Melatonin in mitochondrial dysfunction and related disorders

Autores
Srinivasan, Venkatramanujam; Spence, David Warren; Pandi Perumal, Seithikurippu R.; Brown, Gregory M.; Cardinali, Daniel Pedro
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Mitochondrial dysfunction is considered one of the major causative factors in the aging process, ischemia/reperfusion (I/R), septic shock, and neurodegenerative disorders like Parkinson's disease (PD), Alzheimer's disease (AD), and Huntington's disease (HD). Increased free radical generation, enhanced mitochondrial inducible nitric oxide (NO) synthase activity, enhanced NO production, decreased respiratory complex activity, impaired electron transport system, and opening of mitochondrial permeability transition pore all have been suggested as factors responsible for impaired mitochondrial function. Melatonin, the major hormone of the pineal gland, also acts as an antioxidant and as a regulator of mitochondrial bioenergetic function. Both in vitro and in vivo, melatonin was effective for preventing oxidative stress/nitrosative stress-induced mitochondrial dysfunction seen in experimental models of PD, AD, and HD. In addition, melatonin is known to retard aging and to inhibit the lethal effects of septic shock or I/R lesions by maintaining respiratory complex activities, electron transport chain, and ATP production in mitochondria. Melatonin is selectively taken up by mitochondrial membranes, a function not shared by other antioxidants. Melatonin has thus emerged as a major potential therapeutic tool for treating neurodegenerative disorders such as PD or AD, and for preventing the lethal effects of septic shock or I/R.
Fil: Srinivasan, Venkatramanujam. No especifíca;
Fil: Spence, David Warren. No especifíca;
Fil: Pandi Perumal, Seithikurippu R.. No especifíca;
Fil: Brown, Gregory M.. No especifíca;
Fil: Cardinali, Daniel Pedro. Universidad de Buenos Aires; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
MITOCHONDRIAL DYSFUNCTION
AGING
ALZHEIMER´S DISEASE
MELATONIN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/192058
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/192058
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Melatonin in mitochondrial dysfunction and related disordersSrinivasan, VenkatramanujamSpence, David WarrenPandi Perumal, Seithikurippu R.Brown, Gregory M.Cardinali, Daniel PedroMITOCHONDRIAL DYSFUNCTIONAGINGALZHEIMER´S DISEASEMELATONINhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Mitochondrial dysfunction is considered one of the major causative factors in the aging process, ischemia/reperfusion (I/R), septic shock, and neurodegenerative disorders like Parkinson's disease (PD), Alzheimer's disease (AD), and Huntington's disease (HD). Increased free radical generation, enhanced mitochondrial inducible nitric oxide (NO) synthase activity, enhanced NO production, decreased respiratory complex activity, impaired electron transport system, and opening of mitochondrial permeability transition pore all have been suggested as factors responsible for impaired mitochondrial function. Melatonin, the major hormone of the pineal gland, also acts as an antioxidant and as a regulator of mitochondrial bioenergetic function. Both in vitro and in vivo, melatonin was effective for preventing oxidative stress/nitrosative stress-induced mitochondrial dysfunction seen in experimental models of PD, AD, and HD. In addition, melatonin is known to retard aging and to inhibit the lethal effects of septic shock or I/R lesions by maintaining respiratory complex activities, electron transport chain, and ATP production in mitochondria. Melatonin is selectively taken up by mitochondrial membranes, a function not shared by other antioxidants. Melatonin has thus emerged as a major potential therapeutic tool for treating neurodegenerative disorders such as PD or AD, and for preventing the lethal effects of septic shock or I/R.Fil: Srinivasan, Venkatramanujam. No especifíca;Fil: Spence, David Warren. No especifíca;Fil: Pandi Perumal, Seithikurippu R.. No especifíca;Fil: Brown, Gregory M.. No especifíca;Fil: Cardinali, Daniel Pedro. Universidad de Buenos Aires; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaHindawi Publishing Corporation2011-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/192058Srinivasan, Venkatramanujam; Spence, David Warren; Pandi Perumal, Seithikurippu R.; Brown, Gregory M.; Cardinali, Daniel Pedro; Melatonin in mitochondrial dysfunction and related disorders; Hindawi Publishing Corporation; International Journal of Alzheimer's Disease; 2011; 3-2011; 1-162090-0252CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.4061/2011/326320info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:02:42Zoai:ri.conicet.gov.ar:11336/192058instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:02:42.961CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Melatonin in mitochondrial dysfunction and related disorders
title Melatonin in mitochondrial dysfunction and related disorders
spellingShingle Melatonin in mitochondrial dysfunction and related disorders
Srinivasan, Venkatramanujam
MITOCHONDRIAL DYSFUNCTION
AGING
ALZHEIMER´S DISEASE
MELATONIN
title_short Melatonin in mitochondrial dysfunction and related disorders
title_full Melatonin in mitochondrial dysfunction and related disorders
title_fullStr Melatonin in mitochondrial dysfunction and related disorders
title_full_unstemmed Melatonin in mitochondrial dysfunction and related disorders
title_sort Melatonin in mitochondrial dysfunction and related disorders
dc.creator.none.fl_str_mv Srinivasan, Venkatramanujam
Spence, David Warren
Pandi Perumal, Seithikurippu R.
Brown, Gregory M.
Cardinali, Daniel Pedro
author Srinivasan, Venkatramanujam
author_facet Srinivasan, Venkatramanujam
Spence, David Warren
Pandi Perumal, Seithikurippu R.
Brown, Gregory M.
Cardinali, Daniel Pedro
author_role author
author2 Spence, David Warren
Pandi Perumal, Seithikurippu R.
Brown, Gregory M.
Cardinali, Daniel Pedro
author2_role author
author
author
author
dc.subject.none.fl_str_mv MITOCHONDRIAL DYSFUNCTION
AGING
ALZHEIMER´S DISEASE
MELATONIN
topic MITOCHONDRIAL DYSFUNCTION
AGING
ALZHEIMER´S DISEASE
MELATONIN
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Mitochondrial dysfunction is considered one of the major causative factors in the aging process, ischemia/reperfusion (I/R), septic shock, and neurodegenerative disorders like Parkinson's disease (PD), Alzheimer's disease (AD), and Huntington's disease (HD). Increased free radical generation, enhanced mitochondrial inducible nitric oxide (NO) synthase activity, enhanced NO production, decreased respiratory complex activity, impaired electron transport system, and opening of mitochondrial permeability transition pore all have been suggested as factors responsible for impaired mitochondrial function. Melatonin, the major hormone of the pineal gland, also acts as an antioxidant and as a regulator of mitochondrial bioenergetic function. Both in vitro and in vivo, melatonin was effective for preventing oxidative stress/nitrosative stress-induced mitochondrial dysfunction seen in experimental models of PD, AD, and HD. In addition, melatonin is known to retard aging and to inhibit the lethal effects of septic shock or I/R lesions by maintaining respiratory complex activities, electron transport chain, and ATP production in mitochondria. Melatonin is selectively taken up by mitochondrial membranes, a function not shared by other antioxidants. Melatonin has thus emerged as a major potential therapeutic tool for treating neurodegenerative disorders such as PD or AD, and for preventing the lethal effects of septic shock or I/R.
Fil: Srinivasan, Venkatramanujam. No especifíca;
Fil: Spence, David Warren. No especifíca;
Fil: Pandi Perumal, Seithikurippu R.. No especifíca;
Fil: Brown, Gregory M.. No especifíca;
Fil: Cardinali, Daniel Pedro. Universidad de Buenos Aires; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Mitochondrial dysfunction is considered one of the major causative factors in the aging process, ischemia/reperfusion (I/R), septic shock, and neurodegenerative disorders like Parkinson's disease (PD), Alzheimer's disease (AD), and Huntington's disease (HD). Increased free radical generation, enhanced mitochondrial inducible nitric oxide (NO) synthase activity, enhanced NO production, decreased respiratory complex activity, impaired electron transport system, and opening of mitochondrial permeability transition pore all have been suggested as factors responsible for impaired mitochondrial function. Melatonin, the major hormone of the pineal gland, also acts as an antioxidant and as a regulator of mitochondrial bioenergetic function. Both in vitro and in vivo, melatonin was effective for preventing oxidative stress/nitrosative stress-induced mitochondrial dysfunction seen in experimental models of PD, AD, and HD. In addition, melatonin is known to retard aging and to inhibit the lethal effects of septic shock or I/R lesions by maintaining respiratory complex activities, electron transport chain, and ATP production in mitochondria. Melatonin is selectively taken up by mitochondrial membranes, a function not shared by other antioxidants. Melatonin has thus emerged as a major potential therapeutic tool for treating neurodegenerative disorders such as PD or AD, and for preventing the lethal effects of septic shock or I/R.
publishDate 2011
dc.date.none.fl_str_mv 2011-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/192058
Srinivasan, Venkatramanujam; Spence, David Warren; Pandi Perumal, Seithikurippu R.; Brown, Gregory M.; Cardinali, Daniel Pedro; Melatonin in mitochondrial dysfunction and related disorders; Hindawi Publishing Corporation; International Journal of Alzheimer's Disease; 2011; 3-2011; 1-16
2090-0252
CONICET Digital
CONICET
url http://hdl.handle.net/11336/192058
identifier_str_mv Srinivasan, Venkatramanujam; Spence, David Warren; Pandi Perumal, Seithikurippu R.; Brown, Gregory M.; Cardinali, Daniel Pedro; Melatonin in mitochondrial dysfunction and related disorders; Hindawi Publishing Corporation; International Journal of Alzheimer's Disease; 2011; 3-2011; 1-16
2090-0252
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.4061/2011/326320
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842980034559606784
score 12.993085

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