Antifungal activity of extracts and prenylated coumarins isolated from baccharis darwinii hook & arn. (asteraceae)

Autores
Kurdelas, Rita Rosa; Lima, Beatriz Viviana; Tapia, Aníbal Alejandro; Feresin, Gabriela Egly; Gonzalez Sierra, Manuel; Rodriguez, María Victoria; Zacchino, Susana Alicia Stella; Enriz, Ricardo Daniel; Freile, Monica Liliana
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The petroleum ether extract of Baccharis darwinii showed activity against Cryptococcus neoformans and dermatophytes. Bioactivity-guided fractionation of Baccharis darwinii has resulted in the isolation of three coumarins: 5'-hydroxy aurapten (anisocoumarin H, 1), aurapten (7-geranyloxycoumarin, 2) and 5'-oxoaurapten (diversinin, 3). The structures of these compounds were characterized by spectroscopic methods. These compounds were evaluated for their antimicrobial activity against a panel of each, bacteria and fungi. Compound 3 showed the best activities against Microsporum gypseum, Trichophyton rubrum and Trichophyton mentagrophytes with MICs = 15.6 μg/mL, followed by compound 1 whose MICs against the same fungi were 62.5 μg/mL. In addition they showed fungicidal rather than fungistatic activity. Both compounds showed moderate activity (MICs = 125 μg/mL) against Cryptococcus neoformans. This is the first report of the presence of compound 1 in B. darwinii.
Fil: Kurdelas, Rita Rosa. Universidad Nacional de la Patagonia "San Juan Bosco"; Argentina
Fil: Lima, Beatriz Viviana. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina
Fil: Tapia, Aníbal Alejandro. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
Fil: Feresin, Gabriela Egly. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
Fil: Gonzalez Sierra, Manuel. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Rodriguez, María Victoria. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Enriz, Ricardo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Freile, Monica Liliana. Universidad Nacional de la Patagonia "San Juan Bosco"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
ANTIMICROBIAL ACTIVITY
ASTERACEAE
AURAPTENE
BACCHARIS DARWINII
PRENYLATED COUMARINS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/127398
Acceder
id CONICETDig_f72ea90bee165ee8aff1a929fa13188e
oai_identifier_str oai:ri.conicet.gov.ar:11336/127398
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Antifungal activity of extracts and prenylated coumarins isolated from baccharis darwinii hook & arn. (asteraceae)Kurdelas, Rita RosaLima, Beatriz VivianaTapia, Aníbal AlejandroFeresin, Gabriela EglyGonzalez Sierra, ManuelRodriguez, María VictoriaZacchino, Susana Alicia StellaEnriz, Ricardo DanielFreile, Monica LilianaANTIMICROBIAL ACTIVITYASTERACEAEAURAPTENEBACCHARIS DARWINIIPRENYLATED COUMARINShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The petroleum ether extract of Baccharis darwinii showed activity against Cryptococcus neoformans and dermatophytes. Bioactivity-guided fractionation of Baccharis darwinii has resulted in the isolation of three coumarins: 5'-hydroxy aurapten (anisocoumarin H, 1), aurapten (7-geranyloxycoumarin, 2) and 5'-oxoaurapten (diversinin, 3). The structures of these compounds were characterized by spectroscopic methods. These compounds were evaluated for their antimicrobial activity against a panel of each, bacteria and fungi. Compound 3 showed the best activities against Microsporum gypseum, Trichophyton rubrum and Trichophyton mentagrophytes with MICs = 15.6 μg/mL, followed by compound 1 whose MICs against the same fungi were 62.5 μg/mL. In addition they showed fungicidal rather than fungistatic activity. Both compounds showed moderate activity (MICs = 125 μg/mL) against Cryptococcus neoformans. This is the first report of the presence of compound 1 in B. darwinii.Fil: Kurdelas, Rita Rosa. Universidad Nacional de la Patagonia "San Juan Bosco"; ArgentinaFil: Lima, Beatriz Viviana. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; ArgentinaFil: Tapia, Aníbal Alejandro. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; ArgentinaFil: Feresin, Gabriela Egly. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; ArgentinaFil: Gonzalez Sierra, Manuel. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Rodriguez, María Victoria. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Enriz, Ricardo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Freile, Monica Liliana. Universidad Nacional de la Patagonia "San Juan Bosco"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaMolecular Diversity Preservation International2010-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/127398Kurdelas, Rita Rosa; Lima, Beatriz Viviana; Tapia, Aníbal Alejandro; Feresin, Gabriela Egly; Gonzalez Sierra, Manuel; et al.; Antifungal activity of extracts and prenylated coumarins isolated from baccharis darwinii hook & arn. (asteraceae); Molecular Diversity Preservation International; Molecules; 15; 7; 7-2010; 4898-49071420-3049CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/1420-3049/15/7/4898/info:eu-repo/semantics/altIdentifier/doi/10.3390/molecules15074898info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:36:31Zoai:ri.conicet.gov.ar:11336/127398instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:36:32.145CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antifungal activity of extracts and prenylated coumarins isolated from baccharis darwinii hook & arn. (asteraceae)
title Antifungal activity of extracts and prenylated coumarins isolated from baccharis darwinii hook & arn. (asteraceae)
spellingShingle Antifungal activity of extracts and prenylated coumarins isolated from baccharis darwinii hook & arn. (asteraceae)
Kurdelas, Rita Rosa
ANTIMICROBIAL ACTIVITY
ASTERACEAE
AURAPTENE
BACCHARIS DARWINII
PRENYLATED COUMARINS
title_short Antifungal activity of extracts and prenylated coumarins isolated from baccharis darwinii hook & arn. (asteraceae)
title_full Antifungal activity of extracts and prenylated coumarins isolated from baccharis darwinii hook & arn. (asteraceae)
title_fullStr Antifungal activity of extracts and prenylated coumarins isolated from baccharis darwinii hook & arn. (asteraceae)
title_full_unstemmed Antifungal activity of extracts and prenylated coumarins isolated from baccharis darwinii hook & arn. (asteraceae)
title_sort Antifungal activity of extracts and prenylated coumarins isolated from baccharis darwinii hook & arn. (asteraceae)
dc.creator.none.fl_str_mv Kurdelas, Rita Rosa
Lima, Beatriz Viviana
Tapia, Aníbal Alejandro
Feresin, Gabriela Egly
Gonzalez Sierra, Manuel
Rodriguez, María Victoria
Zacchino, Susana Alicia Stella
Enriz, Ricardo Daniel
Freile, Monica Liliana
author Kurdelas, Rita Rosa
author_facet Kurdelas, Rita Rosa
Lima, Beatriz Viviana
Tapia, Aníbal Alejandro
Feresin, Gabriela Egly
Gonzalez Sierra, Manuel
Rodriguez, María Victoria
Zacchino, Susana Alicia Stella
Enriz, Ricardo Daniel
Freile, Monica Liliana
author_role author
author2 Lima, Beatriz Viviana
Tapia, Aníbal Alejandro
Feresin, Gabriela Egly
Gonzalez Sierra, Manuel
Rodriguez, María Victoria
Zacchino, Susana Alicia Stella
Enriz, Ricardo Daniel
Freile, Monica Liliana
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ANTIMICROBIAL ACTIVITY
ASTERACEAE
AURAPTENE
BACCHARIS DARWINII
PRENYLATED COUMARINS
topic ANTIMICROBIAL ACTIVITY
ASTERACEAE
AURAPTENE
BACCHARIS DARWINII
PRENYLATED COUMARINS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The petroleum ether extract of Baccharis darwinii showed activity against Cryptococcus neoformans and dermatophytes. Bioactivity-guided fractionation of Baccharis darwinii has resulted in the isolation of three coumarins: 5'-hydroxy aurapten (anisocoumarin H, 1), aurapten (7-geranyloxycoumarin, 2) and 5'-oxoaurapten (diversinin, 3). The structures of these compounds were characterized by spectroscopic methods. These compounds were evaluated for their antimicrobial activity against a panel of each, bacteria and fungi. Compound 3 showed the best activities against Microsporum gypseum, Trichophyton rubrum and Trichophyton mentagrophytes with MICs = 15.6 μg/mL, followed by compound 1 whose MICs against the same fungi were 62.5 μg/mL. In addition they showed fungicidal rather than fungistatic activity. Both compounds showed moderate activity (MICs = 125 μg/mL) against Cryptococcus neoformans. This is the first report of the presence of compound 1 in B. darwinii.
Fil: Kurdelas, Rita Rosa. Universidad Nacional de la Patagonia "San Juan Bosco"; Argentina
Fil: Lima, Beatriz Viviana. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina
Fil: Tapia, Aníbal Alejandro. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
Fil: Feresin, Gabriela Egly. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
Fil: Gonzalez Sierra, Manuel. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
Fil: Rodriguez, María Victoria. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Enriz, Ricardo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Freile, Monica Liliana. Universidad Nacional de la Patagonia "San Juan Bosco"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The petroleum ether extract of Baccharis darwinii showed activity against Cryptococcus neoformans and dermatophytes. Bioactivity-guided fractionation of Baccharis darwinii has resulted in the isolation of three coumarins: 5'-hydroxy aurapten (anisocoumarin H, 1), aurapten (7-geranyloxycoumarin, 2) and 5'-oxoaurapten (diversinin, 3). The structures of these compounds were characterized by spectroscopic methods. These compounds were evaluated for their antimicrobial activity against a panel of each, bacteria and fungi. Compound 3 showed the best activities against Microsporum gypseum, Trichophyton rubrum and Trichophyton mentagrophytes with MICs = 15.6 μg/mL, followed by compound 1 whose MICs against the same fungi were 62.5 μg/mL. In addition they showed fungicidal rather than fungistatic activity. Both compounds showed moderate activity (MICs = 125 μg/mL) against Cryptococcus neoformans. This is the first report of the presence of compound 1 in B. darwinii.
publishDate 2010
dc.date.none.fl_str_mv 2010-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/127398
Kurdelas, Rita Rosa; Lima, Beatriz Viviana; Tapia, Aníbal Alejandro; Feresin, Gabriela Egly; Gonzalez Sierra, Manuel; et al.; Antifungal activity of extracts and prenylated coumarins isolated from baccharis darwinii hook & arn. (asteraceae); Molecular Diversity Preservation International; Molecules; 15; 7; 7-2010; 4898-4907
1420-3049
CONICET Digital
CONICET
url http://hdl.handle.net/11336/127398
identifier_str_mv Kurdelas, Rita Rosa; Lima, Beatriz Viviana; Tapia, Aníbal Alejandro; Feresin, Gabriela Egly; Gonzalez Sierra, Manuel; et al.; Antifungal activity of extracts and prenylated coumarins isolated from baccharis darwinii hook & arn. (asteraceae); Molecular Diversity Preservation International; Molecules; 15; 7; 7-2010; 4898-4907
1420-3049
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/1420-3049/15/7/4898/
info:eu-repo/semantics/altIdentifier/doi/10.3390/molecules15074898
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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