Divergent effects of the major mast cell products histamine, tryptase and TNF-alpha on human fibroblast behaviour

Autores
Albrecht, Martín; Frungieri, Monica Beatriz; Kunz, L.; Rämsch, R.; Meineke, V.; Köhn, F.M.; Mayerhofer, Artur
Año de publicación
2005
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fibroblast proliferation is a key process in tissue remodeling and mast cells (MCs) are thought to play a crucial role. Having established that the three major MC products, tryptase, histamine and TNF-alpha (TNF) are normally present in human skin MCs, which are in close proximity to dermal fibroblasts, we studied their individual effects on cell cycle-controlled human dermal fibroblasts (HFFF2). These cells express receptors (H1, PAR2, TNFR1/2) for the major MC mediators, but only tryptase or a PAR2 agonist peptide stimulated proliferation and gene expression. TNF was antimitotic, and histamine, while elevating intracellular Ca2+ levels at high concentrations, did not affect proliferation. We conclude that MC products but also composition and numbers of respective receptors on fibroblasts are crucially responsible for fibroproliferative events. © Birkhäuser Verlag, 2005.
Fil: Albrecht, Martín. Ludwig Maximilians Universitat; Alemania
Fil: Frungieri, Monica Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Ludwig Maximilians Universitat; Alemania
Fil: Kunz, L.. Ludwig Maximilians Universitat; Alemania
Fil: Rämsch, R.. Ludwig Maximilians Universitat; Alemania
Fil: Meineke, V.. Sanitätsakademie der Bundeswehr; Alemania
Fil: Köhn, F.M.. Technical University; Alemania
Fil: Mayerhofer, Artur. Ludwig Maximilians Universitat; Alemania
Materia
Calcium
Histamine
Mast Cell
Proliferation
Tissue Remodeling
Tnf-Alpha
Tryptase
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/78703
Acceder
id CONICETDig_9d8242369dbdb72ae28f05fabe9583b9
oai_identifier_str oai:ri.conicet.gov.ar:11336/78703
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Divergent effects of the major mast cell products histamine, tryptase and TNF-alpha on human fibroblast behaviourAlbrecht, MartínFrungieri, Monica BeatrizKunz, L.Rämsch, R.Meineke, V.Köhn, F.M.Mayerhofer, ArturCalciumHistamineMast CellProliferationTissue RemodelingTnf-AlphaTryptasehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Fibroblast proliferation is a key process in tissue remodeling and mast cells (MCs) are thought to play a crucial role. Having established that the three major MC products, tryptase, histamine and TNF-alpha (TNF) are normally present in human skin MCs, which are in close proximity to dermal fibroblasts, we studied their individual effects on cell cycle-controlled human dermal fibroblasts (HFFF2). These cells express receptors (H1, PAR2, TNFR1/2) for the major MC mediators, but only tryptase or a PAR2 agonist peptide stimulated proliferation and gene expression. TNF was antimitotic, and histamine, while elevating intracellular Ca2+ levels at high concentrations, did not affect proliferation. We conclude that MC products but also composition and numbers of respective receptors on fibroblasts are crucially responsible for fibroproliferative events. © Birkhäuser Verlag, 2005.Fil: Albrecht, Martín. Ludwig Maximilians Universitat; AlemaniaFil: Frungieri, Monica Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Ludwig Maximilians Universitat; AlemaniaFil: Kunz, L.. Ludwig Maximilians Universitat; AlemaniaFil: Rämsch, R.. Ludwig Maximilians Universitat; AlemaniaFil: Meineke, V.. Sanitätsakademie der Bundeswehr; AlemaniaFil: Köhn, F.M.. Technical University; AlemaniaFil: Mayerhofer, Artur. Ludwig Maximilians Universitat; AlemaniaBirkhauser Verlag Ag2005-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/78703Albrecht, Martín; Frungieri, Monica Beatriz; Kunz, L.; Rämsch, R.; Meineke, V.; et al.; Divergent effects of the major mast cell products histamine, tryptase and TNF-alpha on human fibroblast behaviour; Birkhauser Verlag Ag; Cellular and Molecular Life Sciences; 62; 23; 12-2005; 2867-28761420-682XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s00018-005-5289-7info:eu-repo/semantics/altIdentifier/doi/10.1007/s00018-005-5289-7info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:36:21Zoai:ri.conicet.gov.ar:11336/78703instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:36:21.335CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Divergent effects of the major mast cell products histamine, tryptase and TNF-alpha on human fibroblast behaviour
title Divergent effects of the major mast cell products histamine, tryptase and TNF-alpha on human fibroblast behaviour
spellingShingle Divergent effects of the major mast cell products histamine, tryptase and TNF-alpha on human fibroblast behaviour
Albrecht, Martín
Calcium
Histamine
Mast Cell
Proliferation
Tissue Remodeling
Tnf-Alpha
Tryptase
title_short Divergent effects of the major mast cell products histamine, tryptase and TNF-alpha on human fibroblast behaviour
title_full Divergent effects of the major mast cell products histamine, tryptase and TNF-alpha on human fibroblast behaviour
title_fullStr Divergent effects of the major mast cell products histamine, tryptase and TNF-alpha on human fibroblast behaviour
title_full_unstemmed Divergent effects of the major mast cell products histamine, tryptase and TNF-alpha on human fibroblast behaviour
title_sort Divergent effects of the major mast cell products histamine, tryptase and TNF-alpha on human fibroblast behaviour
dc.creator.none.fl_str_mv Albrecht, Martín
Frungieri, Monica Beatriz
Kunz, L.
Rämsch, R.
Meineke, V.
Köhn, F.M.
Mayerhofer, Artur
author Albrecht, Martín
author_facet Albrecht, Martín
Frungieri, Monica Beatriz
Kunz, L.
Rämsch, R.
Meineke, V.
Köhn, F.M.
Mayerhofer, Artur
author_role author
author2 Frungieri, Monica Beatriz
Kunz, L.
Rämsch, R.
Meineke, V.
Köhn, F.M.
Mayerhofer, Artur
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Calcium
Histamine
Mast Cell
Proliferation
Tissue Remodeling
Tnf-Alpha
Tryptase
topic Calcium
Histamine
Mast Cell
Proliferation
Tissue Remodeling
Tnf-Alpha
Tryptase
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Fibroblast proliferation is a key process in tissue remodeling and mast cells (MCs) are thought to play a crucial role. Having established that the three major MC products, tryptase, histamine and TNF-alpha (TNF) are normally present in human skin MCs, which are in close proximity to dermal fibroblasts, we studied their individual effects on cell cycle-controlled human dermal fibroblasts (HFFF2). These cells express receptors (H1, PAR2, TNFR1/2) for the major MC mediators, but only tryptase or a PAR2 agonist peptide stimulated proliferation and gene expression. TNF was antimitotic, and histamine, while elevating intracellular Ca2+ levels at high concentrations, did not affect proliferation. We conclude that MC products but also composition and numbers of respective receptors on fibroblasts are crucially responsible for fibroproliferative events. © Birkhäuser Verlag, 2005.
Fil: Albrecht, Martín. Ludwig Maximilians Universitat; Alemania
Fil: Frungieri, Monica Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Ludwig Maximilians Universitat; Alemania
Fil: Kunz, L.. Ludwig Maximilians Universitat; Alemania
Fil: Rämsch, R.. Ludwig Maximilians Universitat; Alemania
Fil: Meineke, V.. Sanitätsakademie der Bundeswehr; Alemania
Fil: Köhn, F.M.. Technical University; Alemania
Fil: Mayerhofer, Artur. Ludwig Maximilians Universitat; Alemania
description Fibroblast proliferation is a key process in tissue remodeling and mast cells (MCs) are thought to play a crucial role. Having established that the three major MC products, tryptase, histamine and TNF-alpha (TNF) are normally present in human skin MCs, which are in close proximity to dermal fibroblasts, we studied their individual effects on cell cycle-controlled human dermal fibroblasts (HFFF2). These cells express receptors (H1, PAR2, TNFR1/2) for the major MC mediators, but only tryptase or a PAR2 agonist peptide stimulated proliferation and gene expression. TNF was antimitotic, and histamine, while elevating intracellular Ca2+ levels at high concentrations, did not affect proliferation. We conclude that MC products but also composition and numbers of respective receptors on fibroblasts are crucially responsible for fibroproliferative events. © Birkhäuser Verlag, 2005.
publishDate 2005
dc.date.none.fl_str_mv 2005-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/78703
Albrecht, Martín; Frungieri, Monica Beatriz; Kunz, L.; Rämsch, R.; Meineke, V.; et al.; Divergent effects of the major mast cell products histamine, tryptase and TNF-alpha on human fibroblast behaviour; Birkhauser Verlag Ag; Cellular and Molecular Life Sciences; 62; 23; 12-2005; 2867-2876
1420-682X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/78703
identifier_str_mv Albrecht, Martín; Frungieri, Monica Beatriz; Kunz, L.; Rämsch, R.; Meineke, V.; et al.; Divergent effects of the major mast cell products histamine, tryptase and TNF-alpha on human fibroblast behaviour; Birkhauser Verlag Ag; Cellular and Molecular Life Sciences; 62; 23; 12-2005; 2867-2876
1420-682X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s00018-005-5289-7
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00018-005-5289-7
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Birkhauser Verlag Ag
publisher.none.fl_str_mv Birkhauser Verlag Ag
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613139283312640
score 13.070432

Publicaciones similares