHYA LARREA DIVARICATA MICE PLANTS PLUS-MAZE |
topic |
CECROPIA PACHYSTACHYA LARREA DIVARICATA MICE PLANTS PLUS-MAZE |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Our studies were performed to investigate the effects of the aqueous extracts of Cecropia pachystachya and Larrea divaricata. These plants are used in folkloric medicine in infusion and were administered orally (0.76 g/kg) to male Albino Swiss mice for 16 days, on drink intake, organ weight/body weight (OW/BW × 100) ratio, histology, broqueoalveolar fluid (BALF) and elevated plus-maze (EPM). Feeding as well as body weight were unaffected by the consumption of these extracts. There were no signs of toxicity in BALF, morbidity or mortality during the study. C. pachystachya caused an increase in relative kidney OW/BW (p ≤.05 vs control). The macroscopic and microscopic morphologic analyses of the organs were not altered by administration of these plants. A non-anxiolytic-like activity of an aqueous extract prepared from the leaves of C. pachystachya and L. divaricata in EPM was observed. We conclude that the crude aqueous extracts of leaves tested on mice orally did not produce signs of toxicity or behavioral changes in routine histological and clinical evaluation. However, knowledge of the biological activity of many herbal medicine used in Latin American is still deficient and more studies will be needed to elucidate the possible toxic effects. Fil: Bigliani, María Celeste. Universidad Nacional de la Rioja. Departamento de Cs.de la Salud y Educacion; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Grondona, Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina Fil: Zunino, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina Fil: Ponce, A. A.. Universidad Nacional de la Rioja. Departamento de Cs.de la Salud y Educacion; Argentina |
description |
Our studies were performed to investigate the effects of the aqueous extracts of Cecropia pachystachya and Larrea divaricata. These plants are used in folkloric medicine in infusion and were administered orally (0.76 g/kg) to male Albino Swiss mice for 16 days, on drink intake, organ weight/body weight (OW/BW × 100) ratio, histology, broqueoalveolar fluid (BALF) and elevated plus-maze (EPM). Feeding as well as body weight were unaffected by the consumption of these extracts. There were no signs of toxicity in BALF, morbidity or mortality during the study. C. pachystachya caused an increase in relative kidney OW/BW (p ≤.05 vs control). The macroscopic and microscopic morphologic analyses of the organs were not altered by administration of these plants. A non-anxiolytic-like activity of an aqueous extract prepared from the leaves of C. pachystachya and L. divaricata in EPM was observed. We conclude that the crude aqueous extracts of leaves tested on mice orally did not produce signs of toxicity or behavioral changes in routine histological and clinical evaluation. However, knowledge of the biological activity of many herbal medicine used in Latin American is still deficient and more studies will be needed to elucidate the possible toxic effects. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/85708 Bigliani, María Celeste; Grondona, Ezequiel; Zunino, María Paula; Ponce, A. A.; Effects of Cecropia pachystachya and Larrea divaricata aqueous extracts in mice; Sage Publications Ltd; Human and Experimental Toxicoloxy; 29; 7; 7-2010; 601-606 0960-3271 1477-0903 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/85708 |
identifier_str_mv |
Bigliani, María Celeste; Grondona, Ezequiel; Zunino, María Paula; Ponce, A. A.; Effects of Cecropia pachystachya and Larrea divaricata aqueous extracts in mice; Sage Publications Ltd; Human and Experimental Toxicoloxy; 29; 7; 7-2010; 601-606 0960-3271 1477-0903 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/20051458 info:eu-repo/semantics/altIdentifier/doi/10.1177/0960327109358613 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Sage Publications Ltd |
publisher.none.fl_str_mv |
Sage Publications Ltd |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842269368714526720 |
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13.13397 |