Mechanisms of interaction between Candida albicans and Streptococcus mutans: An experimental and mathematical modelling study

Autores
Brusca, María Isabel; Irastorza, Ramiro Miguel; Cattoni, Diego Ignacio; Ozu, Marcelo; Chara, Osvaldo
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
OBJECTIVE: To evaluate the mechanisms of microbial interaction between the oral pathogens Candida albicans and Streptococcus mutans. MATERIALS AND METHODS: Growth kinetics for the two micro-organisms, cultured individually or together, were followed experimentally for 36 h. The different growth curves were analysed by means of mathematical modelling. RESULTS: Under the experimental conditions, S. mutans final concentration, when grown individually, was 5-times that of C. albicans. Contrarily, when both micro-organisms grew together, this ratio was inversed and C. albicans final concentration was even higher than that of S. mutans. When both micro-organisms share the niche, a model including linear competition among one another was best suited to reproduce the experimental observations. The results of this model show that the initial growth rates of both species are positively influenced by their mutual interaction. However, at longer incubation times, C. albicans prevents bacterial growth and achieves concentrations 4-times higher than when grown individually. CONCLUSIONS: The results suggest that C. albicans biofilm formation could be potentiated by the presence of S. mutans by two mechanisms: synergically at short times and by competition at longer periods.
Fil: Brusca, María Isabel. Universidad Nacional de la Plata. Facultad de Odontologia; Argentina
Fil: Irastorza, Ramiro Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina
Fil: Cattoni, Diego Ignacio. Universite Montpellier II; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ozu, Marcelo. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Biomembranas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Chara, Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina. Universität Dresden; Alemania
Materia
Oral Microbiology
Biofilms
Streptococcus
Candida
Computational Models
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/23552
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/23552
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Mechanisms of interaction between Candida albicans and Streptococcus mutans: An experimental and mathematical modelling studyBrusca, María IsabelIrastorza, Ramiro MiguelCattoni, Diego IgnacioOzu, MarceloChara, OsvaldoOral MicrobiologyBiofilmsStreptococcusCandidaComputational Modelshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3OBJECTIVE: To evaluate the mechanisms of microbial interaction between the oral pathogens Candida albicans and Streptococcus mutans. MATERIALS AND METHODS: Growth kinetics for the two micro-organisms, cultured individually or together, were followed experimentally for 36 h. The different growth curves were analysed by means of mathematical modelling. RESULTS: Under the experimental conditions, S. mutans final concentration, when grown individually, was 5-times that of C. albicans. Contrarily, when both micro-organisms grew together, this ratio was inversed and C. albicans final concentration was even higher than that of S. mutans. When both micro-organisms share the niche, a model including linear competition among one another was best suited to reproduce the experimental observations. The results of this model show that the initial growth rates of both species are positively influenced by their mutual interaction. However, at longer incubation times, C. albicans prevents bacterial growth and achieves concentrations 4-times higher than when grown individually. CONCLUSIONS: The results suggest that C. albicans biofilm formation could be potentiated by the presence of S. mutans by two mechanisms: synergically at short times and by competition at longer periods.Fil: Brusca, María Isabel. Universidad Nacional de la Plata. Facultad de Odontologia; ArgentinaFil: Irastorza, Ramiro Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; ArgentinaFil: Cattoni, Diego Ignacio. Universite Montpellier II; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ozu, Marcelo. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Biomembranas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Chara, Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina. Universität Dresden; AlemaniaTaylor & Francis2013-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/23552Brusca, María Isabel; Irastorza, Ramiro Miguel; Cattoni, Diego Ignacio; Ozu, Marcelo; Chara, Osvaldo; Mechanisms of interaction between Candida albicans and Streptococcus mutans: An experimental and mathematical modelling study; Taylor & Francis; Acta Odontologica Scandinavica; 71; 3-4; 5-2013; 416-4230001-6357CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.3109/00016357.2012.690530info:eu-repo/semantics/altIdentifier/doi/10.3109/00016357.2012.690530info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:22:31Zoai:ri.conicet.gov.ar:11336/23552instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:22:31.735CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Mechanisms of interaction between Candida albicans and Streptococcus mutans: An experimental and mathematical modelling study
title Mechanisms of interaction between Candida albicans and Streptococcus mutans: An experimental and mathematical modelling study
spellingShingle Mechanisms of interaction between Candida albicans and Streptococcus mutans: An experimental and mathematical modelling study
Brusca, María Isabel
Oral Microbiology
Biofilms
Streptococcus
Candida
Computational Models
title_short Mechanisms of interaction between Candida albicans and Streptococcus mutans: An experimental and mathematical modelling study
title_full Mechanisms of interaction between Candida albicans and Streptococcus mutans: An experimental and mathematical modelling study
title_fullStr Mechanisms of interaction between Candida albicans and Streptococcus mutans: An experimental and mathematical modelling study
title_full_unstemmed Mechanisms of interaction between Candida albicans and Streptococcus mutans: An experimental and mathematical modelling study
title_sort Mechanisms of interaction between Candida albicans and Streptococcus mutans: An experimental and mathematical modelling study
dc.creator.none.fl_str_mv Brusca, María Isabel
Irastorza, Ramiro Miguel
Cattoni, Diego Ignacio
Ozu, Marcelo
Chara, Osvaldo
author Brusca, María Isabel
author_facet Brusca, María Isabel
Irastorza, Ramiro Miguel
Cattoni, Diego Ignacio
Ozu, Marcelo
Chara, Osvaldo
author_role author
author2 Irastorza, Ramiro Miguel
Cattoni, Diego Ignacio
Ozu, Marcelo
Chara, Osvaldo
author2_role author
author
author
author
dc.subject.none.fl_str_mv Oral Microbiology
Biofilms
Streptococcus
Candida
Computational Models
topic Oral Microbiology
Biofilms
Streptococcus
Candida
Computational Models
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv OBJECTIVE: To evaluate the mechanisms of microbial interaction between the oral pathogens Candida albicans and Streptococcus mutans. MATERIALS AND METHODS: Growth kinetics for the two micro-organisms, cultured individually or together, were followed experimentally for 36 h. The different growth curves were analysed by means of mathematical modelling. RESULTS: Under the experimental conditions, S. mutans final concentration, when grown individually, was 5-times that of C. albicans. Contrarily, when both micro-organisms grew together, this ratio was inversed and C. albicans final concentration was even higher than that of S. mutans. When both micro-organisms share the niche, a model including linear competition among one another was best suited to reproduce the experimental observations. The results of this model show that the initial growth rates of both species are positively influenced by their mutual interaction. However, at longer incubation times, C. albicans prevents bacterial growth and achieves concentrations 4-times higher than when grown individually. CONCLUSIONS: The results suggest that C. albicans biofilm formation could be potentiated by the presence of S. mutans by two mechanisms: synergically at short times and by competition at longer periods.
Fil: Brusca, María Isabel. Universidad Nacional de la Plata. Facultad de Odontologia; Argentina
Fil: Irastorza, Ramiro Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina
Fil: Cattoni, Diego Ignacio. Universite Montpellier II; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ozu, Marcelo. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Biomembranas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Chara, Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física de Líquidos y Sistemas Biológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina. Universität Dresden; Alemania
description OBJECTIVE: To evaluate the mechanisms of microbial interaction between the oral pathogens Candida albicans and Streptococcus mutans. MATERIALS AND METHODS: Growth kinetics for the two micro-organisms, cultured individually or together, were followed experimentally for 36 h. The different growth curves were analysed by means of mathematical modelling. RESULTS: Under the experimental conditions, S. mutans final concentration, when grown individually, was 5-times that of C. albicans. Contrarily, when both micro-organisms grew together, this ratio was inversed and C. albicans final concentration was even higher than that of S. mutans. When both micro-organisms share the niche, a model including linear competition among one another was best suited to reproduce the experimental observations. The results of this model show that the initial growth rates of both species are positively influenced by their mutual interaction. However, at longer incubation times, C. albicans prevents bacterial growth and achieves concentrations 4-times higher than when grown individually. CONCLUSIONS: The results suggest that C. albicans biofilm formation could be potentiated by the presence of S. mutans by two mechanisms: synergically at short times and by competition at longer periods.
publishDate 2013
dc.date.none.fl_str_mv 2013-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/23552
Brusca, María Isabel; Irastorza, Ramiro Miguel; Cattoni, Diego Ignacio; Ozu, Marcelo; Chara, Osvaldo; Mechanisms of interaction between Candida albicans and Streptococcus mutans: An experimental and mathematical modelling study; Taylor & Francis; Acta Odontologica Scandinavica; 71; 3-4; 5-2013; 416-423
0001-6357
CONICET Digital
CONICET
url http://hdl.handle.net/11336/23552
identifier_str_mv Brusca, María Isabel; Irastorza, Ramiro Miguel; Cattoni, Diego Ignacio; Ozu, Marcelo; Chara, Osvaldo; Mechanisms of interaction between Candida albicans and Streptococcus mutans: An experimental and mathematical modelling study; Taylor & Francis; Acta Odontologica Scandinavica; 71; 3-4; 5-2013; 416-423
0001-6357
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.3109/00016357.2012.690530
info:eu-repo/semantics/altIdentifier/doi/10.3109/00016357.2012.690530
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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