Discovery of β-glucosidase inhibitors from a chemically engineered extract prepared through ethanolysis

Autores
Ramallo, Ivana Ayelen; González Sierra, Manuel; Furlan, Ricardo Luis Eugenio
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A series of vegetal extracts have been chemically altered by ethanolysis. The effect of the reaction on the inhibition of the enzyme β-glucosidase properties of the mixtures was studied using thin layer chromatography (TLC) with biodetection. Glucosidase inhibitory activity guided fractionation of one of the produced chemically engineered extracts led to the isolation of apigenin and ethyl p-cumarate. Both compounds were generated during the chemical modification step.
Fil: Ramallo, Ivana Ayelen. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: González Sierra, Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Furlan, Ricardo Luis Eugenio. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Materia
Β-GLUCOSIDASE INHIBITION
CHEMICALLY ENGINEERED EXTRACTS
ETHANOLYSIS
TLC BIODETECTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/196384
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Discovery of β-glucosidase inhibitors from a chemically engineered extract prepared through ethanolysisRamallo, Ivana AyelenGonzález Sierra, ManuelFurlan, Ricardo Luis EugenioΒ-GLUCOSIDASE INHIBITIONCHEMICALLY ENGINEERED EXTRACTSETHANOLYSISTLC BIODETECTIONhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1A series of vegetal extracts have been chemically altered by ethanolysis. The effect of the reaction on the inhibition of the enzyme β-glucosidase properties of the mixtures was studied using thin layer chromatography (TLC) with biodetection. Glucosidase inhibitory activity guided fractionation of one of the produced chemically engineered extracts led to the isolation of apigenin and ethyl p-cumarate. Both compounds were generated during the chemical modification step.Fil: Ramallo, Ivana Ayelen. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: González Sierra, Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Furlan, Ricardo Luis Eugenio. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaBentham Science Publishers2012-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/196384Ramallo, Ivana Ayelen; González Sierra, Manuel ; Furlan, Ricardo Luis Eugenio; Discovery of β-glucosidase inhibitors from a chemically engineered extract prepared through ethanolysis; Bentham Science Publishers; Medicinal Chemistry; 8; 1; 1-2012; 112-1171573-4064CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://benthamscience.com/article/34526info:eu-repo/semantics/altIdentifier/doi/10.2174/157340612799278559info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:01:39Zoai:ri.conicet.gov.ar:11336/196384instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:01:39.759CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Discovery of β-glucosidase inhibitors from a chemically engineered extract prepared through ethanolysis
title Discovery of β-glucosidase inhibitors from a chemically engineered extract prepared through ethanolysis
spellingShingle Discovery of β-glucosidase inhibitors from a chemically engineered extract prepared through ethanolysis
Ramallo, Ivana Ayelen
Β-GLUCOSIDASE INHIBITION
CHEMICALLY ENGINEERED EXTRACTS
ETHANOLYSIS
TLC BIODETECTION
title_short Discovery of β-glucosidase inhibitors from a chemically engineered extract prepared through ethanolysis
title_full Discovery of β-glucosidase inhibitors from a chemically engineered extract prepared through ethanolysis
title_fullStr Discovery of β-glucosidase inhibitors from a chemically engineered extract prepared through ethanolysis
title_full_unstemmed Discovery of β-glucosidase inhibitors from a chemically engineered extract prepared through ethanolysis
title_sort Discovery of β-glucosidase inhibitors from a chemically engineered extract prepared through ethanolysis
dc.creator.none.fl_str_mv Ramallo, Ivana Ayelen
González Sierra, Manuel
Furlan, Ricardo Luis Eugenio
author Ramallo, Ivana Ayelen
author_facet Ramallo, Ivana Ayelen
González Sierra, Manuel
Furlan, Ricardo Luis Eugenio
author_role author
author2 González Sierra, Manuel
Furlan, Ricardo Luis Eugenio
author2_role author
author
dc.subject.none.fl_str_mv Β-GLUCOSIDASE INHIBITION
CHEMICALLY ENGINEERED EXTRACTS
ETHANOLYSIS
TLC BIODETECTION
topic Β-GLUCOSIDASE INHIBITION
CHEMICALLY ENGINEERED EXTRACTS
ETHANOLYSIS
TLC BIODETECTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A series of vegetal extracts have been chemically altered by ethanolysis. The effect of the reaction on the inhibition of the enzyme β-glucosidase properties of the mixtures was studied using thin layer chromatography (TLC) with biodetection. Glucosidase inhibitory activity guided fractionation of one of the produced chemically engineered extracts led to the isolation of apigenin and ethyl p-cumarate. Both compounds were generated during the chemical modification step.
Fil: Ramallo, Ivana Ayelen. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: González Sierra, Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Furlan, Ricardo Luis Eugenio. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
description A series of vegetal extracts have been chemically altered by ethanolysis. The effect of the reaction on the inhibition of the enzyme β-glucosidase properties of the mixtures was studied using thin layer chromatography (TLC) with biodetection. Glucosidase inhibitory activity guided fractionation of one of the produced chemically engineered extracts led to the isolation of apigenin and ethyl p-cumarate. Both compounds were generated during the chemical modification step.
publishDate 2012
dc.date.none.fl_str_mv 2012-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/196384
Ramallo, Ivana Ayelen; González Sierra, Manuel ; Furlan, Ricardo Luis Eugenio; Discovery of β-glucosidase inhibitors from a chemically engineered extract prepared through ethanolysis; Bentham Science Publishers; Medicinal Chemistry; 8; 1; 1-2012; 112-117
1573-4064
CONICET Digital
CONICET
url http://hdl.handle.net/11336/196384
identifier_str_mv Ramallo, Ivana Ayelen; González Sierra, Manuel ; Furlan, Ricardo Luis Eugenio; Discovery of β-glucosidase inhibitors from a chemically engineered extract prepared through ethanolysis; Bentham Science Publishers; Medicinal Chemistry; 8; 1; 1-2012; 112-117
1573-4064
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://benthamscience.com/article/34526
info:eu-repo/semantics/altIdentifier/doi/10.2174/157340612799278559
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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