Disruption of transfer entropy and inter-hemispheric brain functional connectivity in patients with disorder of consciousness

Autores
Exposito, Veronica; Diez, Ibai; Cortes, Jesus M.; Chialvo, Dante Renato; Villarreal, Mirta Fabiana
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Severe traumatic brain injury can lead to disorders of consciousness (DOC) characterized by deficit in conscious awareness and cognitive impairment including coma, vegetative state, minimally consciousness, and lock-in syndrome. Of crucial importance is to find objective markers that can account for the large-scale disturbances of brain function to help the diagnosis and prognosis of DOC patients and eventually the prediction of the coma outcome. Following recent studies suggesting that the functional organization of brain networks can be altered in comatose patients, this work analyzes brain functional connectivity (FC) networks obtained from resting-state functional magnetic resonance imaging (rs-fMRI). Two approaches are used to estimate the FC: the Partial Correlation (PC) and the Transfer Entropy (TE). Both the PC and the TE show significant statistical differences between the group of patients and control subjects; in brief, the inter-hemispheric PC and the intra-hemispheric TE account for such differences. Overall, these results suggest two possible rs-fMRI markers useful to design new strategies for the management and neuropsychological rehabilitation of DOC patients.
Fil: Exposito, Veronica. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Diez, Ibai. Biocruces Instituto de Investigación Sanitaria; España
Fil: Cortes, Jesus M.. Biocruces Instituto de Investigación Sanitaria; España
Fil: Chialvo, Dante Renato. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Villarreal, Mirta Fabiana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
DISORDER OF CONSCIOUSNESS
FMRI
RESTING STATE
FUNCTIONAL MAGNETIC RESONANCE IMAGING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/22152
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Disruption of transfer entropy and inter-hemispheric brain functional connectivity in patients with disorder of consciousnessExposito, VeronicaDiez, IbaiCortes, Jesus M.Chialvo, Dante RenatoVillarreal, Mirta FabianaDISORDER OF CONSCIOUSNESSFMRIRESTING STATEFUNCTIONAL MAGNETIC RESONANCE IMAGINGhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Severe traumatic brain injury can lead to disorders of consciousness (DOC) characterized by deficit in conscious awareness and cognitive impairment including coma, vegetative state, minimally consciousness, and lock-in syndrome. Of crucial importance is to find objective markers that can account for the large-scale disturbances of brain function to help the diagnosis and prognosis of DOC patients and eventually the prediction of the coma outcome. Following recent studies suggesting that the functional organization of brain networks can be altered in comatose patients, this work analyzes brain functional connectivity (FC) networks obtained from resting-state functional magnetic resonance imaging (rs-fMRI). Two approaches are used to estimate the FC: the Partial Correlation (PC) and the Transfer Entropy (TE). Both the PC and the TE show significant statistical differences between the group of patients and control subjects; in brief, the inter-hemispheric PC and the intra-hemispheric TE account for such differences. Overall, these results suggest two possible rs-fMRI markers useful to design new strategies for the management and neuropsychological rehabilitation of DOC patients.Fil: Exposito, Veronica. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Diez, Ibai. Biocruces Instituto de Investigación Sanitaria; EspañaFil: Cortes, Jesus M.. Biocruces Instituto de Investigación Sanitaria; EspañaFil: Chialvo, Dante Renato. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Villarreal, Mirta Fabiana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFrontiers2013-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/22152Exposito, Veronica; Diez, Ibai; Cortes, Jesus M.; Chialvo, Dante Renato; Villarreal, Mirta Fabiana; Disruption of transfer entropy and inter-hemispheric brain functional connectivity in patients with disorder of consciousness; Frontiers; Frontiers in Neuroinformatics; 7; 11-2013; 1-10; 241662-5196CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fninf.2013.00024info:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/article/10.3389/fninf.2013.00024/fullinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:04:28Zoai:ri.conicet.gov.ar:11336/22152instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:04:29.235CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Disruption of transfer entropy and inter-hemispheric brain functional connectivity in patients with disorder of consciousness
title Disruption of transfer entropy and inter-hemispheric brain functional connectivity in patients with disorder of consciousness
spellingShingle Disruption of transfer entropy and inter-hemispheric brain functional connectivity in patients with disorder of consciousness
Exposito, Veronica
DISORDER OF CONSCIOUSNESS
FMRI
RESTING STATE
FUNCTIONAL MAGNETIC RESONANCE IMAGING
title_short Disruption of transfer entropy and inter-hemispheric brain functional connectivity in patients with disorder of consciousness
title_full Disruption of transfer entropy and inter-hemispheric brain functional connectivity in patients with disorder of consciousness
title_fullStr Disruption of transfer entropy and inter-hemispheric brain functional connectivity in patients with disorder of consciousness
title_full_unstemmed Disruption of transfer entropy and inter-hemispheric brain functional connectivity in patients with disorder of consciousness
title_sort Disruption of transfer entropy and inter-hemispheric brain functional connectivity in patients with disorder of consciousness
dc.creator.none.fl_str_mv Exposito, Veronica
Diez, Ibai
Cortes, Jesus M.
Chialvo, Dante Renato
Villarreal, Mirta Fabiana
author Exposito, Veronica
author_facet Exposito, Veronica
Diez, Ibai
Cortes, Jesus M.
Chialvo, Dante Renato
Villarreal, Mirta Fabiana
author_role author
author2 Diez, Ibai
Cortes, Jesus M.
Chialvo, Dante Renato
Villarreal, Mirta Fabiana
author2_role author
author
author
author
dc.subject.none.fl_str_mv DISORDER OF CONSCIOUSNESS
FMRI
RESTING STATE
FUNCTIONAL MAGNETIC RESONANCE IMAGING
topic DISORDER OF CONSCIOUSNESS
FMRI
RESTING STATE
FUNCTIONAL MAGNETIC RESONANCE IMAGING
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Severe traumatic brain injury can lead to disorders of consciousness (DOC) characterized by deficit in conscious awareness and cognitive impairment including coma, vegetative state, minimally consciousness, and lock-in syndrome. Of crucial importance is to find objective markers that can account for the large-scale disturbances of brain function to help the diagnosis and prognosis of DOC patients and eventually the prediction of the coma outcome. Following recent studies suggesting that the functional organization of brain networks can be altered in comatose patients, this work analyzes brain functional connectivity (FC) networks obtained from resting-state functional magnetic resonance imaging (rs-fMRI). Two approaches are used to estimate the FC: the Partial Correlation (PC) and the Transfer Entropy (TE). Both the PC and the TE show significant statistical differences between the group of patients and control subjects; in brief, the inter-hemispheric PC and the intra-hemispheric TE account for such differences. Overall, these results suggest two possible rs-fMRI markers useful to design new strategies for the management and neuropsychological rehabilitation of DOC patients.
Fil: Exposito, Veronica. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Diez, Ibai. Biocruces Instituto de Investigación Sanitaria; España
Fil: Cortes, Jesus M.. Biocruces Instituto de Investigación Sanitaria; España
Fil: Chialvo, Dante Renato. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Villarreal, Mirta Fabiana. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Severe traumatic brain injury can lead to disorders of consciousness (DOC) characterized by deficit in conscious awareness and cognitive impairment including coma, vegetative state, minimally consciousness, and lock-in syndrome. Of crucial importance is to find objective markers that can account for the large-scale disturbances of brain function to help the diagnosis and prognosis of DOC patients and eventually the prediction of the coma outcome. Following recent studies suggesting that the functional organization of brain networks can be altered in comatose patients, this work analyzes brain functional connectivity (FC) networks obtained from resting-state functional magnetic resonance imaging (rs-fMRI). Two approaches are used to estimate the FC: the Partial Correlation (PC) and the Transfer Entropy (TE). Both the PC and the TE show significant statistical differences between the group of patients and control subjects; in brief, the inter-hemispheric PC and the intra-hemispheric TE account for such differences. Overall, these results suggest two possible rs-fMRI markers useful to design new strategies for the management and neuropsychological rehabilitation of DOC patients.
publishDate 2013
dc.date.none.fl_str_mv 2013-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/22152
Exposito, Veronica; Diez, Ibai; Cortes, Jesus M.; Chialvo, Dante Renato; Villarreal, Mirta Fabiana; Disruption of transfer entropy and inter-hemispheric brain functional connectivity in patients with disorder of consciousness; Frontiers; Frontiers in Neuroinformatics; 7; 11-2013; 1-10; 24
1662-5196
CONICET Digital
CONICET
url http://hdl.handle.net/11336/22152
identifier_str_mv Exposito, Veronica; Diez, Ibai; Cortes, Jesus M.; Chialvo, Dante Renato; Villarreal, Mirta Fabiana; Disruption of transfer entropy and inter-hemispheric brain functional connectivity in patients with disorder of consciousness; Frontiers; Frontiers in Neuroinformatics; 7; 11-2013; 1-10; 24
1662-5196
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fninf.2013.00024
info:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/article/10.3389/fninf.2013.00024/full
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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