Potential effects of melatonin and micronutrients on mitochondrial dysfunction during a cytokine storm typical of oxidative inflammatory diseases

Autores
Martín Giménez, Virna Margarita; de Las Heras, Natalia; Ferder, Leon Fernando; Lahera Juliá, Vicente; Reiter, Russel; Manucha, Walter Ariel Fernando
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Exaggerated oxidative stress and hyper-inflammation are essential features of oxida-tive/inflammatory diseases. Simultaneously, both processes may be the cause or consequence of mitochondrial dysfunction, thus establishing a vicious cycle among these three factors. However, several natural substances, including melatonin and micronutrients, may prevent or attenuate mitochondrial damage and may preserve an optimal state of health by managing the general oxidative and inflammatory status. This review aims to describe the crucial role of mitochondria in the development and progression of multiple diseases, as well as the close relationship among mitochondrial dysfunction, oxidative stress, and cytokine storm. Likewise, it attempts to summarize the main findings related to the powerful effects of melatonin and some micronutrients (vitamins and minerals), which may be useful (alone or in combination) as therapeutic agents in the treatment of several examples of oxidative/inflammatory pathologies, including sepsis, as well as cardiovascular, renal, neurodegenerative and metabolic disorders.
Fil: Martín Giménez, Virna Margarita. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Ciencias de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación en Ciencias Químicas; Argentina
Fil: de Las Heras, Natalia. Universidad Complutense de Madrid. Facultad de Medicina. Departamento de Fisiología; España
Fil: Ferder, Leon Fernando. Universidad de Maimónides; Argentina
Fil: Lahera Juliá, Vicente. Universidad Complutense de Madrid. Facultad de Medicina. Departamento de Fisiología; España
Fil: Reiter, Russel. University Of Texas At San Antonio. University Of Texas Health Science Center At San Antonio (ut Health San Antonio); Estados Unidos
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Materia
MITOCHONDRIAL DYSFUNCTION
MELATONIN
MICRONUTRIENTS
COVID-19
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/173284
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Potential effects of melatonin and micronutrients on mitochondrial dysfunction during a cytokine storm typical of oxidative inflammatory diseasesMartín Giménez, Virna Margaritade Las Heras, NataliaFerder, Leon FernandoLahera Juliá, VicenteReiter, RusselManucha, Walter Ariel FernandoMITOCHONDRIAL DYSFUNCTIONMELATONINMICRONUTRIENTSCOVID-19https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Exaggerated oxidative stress and hyper-inflammation are essential features of oxida-tive/inflammatory diseases. Simultaneously, both processes may be the cause or consequence of mitochondrial dysfunction, thus establishing a vicious cycle among these three factors. However, several natural substances, including melatonin and micronutrients, may prevent or attenuate mitochondrial damage and may preserve an optimal state of health by managing the general oxidative and inflammatory status. This review aims to describe the crucial role of mitochondria in the development and progression of multiple diseases, as well as the close relationship among mitochondrial dysfunction, oxidative stress, and cytokine storm. Likewise, it attempts to summarize the main findings related to the powerful effects of melatonin and some micronutrients (vitamins and minerals), which may be useful (alone or in combination) as therapeutic agents in the treatment of several examples of oxidative/inflammatory pathologies, including sepsis, as well as cardiovascular, renal, neurodegenerative and metabolic disorders.Fil: Martín Giménez, Virna Margarita. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Ciencias de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación en Ciencias Químicas; ArgentinaFil: de Las Heras, Natalia. Universidad Complutense de Madrid. Facultad de Medicina. Departamento de Fisiología; EspañaFil: Ferder, Leon Fernando. Universidad de Maimónides; ArgentinaFil: Lahera Juliá, Vicente. Universidad Complutense de Madrid. Facultad de Medicina. Departamento de Fisiología; EspañaFil: Reiter, Russel. University Of Texas At San Antonio. University Of Texas Health Science Center At San Antonio (ut Health San Antonio); Estados UnidosFil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaMultidisciplinary Digital Publishing Institute2021-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/173284Martín Giménez, Virna Margarita; de Las Heras, Natalia; Ferder, Leon Fernando; Lahera Juliá, Vicente; Reiter, Russel; et al.; Potential effects of melatonin and micronutrients on mitochondrial dysfunction during a cytokine storm typical of oxidative inflammatory diseases; Multidisciplinary Digital Publishing Institute; Diseases; 9; 30; 4-2021; 1-212079-9721CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2079-9721/9/2/30info:eu-repo/semantics/altIdentifier/doi/10.3390/diseases9020030info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:47:37Zoai:ri.conicet.gov.ar:11336/173284instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:47:38.001CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Potential effects of melatonin and micronutrients on mitochondrial dysfunction during a cytokine storm typical of oxidative inflammatory diseases
title Potential effects of melatonin and micronutrients on mitochondrial dysfunction during a cytokine storm typical of oxidative inflammatory diseases
spellingShingle Potential effects of melatonin and micronutrients on mitochondrial dysfunction during a cytokine storm typical of oxidative inflammatory diseases
Martín Giménez, Virna Margarita
MITOCHONDRIAL DYSFUNCTION
MELATONIN
MICRONUTRIENTS
COVID-19
title_short Potential effects of melatonin and micronutrients on mitochondrial dysfunction during a cytokine storm typical of oxidative inflammatory diseases
title_full Potential effects of melatonin and micronutrients on mitochondrial dysfunction during a cytokine storm typical of oxidative inflammatory diseases
title_fullStr Potential effects of melatonin and micronutrients on mitochondrial dysfunction during a cytokine storm typical of oxidative inflammatory diseases
title_full_unstemmed Potential effects of melatonin and micronutrients on mitochondrial dysfunction during a cytokine storm typical of oxidative inflammatory diseases
title_sort Potential effects of melatonin and micronutrients on mitochondrial dysfunction during a cytokine storm typical of oxidative inflammatory diseases
dc.creator.none.fl_str_mv Martín Giménez, Virna Margarita
de Las Heras, Natalia
Ferder, Leon Fernando
Lahera Juliá, Vicente
Reiter, Russel
Manucha, Walter Ariel Fernando
author Martín Giménez, Virna Margarita
author_facet Martín Giménez, Virna Margarita
de Las Heras, Natalia
Ferder, Leon Fernando
Lahera Juliá, Vicente
Reiter, Russel
Manucha, Walter Ariel Fernando
author_role author
author2 de Las Heras, Natalia
Ferder, Leon Fernando
Lahera Juliá, Vicente
Reiter, Russel
Manucha, Walter Ariel Fernando
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv MITOCHONDRIAL DYSFUNCTION
MELATONIN
MICRONUTRIENTS
COVID-19
topic MITOCHONDRIAL DYSFUNCTION
MELATONIN
MICRONUTRIENTS
COVID-19
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Exaggerated oxidative stress and hyper-inflammation are essential features of oxida-tive/inflammatory diseases. Simultaneously, both processes may be the cause or consequence of mitochondrial dysfunction, thus establishing a vicious cycle among these three factors. However, several natural substances, including melatonin and micronutrients, may prevent or attenuate mitochondrial damage and may preserve an optimal state of health by managing the general oxidative and inflammatory status. This review aims to describe the crucial role of mitochondria in the development and progression of multiple diseases, as well as the close relationship among mitochondrial dysfunction, oxidative stress, and cytokine storm. Likewise, it attempts to summarize the main findings related to the powerful effects of melatonin and some micronutrients (vitamins and minerals), which may be useful (alone or in combination) as therapeutic agents in the treatment of several examples of oxidative/inflammatory pathologies, including sepsis, as well as cardiovascular, renal, neurodegenerative and metabolic disorders.
Fil: Martín Giménez, Virna Margarita. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Ciencias de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación en Ciencias Químicas; Argentina
Fil: de Las Heras, Natalia. Universidad Complutense de Madrid. Facultad de Medicina. Departamento de Fisiología; España
Fil: Ferder, Leon Fernando. Universidad de Maimónides; Argentina
Fil: Lahera Juliá, Vicente. Universidad Complutense de Madrid. Facultad de Medicina. Departamento de Fisiología; España
Fil: Reiter, Russel. University Of Texas At San Antonio. University Of Texas Health Science Center At San Antonio (ut Health San Antonio); Estados Unidos
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
description Exaggerated oxidative stress and hyper-inflammation are essential features of oxida-tive/inflammatory diseases. Simultaneously, both processes may be the cause or consequence of mitochondrial dysfunction, thus establishing a vicious cycle among these three factors. However, several natural substances, including melatonin and micronutrients, may prevent or attenuate mitochondrial damage and may preserve an optimal state of health by managing the general oxidative and inflammatory status. This review aims to describe the crucial role of mitochondria in the development and progression of multiple diseases, as well as the close relationship among mitochondrial dysfunction, oxidative stress, and cytokine storm. Likewise, it attempts to summarize the main findings related to the powerful effects of melatonin and some micronutrients (vitamins and minerals), which may be useful (alone or in combination) as therapeutic agents in the treatment of several examples of oxidative/inflammatory pathologies, including sepsis, as well as cardiovascular, renal, neurodegenerative and metabolic disorders.
publishDate 2021
dc.date.none.fl_str_mv 2021-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/173284
Martín Giménez, Virna Margarita; de Las Heras, Natalia; Ferder, Leon Fernando; Lahera Juliá, Vicente; Reiter, Russel; et al.; Potential effects of melatonin and micronutrients on mitochondrial dysfunction during a cytokine storm typical of oxidative inflammatory diseases; Multidisciplinary Digital Publishing Institute; Diseases; 9; 30; 4-2021; 1-21
2079-9721
CONICET Digital
CONICET
url http://hdl.handle.net/11336/173284
identifier_str_mv Martín Giménez, Virna Margarita; de Las Heras, Natalia; Ferder, Leon Fernando; Lahera Juliá, Vicente; Reiter, Russel; et al.; Potential effects of melatonin and micronutrients on mitochondrial dysfunction during a cytokine storm typical of oxidative inflammatory diseases; Multidisciplinary Digital Publishing Institute; Diseases; 9; 30; 4-2021; 1-21
2079-9721
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2079-9721/9/2/30
info:eu-repo/semantics/altIdentifier/doi/10.3390/diseases9020030
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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