Amphiphilic electrospun scaffolds of PLLA-PEO-PPO block copolymers: preparation, characterization and drug-release behaviour

Autores
Loiola, Lívia M. D.; Cortez Tornello, Pablo Roberto; Abraham, Gustavo Abel; Felisberti, Maria I.
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Biocompatible amphiphilic copolymers are attractive candidates for the fabrication of electrospun scaffolds to be used for tissue engineering and the delivery of biologically active compounds. The amphiphilic block copolymers poly(l-lactide)-b-poly(ethylene oxide)-b-poly(l-lactide) (PELA) and poly(l-lactide)-b-poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide)-b-poly(l-lactide) (PEPELA), which contain amorphous/crystalline and hydrophilic/hydrophobic blocks, were synthesized by ring-opening polymerization, and then electrospun to obtain non-woven fibrous scaffolds. Acetaminophen (AC) and celecoxib (CL) were used as hydrophilic and hydrophobic model drugs, respectively, to prepare drug-loaded scaffolds. The pure and drug-loaded scaffolds present a morphology characterized by randomly oriented fibres with integrated beads. The drug encapsulation and release profiles were determined by ultraviolet-visible spectroscopy. Due to the amphiphilic nature of PELA and PEPELA, both hydrophilic and hydrophobic drugs could be entrapped within the polymeric scaffolds, allowing the design of drug-delivery systems for specific applications. The combination of confocal Raman spectroscopy mapping and dynamic mechanical analysis revealed that the AC drug is preferentially maintained in the PEO phase, while the CL drug is fractionated between polyether and polyester phases and distributed throughout the fibrous structure due to its hydrophobic character.
Fil: Loiola, Lívia M. D.. Universidade Estadual de Campinas; Brasil
Fil: Cortez Tornello, Pablo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Felisberti, Maria I.. Universidade Estadual de Campinas; Brasil
Materia
ELECTROSPINNING
AMPHIPHILIC COPOLYMERS
DRUG RELEASE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/64134
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Amphiphilic electrospun scaffolds of PLLA-PEO-PPO block copolymers: preparation, characterization and drug-release behaviourLoiola, Lívia M. D.Cortez Tornello, Pablo RobertoAbraham, Gustavo AbelFelisberti, Maria I.ELECTROSPINNINGAMPHIPHILIC COPOLYMERSDRUG RELEASEhttps://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2https://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2Biocompatible amphiphilic copolymers are attractive candidates for the fabrication of electrospun scaffolds to be used for tissue engineering and the delivery of biologically active compounds. The amphiphilic block copolymers poly(l-lactide)-b-poly(ethylene oxide)-b-poly(l-lactide) (PELA) and poly(l-lactide)-b-poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide)-b-poly(l-lactide) (PEPELA), which contain amorphous/crystalline and hydrophilic/hydrophobic blocks, were synthesized by ring-opening polymerization, and then electrospun to obtain non-woven fibrous scaffolds. Acetaminophen (AC) and celecoxib (CL) were used as hydrophilic and hydrophobic model drugs, respectively, to prepare drug-loaded scaffolds. The pure and drug-loaded scaffolds present a morphology characterized by randomly oriented fibres with integrated beads. The drug encapsulation and release profiles were determined by ultraviolet-visible spectroscopy. Due to the amphiphilic nature of PELA and PEPELA, both hydrophilic and hydrophobic drugs could be entrapped within the polymeric scaffolds, allowing the design of drug-delivery systems for specific applications. The combination of confocal Raman spectroscopy mapping and dynamic mechanical analysis revealed that the AC drug is preferentially maintained in the PEO phase, while the CL drug is fractionated between polyether and polyester phases and distributed throughout the fibrous structure due to its hydrophobic character.Fil: Loiola, Lívia M. D.. Universidade Estadual de Campinas; BrasilFil: Cortez Tornello, Pablo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Felisberti, Maria I.. Universidade Estadual de Campinas; BrasilRoyal Society of Chemistry2017-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/64134Loiola, Lívia M. D.; Cortez Tornello, Pablo Roberto; Abraham, Gustavo Abel; Felisberti, Maria I.; Amphiphilic electrospun scaffolds of PLLA-PEO-PPO block copolymers: preparation, characterization and drug-release behaviour; Royal Society of Chemistry; RSC Advances; 7; 1; 1-2017; 161-1722046-2069CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1039/c6ra25023hinfo:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/Content/ArticleLanding/2017/RA/C6RA25023Hinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:54:21Zoai:ri.conicet.gov.ar:11336/64134instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:54:22.241CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Amphiphilic electrospun scaffolds of PLLA-PEO-PPO block copolymers: preparation, characterization and drug-release behaviour
title Amphiphilic electrospun scaffolds of PLLA-PEO-PPO block copolymers: preparation, characterization and drug-release behaviour
spellingShingle Amphiphilic electrospun scaffolds of PLLA-PEO-PPO block copolymers: preparation, characterization and drug-release behaviour
Loiola, Lívia M. D.
ELECTROSPINNING
AMPHIPHILIC COPOLYMERS
DRUG RELEASE
title_short Amphiphilic electrospun scaffolds of PLLA-PEO-PPO block copolymers: preparation, characterization and drug-release behaviour
title_full Amphiphilic electrospun scaffolds of PLLA-PEO-PPO block copolymers: preparation, characterization and drug-release behaviour
title_fullStr Amphiphilic electrospun scaffolds of PLLA-PEO-PPO block copolymers: preparation, characterization and drug-release behaviour
title_full_unstemmed Amphiphilic electrospun scaffolds of PLLA-PEO-PPO block copolymers: preparation, characterization and drug-release behaviour
title_sort Amphiphilic electrospun scaffolds of PLLA-PEO-PPO block copolymers: preparation, characterization and drug-release behaviour
dc.creator.none.fl_str_mv Loiola, Lívia M. D.
Cortez Tornello, Pablo Roberto
Abraham, Gustavo Abel
Felisberti, Maria I.
author Loiola, Lívia M. D.
author_facet Loiola, Lívia M. D.
Cortez Tornello, Pablo Roberto
Abraham, Gustavo Abel
Felisberti, Maria I.
author_role author
author2 Cortez Tornello, Pablo Roberto
Abraham, Gustavo Abel
Felisberti, Maria I.
author2_role author
author
author
dc.subject.none.fl_str_mv ELECTROSPINNING
AMPHIPHILIC COPOLYMERS
DRUG RELEASE
topic ELECTROSPINNING
AMPHIPHILIC COPOLYMERS
DRUG RELEASE
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Biocompatible amphiphilic copolymers are attractive candidates for the fabrication of electrospun scaffolds to be used for tissue engineering and the delivery of biologically active compounds. The amphiphilic block copolymers poly(l-lactide)-b-poly(ethylene oxide)-b-poly(l-lactide) (PELA) and poly(l-lactide)-b-poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide)-b-poly(l-lactide) (PEPELA), which contain amorphous/crystalline and hydrophilic/hydrophobic blocks, were synthesized by ring-opening polymerization, and then electrospun to obtain non-woven fibrous scaffolds. Acetaminophen (AC) and celecoxib (CL) were used as hydrophilic and hydrophobic model drugs, respectively, to prepare drug-loaded scaffolds. The pure and drug-loaded scaffolds present a morphology characterized by randomly oriented fibres with integrated beads. The drug encapsulation and release profiles were determined by ultraviolet-visible spectroscopy. Due to the amphiphilic nature of PELA and PEPELA, both hydrophilic and hydrophobic drugs could be entrapped within the polymeric scaffolds, allowing the design of drug-delivery systems for specific applications. The combination of confocal Raman spectroscopy mapping and dynamic mechanical analysis revealed that the AC drug is preferentially maintained in the PEO phase, while the CL drug is fractionated between polyether and polyester phases and distributed throughout the fibrous structure due to its hydrophobic character.
Fil: Loiola, Lívia M. D.. Universidade Estadual de Campinas; Brasil
Fil: Cortez Tornello, Pablo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Felisberti, Maria I.. Universidade Estadual de Campinas; Brasil
description Biocompatible amphiphilic copolymers are attractive candidates for the fabrication of electrospun scaffolds to be used for tissue engineering and the delivery of biologically active compounds. The amphiphilic block copolymers poly(l-lactide)-b-poly(ethylene oxide)-b-poly(l-lactide) (PELA) and poly(l-lactide)-b-poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide)-b-poly(l-lactide) (PEPELA), which contain amorphous/crystalline and hydrophilic/hydrophobic blocks, were synthesized by ring-opening polymerization, and then electrospun to obtain non-woven fibrous scaffolds. Acetaminophen (AC) and celecoxib (CL) were used as hydrophilic and hydrophobic model drugs, respectively, to prepare drug-loaded scaffolds. The pure and drug-loaded scaffolds present a morphology characterized by randomly oriented fibres with integrated beads. The drug encapsulation and release profiles were determined by ultraviolet-visible spectroscopy. Due to the amphiphilic nature of PELA and PEPELA, both hydrophilic and hydrophobic drugs could be entrapped within the polymeric scaffolds, allowing the design of drug-delivery systems for specific applications. The combination of confocal Raman spectroscopy mapping and dynamic mechanical analysis revealed that the AC drug is preferentially maintained in the PEO phase, while the CL drug is fractionated between polyether and polyester phases and distributed throughout the fibrous structure due to its hydrophobic character.
publishDate 2017
dc.date.none.fl_str_mv 2017-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/64134
Loiola, Lívia M. D.; Cortez Tornello, Pablo Roberto; Abraham, Gustavo Abel; Felisberti, Maria I.; Amphiphilic electrospun scaffolds of PLLA-PEO-PPO block copolymers: preparation, characterization and drug-release behaviour; Royal Society of Chemistry; RSC Advances; 7; 1; 1-2017; 161-172
2046-2069
CONICET Digital
CONICET
url http://hdl.handle.net/11336/64134
identifier_str_mv Loiola, Lívia M. D.; Cortez Tornello, Pablo Roberto; Abraham, Gustavo Abel; Felisberti, Maria I.; Amphiphilic electrospun scaffolds of PLLA-PEO-PPO block copolymers: preparation, characterization and drug-release behaviour; Royal Society of Chemistry; RSC Advances; 7; 1; 1-2017; 161-172
2046-2069
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1039/c6ra25023h
info:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/Content/ArticleLanding/2017/RA/C6RA25023H
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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