Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?"

Autores
Jiang, Peng; Ventura, Alejandra; Sontag, Eduardo D.; Merajver, Sofia D.; Ninfa, Alexander J.; Del Vecchio, Domitilla
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Straube suggests that a model that reflects the bifunctional nature of the cycle enzyme uridylyltransferase/uridylyl-removing enzyme (UTase/UR) should be used, in which the UT and UR activities are distinct and reciprocally regulated activity states of the enzyme, and notes that if such a model is used, the effects of retroactivity at intermediate stimulation will be different. However, such a model does not accurately match the observed enzyme regulatory properties and fails to predict the ultrasensitive response obtained in the experiments. Here, we argue that modeling the UTase/UR enzyme as a bifunctional enzyme with reciprocally regulated activity states misses important aspects of the system.
Fil: Jiang, Peng. University of Michigan; Estados Unidos
Fil: Ventura, Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Fisiología de Insectos; Argentina
Fil: Sontag, Eduardo D.. Rutgers University; Estados Unidos
Fil: Merajver, Sofia D.. University of Michigan; Estados Unidos
Fil: Ninfa, Alexander J.. University of Michigan; Estados Unidos
Fil: Del Vecchio, Domitilla. Massachusetts Institute of Technology; Estados Unidos
Materia
Retroactivity
Cell signaling
Theoretical biology
Bifunctionality
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/85640
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?"Jiang, PengVentura, AlejandraSontag, Eduardo D.Merajver, Sofia D.Ninfa, Alexander J.Del Vecchio, DomitillaRetroactivityCell signalingTheoretical biologyBifunctionalityhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Straube suggests that a model that reflects the bifunctional nature of the cycle enzyme uridylyltransferase/uridylyl-removing enzyme (UTase/UR) should be used, in which the UT and UR activities are distinct and reciprocally regulated activity states of the enzyme, and notes that if such a model is used, the effects of retroactivity at intermediate stimulation will be different. However, such a model does not accurately match the observed enzyme regulatory properties and fails to predict the ultrasensitive response obtained in the experiments. Here, we argue that modeling the UTase/UR enzyme as a bifunctional enzyme with reciprocally regulated activity states misses important aspects of the system.Fil: Jiang, Peng. University of Michigan; Estados UnidosFil: Ventura, Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Fisiología de Insectos; ArgentinaFil: Sontag, Eduardo D.. Rutgers University; Estados UnidosFil: Merajver, Sofia D.. University of Michigan; Estados UnidosFil: Ninfa, Alexander J.. University of Michigan; Estados UnidosFil: Del Vecchio, Domitilla. Massachusetts Institute of Technology; Estados UnidosAmerican Association for Cancer Research2012-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/85640Jiang, Peng; Ventura, Alejandra; Sontag, Eduardo D.; Merajver, Sofia D.; Ninfa, Alexander J.; et al.; Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?"; American Association for Cancer Research; Science Signaling; 5; 205; 1-2012; 1-21937-9145CONICET DigitalCONICETenginfo:eu-repo/semantics/reference/url/https://stke.sciencemag.org/content/4/194/ra67.abstractinfo:eu-repo/semantics/reference/doi/https://doi.org/10.1126/scisignal.2002152info:eu-repo/semantics/altIdentifier/doi/10.1126/scisignal.2002716info:eu-repo/semantics/altIdentifier/url/https://stke.sciencemag.org/content/5/205/lc2info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:58:01Zoai:ri.conicet.gov.ar:11336/85640instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:58:02.064CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?"
title Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?"
spellingShingle Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?"
Jiang, Peng
Retroactivity
Cell signaling
Theoretical biology
Bifunctionality
title_short Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?"
title_full Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?"
title_fullStr Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?"
title_full_unstemmed Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?"
title_sort Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?"
dc.creator.none.fl_str_mv Jiang, Peng
Ventura, Alejandra
Sontag, Eduardo D.
Merajver, Sofia D.
Ninfa, Alexander J.
Del Vecchio, Domitilla
author Jiang, Peng
author_facet Jiang, Peng
Ventura, Alejandra
Sontag, Eduardo D.
Merajver, Sofia D.
Ninfa, Alexander J.
Del Vecchio, Domitilla
author_role author
author2 Ventura, Alejandra
Sontag, Eduardo D.
Merajver, Sofia D.
Ninfa, Alexander J.
Del Vecchio, Domitilla
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Retroactivity
Cell signaling
Theoretical biology
Bifunctionality
topic Retroactivity
Cell signaling
Theoretical biology
Bifunctionality
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Straube suggests that a model that reflects the bifunctional nature of the cycle enzyme uridylyltransferase/uridylyl-removing enzyme (UTase/UR) should be used, in which the UT and UR activities are distinct and reciprocally regulated activity states of the enzyme, and notes that if such a model is used, the effects of retroactivity at intermediate stimulation will be different. However, such a model does not accurately match the observed enzyme regulatory properties and fails to predict the ultrasensitive response obtained in the experiments. Here, we argue that modeling the UTase/UR enzyme as a bifunctional enzyme with reciprocally regulated activity states misses important aspects of the system.
Fil: Jiang, Peng. University of Michigan; Estados Unidos
Fil: Ventura, Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Fisiología de Insectos; Argentina
Fil: Sontag, Eduardo D.. Rutgers University; Estados Unidos
Fil: Merajver, Sofia D.. University of Michigan; Estados Unidos
Fil: Ninfa, Alexander J.. University of Michigan; Estados Unidos
Fil: Del Vecchio, Domitilla. Massachusetts Institute of Technology; Estados Unidos
description Straube suggests that a model that reflects the bifunctional nature of the cycle enzyme uridylyltransferase/uridylyl-removing enzyme (UTase/UR) should be used, in which the UT and UR activities are distinct and reciprocally regulated activity states of the enzyme, and notes that if such a model is used, the effects of retroactivity at intermediate stimulation will be different. However, such a model does not accurately match the observed enzyme regulatory properties and fails to predict the ultrasensitive response obtained in the experiments. Here, we argue that modeling the UTase/UR enzyme as a bifunctional enzyme with reciprocally regulated activity states misses important aspects of the system.
publishDate 2012
dc.date.none.fl_str_mv 2012-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/85640
Jiang, Peng; Ventura, Alejandra; Sontag, Eduardo D.; Merajver, Sofia D.; Ninfa, Alexander J.; et al.; Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?"; American Association for Cancer Research; Science Signaling; 5; 205; 1-2012; 1-2
1937-9145
CONICET Digital
CONICET
url http://hdl.handle.net/11336/85640
identifier_str_mv Jiang, Peng; Ventura, Alejandra; Sontag, Eduardo D.; Merajver, Sofia D.; Ninfa, Alexander J.; et al.; Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?"; American Association for Cancer Research; Science Signaling; 5; 205; 1-2012; 1-2
1937-9145
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/reference/url/https://stke.sciencemag.org/content/4/194/ra67.abstract
info:eu-repo/semantics/reference/doi/https://doi.org/10.1126/scisignal.2002152
info:eu-repo/semantics/altIdentifier/doi/10.1126/scisignal.2002716
info:eu-repo/semantics/altIdentifier/url/https://stke.sciencemag.org/content/5/205/lc2
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Association for Cancer Research
publisher.none.fl_str_mv American Association for Cancer Research
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613732166008832
score 13.070432

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