Random and aligned PLLA: PRGF electrospun scaffolds for regenerative medicine

Autores
Díaz Gómez, Luis; Montini Ballarin, Florencia; Abraham, Gustavo Abel; Concheiro, Angel; Alvarez-lorenzo, Carmen
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Random and aligned electrospun scaffolds were prepared combining poly(l-lactic acid) (PLLA) and activated platelet-rich plasma (PRGF) at various proportions, with the aim of elucidating the role of nanofibers orientation and growth factors on cell attachment and proliferation. PRGF is released from scaffolds in a sustained way for at least 3 weeks, without an initial burst effect. Mesenchymal stem cells (MSCs) seeded on the random scaffolds present a polygonal and random orientation in any direction of the scaffold. On the other hand, aligned scaffolds are able to promote cell attachment and proliferation in the direction of the nanofibers. The incorporation of PRGF in the scaffolds enhances cell proliferation for at least 2 weeks. Overall, aligned electrospun PLLA : PRGF scaffolds can encapsulate growth factors at relatively large proportions and sustain their release to enhance cell attachment and proliferation as well as eliciting cell alignment.
Fil: Díaz Gómez, Luis. Universidad de Santiago de Compostela. Facultad de Farmacia; España
Fil: Montini Ballarin, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación En Ciencia y Tecnología de Materiales (i); Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; Argentina
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación En Ciencia y Tecnología de Materiales (i); Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; Argentina
Fil: Concheiro, Angel. Universidad de Santiago de Compostela. Facultad de Farmacia; España
Fil: Alvarez-lorenzo, Carmen. Universidad de Santiago de Compostela. Facultad de Farmacia; España
Materia
Biomaterials
Electrospinning
Fibers
Polyesters
Proteins
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/4942
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/4942
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Random and aligned PLLA: PRGF electrospun scaffolds for regenerative medicineDíaz Gómez, LuisMontini Ballarin, FlorenciaAbraham, Gustavo AbelConcheiro, AngelAlvarez-lorenzo, CarmenBiomaterialsElectrospinningFibersPolyestersProteinshttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Random and aligned electrospun scaffolds were prepared combining poly(l-lactic acid) (PLLA) and activated platelet-rich plasma (PRGF) at various proportions, with the aim of elucidating the role of nanofibers orientation and growth factors on cell attachment and proliferation. PRGF is released from scaffolds in a sustained way for at least 3 weeks, without an initial burst effect. Mesenchymal stem cells (MSCs) seeded on the random scaffolds present a polygonal and random orientation in any direction of the scaffold. On the other hand, aligned scaffolds are able to promote cell attachment and proliferation in the direction of the nanofibers. The incorporation of PRGF in the scaffolds enhances cell proliferation for at least 2 weeks. Overall, aligned electrospun PLLA : PRGF scaffolds can encapsulate growth factors at relatively large proportions and sustain their release to enhance cell attachment and proliferation as well as eliciting cell alignment.Fil: Díaz Gómez, Luis. Universidad de Santiago de Compostela. Facultad de Farmacia; EspañaFil: Montini Ballarin, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación En Ciencia y Tecnología de Materiales (i); Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; ArgentinaFil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación En Ciencia y Tecnología de Materiales (i); Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; ArgentinaFil: Concheiro, Angel. Universidad de Santiago de Compostela. Facultad de Farmacia; EspañaFil: Alvarez-lorenzo, Carmen. Universidad de Santiago de Compostela. Facultad de Farmacia; EspañaWiley2014-08-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/4942Díaz Gómez, Luis; Montini Ballarin, Florencia; Abraham, Gustavo Abel; Concheiro, Angel; Alvarez-lorenzo, Carmen; Random and aligned PLLA: PRGF electrospun scaffolds for regenerative medicine; Wiley; Journal Of Applied Polymer Science; 132; 5; 27-8-2014; 41372-413721097-4628enginfo:eu-repo/semantics/altIdentifier/issn/1097-4628info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/app.41372/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1002/app.41372info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:24:28Zoai:ri.conicet.gov.ar:11336/4942instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:24:28.784CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Random and aligned PLLA: PRGF electrospun scaffolds for regenerative medicine
title Random and aligned PLLA: PRGF electrospun scaffolds for regenerative medicine
spellingShingle Random and aligned PLLA: PRGF electrospun scaffolds for regenerative medicine
Díaz Gómez, Luis
Biomaterials
Electrospinning
Fibers
Polyesters
Proteins
title_short Random and aligned PLLA: PRGF electrospun scaffolds for regenerative medicine
title_full Random and aligned PLLA: PRGF electrospun scaffolds for regenerative medicine
title_fullStr Random and aligned PLLA: PRGF electrospun scaffolds for regenerative medicine
title_full_unstemmed Random and aligned PLLA: PRGF electrospun scaffolds for regenerative medicine
title_sort Random and aligned PLLA: PRGF electrospun scaffolds for regenerative medicine
dc.creator.none.fl_str_mv Díaz Gómez, Luis
Montini Ballarin, Florencia
Abraham, Gustavo Abel
Concheiro, Angel
Alvarez-lorenzo, Carmen
author Díaz Gómez, Luis
author_facet Díaz Gómez, Luis
Montini Ballarin, Florencia
Abraham, Gustavo Abel
Concheiro, Angel
Alvarez-lorenzo, Carmen
author_role author
author2 Montini Ballarin, Florencia
Abraham, Gustavo Abel
Concheiro, Angel
Alvarez-lorenzo, Carmen
author2_role author
author
author
author
dc.subject.none.fl_str_mv Biomaterials
Electrospinning
Fibers
Polyesters
Proteins
topic Biomaterials
Electrospinning
Fibers
Polyesters
Proteins
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Random and aligned electrospun scaffolds were prepared combining poly(l-lactic acid) (PLLA) and activated platelet-rich plasma (PRGF) at various proportions, with the aim of elucidating the role of nanofibers orientation and growth factors on cell attachment and proliferation. PRGF is released from scaffolds in a sustained way for at least 3 weeks, without an initial burst effect. Mesenchymal stem cells (MSCs) seeded on the random scaffolds present a polygonal and random orientation in any direction of the scaffold. On the other hand, aligned scaffolds are able to promote cell attachment and proliferation in the direction of the nanofibers. The incorporation of PRGF in the scaffolds enhances cell proliferation for at least 2 weeks. Overall, aligned electrospun PLLA : PRGF scaffolds can encapsulate growth factors at relatively large proportions and sustain their release to enhance cell attachment and proliferation as well as eliciting cell alignment.
Fil: Díaz Gómez, Luis. Universidad de Santiago de Compostela. Facultad de Farmacia; España
Fil: Montini Ballarin, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación En Ciencia y Tecnología de Materiales (i); Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; Argentina
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación En Ciencia y Tecnología de Materiales (i); Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; Argentina
Fil: Concheiro, Angel. Universidad de Santiago de Compostela. Facultad de Farmacia; España
Fil: Alvarez-lorenzo, Carmen. Universidad de Santiago de Compostela. Facultad de Farmacia; España
description Random and aligned electrospun scaffolds were prepared combining poly(l-lactic acid) (PLLA) and activated platelet-rich plasma (PRGF) at various proportions, with the aim of elucidating the role of nanofibers orientation and growth factors on cell attachment and proliferation. PRGF is released from scaffolds in a sustained way for at least 3 weeks, without an initial burst effect. Mesenchymal stem cells (MSCs) seeded on the random scaffolds present a polygonal and random orientation in any direction of the scaffold. On the other hand, aligned scaffolds are able to promote cell attachment and proliferation in the direction of the nanofibers. The incorporation of PRGF in the scaffolds enhances cell proliferation for at least 2 weeks. Overall, aligned electrospun PLLA : PRGF scaffolds can encapsulate growth factors at relatively large proportions and sustain their release to enhance cell attachment and proliferation as well as eliciting cell alignment.
publishDate 2014
dc.date.none.fl_str_mv 2014-08-27
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/4942
Díaz Gómez, Luis; Montini Ballarin, Florencia; Abraham, Gustavo Abel; Concheiro, Angel; Alvarez-lorenzo, Carmen; Random and aligned PLLA: PRGF electrospun scaffolds for regenerative medicine; Wiley; Journal Of Applied Polymer Science; 132; 5; 27-8-2014; 41372-41372
1097-4628
url http://hdl.handle.net/11336/4942
identifier_str_mv Díaz Gómez, Luis; Montini Ballarin, Florencia; Abraham, Gustavo Abel; Concheiro, Angel; Alvarez-lorenzo, Carmen; Random and aligned PLLA: PRGF electrospun scaffolds for regenerative medicine; Wiley; Journal Of Applied Polymer Science; 132; 5; 27-8-2014; 41372-41372
1097-4628
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1097-4628
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/app.41372/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1002/app.41372
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.48226

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