Nasal airflow simulations suggest convergent adaptation in Neanderthals and modern humans
- Autores
- de Azevedo, Soledad; González, M. F.; Cintas, Celia; Ramallo, Virginia; Quinto Sanchez, Mirsha Emmanuel; Marquez, Federico; Hünemeier, Tábita; Paschetta, Carolina Andrea; Ruderman, Anahí; Navarro, Jose Pablo; Pazos, Bruno Alfredo; Silva de Cerqueira, Caio Cesar; Velan, O.; Ramírez Rozzi, F.; Calvo, N.; Castro, Hugo Guillermo; Paz, Rodrigo Rafael; González José, Rolando
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Both modern humans (MHs) and Neanderthals successfully settled across western Eurasian cold-climate landscapes. Among the many adaptations considered as essential to survival in such landscapes, changes in the nasal morphology and/or function aimed to humidify and warm the air before it reaches the lungs are of key importance. Unfortunately, the lack of soft-tissue evidence in the fossil record turns difficult any comparative study of respiratory performance. Here, we reconstruct the internal nasal cavity of a Neanderthal plus two representatives of climatically divergent MH populations (southwestern Europeans and northeastern Asians). The reconstruction includes mucosa distribution enabling a realistic simulation of the breathing cycle in different climatic conditions via computational fluid dynamics. Striking across-specimens differences in fluid residence times affecting humidification and warming performance at the anterior tract were found under cold/dry climate simulations. Specifically, the Asian model achieves a rapid air conditioning, followed by the Neanderthals, whereas the European model attains a proper conditioning only around the medium-posterior tract. In addition, quantitative-genetic evolutionary analyses of nasal morphology provided signals of stabilizing selection for MH populations, with the removal of Arctic populations turning covariation patterns compatible with evolution by genetic drift. Both results indicate that, departing from important craniofacial differences existing among Neanderthals and MHs, an advantageous species-specific respiratory performance in cold climates may have occurred in both species. Fluid dynamics and evolutionary biology independently provided evidence of nasal evolution, suggesting that adaptive explanations regarding complex functional phenotypes require interdisciplinary approaches aimed to quantify both performance and evolutionary signals on covariation patterns.
Fil: de Azevedo, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
Fil: González, M. F.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
Fil: Cintas, Celia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
Fil: Ramallo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
Fil: Quinto Sanchez, Mirsha Emmanuel. Universidad Nacional Autónoma de México; México
Fil: Marquez, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Biología de Organismos Marinos; Argentina
Fil: Hünemeier, Tábita. Universidade de Sao Paulo; Brasil
Fil: Paschetta, Carolina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
Fil: Ruderman, Anahí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
Fil: Navarro, Jose Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
Fil: Pazos, Bruno Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
Fil: Silva de Cerqueira, Caio Cesar. Superintendência da Polícia Técnico-Científica do Estado de São Paulo, Equipe de Perícias Criminalísticas de Ourinhos; Brasil
Fil: Velan, O.. Hospital Italiano; Argentina
Fil: Ramírez Rozzi, F.. Anthropologie Moléculaire et Imagerie de Synthèse; Francia
Fil: Calvo, N.. Universidad Nacional del Litoral; Argentina
Fil: Castro, Hugo Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Modelado e Innovación Tecnológica. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Instituto de Modelado e Innovación Tecnológica; Argentina
Fil: Paz, Rodrigo Rafael. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Livermore Software Technology Corporation.; Estados Unidos
Fil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina - Materia
-
Nasal Morphology
Computational Fluid Dynamics
Quantitative Genetics
Neanderthal - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/43909
Ver los metadatos del registro completo
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Nasal airflow simulations suggest convergent adaptation in Neanderthals and modern humansde Azevedo, SoledadGonzález, M. F.Cintas, CeliaRamallo, VirginiaQuinto Sanchez, Mirsha EmmanuelMarquez, FedericoHünemeier, TábitaPaschetta, Carolina AndreaRuderman, AnahíNavarro, Jose PabloPazos, Bruno AlfredoSilva de Cerqueira, Caio CesarVelan, O.Ramírez Rozzi, F.Calvo, N.Castro, Hugo GuillermoPaz, Rodrigo RafaelGonzález José, RolandoNasal MorphologyComputational Fluid DynamicsQuantitative GeneticsNeanderthalhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Both modern humans (MHs) and Neanderthals successfully settled across western Eurasian cold-climate landscapes. Among the many adaptations considered as essential to survival in such landscapes, changes in the nasal morphology and/or function aimed to humidify and warm the air before it reaches the lungs are of key importance. Unfortunately, the lack of soft-tissue evidence in the fossil record turns difficult any comparative study of respiratory performance. Here, we reconstruct the internal nasal cavity of a Neanderthal plus two representatives of climatically divergent MH populations (southwestern Europeans and northeastern Asians). The reconstruction includes mucosa distribution enabling a realistic simulation of the breathing cycle in different climatic conditions via computational fluid dynamics. Striking across-specimens differences in fluid residence times affecting humidification and warming performance at the anterior tract were found under cold/dry climate simulations. Specifically, the Asian model achieves a rapid air conditioning, followed by the Neanderthals, whereas the European model attains a proper conditioning only around the medium-posterior tract. In addition, quantitative-genetic evolutionary analyses of nasal morphology provided signals of stabilizing selection for MH populations, with the removal of Arctic populations turning covariation patterns compatible with evolution by genetic drift. Both results indicate that, departing from important craniofacial differences existing among Neanderthals and MHs, an advantageous species-specific respiratory performance in cold climates may have occurred in both species. Fluid dynamics and evolutionary biology independently provided evidence of nasal evolution, suggesting that adaptive explanations regarding complex functional phenotypes require interdisciplinary approaches aimed to quantify both performance and evolutionary signals on covariation patterns.Fil: de Azevedo, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; ArgentinaFil: González, M. F.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; ArgentinaFil: Cintas, Celia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; ArgentinaFil: Ramallo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; ArgentinaFil: Quinto Sanchez, Mirsha Emmanuel. Universidad Nacional Autónoma de México; MéxicoFil: Marquez, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Biología de Organismos Marinos; ArgentinaFil: Hünemeier, Tábita. Universidade de Sao Paulo; BrasilFil: Paschetta, Carolina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; ArgentinaFil: Ruderman, Anahí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; ArgentinaFil: Navarro, Jose Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; ArgentinaFil: Pazos, Bruno Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; ArgentinaFil: Silva de Cerqueira, Caio Cesar. Superintendência da Polícia Técnico-Científica do Estado de São Paulo, Equipe de Perícias Criminalísticas de Ourinhos; BrasilFil: Velan, O.. Hospital Italiano; ArgentinaFil: Ramírez Rozzi, F.. Anthropologie Moléculaire et Imagerie de Synthèse; FranciaFil: Calvo, N.. Universidad Nacional del Litoral; ArgentinaFil: Castro, Hugo Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Modelado e Innovación Tecnológica. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Instituto de Modelado e Innovación Tecnológica; ArgentinaFil: Paz, Rodrigo Rafael. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Livermore Software Technology Corporation.; Estados UnidosFil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; ArgentinaNational Academy of Sciences2017-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/43909de Azevedo, Soledad; González, M. F.; Cintas, Celia; Ramallo, Virginia; Quinto Sanchez, Mirsha Emmanuel; et al.; Nasal airflow simulations suggest convergent adaptation in Neanderthals and modern humans; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 114; 47; 10-2017; 12442-124470027-8424CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.1703790114info:eu-repo/semantics/altIdentifier/url/http://www.pnas.org/content/114/47/12442info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:23:34Zoai:ri.conicet.gov.ar:11336/43909instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:23:35.151CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Nasal airflow simulations suggest convergent adaptation in Neanderthals and modern humans |
| title |
Nasal airflow simulations suggest convergent adaptation in Neanderthals and modern humans |
| spellingShingle |
Nasal airflow simulations suggest convergent adaptation in Neanderthals and modern humans de Azevedo, Soledad Nasal Morphology Computational Fluid Dynamics Quantitative Genetics Neanderthal |
| title_short |
Nasal airflow simulations suggest convergent adaptation in Neanderthals and modern humans |
| title_full |
Nasal airflow simulations suggest convergent adaptation in Neanderthals and modern humans |
| title_fullStr |
Nasal airflow simulations suggest convergent adaptation in Neanderthals and modern humans |
| title_full_unstemmed |
Nasal airflow simulations suggest convergent adaptation in Neanderthals and modern humans |
| title_sort |
Nasal airflow simulations suggest convergent adaptation in Neanderthals and modern humans |
| dc.creator.none.fl_str_mv |
de Azevedo, Soledad González, M. F. Cintas, Celia Ramallo, Virginia Quinto Sanchez, Mirsha Emmanuel Marquez, Federico Hünemeier, Tábita Paschetta, Carolina Andrea Ruderman, Anahí Navarro, Jose Pablo Pazos, Bruno Alfredo Silva de Cerqueira, Caio Cesar Velan, O. Ramírez Rozzi, F. Calvo, N. Castro, Hugo Guillermo Paz, Rodrigo Rafael González José, Rolando |
| author |
de Azevedo, Soledad |
| author_facet |
de Azevedo, Soledad González, M. F. Cintas, Celia Ramallo, Virginia Quinto Sanchez, Mirsha Emmanuel Marquez, Federico Hünemeier, Tábita Paschetta, Carolina Andrea Ruderman, Anahí Navarro, Jose Pablo Pazos, Bruno Alfredo Silva de Cerqueira, Caio Cesar Velan, O. Ramírez Rozzi, F. Calvo, N. Castro, Hugo Guillermo Paz, Rodrigo Rafael González José, Rolando |
| author_role |
author |
| author2 |
González, M. F. Cintas, Celia Ramallo, Virginia Quinto Sanchez, Mirsha Emmanuel Marquez, Federico Hünemeier, Tábita Paschetta, Carolina Andrea Ruderman, Anahí Navarro, Jose Pablo Pazos, Bruno Alfredo Silva de Cerqueira, Caio Cesar Velan, O. Ramírez Rozzi, F. Calvo, N. Castro, Hugo Guillermo Paz, Rodrigo Rafael González José, Rolando |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Nasal Morphology Computational Fluid Dynamics Quantitative Genetics Neanderthal |
| topic |
Nasal Morphology Computational Fluid Dynamics Quantitative Genetics Neanderthal |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
Both modern humans (MHs) and Neanderthals successfully settled across western Eurasian cold-climate landscapes. Among the many adaptations considered as essential to survival in such landscapes, changes in the nasal morphology and/or function aimed to humidify and warm the air before it reaches the lungs are of key importance. Unfortunately, the lack of soft-tissue evidence in the fossil record turns difficult any comparative study of respiratory performance. Here, we reconstruct the internal nasal cavity of a Neanderthal plus two representatives of climatically divergent MH populations (southwestern Europeans and northeastern Asians). The reconstruction includes mucosa distribution enabling a realistic simulation of the breathing cycle in different climatic conditions via computational fluid dynamics. Striking across-specimens differences in fluid residence times affecting humidification and warming performance at the anterior tract were found under cold/dry climate simulations. Specifically, the Asian model achieves a rapid air conditioning, followed by the Neanderthals, whereas the European model attains a proper conditioning only around the medium-posterior tract. In addition, quantitative-genetic evolutionary analyses of nasal morphology provided signals of stabilizing selection for MH populations, with the removal of Arctic populations turning covariation patterns compatible with evolution by genetic drift. Both results indicate that, departing from important craniofacial differences existing among Neanderthals and MHs, an advantageous species-specific respiratory performance in cold climates may have occurred in both species. Fluid dynamics and evolutionary biology independently provided evidence of nasal evolution, suggesting that adaptive explanations regarding complex functional phenotypes require interdisciplinary approaches aimed to quantify both performance and evolutionary signals on covariation patterns. Fil: de Azevedo, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina Fil: González, M. F.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina Fil: Cintas, Celia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina Fil: Ramallo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina Fil: Quinto Sanchez, Mirsha Emmanuel. Universidad Nacional Autónoma de México; México Fil: Marquez, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Biología de Organismos Marinos; Argentina Fil: Hünemeier, Tábita. Universidade de Sao Paulo; Brasil Fil: Paschetta, Carolina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina Fil: Ruderman, Anahí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina Fil: Navarro, Jose Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina Fil: Pazos, Bruno Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina Fil: Silva de Cerqueira, Caio Cesar. Superintendência da Polícia Técnico-Científica do Estado de São Paulo, Equipe de Perícias Criminalísticas de Ourinhos; Brasil Fil: Velan, O.. Hospital Italiano; Argentina Fil: Ramírez Rozzi, F.. Anthropologie Moléculaire et Imagerie de Synthèse; Francia Fil: Calvo, N.. Universidad Nacional del Litoral; Argentina Fil: Castro, Hugo Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Modelado e Innovación Tecnológica. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Instituto de Modelado e Innovación Tecnológica; Argentina Fil: Paz, Rodrigo Rafael. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Livermore Software Technology Corporation.; Estados Unidos Fil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina |
| description |
Both modern humans (MHs) and Neanderthals successfully settled across western Eurasian cold-climate landscapes. Among the many adaptations considered as essential to survival in such landscapes, changes in the nasal morphology and/or function aimed to humidify and warm the air before it reaches the lungs are of key importance. Unfortunately, the lack of soft-tissue evidence in the fossil record turns difficult any comparative study of respiratory performance. Here, we reconstruct the internal nasal cavity of a Neanderthal plus two representatives of climatically divergent MH populations (southwestern Europeans and northeastern Asians). The reconstruction includes mucosa distribution enabling a realistic simulation of the breathing cycle in different climatic conditions via computational fluid dynamics. Striking across-specimens differences in fluid residence times affecting humidification and warming performance at the anterior tract were found under cold/dry climate simulations. Specifically, the Asian model achieves a rapid air conditioning, followed by the Neanderthals, whereas the European model attains a proper conditioning only around the medium-posterior tract. In addition, quantitative-genetic evolutionary analyses of nasal morphology provided signals of stabilizing selection for MH populations, with the removal of Arctic populations turning covariation patterns compatible with evolution by genetic drift. Both results indicate that, departing from important craniofacial differences existing among Neanderthals and MHs, an advantageous species-specific respiratory performance in cold climates may have occurred in both species. Fluid dynamics and evolutionary biology independently provided evidence of nasal evolution, suggesting that adaptive explanations regarding complex functional phenotypes require interdisciplinary approaches aimed to quantify both performance and evolutionary signals on covariation patterns. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017-10 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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http://hdl.handle.net/11336/43909 de Azevedo, Soledad; González, M. F.; Cintas, Celia; Ramallo, Virginia; Quinto Sanchez, Mirsha Emmanuel; et al.; Nasal airflow simulations suggest convergent adaptation in Neanderthals and modern humans; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 114; 47; 10-2017; 12442-12447 0027-8424 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/43909 |
| identifier_str_mv |
de Azevedo, Soledad; González, M. F.; Cintas, Celia; Ramallo, Virginia; Quinto Sanchez, Mirsha Emmanuel; et al.; Nasal airflow simulations suggest convergent adaptation in Neanderthals and modern humans; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 114; 47; 10-2017; 12442-12447 0027-8424 CONICET Digital CONICET |
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eng |
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eng |
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info:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.1703790114 info:eu-repo/semantics/altIdentifier/url/http://www.pnas.org/content/114/47/12442 |
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