Cochlear hair cells: The sound-sensing machines

Autores
Goutman, Juan Diego; Elgoyhen, Ana Belen; Gomez Casati, Maria Eugenia
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The sensory epithelium of the mammalian inner ear contains two types of mechanosensory cells:inner (IHC) and outer hair cells (OHC). They both transduce mechanical force generated by soundwaves into electrical signals. In their apical end, these cells possess a set of stereocilia representingthe mechanosensing organelles. IHC are responsible for detecting sounds and transmitting theacoustic information to the brain by converting graded depolarization into trains of actionpotentials in auditory nerve fibers. OHC are responsible for the active mechanical amplificationprocess that leads to the fine tuning and high sensitivity of the mammalian inner ear. This activeamplification is the consequence of the ability of OHC to alter their cell length in response tochanges in membrane potential, and is controlled by an efferent inhibitory innervation. Medialolivocochlear efferent fibers, originating in the brainstem, synapse directly at the base of OHC andrelease acetylcholine. A very special type of nicotinic receptor, assembled by a9a10 subunits,participates in this synapse. Here we review recent knowledge and the role of both afferent andefferent synapse in the inner ear.
Fil: Goutman, Juan Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina
Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Farmacología; Argentina
Fil: Gomez Casati, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Farmacología; Argentina
Materia
Cochlear Hair Cells
Afferent Synapse
Efferent Synapse
Noise Induced-Hearing Loss
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/3948
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Cochlear hair cells: The sound-sensing machinesGoutman, Juan DiegoElgoyhen, Ana BelenGomez Casati, Maria EugeniaCochlear Hair CellsAfferent SynapseEfferent SynapseNoise Induced-Hearing Losshttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The sensory epithelium of the mammalian inner ear contains two types of mechanosensory cells:inner (IHC) and outer hair cells (OHC). They both transduce mechanical force generated by soundwaves into electrical signals. In their apical end, these cells possess a set of stereocilia representingthe mechanosensing organelles. IHC are responsible for detecting sounds and transmitting theacoustic information to the brain by converting graded depolarization into trains of actionpotentials in auditory nerve fibers. OHC are responsible for the active mechanical amplificationprocess that leads to the fine tuning and high sensitivity of the mammalian inner ear. This activeamplification is the consequence of the ability of OHC to alter their cell length in response tochanges in membrane potential, and is controlled by an efferent inhibitory innervation. Medialolivocochlear efferent fibers, originating in the brainstem, synapse directly at the base of OHC andrelease acetylcholine. A very special type of nicotinic receptor, assembled by a9a10 subunits,participates in this synapse. Here we review recent knowledge and the role of both afferent andefferent synapse in the inner ear.Fil: Goutman, Juan Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; ArgentinaFil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Farmacología; ArgentinaFil: Gomez Casati, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Farmacología; ArgentinaElsevier2015-08-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/3948Goutman, Juan Diego; Elgoyhen, Ana Belen; Gomez Casati, Maria Eugenia; Cochlear hair cells: The sound-sensing machines; Elsevier; Febs Letters; 589; 22; 31-8-2015; 3354–33610014-5793enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0014579315007309info:eu-repo/semantics/altIdentifier/doi/10.1016/j.febslet.2015.08.030info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2015.08.030/abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:55:13Zoai:ri.conicet.gov.ar:11336/3948instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:55:13.488CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cochlear hair cells: The sound-sensing machines
title Cochlear hair cells: The sound-sensing machines
spellingShingle Cochlear hair cells: The sound-sensing machines
Goutman, Juan Diego
Cochlear Hair Cells
Afferent Synapse
Efferent Synapse
Noise Induced-Hearing Loss
title_short Cochlear hair cells: The sound-sensing machines
title_full Cochlear hair cells: The sound-sensing machines
title_fullStr Cochlear hair cells: The sound-sensing machines
title_full_unstemmed Cochlear hair cells: The sound-sensing machines
title_sort Cochlear hair cells: The sound-sensing machines
dc.creator.none.fl_str_mv Goutman, Juan Diego
Elgoyhen, Ana Belen
Gomez Casati, Maria Eugenia
author Goutman, Juan Diego
author_facet Goutman, Juan Diego
Elgoyhen, Ana Belen
Gomez Casati, Maria Eugenia
author_role author
author2 Elgoyhen, Ana Belen
Gomez Casati, Maria Eugenia
author2_role author
author
dc.subject.none.fl_str_mv Cochlear Hair Cells
Afferent Synapse
Efferent Synapse
Noise Induced-Hearing Loss
topic Cochlear Hair Cells
Afferent Synapse
Efferent Synapse
Noise Induced-Hearing Loss
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The sensory epithelium of the mammalian inner ear contains two types of mechanosensory cells:inner (IHC) and outer hair cells (OHC). They both transduce mechanical force generated by soundwaves into electrical signals. In their apical end, these cells possess a set of stereocilia representingthe mechanosensing organelles. IHC are responsible for detecting sounds and transmitting theacoustic information to the brain by converting graded depolarization into trains of actionpotentials in auditory nerve fibers. OHC are responsible for the active mechanical amplificationprocess that leads to the fine tuning and high sensitivity of the mammalian inner ear. This activeamplification is the consequence of the ability of OHC to alter their cell length in response tochanges in membrane potential, and is controlled by an efferent inhibitory innervation. Medialolivocochlear efferent fibers, originating in the brainstem, synapse directly at the base of OHC andrelease acetylcholine. A very special type of nicotinic receptor, assembled by a9a10 subunits,participates in this synapse. Here we review recent knowledge and the role of both afferent andefferent synapse in the inner ear.
Fil: Goutman, Juan Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina
Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Farmacología; Argentina
Fil: Gomez Casati, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Farmacología; Argentina
description The sensory epithelium of the mammalian inner ear contains two types of mechanosensory cells:inner (IHC) and outer hair cells (OHC). They both transduce mechanical force generated by soundwaves into electrical signals. In their apical end, these cells possess a set of stereocilia representingthe mechanosensing organelles. IHC are responsible for detecting sounds and transmitting theacoustic information to the brain by converting graded depolarization into trains of actionpotentials in auditory nerve fibers. OHC are responsible for the active mechanical amplificationprocess that leads to the fine tuning and high sensitivity of the mammalian inner ear. This activeamplification is the consequence of the ability of OHC to alter their cell length in response tochanges in membrane potential, and is controlled by an efferent inhibitory innervation. Medialolivocochlear efferent fibers, originating in the brainstem, synapse directly at the base of OHC andrelease acetylcholine. A very special type of nicotinic receptor, assembled by a9a10 subunits,participates in this synapse. Here we review recent knowledge and the role of both afferent andefferent synapse in the inner ear.
publishDate 2015
dc.date.none.fl_str_mv 2015-08-31
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/3948
Goutman, Juan Diego; Elgoyhen, Ana Belen; Gomez Casati, Maria Eugenia; Cochlear hair cells: The sound-sensing machines; Elsevier; Febs Letters; 589; 22; 31-8-2015; 3354–3361
0014-5793
url http://hdl.handle.net/11336/3948
identifier_str_mv Goutman, Juan Diego; Elgoyhen, Ana Belen; Gomez Casati, Maria Eugenia; Cochlear hair cells: The sound-sensing machines; Elsevier; Febs Letters; 589; 22; 31-8-2015; 3354–3361
0014-5793
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0014579315007309
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.febslet.2015.08.030
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2015.08.030/abstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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