The strongyloides stercoralis-hookworms association as a path to the estimation of the global burden of strongyloidiasis: A systematic review

Autores
Fleitas, Pedro Emanuel; Travacio, Marina; Martí Soler, Helena; Socías, María Eugenia; Lopez, Walter R.; Krolewiecki, Alejandro Javier
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Soil-transmitted helminths (STH) represent a significant public health problem. However, Strongyloides stercoralis is not yet integrated into the control strategy against STH, given limitations to accurately assess its burden. Considering that S. stercoralis shares biological and epidemiological characteristics with hookworms, we describe a new approach for an improved estimation of the burden of infections by S. stercoralis based on the prevalence and burden of hookworms and the relationship between these species. A systematic review of publications reporting prevalence rates for S. stercoralis and hookworms was carried out. The data was classified into two categories: 1) “Community”, with surveys including all age groups, and 2) “SAC”, with surveys limited to school-aged children. The relationship between S. stercoralis and hookworms was characterized in order to estimate the global burden of S. stercoralis infections. The study is registered in PROSPERO (CRD42019131127). Spearman correlation coefficient between S. stercoralis and hookworms was estimated and the global burden of S. stercoralis infections was estimated using a regression model. A total of 119 articles were included, and a significant positive correlation between the burden of S. stercoralis and hookworms was identified. Spearman’s coefficient for Community surveys was 0.94 and for SAC surveys it was 0.63. Based on the linear model, the global burden of S. stercoralis infections was estimated at 386 million (95%CI 324–449 million) people, including 22 million (95%CI 20–24 million) SAC. The significant relationship between S. stercoralis and hookworms allows an estimation of the global burden of S. stercoralis infections in most epidemiologic settings using hookworm burden and justifies the search of integrated control activities.
Fil: Fleitas, Pedro Emanuel. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; Argentina. Universidad Nacional de Salta. Facultad de Ciencias Naturales. Escuela de Biología. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta; Argentina
Fil: Travacio, Marina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; Argentina
Fil: Martí Soler, Helena. Universidad de Barcelona; España
Fil: Socías, María Eugenia. University of British Columbia; Canadá
Fil: Lopez, Walter R.. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; Argentina
Fil: Krolewiecki, Alejandro Javier. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; Argentina. Universidad de Barcelona; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta; Argentina
Materia
STRONGYLOIDES
HOOKWORM
NEGLECTED TROPICAL DISEASES
MODELLING
GLOBAL BURDEN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/128002
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/128002
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The strongyloides stercoralis-hookworms association as a path to the estimation of the global burden of strongyloidiasis: A systematic reviewFleitas, Pedro EmanuelTravacio, MarinaMartí Soler, HelenaSocías, María EugeniaLopez, Walter R.Krolewiecki, Alejandro JavierSTRONGYLOIDESHOOKWORMNEGLECTED TROPICAL DISEASESMODELLINGGLOBAL BURDENhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Soil-transmitted helminths (STH) represent a significant public health problem. However, Strongyloides stercoralis is not yet integrated into the control strategy against STH, given limitations to accurately assess its burden. Considering that S. stercoralis shares biological and epidemiological characteristics with hookworms, we describe a new approach for an improved estimation of the burden of infections by S. stercoralis based on the prevalence and burden of hookworms and the relationship between these species. A systematic review of publications reporting prevalence rates for S. stercoralis and hookworms was carried out. The data was classified into two categories: 1) “Community”, with surveys including all age groups, and 2) “SAC”, with surveys limited to school-aged children. The relationship between S. stercoralis and hookworms was characterized in order to estimate the global burden of S. stercoralis infections. The study is registered in PROSPERO (CRD42019131127). Spearman correlation coefficient between S. stercoralis and hookworms was estimated and the global burden of S. stercoralis infections was estimated using a regression model. A total of 119 articles were included, and a significant positive correlation between the burden of S. stercoralis and hookworms was identified. Spearman’s coefficient for Community surveys was 0.94 and for SAC surveys it was 0.63. Based on the linear model, the global burden of S. stercoralis infections was estimated at 386 million (95%CI 324–449 million) people, including 22 million (95%CI 20–24 million) SAC. The significant relationship between S. stercoralis and hookworms allows an estimation of the global burden of S. stercoralis infections in most epidemiologic settings using hookworm burden and justifies the search of integrated control activities.Fil: Fleitas, Pedro Emanuel. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; Argentina. Universidad Nacional de Salta. Facultad de Ciencias Naturales. Escuela de Biología. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta; ArgentinaFil: Travacio, Marina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; ArgentinaFil: Martí Soler, Helena. Universidad de Barcelona; EspañaFil: Socías, María Eugenia. University of British Columbia; CanadáFil: Lopez, Walter R.. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; ArgentinaFil: Krolewiecki, Alejandro Javier. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; Argentina. Universidad de Barcelona; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta; ArgentinaPublic Library of Science2020-04-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/128002Fleitas, Pedro Emanuel; Travacio, Marina; Martí Soler, Helena; Socías, María Eugenia; Lopez, Walter R.; et al.; The strongyloides stercoralis-hookworms association as a path to the estimation of the global burden of strongyloidiasis: A systematic review; Public Library of Science; Neglected Tropical Diseases; 14; 4; 13-4-2020; 1-131935-27351935-2727CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://dx.plos.org/10.1371/journal.pntd.0008184info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pntd.0008184info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:41:36Zoai:ri.conicet.gov.ar:11336/128002instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:41:37.112CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The strongyloides stercoralis-hookworms association as a path to the estimation of the global burden of strongyloidiasis: A systematic review
title The strongyloides stercoralis-hookworms association as a path to the estimation of the global burden of strongyloidiasis: A systematic review
spellingShingle The strongyloides stercoralis-hookworms association as a path to the estimation of the global burden of strongyloidiasis: A systematic review
Fleitas, Pedro Emanuel
STRONGYLOIDES
HOOKWORM
NEGLECTED TROPICAL DISEASES
MODELLING
GLOBAL BURDEN
title_short The strongyloides stercoralis-hookworms association as a path to the estimation of the global burden of strongyloidiasis: A systematic review
title_full The strongyloides stercoralis-hookworms association as a path to the estimation of the global burden of strongyloidiasis: A systematic review
title_fullStr The strongyloides stercoralis-hookworms association as a path to the estimation of the global burden of strongyloidiasis: A systematic review
title_full_unstemmed The strongyloides stercoralis-hookworms association as a path to the estimation of the global burden of strongyloidiasis: A systematic review
title_sort The strongyloides stercoralis-hookworms association as a path to the estimation of the global burden of strongyloidiasis: A systematic review
dc.creator.none.fl_str_mv Fleitas, Pedro Emanuel
Travacio, Marina
Martí Soler, Helena
Socías, María Eugenia
Lopez, Walter R.
Krolewiecki, Alejandro Javier
author Fleitas, Pedro Emanuel
author_facet Fleitas, Pedro Emanuel
Travacio, Marina
Martí Soler, Helena
Socías, María Eugenia
Lopez, Walter R.
Krolewiecki, Alejandro Javier
author_role author
author2 Travacio, Marina
Martí Soler, Helena
Socías, María Eugenia
Lopez, Walter R.
Krolewiecki, Alejandro Javier
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv STRONGYLOIDES
HOOKWORM
NEGLECTED TROPICAL DISEASES
MODELLING
GLOBAL BURDEN
topic STRONGYLOIDES
HOOKWORM
NEGLECTED TROPICAL DISEASES
MODELLING
GLOBAL BURDEN
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Soil-transmitted helminths (STH) represent a significant public health problem. However, Strongyloides stercoralis is not yet integrated into the control strategy against STH, given limitations to accurately assess its burden. Considering that S. stercoralis shares biological and epidemiological characteristics with hookworms, we describe a new approach for an improved estimation of the burden of infections by S. stercoralis based on the prevalence and burden of hookworms and the relationship between these species. A systematic review of publications reporting prevalence rates for S. stercoralis and hookworms was carried out. The data was classified into two categories: 1) “Community”, with surveys including all age groups, and 2) “SAC”, with surveys limited to school-aged children. The relationship between S. stercoralis and hookworms was characterized in order to estimate the global burden of S. stercoralis infections. The study is registered in PROSPERO (CRD42019131127). Spearman correlation coefficient between S. stercoralis and hookworms was estimated and the global burden of S. stercoralis infections was estimated using a regression model. A total of 119 articles were included, and a significant positive correlation between the burden of S. stercoralis and hookworms was identified. Spearman’s coefficient for Community surveys was 0.94 and for SAC surveys it was 0.63. Based on the linear model, the global burden of S. stercoralis infections was estimated at 386 million (95%CI 324–449 million) people, including 22 million (95%CI 20–24 million) SAC. The significant relationship between S. stercoralis and hookworms allows an estimation of the global burden of S. stercoralis infections in most epidemiologic settings using hookworm burden and justifies the search of integrated control activities.
Fil: Fleitas, Pedro Emanuel. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; Argentina. Universidad Nacional de Salta. Facultad de Ciencias Naturales. Escuela de Biología. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta; Argentina
Fil: Travacio, Marina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; Argentina
Fil: Martí Soler, Helena. Universidad de Barcelona; España
Fil: Socías, María Eugenia. University of British Columbia; Canadá
Fil: Lopez, Walter R.. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; Argentina
Fil: Krolewiecki, Alejandro Javier. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; Argentina. Universidad de Barcelona; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta; Argentina
description Soil-transmitted helminths (STH) represent a significant public health problem. However, Strongyloides stercoralis is not yet integrated into the control strategy against STH, given limitations to accurately assess its burden. Considering that S. stercoralis shares biological and epidemiological characteristics with hookworms, we describe a new approach for an improved estimation of the burden of infections by S. stercoralis based on the prevalence and burden of hookworms and the relationship between these species. A systematic review of publications reporting prevalence rates for S. stercoralis and hookworms was carried out. The data was classified into two categories: 1) “Community”, with surveys including all age groups, and 2) “SAC”, with surveys limited to school-aged children. The relationship between S. stercoralis and hookworms was characterized in order to estimate the global burden of S. stercoralis infections. The study is registered in PROSPERO (CRD42019131127). Spearman correlation coefficient between S. stercoralis and hookworms was estimated and the global burden of S. stercoralis infections was estimated using a regression model. A total of 119 articles were included, and a significant positive correlation between the burden of S. stercoralis and hookworms was identified. Spearman’s coefficient for Community surveys was 0.94 and for SAC surveys it was 0.63. Based on the linear model, the global burden of S. stercoralis infections was estimated at 386 million (95%CI 324–449 million) people, including 22 million (95%CI 20–24 million) SAC. The significant relationship between S. stercoralis and hookworms allows an estimation of the global burden of S. stercoralis infections in most epidemiologic settings using hookworm burden and justifies the search of integrated control activities.
publishDate 2020
dc.date.none.fl_str_mv 2020-04-13
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/128002
Fleitas, Pedro Emanuel; Travacio, Marina; Martí Soler, Helena; Socías, María Eugenia; Lopez, Walter R.; et al.; The strongyloides stercoralis-hookworms association as a path to the estimation of the global burden of strongyloidiasis: A systematic review; Public Library of Science; Neglected Tropical Diseases; 14; 4; 13-4-2020; 1-13
1935-2735
1935-2727
CONICET Digital
CONICET
url http://hdl.handle.net/11336/128002
identifier_str_mv Fleitas, Pedro Emanuel; Travacio, Marina; Martí Soler, Helena; Socías, María Eugenia; Lopez, Walter R.; et al.; The strongyloides stercoralis-hookworms association as a path to the estimation of the global burden of strongyloidiasis: A systematic review; Public Library of Science; Neglected Tropical Diseases; 14; 4; 13-4-2020; 1-13
1935-2735
1935-2727
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pntd.0008184
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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