Diabetes mellitus remission in three cats with hypersomatotropism after cabergoline treatment

Autores
Miceli, Diego Daniel; Vidal, Patricia Noemi; Pompili, Gustavo A; Castillo, Víctor A; Soler Arias, Elber A; Niessen, Stijn JM
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Three diabetic cats presented with polyuria, polydipsia, polyphagia and poor glycemic control. Cat 1 displayed prognathia inferior and had a body condition score (BCS) of 4/5; cat 2 had a BCS of 5/5; and cat 3 had broad facial features. Serum insulin-like growth factor 1 concentrations were compatible with hypersomatotropism in cat 1 and cat 2 (>1500 ng/ml and 1200 ng/ml, respectively) and just below the cut-off of 1000 ng/ml (947 ng/ml) in cat 3; in this last cat diagnosis was further supported by the presence of pituitary enlargement on MRI. Oral cabergoline (10 μg/kg q48h) was initiated. Insulin requirements progressively reduced, as evidenced by daily blood glucose monitoring and weekly blood glucose curves. Diabetic remission occurred in all three cats between the second and third months of cabergoline treatment. At the time of writing, remission has persisted thus far (cat 1: 23 months; cat 2: 14 months; cat 3: 38 months). Relevance and novel information: To our knowledge, these are the first reported cases of diabetic remission in cats with hypersomatotropism after cabergoline treatment, despite previous reports of this being an ineffective treatment. Further work is indicated to determine why some cats do, and others do not, respond to this treatment.
Fil: Miceli, Diego Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires; Argentina
Fil: Vidal, Patricia Noemi. Universidad de Buenos Aires; Argentina
Fil: Pompili, Gustavo A. Universidad de Buenos Aires; Argentina
Fil: Castillo, Víctor A. Universidad de Buenos Aires; Argentina
Fil: Soler Arias, Elber A. Universidad de Buenos Aires; Argentina
Fil: Niessen, Stijn JM. Royal Veterinary College University ; Reino Unido
Materia
ACROMEGALY
CABERGOLINE
DIABETES MELLITUS REMISSION
HYPERSOMATOTROPISM
INSULIN RESISTANCE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/140168
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/140168
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Diabetes mellitus remission in three cats with hypersomatotropism after cabergoline treatmentMiceli, Diego DanielVidal, Patricia NoemiPompili, Gustavo ACastillo, Víctor ASoler Arias, Elber ANiessen, Stijn JMACROMEGALYCABERGOLINEDIABETES MELLITUS REMISSIONHYPERSOMATOTROPISMINSULIN RESISTANCEhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Three diabetic cats presented with polyuria, polydipsia, polyphagia and poor glycemic control. Cat 1 displayed prognathia inferior and had a body condition score (BCS) of 4/5; cat 2 had a BCS of 5/5; and cat 3 had broad facial features. Serum insulin-like growth factor 1 concentrations were compatible with hypersomatotropism in cat 1 and cat 2 (>1500 ng/ml and 1200 ng/ml, respectively) and just below the cut-off of 1000 ng/ml (947 ng/ml) in cat 3; in this last cat diagnosis was further supported by the presence of pituitary enlargement on MRI. Oral cabergoline (10 μg/kg q48h) was initiated. Insulin requirements progressively reduced, as evidenced by daily blood glucose monitoring and weekly blood glucose curves. Diabetic remission occurred in all three cats between the second and third months of cabergoline treatment. At the time of writing, remission has persisted thus far (cat 1: 23 months; cat 2: 14 months; cat 3: 38 months). Relevance and novel information: To our knowledge, these are the first reported cases of diabetic remission in cats with hypersomatotropism after cabergoline treatment, despite previous reports of this being an ineffective treatment. Further work is indicated to determine why some cats do, and others do not, respond to this treatment.Fil: Miceli, Diego Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires; ArgentinaFil: Vidal, Patricia Noemi. Universidad de Buenos Aires; ArgentinaFil: Pompili, Gustavo A. Universidad de Buenos Aires; ArgentinaFil: Castillo, Víctor A. Universidad de Buenos Aires; ArgentinaFil: Soler Arias, Elber A. Universidad de Buenos Aires; ArgentinaFil: Niessen, Stijn JM. Royal Veterinary College University ; Reino UnidoSAGE Publications Ltd2021-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/140168Miceli, Diego Daniel; Vidal, Patricia Noemi; Pompili, Gustavo A; Castillo, Víctor A; Soler Arias, Elber A; et al.; Diabetes mellitus remission in three cats with hypersomatotropism after cabergoline treatment; SAGE Publications Ltd; Journal of Feline Medicine and Surgery Open Reports; 7; 1; 6-2021; 1-62055-1169CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186120/info:eu-repo/semantics/altIdentifier/doi/10.1177/20551169211018991info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:47:38Zoai:ri.conicet.gov.ar:11336/140168instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:47:40.062CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Diabetes mellitus remission in three cats with hypersomatotropism after cabergoline treatment
title Diabetes mellitus remission in three cats with hypersomatotropism after cabergoline treatment
spellingShingle Diabetes mellitus remission in three cats with hypersomatotropism after cabergoline treatment
Miceli, Diego Daniel
ACROMEGALY
CABERGOLINE
DIABETES MELLITUS REMISSION
HYPERSOMATOTROPISM
INSULIN RESISTANCE
title_short Diabetes mellitus remission in three cats with hypersomatotropism after cabergoline treatment
title_full Diabetes mellitus remission in three cats with hypersomatotropism after cabergoline treatment
title_fullStr Diabetes mellitus remission in three cats with hypersomatotropism after cabergoline treatment
title_full_unstemmed Diabetes mellitus remission in three cats with hypersomatotropism after cabergoline treatment
title_sort Diabetes mellitus remission in three cats with hypersomatotropism after cabergoline treatment
dc.creator.none.fl_str_mv Miceli, Diego Daniel
Vidal, Patricia Noemi
Pompili, Gustavo A
Castillo, Víctor A
Soler Arias, Elber A
Niessen, Stijn JM
author Miceli, Diego Daniel
author_facet Miceli, Diego Daniel
Vidal, Patricia Noemi
Pompili, Gustavo A
Castillo, Víctor A
Soler Arias, Elber A
Niessen, Stijn JM
author_role author
author2 Vidal, Patricia Noemi
Pompili, Gustavo A
Castillo, Víctor A
Soler Arias, Elber A
Niessen, Stijn JM
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ACROMEGALY
CABERGOLINE
DIABETES MELLITUS REMISSION
HYPERSOMATOTROPISM
INSULIN RESISTANCE
topic ACROMEGALY
CABERGOLINE
DIABETES MELLITUS REMISSION
HYPERSOMATOTROPISM
INSULIN RESISTANCE
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Three diabetic cats presented with polyuria, polydipsia, polyphagia and poor glycemic control. Cat 1 displayed prognathia inferior and had a body condition score (BCS) of 4/5; cat 2 had a BCS of 5/5; and cat 3 had broad facial features. Serum insulin-like growth factor 1 concentrations were compatible with hypersomatotropism in cat 1 and cat 2 (>1500 ng/ml and 1200 ng/ml, respectively) and just below the cut-off of 1000 ng/ml (947 ng/ml) in cat 3; in this last cat diagnosis was further supported by the presence of pituitary enlargement on MRI. Oral cabergoline (10 μg/kg q48h) was initiated. Insulin requirements progressively reduced, as evidenced by daily blood glucose monitoring and weekly blood glucose curves. Diabetic remission occurred in all three cats between the second and third months of cabergoline treatment. At the time of writing, remission has persisted thus far (cat 1: 23 months; cat 2: 14 months; cat 3: 38 months). Relevance and novel information: To our knowledge, these are the first reported cases of diabetic remission in cats with hypersomatotropism after cabergoline treatment, despite previous reports of this being an ineffective treatment. Further work is indicated to determine why some cats do, and others do not, respond to this treatment.
Fil: Miceli, Diego Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires; Argentina
Fil: Vidal, Patricia Noemi. Universidad de Buenos Aires; Argentina
Fil: Pompili, Gustavo A. Universidad de Buenos Aires; Argentina
Fil: Castillo, Víctor A. Universidad de Buenos Aires; Argentina
Fil: Soler Arias, Elber A. Universidad de Buenos Aires; Argentina
Fil: Niessen, Stijn JM. Royal Veterinary College University ; Reino Unido
description Three diabetic cats presented with polyuria, polydipsia, polyphagia and poor glycemic control. Cat 1 displayed prognathia inferior and had a body condition score (BCS) of 4/5; cat 2 had a BCS of 5/5; and cat 3 had broad facial features. Serum insulin-like growth factor 1 concentrations were compatible with hypersomatotropism in cat 1 and cat 2 (>1500 ng/ml and 1200 ng/ml, respectively) and just below the cut-off of 1000 ng/ml (947 ng/ml) in cat 3; in this last cat diagnosis was further supported by the presence of pituitary enlargement on MRI. Oral cabergoline (10 μg/kg q48h) was initiated. Insulin requirements progressively reduced, as evidenced by daily blood glucose monitoring and weekly blood glucose curves. Diabetic remission occurred in all three cats between the second and third months of cabergoline treatment. At the time of writing, remission has persisted thus far (cat 1: 23 months; cat 2: 14 months; cat 3: 38 months). Relevance and novel information: To our knowledge, these are the first reported cases of diabetic remission in cats with hypersomatotropism after cabergoline treatment, despite previous reports of this being an ineffective treatment. Further work is indicated to determine why some cats do, and others do not, respond to this treatment.
publishDate 2021
dc.date.none.fl_str_mv 2021-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/140168
Miceli, Diego Daniel; Vidal, Patricia Noemi; Pompili, Gustavo A; Castillo, Víctor A; Soler Arias, Elber A; et al.; Diabetes mellitus remission in three cats with hypersomatotropism after cabergoline treatment; SAGE Publications Ltd; Journal of Feline Medicine and Surgery Open Reports; 7; 1; 6-2021; 1-6
2055-1169
CONICET Digital
CONICET
url http://hdl.handle.net/11336/140168
identifier_str_mv Miceli, Diego Daniel; Vidal, Patricia Noemi; Pompili, Gustavo A; Castillo, Víctor A; Soler Arias, Elber A; et al.; Diabetes mellitus remission in three cats with hypersomatotropism after cabergoline treatment; SAGE Publications Ltd; Journal of Feline Medicine and Surgery Open Reports; 7; 1; 6-2021; 1-6
2055-1169
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186120/
info:eu-repo/semantics/altIdentifier/doi/10.1177/20551169211018991
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv SAGE Publications Ltd
publisher.none.fl_str_mv SAGE Publications Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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