Retrieval induces reconsolidation of fear extinction memory

Autores
Rossato, Janine I.; Bevilaqua, Lia R.; Izquierdo, Iván; Medina, Jorge Horacio; Cammarota, Martin Pablo
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The nonreinforced expression of long-tem memory may lead to two opposite protein synthesis-dependent processes: extinction and reconsolidation. Extinction weakens consolidated memories, whereas reconsolidation allows incorporation of additional information into them. Knowledge about these two processes has accumulated in recent years, but their possible interaction has not been evaluated yet. Here, we report that inhibition of protein synthesis in the CA1 region of the dorsal hippocampus after retrieval of fear extinction impedes subsequent reactivation of the extinction memory trace without affecting its storage or that of the initial fear memory. Our results suggest that extinction memory is susceptible to a retrieval-induced process similar to reconsolidation in the hippocampus.
Fil: Rossato, Janine I.. Pontificia Universidade Católica do Rio Grande do Sul; Brasil. Conselho Nacional de Desenvolvimiento Científico y Tecnológico; Brasil
Fil: Bevilaqua, Lia R.. Conselho Nacional de Desenvolvimiento Científico y Tecnológico; Brasil. Pontificia Universidade Católica do Rio Grande do Sul; Brasil
Fil: Izquierdo, Iván. Conselho Nacional de Desenvolvimiento Científico y Tecnológico; Brasil. Pontificia Universidade Católica do Rio Grande do Sul; Brasil
Fil: Medina, Jorge Horacio. Pontificia Universidade Católica do Rio Grande do Sul; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Cammarota, Martin Pablo. Pontificia Universidade Católica do Rio Grande do Sul; Brasil. Conselho Nacional de Desenvolvimiento Científico y Tecnológico; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Materia
AMNESIA
ANISOMYCIN
LEARNING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/91547
Acceder
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spelling Retrieval induces reconsolidation of fear extinction memoryRossato, Janine I.Bevilaqua, Lia R.Izquierdo, IvánMedina, Jorge HoracioCammarota, Martin PabloAMNESIAANISOMYCINLEARNINGhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The nonreinforced expression of long-tem memory may lead to two opposite protein synthesis-dependent processes: extinction and reconsolidation. Extinction weakens consolidated memories, whereas reconsolidation allows incorporation of additional information into them. Knowledge about these two processes has accumulated in recent years, but their possible interaction has not been evaluated yet. Here, we report that inhibition of protein synthesis in the CA1 region of the dorsal hippocampus after retrieval of fear extinction impedes subsequent reactivation of the extinction memory trace without affecting its storage or that of the initial fear memory. Our results suggest that extinction memory is susceptible to a retrieval-induced process similar to reconsolidation in the hippocampus.Fil: Rossato, Janine I.. Pontificia Universidade Católica do Rio Grande do Sul; Brasil. Conselho Nacional de Desenvolvimiento Científico y Tecnológico; BrasilFil: Bevilaqua, Lia R.. Conselho Nacional de Desenvolvimiento Científico y Tecnológico; Brasil. Pontificia Universidade Católica do Rio Grande do Sul; BrasilFil: Izquierdo, Iván. Conselho Nacional de Desenvolvimiento Científico y Tecnológico; Brasil. Pontificia Universidade Católica do Rio Grande do Sul; BrasilFil: Medina, Jorge Horacio. Pontificia Universidade Católica do Rio Grande do Sul; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; ArgentinaFil: Cammarota, Martin Pablo. Pontificia Universidade Católica do Rio Grande do Sul; Brasil. Conselho Nacional de Desenvolvimiento Científico y Tecnológico; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; ArgentinaNational Academy of Sciences2010-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/91547Rossato, Janine I.; Bevilaqua, Lia R.; Izquierdo, Iván; Medina, Jorge Horacio; Cammarota, Martin Pablo; Retrieval induces reconsolidation of fear extinction memory; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 107; 50; 12-2010; 21801-218050027-8424CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.pnas.org/content/107/50/21801info:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.1016254107info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:24:42Zoai:ri.conicet.gov.ar:11336/91547instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:24:43.187CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Retrieval induces reconsolidation of fear extinction memory
title Retrieval induces reconsolidation of fear extinction memory
spellingShingle Retrieval induces reconsolidation of fear extinction memory
Rossato, Janine I.
AMNESIA
ANISOMYCIN
LEARNING
title_short Retrieval induces reconsolidation of fear extinction memory
title_full Retrieval induces reconsolidation of fear extinction memory
title_fullStr Retrieval induces reconsolidation of fear extinction memory
title_full_unstemmed Retrieval induces reconsolidation of fear extinction memory
title_sort Retrieval induces reconsolidation of fear extinction memory
dc.creator.none.fl_str_mv Rossato, Janine I.
Bevilaqua, Lia R.
Izquierdo, Iván
Medina, Jorge Horacio
Cammarota, Martin Pablo
author Rossato, Janine I.
author_facet Rossato, Janine I.
Bevilaqua, Lia R.
Izquierdo, Iván
Medina, Jorge Horacio
Cammarota, Martin Pablo
author_role author
author2 Bevilaqua, Lia R.
Izquierdo, Iván
Medina, Jorge Horacio
Cammarota, Martin Pablo
author2_role author
author
author
author
dc.subject.none.fl_str_mv AMNESIA
ANISOMYCIN
LEARNING
topic AMNESIA
ANISOMYCIN
LEARNING
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The nonreinforced expression of long-tem memory may lead to two opposite protein synthesis-dependent processes: extinction and reconsolidation. Extinction weakens consolidated memories, whereas reconsolidation allows incorporation of additional information into them. Knowledge about these two processes has accumulated in recent years, but their possible interaction has not been evaluated yet. Here, we report that inhibition of protein synthesis in the CA1 region of the dorsal hippocampus after retrieval of fear extinction impedes subsequent reactivation of the extinction memory trace without affecting its storage or that of the initial fear memory. Our results suggest that extinction memory is susceptible to a retrieval-induced process similar to reconsolidation in the hippocampus.
Fil: Rossato, Janine I.. Pontificia Universidade Católica do Rio Grande do Sul; Brasil. Conselho Nacional de Desenvolvimiento Científico y Tecnológico; Brasil
Fil: Bevilaqua, Lia R.. Conselho Nacional de Desenvolvimiento Científico y Tecnológico; Brasil. Pontificia Universidade Católica do Rio Grande do Sul; Brasil
Fil: Izquierdo, Iván. Conselho Nacional de Desenvolvimiento Científico y Tecnológico; Brasil. Pontificia Universidade Católica do Rio Grande do Sul; Brasil
Fil: Medina, Jorge Horacio. Pontificia Universidade Católica do Rio Grande do Sul; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Cammarota, Martin Pablo. Pontificia Universidade Católica do Rio Grande do Sul; Brasil. Conselho Nacional de Desenvolvimiento Científico y Tecnológico; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
description The nonreinforced expression of long-tem memory may lead to two opposite protein synthesis-dependent processes: extinction and reconsolidation. Extinction weakens consolidated memories, whereas reconsolidation allows incorporation of additional information into them. Knowledge about these two processes has accumulated in recent years, but their possible interaction has not been evaluated yet. Here, we report that inhibition of protein synthesis in the CA1 region of the dorsal hippocampus after retrieval of fear extinction impedes subsequent reactivation of the extinction memory trace without affecting its storage or that of the initial fear memory. Our results suggest that extinction memory is susceptible to a retrieval-induced process similar to reconsolidation in the hippocampus.
publishDate 2010
dc.date.none.fl_str_mv 2010-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/91547
Rossato, Janine I.; Bevilaqua, Lia R.; Izquierdo, Iván; Medina, Jorge Horacio; Cammarota, Martin Pablo; Retrieval induces reconsolidation of fear extinction memory; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 107; 50; 12-2010; 21801-21805
0027-8424
CONICET Digital
CONICET
url http://hdl.handle.net/11336/91547
identifier_str_mv Rossato, Janine I.; Bevilaqua, Lia R.; Izquierdo, Iván; Medina, Jorge Horacio; Cammarota, Martin Pablo; Retrieval induces reconsolidation of fear extinction memory; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 107; 50; 12-2010; 21801-21805
0027-8424
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.pnas.org/content/107/50/21801
info:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.1016254107
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv National Academy of Sciences
publisher.none.fl_str_mv National Academy of Sciences
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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